Patent application title: COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELLS BASED ON PEPTIDE BINDING
Inventors:
Renata Pasqualini (Houston, TX, US)
Renata Pasqualini (Houston, TX, US)
Wadih Arap (Houston, TX, US)
Mikhail Kolonin (Houston, TX, US)
IPC8 Class: AA61K3808FI
USPC Class:
514 193
Class name: Peptide (e.g., protein, etc.) containing doai neoplastic condition affecting cancer
Publication date: 2010-11-25
Patent application number: 20100298233
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Patent application title: COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELLS BASED ON PEPTIDE BINDING
Inventors:
Renata Pasqualini
Wadih Arap
Mikhail Kolonin
Agents:
FULBRIGHT & JAWORSKI L.L.P.
Assignees:
Origin: AUSTIN, TX US
IPC8 Class: AA61K3808FI
USPC Class:
Publication date: 11/25/2010
Patent application number: 20100298233
Abstract:
Methods and compositions are described for classifying cells and/or
peptides that associate or bind with a particular characteristic pattern
to a plurality of cells or cell lines. Aspects of the invention also
include the use of peptide(s) having an appropriate binding
characteristic to deliver a drug to a cell or cell population.Claims:
1. A method of profiling cell lines comprising:a) providing a plurality of
cell lines;b) contacting each cell line with a library of phage
displaying random heterologous peptides on their surface;c) obtaining
phage that bind each of the cell lines;d) identifying peptides that bind
each cell line; ande) classifying each cell line based on the identified
peptides.
2. The method of claim 1, further comprising classifying each identified peptide based on the cell lines that bind each identified peptide.
3. The method of claim 1, wherein the panel includes cancer cell lines.
4. The method of claim 3, wherein the cancer cell lines include kidney, breast, colon, lung, prostate, brain, liver, pancreatic, uterine, neuronal, skin, head and neck, leukemic, lymphocytic, or ovarian cancer cell lines.
5. The method of claim 3, wherein the panel is cancer cell lines.
6. The method of claim 5, wherein the panel is a NCI 60 panel of cancer cell lines.
7. The method of claim 3, further comprising identifying a peptide that binds to a majority of the cancer cell lines or cancer cells of common origin.
8. The method of claim 1, further comprising analyzing the identified peptides to identify similarities with known receptor ligands.
9. The method of claim 1, wherein classifying the cell line is performed by clustering analysis.
10. The method of claim 9, wherein the clustering analysis is used to construct a clustered image map.
11. The method of claim 2, wherein classifying the identified peptide is performed by clustering analysis.
12. The method of claim 11, wherein the clustering analysis is used to construct a clustered image map.
13. The method of claim 1, further comprising identifying receptors for at least one of the identified peptides comprising the steps of:a) providing an identified peptide;b) labeling the identified peptide;c) contacting an appropriate cell line with the labeled peptide;d) isolating a receptor-peptide complex; ande) identifying the receptor bound to the labeled peptide.
14. A group of peptides comprising five or more peptides that selectively bind to a sub-population of cell lines, wherein the peptides comprise those listed in Table 3.
15. A method of classifying a cell or cell line comprising:a) contacting the cell with a group of selected peptides or polypeptides that differentially bind cells of a known origin;b) detecting the peptides or polypeptides that bind the cell line; andc) assessing the classification of the cell or cell line based on the peptide(s) that bind the cell.
16. The method of claim 15, wherein the selected peptides or polypeptides are phage particles.
17. The method of claim 15, wherein the selected peptides or polypeptides are labeled.
18. The method of claim 175, wherein the selected peptides or polypeptides are labeled with a fluorophor, an enzyme or a radioisotope.
19. The method of claim 15, wherein the group of selected peptides or polypeptides comprise at least 3 different peptides or polypeptides.
20. The method of claim 15, wherein the selected peptides or polypeptides comprise are cyclic.
21. The method of claim 15, wherein the selected peptides or polypeptides comprise at least 3 of the amino acid sequences from Table 3.
22. The method of claim 15, wherein the cell or cell line is a cancer cell or cancer cell line.
23. The method of claim 15, wherein classifying a cell comprises determineing the tissue origin of the cell or whether the cell expresses a particaulr receptor.
24. The method of claim 15, wherein classifying a cell comprises determineing wether the cell is resistant to an anti cancer therapy.
25. The method of claim 15, wherein the selected peptides or polypeptides differentially bind to a panel of cells of a known origin.
