Top Document: FAQ: CFS FAQ
Previous Document: 1.02 What causes CFS?
Next Document: 1.04 Who gets CFS?
See reader questions & answers on this topic! - Help others by sharing your knowledge
At this early point, many practicing clinicians remain unconvinced that CFS= is a genuine illness, although it is slowly increasing in acceptance. The reluctance is = due in part to the facts that (1) no specific cause has yet been found, (2) there is no observ= able marker that doctors can use to specifically identify the illness, and (3) most doc= tors are not yet familiar with the peer-reviewed research which does tend to legitimize this= disease. Emerging illnesses such as CFS typically go through a period of many years = before they are accepted by the medical community, and during that interim time pa= tients who have these new, unproven illnesses are all too often dismissed as being "ps= ychiatric cases". This has been the experience with CFS as well. But many top-level researchers are showing that this is a distinct, organic= illness. This includes research by Anthony Komaroff (Harvard), Jay Levy (UCSF), Nancy Kli= mas (U. Miami), Andrew Lloyd (U. New South Wales), Stephen Straus (NIH), and ot= hers. Physicians and scientists may find the following citations of interest: Levine P; et al. "CFS: Current Concepts" (proceedings of the Oct. 1992 CFS = medical conference), Vol. 18 Suppl. 1, January 1994, Clinical Infectious Diseases. Klimas N; Salvato F; Morgan R; Fletcher M; "Immunologic abnormalities in ch= ronic fatigue syndrome". J of Clinical Microbiology 28:1403-1410 (June 90) [Study= showing that NK cells (a kind of immune cell) malfunction in CFS patients; other ab= normalities] Buchwald D; Komaroff A; Cheney P; et al.; "A chronic illness characterized = by fatigue, neurologic and immunologic disorders and HHV-6 infection". Ann Int Med 116:103-112 (Jan 1992) [Study showing many CFS patients have HHV-6 infectio= ns] Demitrack M; Dale J; Straus S; et al.; "Evidence for Impaired Activation of= the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndro= me". J of Clinical Endocrinology & Metabolism 73:1224-34 (Dec 1991) [shows chemical abnormalities in the brains of CFS patients] Straus S; Strober W; Dale J; Fritz S; Gould B; "Lymphocyte Phenotype and Fu= nction in the Chronic Fatigue Syndrome". J of Clinical Immunology 13:30-40 (Jan 93= ) [Study showing T4 cell (a type of immune cell) abnormalities in CFS patients] Lusso P; Malnati M; Garzino-Demo; Crowley; Long; Gallo; "Infection of natur= al killer cells by human herpesvirus 6". Nature 362:458-462 (April 1 1993) [HHV-6 -- previously found in CFS patients -- now shown to kill NK cells (a type of i= mmune cell) -- a small but important advance in research] Schwartz R, Komaroff A, Garada B, Gleit M, Doolittle T, Bates D, Vasile R, = Holman B. "SPECT Imaging of the Brain: Comparison of Findings in Patients with Chr= onic Fatigue Syndrome, AIDS Dementia Complex, and Major Unipolar Depression" AJR 1994:162:943-951. Schwartz R, Garada B, Komaroff A, Tice H, Gleit M, Jolesz F, Holman B. "Det= ection of Intercranial Abnormalities in Patients with Chronic Fatigue Syndrome: Co= mparison of MR Imaging and SPECT" AJR 1994:162:935-941. Rowe, P; Bou-Holaigah, I; Kan, J; Calkins, H;. "Is Neurally Mediated Hypote= nsion an Unrecognized Cause of Chronic Fatigue?". Lancet 345:623-624 (March 11, 1995= ). Bou-Holaigah, I; Rowe, P; Kan, J; Calkins, H. "The Relationship Between Neu= rally Mediated Hypotension and the Chronic Fatigue Syndrome". JAMA, Sept. 27, 199= 5 274:12:961-7. Suhadolnik RJ, Peterson DL, O'Brien K, Cheney PR, et al. Biochemical Eviden= ce for a Novel Low Molecular Weight 2-5A-Dependent RNase L in Chronic Fatigue Syndrome. Journal of Interferon and Cytokine Research, July 1997, 17:377-38= 5.=20