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Treatments tend to address the symptoms, since the underlying mechanism of = the disease is not really understood. Medications which are helpful are often t= hose which have immune-modulating characteristics. CFS patients are unusually sensitiv= e to drugs and they usually must take doses that are 1/4 or less than standard doses. = Some drugs will be a big help to some patients and little or no help to others. And dr= ugs that seem to work for a while may stop being effective later. According to studies presented at the October 1994 CFS medical conference, = widely used treatments included: SSRIs ("selective serotonin re-uptake inhibitors"= such as Zoloft, Paxil and Prozac) used to address fatigue, cognitive dysfunction an= d depression; low dose TCAs ("tricyclic anti-depressants" such as doxepin and amitriptyline) for sleep disorder, and muscle and joint pain; and NSAIDs ("non-steroidal anti-inflammatory drugs" such as ibuprofen and naproxen) fo= r headache, and muscle and joint pain. Other treatments often prescribed are = Klonopin, intra-muscular gamma globulin (IMgG), nutritional supplements (particularly anti-oxidants, B-vitamins generally and B-12 specifically), herbs, and acup= uncture. Less often prescribed were chiropractic therapy, intra-muscular gamma globu= lin (IVgG), kutapressin, antivirals, interferon, and transfer factor. Research from Johns Hopkins University in 1995 indicate that treatment for = neurally mediated hypotension may be effective for the many CFS patients who may sho= w positive for that condition.