26. A method of classifying a peptide comprising:a) contacting a plurality of cell lines with a library of peptides that differentially bind the cells;b) detecting the peptides that bind the cell line; andc) classifying the peptides based on the cells that bind the peptide.
27. An EphA5 receptor targeting peptide comprising a peptide sequence of CSGIGSGGC or CRFESSGGC.
28. The peptide of claim 27, wherein the peptide is cyclic.
29. The peptide of claim 27, further comprising a therapeutic.
30. The peptide of claim 29, wherein the therapeutic is a small molecule or a therapeutic polypeptide.
31. The peptide of claim 27, further comprising an imaging agent.
Description:
[0001]This application claims the benefit of U.S. Provisional Patent
Application No. 60/780,893, filed on Mar. 9, 2006.
TECHNICAL FIELD
[0003]The present invention is directed generally to method and compositions related to molecular biology, virology, and oncology. In certain aspects it is directed to compositions comprising and methods of profiling and/or classifying a plurality of cells or cell lines based on peptide binding characteristics.
BRIEF SUMMARY OF THE INVENTION
[0004]An embodiment of the invention includes methods of profiling cell lines and/or identifying peptide sequences or structures that bind a target population or family of cells. The methods include providing a plurality of cell lines; contacting each cell line with a library of phage displaying random heterologous peptides on their surface; obtaining phage that bind each of the cell lines; identifying peptides that bind each cell line; and classifying each cell line based on the identified peptides. The method can further comprise classifying each identified peptide based on the cell lines that bind each identified peptide. In one aspect, the cell lines include cancer cell lines. Cancer cell lines may include, but are not limited to kidney, breast, colon, lung, prostate, brain, liver, pancreatic, uterine, neuronal, skin, head and neck, leukemic, lymphocytic, or ovarian cancer cell lines. In another aspect, the panel is cancer cell lines. In a particular aspect, the panel is a NCI 60 panel of cancer cell lines. The methods further include identifying a peptide that binds to a majority of the cancer cell lines or cancer cells of common origin. Furthermore, methods can also include analyzing the identified peptides to identify similarities with known receptor ligands.
[0005]In certain aspects, classifying the cell line is performed by clustering analysis. Clustering analysis can be used to construct a clustered image map (CIM). In a particular aspect, classifying the identified peptide is performed by clustering analysis. Clustering analysis can be used to construct a clustered image map. In another aspect, the methods may also include identifying receptors for at least one of the identified peptides comprising the steps of providing an identified peptide; labeling the identified peptide; contacting an appropriate cell line with the labeled peptide; isolating a receptor-peptide complex; and identifying the receptor bound to the labeled peptide.
[0006]In another embodiment, a group of peptides comprising five or more peptides can be classified or identified as selectively bind to a sub-population of cell lines, wherein the peptides include, but are not limited to those listed in Table 3 and described herein. In certain aspects, a sub sequence of the peptide may be identified as conferring to the peptide a certain binding characteristic.
[0007]In still further embodiments, methods of the invention can be used to classify a cell or cell line. Methods of classifying a cell line include, but are not limited to steps comprising: contacting a cell with a group of selected peptides or polypeptides that differentially bind cells of a known origin; detecting the peptides that bind the cell line; and assessing the classification of the cell line based on the peptide(s) that bind the cell line. Thus, in certain aspects, classifying a cell may comprise determining whether as cell expresses a certain receptor polypeptide, is susceptible to a particular therapy or determining the tissue of origin for the cell. In certain aspects of the invention, a group of selected peptide for use according to the invention are further defined as cyclic or partially peptides, such as peptides comprising a disulfide bond. In certain cases, a group of selected peptides or polypeptides may comprise at least 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30 or more distinct peptides or polypeptides.
[0008]Thus, in a further specific embodiment there is provided a method for classifying a cell comprising obtaining or having a sample comprising a cell; contacting the cell with a group of peptides or polypeptides that differentially bind cells of a known origin or type; detecting the peptides that bind to the cell and classifying the cell based on the peptide binding. As described supra, in certain aspects, a group of selected peptides or polypeptides comprise amino acid sequences selected from those provided in Table 3. Thus, in certain cases a group of selected peptides or polypeptides comprise 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30 or more members that comprising an amino acid sequence according to Table 3. The skilled artisan will recognize that selected peptide or polypeptides of the invention may in some aspects be labeled for example with an enzyme, a fluorophor or a radio isotope.
[0009]In some aspects, a selected peptide or polypeptide may be a cyclic or partially polypeptide such as a peptide or polypeptide comprising a disulfide bond. In some preffered aspects, the cyclic region of a peptide or polypeptide comprises 5, 6, 7, 8, 9, 10 or more amino acids. For example, in certain aspects, a selected peptide or polypeptide comprises an amino acid sequence provided in Table 3 wherein the given amino acid sequence is comprised in the cyclic region of the polypeptide. Thus, it is contemplated that a selected peptide or polypeptide may comprise an amino acid sequence of Table 3 wherein the sequence is flanked by cysteine residues such that the cysteine residues may be linked by a disulfide bond.
[0010]In some aspects of the invention a method for classifying a cell according to the invention may comprise comparing the binding profile of a group of selected peptides or polypeptides to a cell to a similar binding profile from a cell with a known classification. Such a comparison may be performed directly or may performed by consulting a chart or database of binding profiles. For example, a chart or database of binding profiles may comprise binding profiles from cells of 5, 10, 15, 20, 25 or more different classifications. In certain aspects, a chart or database of binding profiles may comprise clustering analysis of the binding of selected peptides or polypeptide to cells of different classification. Thus, in some cases a chart or database of binding profiles may comprise a clustered image map (CIM). Thus, classifying a cell may be performed by for example clustering analysis.
[0011]In still further aspects of the invention there is provided a method for treating a subject comprising obtaining or having a sample from the subject comprising a cell; classifying the cell (e.g., by the methods described supra); and treating the subject with a therapeutic based upon the classification of the cell. For example, in some cases a subject may be defined as a cancer patient. In this case a cancer cell from the subject may be classified. Classification of the cell may for example comprising determining the tissue of origin, receptor status or susceptibility of the cell to particular anticancer therapy. Thus, based upon the classification of the cell the subject may be treated with an appropriate anticancer therapy. For example, methods of the invention may be used to classify a cell as susceptible or resistant to radiation therapy, immunotherapy, surgical therapy or chemotherapy. Furthermore, methods of the invention may be used to classify the cell as susceptible or resistant to a particular chemotherapeutic agent or class of chemotherapeutic agents. Thus, methods of the invention may involve classifying a cancer cell from a subject as susceptible or resistant to an anticancer therapy and treating the subject with one or more anticancer therapies that the cell is susceptible to.
[0012]In certain aspects the invention concerns obtaining or having a sample such as a cell. It is contemplated that in cases where a sample is from a subject the sample may be directly obtained or may be obtained by a third party and subsequently subjected to methods described herein. Furthermore, in certain aspects it is contemplated that methods of the invention may be defined as a method for aiding in the therapy of a subject comprising classify a cell from the subject (e.g., as having certain protein receptor expression or being from a tissue of a particular origin) and providing the classification information to a third party such as a medical professional to aid in the therapy of the subject.
[0013]In yet another embodiment of the invention includes a method of classifying a peptide(s). Methods of peptide classification include, but are not limited to steps comprising: contacting a plurality of cell lines with a library of peptides that differentially bind the cells; detecting the peptides that bind the cell line; and classifying the peptides based on the cells that bind the peptide.
[0014]In certain aspects an EphA5 receptor can be targeted by using a composition comprising a peptide sequence of CSGIGSGGC (SEQ ID NO:2) or CRFESSGGC (SEQ ID NO:3). The skilled artisan will further recognize that in certain aspects a peptide targeting sequence of the invention is cyclic. Thus, there is provided EphA5 receptor targeting composition comprising a cyclic polypeptide wherein the cyclic polypeptide comprises the amino acid sequence SGIGSGG (SEQ ID NO:4) or RFESSGG (SEQ ID NO:5). As exemplified herein in certain aspects an cyclic EphA5 targeting composition may comprise a peptide sequence according to SEQ ID NO:4 or SEQ ID NO:5 flanked by cysteine residues thereby forming a cyclic targeting agent via disulfide bonds between the cysteine residues. As used herein the termed flanked means that the indicated amino acid sequence are between two cysteine residues however it is contemplated that in some cases additional amino acids may also be comprised between the two cysteine residues.
[0015]A composition of the invention can be coupled (either non-covalently or covalently, or indirectly via an intermediate such as a liposome or directly) to a therapeutic or imaging agent. The therapeutic can include, but is not limited to a small molecule, a drug, or a therapeutic peptide. For example, in certain aspects, a therapeutic composition of the invention comprises a polypeptide. In these aspects the therapeutic Eph5A receptor targeting composition may comprise a fusion protein. Thus, in some very specific cases the therapeutic polypeptide may be a toxin or other cytotoxic molecule capable of inducing cell death in Eph5A receptor expressing cells. Imaging agents for use in the invention include but are not limited to MRI contrast agents, radio isotopes, fluorophors and mass tags (e.g., for detection via mass spectrometry).
[0016]In certain aspects there is provided an EphA5 receptor agonist comprising the amino acid sequence SGIGSGG (SEQ ID NO:4) or RFESSGG (SEQ ID NO:5). As described above in some cases the EphA5 receptor agonist is a cyclic peptide or polypeptide wherein the cyclic region comprises the amino acid sequence of SEQ ID NO:4 or SEQ ID NO:5. Thus, in some case the agonist is a cyclic peptide or polypeptide comprising a disulfide bond such as a peptide or polypeptide wherein the amino acid sequence of SEQ ID NO:4 or SEQ ID NO:5 are flanked by cysteine residues (e.g., as in SEQ ID NO:2 or SEQ ID NO:3).
[0017]Thus, in still further aspects of the invention there is provided a method for treating an Eph5A receptor positive cell comprising administering to the cell an EphA5 receptor targeting therapeutic as described supra. Thus, in some aspects a method of the invention may be further defined as a methods for treating a subject comprising an EphA5 receptor positive cell by administering an effective amount of an EphA5 receptor targeting therapeutic. For example, in certain cases a subject may be a cancer patient comprising an EphA5 receptor positive positive cancer such as a lung cancer or neuronal cancer. In still further aspects there is provided a method for treating a subject with a an EphA5 receptor positive cancer by administering an EphA5 receptor targeting therapeutic wherein the therapeutic comprising a cytotoxic agent or an anticancer agent.
[0018]The use of the word "a" or "an" when used in conjunction with the term "comprising" in the claims and/or the specification may mean "one," but it is also consistent with the meaning of "one or more," "at least one," and "one or more than one."
[0019]The use of the term "or" in the claims is used to mean "and/or" unless explicitly indicated to refer to alternatives only or the alternative are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and "and/or."
[0020]Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this
BRIEF DESCRIPTION OF THE DRAWINGS
[0021]For a more complete understanding of the present invention, reference is now made to the following descriptions taken in conjunction with the accompanying drawing, in which:
[0022]FIG. 1: Selectivity of broad-specificity tripeptides for clusters of NCI-60 cell lines. Two-dimensional hierarchical clustering was applied to the frequencies of 38 tripeptides (rows) encountered in CX7C peptides selected on NCI-60 cell lines (columns). Tripeptides selected on all but one cell line of common origin were clustered based on their correlations with cell lines; cell lines were clustered based on their correlations with the tripeptides. Tripeptide frequencies were mean subtracted and average linkage clustered with correlation metric. Amino acid color code: red, hydrophobic; green, neutral and polar; purple, basic. The color in each CIM segment ranges from blue (negative correlation) to red (positive correlation), as indicated by the scale bar. Cell lines are color-coded based on previously defined histologic tumor origin (Monks et al., 1991, Weinstein et al., 1997. Bars underneath dendrogram, clusters of cells of similar tumor tissue origin (one exception allowed). Boxed, cluster of lung cancer-derived cell lines and associated/dissociated tripeptides.
[0023]FIGS. 2A-B: Identification of peptides mimicking EGFR ligands. FIG. 2A, EGFR-binding peptide sequences isolated from the SKOV-3 selected phage pool were matched in each orientation to protein sequences of biological human EGFR ligands (leader peptide sequence underlined). Matches displayed are peptides with three or more amino acids being identical (red) and one or more being from the same class (green) as the correspondingly positioned protein amino acids. Tripeptides listed in Table 1 (yellow). FIG. 2B, isolation of peptides targeting EGFR. Binding of SKOV3-selected phage pool to immobilized EGFR compared with BSA in rounds 1 and 2 of biopanning of SKOV3-selected phage pool on immobilized human EGFR.
[0024]FIGS. 3A-3B: Phage selection on immobilized EphA5 receptor. FIG. 3A, Ephrin-mimic phage displaying the enriched motif GGS were selected on EphA5-coated microtiter wells. Phage showing specific binding to EphA5 was analyzed for its distinctive binding to EphA5 compared to EphA4 receptor (FIG. 3B). BSA and fd-tet insertless phage were used as negative controls.
[0025]FIG. 4: EphA5 receptor expression in the NCI-60. From microarray analysis reported at dtp.nci.nih.gov/mtweb/servlet/moltidsearch?moltid=MT894.
[0026]FIG. 5: EphA5 and EphA4 receptor expression by the lung cancer cell lines Hop92 and H460. The OVCAR3 cell line was used as negative control. 10× magnification.
[0027]FIG. 6: Specific binding of the CSGIGSGGC (SEQ ID NO:2) and CRFESSGGC (SEQ ID NO:3)-phage to lung cancer cells Hop92 and H460 but not to the ovarian cancer cell line OVCAR-3. Insertless phage (fd-tet) was used as negative control.
[0028]FIGS. 7A-B: A. Clustered image map relating all isolated NCI-60-binding tripeptides to NCI-60 cell lines. FIG. 7A, Two-dimensional hierarchical clustering was applied to the frequencies of 3,280 unique tripeptides (rows) found in cell-binding CX7C peptides selected on the NCI-60 cells (columns). Tripeptides were clustered based on their correlations with cell lines; cell lines were clustered based on their correlations with tripeptides. Tripeptide frequencies were mean-subtracted and average-linkage clustered with correlation metric (the data were transformed to the mean of 0; variance of 1). The color in each CIM segment ranges from blue (high negative correlation) to red (high positive correlation), as indicated by the scale bar. Cell lines are color-coded based on previously defined histological tumor origin. FIG. 7B, A control two-dimensional hierarchical clustering applied under the Poisson assumption to 3,280 randomly simulated tripeptide frequencies (rows) showed no obvious pattern, thus indicating that clusters in A were not generated at random.
[0029]FIG. 8: Targeted peptides mediate ligand-receptor cell internalization. CSGIGSGGC (SEQ ID NO:2) and CRFESSGGC (SEQ ID NO:3)-phage were permeabilized into A549 cells. No internalization was observed when cells were incubated with insertless phage
[0030]FIG. 9A-B: Biological effects of the peptides CSGIGSGGC (SEQ ID NO:2) and CRFESSGGC (SEQ ID NO:3 on lung cancer cells. Promotion of cell survival and proliferative response of starved lung cancer cells to the ephrin mimic peptides, control peptide and complete culture medium (A549 (FIG. 9A), H460 cells (FIG. 9B)). Concentrations of peptide were optimized. Values in the Y-axis correspond to the number of viable cells under each experimental condition evaluated after a 72 h incubation period. Data bars represent the mean and corresponding standard error of the mean.
DETAILED DESCRIPTION OF THE INVENTION
[0031]A collection of 60 cell lines derived from human tumors (NCI-60) has been widely explored as a tool for anticancer drug discovery. In one aspect of the invention, the cell surface of the NCI-60 was profiled by high-throughput screening of a phage-displayed random peptide library and classified the cell lines according to the binding selectivity of 26,031 recovered tripeptide motifs. By analyzing selected cell-homing peptide motifs and their NCI-60 recognition patterns, the inventors established that some of these motifs (a) are similar to domains of human proteins known as ligands for tumor cell receptors and (b) segregate among the NCI-60 in a pattern correlating with expression profiles of the corresponding receptors. The inventors biochemically validated some of the motifs as mimic peptides of native ligands for the epidermal growth factor receptor. The results indicate that ligand-directed profiling of tumor cell lines can select functional peptides from combinatorial libraries based on the expression of tumor cell surface molecules, which in turn could be exploited as "druggable" receptors in specific types of cancer (Kolonin et al., 2006).
[0032]The National Cancer Institute panel of human cancer cell lines from different histologic origins and grades (NCI-60) has been extensively used to screen compounds for anticancer activity (Monks et al., 1991; Weinstein et al., 1997). The NCI-60 includes carcinomas of several origins (kidney, breast, colon, lung, prostate, and ovarian), tumors of the central nervous system, malignant melanomas, leukemias, and lymphomas. Gene expression determined by high-throughput microarrays has been used to survey the variation in abundance of thousands of distinct transcripts in the NCI-60; such data provided functional insights about the corresponding gene products in tumor cell transformation (Weinstein et al., 1997; Scherf et al., 2000; Nishizuka et al., 2003). This information-intensive genomic approach has yielded candidate diagnostic tumor markers to be validated at the protein level in prospective studies (Nishizuka et al., 2003). Moreover, systematic proteomic studies based on two-dimensional PAGE (Myers et al., 1997) and protein microarrays (Nishizuka et al., 2003) have also been implemented. Finally, in parallel with the NCI-60 transcriptome and proteome initiatives, pharmacologic sensitivity of the cells to >105 different chemical compounds has been registered (Monks et al., 1991; Weinstein et al., 1997). Indeed, for some genes, correlation of expression data to drug sensitivity profiles has uncovered the mechanistic basis for the drug activity (Scherf et al., 2000; Zaharevitz et al., 2002; Blower et al., 2002; Rabow et al., 2002; Wallqvist et al., 2002; Szakacs et al., 2004). Thus, conventional genomic and proteomic approaches have identified several potential tumor markers and drug targets. However, despite such advances, correlation between drug activity and gene expression profiles has not as yet been established for most of the compounds tested (Wallqvist et al., 2002; Brown, 1997; Walloyist et al., 2003). This suggests the likely existence of unknown factors and the need to develop alternative methodology to discover "druggable" molecular targets.
[0033]Over the past few years, it has been proposed that (a) characterization of molecular diversity at the tumor cell surface level (represented primarily by membrane-associated proteins that are often modified by lipids and carbohydrates) is required for the development of ligand-directed anticancer therapies, and that (Zaharevitz et al., 2002) peptides binding to surface receptors preferentially expressed on tumor cells may be used to ligand-direct therapeutics to sites of disease with potential for increased therapeutic windows (Arap et al., 1998; Kolonin et al., 2001). It has become increasingly clear that selective cell surface features can be mapped by screening libraries of peptides (Kolonin et al., 2001; Pasqualini and Ruoslahti, 1996; Giordano et al., 2001; Arap et al., 2002). In fact, combinatorial peptide libraries displayed from pIII protein of an M13-derived phage have now been successfully screened on intact cells and in vivo (Arap et al., 1998; Kolonin et al., 2001; Pasqualini and Ruoslahti, 1996). Peptide ligands selected from unbiased screens without any predetermined notions about the nature of the cellular receptor repertoire have been used for the subsequent identification of the corresponding target cell surface receptors (Giordano et al., 2001; Arap et al., 2002; Pasqualini et al., 2000; Kolonin et al., 2002; Kolonin et al., 2004; Pasqualini et al., 2001). In addition, novel techniques, such as the biopanning and rapid analysis of selective interactive ligands (BRASIL), have enabled high-throughput phage library screening on cells (Giordano et al., 2001). Here, the BRASIL method is used to systematically screen combinatorial libraries on tumor cells of the NCI-60 panel. Results of this feasibility study suggest that tumor cells can be grouped by profiles of their peptide ligands directed to differentially expressed cell surface receptors. The data support the notion that many tumor cell surface-exposed receptors are expressed irrespective of tumor origin, thus suggesting they could be developed as broad tumor targets. Integration of ligand-directed surface profiling with other approaches related to the NCI-60 may uncover functional ligand-receptor pairs for the targeted drug delivery.
I. Cell Targeting Molecules
[0034]Modified cell targeting molecules of the present invention may be produced by chemical synthetic methods, by chemical linkage between the two moieties or in some cases by fusion of a second polypeptide coding sequence to the targeting moiety. It is contemplated that modified cell targeting molecules of the invention may be used as therapeutics and/or as imaging agents to target specific classes of cells.
[0035]As mentioned above, in certain aspects of the invention, a modified cell targeting moiety may comprise a second polypeptide wherein the two polypeptides together comprise a fusion protein. For example, in certain aspects the second polypeptide may be a therapeutic or cytotoxic (e.g., a toxin) polypeptide as exemplified below. A fusion of two polypeptide coding sequences can be achieved by methods well known in the art of molecular biology. It is preferred that a fusion polynucleotide contain only the AUG translation initiation codon at the 5' end of the first coding sequence without the initiation codon of the second coding sequence to avoid the production of two separate encoded products. In addition, a leader sequence may be placed at the 5' end of the polynucleotide in order to target the expressed product to a specific site or compartment within a host cell to facilitate secretion or subsequent purification after gene expression. The two coding sequences can be fused directly without any linker or by using a flexible polylinker.
A. Cell Targeting Moieties
[0036]Cell targeting moities as provided here may, in some aspects, comprise peptides or polypeptides that exhibit binding to a specific class of cells. For example, in some cases the cell targeting moiety is selected from one of the polypeptide sequences provided in Table 3. The skilled artisan will understand that such sequences may comprise additional amino acids or other covalent modifications. For instance, in preferred embodiments a polypeptide sequence from Table 3 is provided a cyclic polypeptide. Thus, in some specific examples, an amino acid sequence from Table 3 is flanked by cysteine residues that may form a disulfide bond thereby providing a cyclic polypeptide. Thus, in some aspects the invention provides compositions and methods for targeting any of the classes of cells that bind to the peptides and polypeptides provided herein (e.g., as indicated in Table 3) such as leukemia cells, lung cancer cells, colon cancer cells, CNS cancer cells, melanoma cells, ovarian cancer cells, prostate cancer cells, renal cancer cells or breast cancer cells.
B. Therapeutic Moieties
[0037]As mentioned above in certain aspects, a therapeutic moiety may be a toxin such as radioisotopes, holotoxins, modified toxins, catalytic subunits of toxins, cytotoxins (cytotoxic agents), or any molecules or enzymes not normally present in or on the surface of a cell that under defined conditions cause the cell's death. Toxins that may be used according to the methods of the invention include, but are not limited to, radioisotopes known in the art, compounds such as, for example, antibodies (or complement fixing containing portions thereof) that bind an inherent or induced endogenous cytotoxic effector system, thymidine kinase, endonuclease, RNAse, alpha toxin, ricin, abrin, Pseudomonas exotoxin A, diphtheria toxin, saporin, momordin, gelonin, pokeweed antiviral protein, alpha-sarcin and cholera toxin. "Toxin" also includes a cytostatic or cytocidal agent, a therapeutic agent or a radioactive metal ion, e.g., alpha-emitters such as, for example, 213Bi, or other radioisotopes such as, for example, 103Pd, 133Xe, 131I, 68Ge, 57Co, 65Zn, 85Sr, 32P, 35S, 90Y, 153Sm, 153Gd, 169Yb, 51Cr, 54Mn, 75Se, 113Sn, 90Yttrium, 117Tin, 186Rhenium, 166Holmium, and 188Rhenium; luminescent labels, such as luminol; and fluorescent labels, such as fluorescein and rhodamine, and biotin. Furthermore, a therapeutic moiety may be a pro-apoptotic protein such as a BCL2 family member, a caspase or a granzyme.
II. Cancer Therapies
[0038]A variety of conventional cancer therapies are currently used in the treatment of cancer. Thus, in some aspects of the invention there are provided methods for classifying cancer cells such as cells that are sensitive or resistant to an anticancer therapy. Some examples of conventional cancer therapies discussed below. It is contemplated that methods according to the invention may be used to identify cells that are sensitive or resistant to any particular cancer treatment. Furthermore, some aspects of the invention concern compositions and methods for cell targeted anticancer therapy. Thus, it is contemplated that any anticancer method known to those in the art (as exemplified below) may be used in combination or conjunction with compositions and methods provided herein.
[0039]A. Chemotherapy
[0040]Cancer therapies also include a variety of combination therapies with both chemical and radiation based treatments. Combination chemotherapies include, for example, cisplatin (CDDP), carboplatin, procarbazine, mechlorethamine, cyclophosphamide, camptothecin, ifosfamide, melphalan, chlorambucil, busulfan, nitrosurea, dactinomycin, daunorubicin, doxorubicin, bleomycin, plicomycin, mitomycin, etoposide (VP 16), tamoxifen, raloxifene, estrogen receptor binding agents, taxol, gemcitabien, navelbine, farnesyl-protein tansferase inhibitors, transplatinum, 5-fluorouracil, vincristin, vinblastin and methotrexate, or any analog or derivative variant of the foregoing.
[0041]B. Radiotherapy
[0042]Other factors that cause DNA damage and have been used extensively include what are commonly known as γ-rays, X-rays, and/or the directed delivery of radioisotopes to tumor cells. Other forms of DNA damaging factors are also contemplated such as microwaves and UV-irradiation. It is most likely that all of these factors effect a broad range of damage on DNA, on the precursors of DNA, on the replication and repair of DNA, and on the assembly and maintenance of chromosomes. Dosage ranges for X-rays range from daily doses of 50 to 200 roentgens for prolonged periods of time (3 to 4 wk), to single doses of 2000 to 6000 roentgens. Dosage ranges for radioisotopes vary widely, and depend on the half-life of the isotope, the strength and type of radiation emitted, and the uptake by the neoplastic cells.
[0043]The terms "contacted" and "exposed," when applied to a cell, are used herein to describe the process by which a therapeutic construct and a chemotherapeutic or radiotherapeutic agent are delivered to a target cell or are placed in direct juxtaposition with the target cell. To achieve cell killing or stasis, both agents are delivered to a cell in a combined amount effective to kill the cell or prevent it from dividing.
[0044]C. Immunotherapy
[0045]Immunotherapeutics, generally, rely on the use of immune effector cells and molecules to target and destroy cancer cells. The immune effector may be, for example, an antibody specific for some marker on the surface of a tumor cell. The antibody alone may serve as an effector of therapy or it may recruit other cells to actually effect cell killing. The antibody also may be conjugated to a drug or toxin (chemotherapeutic, radionuclide, ricin A chain, cholera toxin, pertussis toxin, etc.) and serve merely as a targeting agent. Alternatively, the effector may be a lymphocyte carrying a surface molecule that interacts, either directly or indirectly, with a tumor cell target. Various effector cells include cytotoxic T cells and NK cells.
[0046]Immunotherapy, thus, could be used as part of a combined therapy, in conjunction with gene therapy. The general approach for combined therapy is discussed below. Generally, the tumor cell must bear some marker that is amenable to targeting, i.e., is not present on the majority of other cells. Many tumor markers exist and any of these may be suitable for targeting in the context of the present invention. Common tumor markers include carcinoembryonic antigen, prostate specific antigen, urinary tumor associated antigen, fetal antigen, tyrosinase (p97), gp68, TAG-72, HMFG, Sialyl Lewis Antigen, MucA, MucB, PLAP, estrogen receptor, laminin receptor, erb B and p155.
III. Examples
Example 1
Combinatorial Library Screening on Cells
[0047]All the NCI-60 cell lines (1), except MDA-N (unavailable), were grown in RPMI 1640 supplemented with 5% fetal bovine serum (FBS) and 5 mmol/L L-glutamine. A phage display random peptide library based on the vector fUSES displaying the insert CX7C (SEQ ID NO:1) was screened by using BRASIL as described (Giordano et al., 2001). Exponentially growing cells were harvested with 0.5 mmol/L EDTA, 0.4 g/L KCl, 8 g/L NaCl, and 1 g/L dextrose, washed once with phosphate buffer saline (PBS), and resuspended in RPMI containing 1% bovine serum albumin (BSA) and 1 mmol/L HEPES. Cells (˜106) were incubated for 2 hours on ice with 109 transduction units (T.U.) of CX7C phage in 200-μL suspension, transferred to the top of a nonmiscible organic lower phase (dibutyl phtalate/cyclohexane, 9:1), and centrifuged at 10,000×g for 10 minutes. The phage-bound cell pellet was incubated with 200 μL of K91 bacterial culture, and the bound phages were amplified and used in the following round. To prevent preferential isolation of peptides containing the RGD motif, which is selected on tissue-cultured cells due to expression of cell adhesion molecules binding to vitronectin, library screening was done in the presence of 1 mg/mL of the synthetic peptide RGD-4C (AnaSpec, San Diego, Calif.) in each round. After three rounds of selection, phage peptide-encoding inserts were sequenced as described (Pasqualini and Ruoslahti, 1996; Arap et al., 2002; Pasqualini et al., 2001).
Example 2
Hierarchical Cluster Analysis of Peptide Motif/Cell Line Association
[0048]The inventors created an interactive sequence management database of all peptide sequences isolated in the screen. Calculation of tripeptide motif frequencies in CX7C peptides (in both directions) was done by using a character pattern recognition program based on SAS (version 8.1.2, SAS Institute, Cary, N.C.) and Perl (version 5.6.1) as described (Arap et al., 2002). To identify the most closely related tripeptides and cell lines, clustered image maps (CIM) were generated by using online software ClMminer available at discover.nci.nih.gov/tools.jsp. Data were centered (mean subtracted and divided by SD) on both cell lines and tripeptide motifs; correlation coefficient metric with average linkage algorithm was used as distance measurement. The tripeptide motif frequencies across the NCI-60 cell lines formed a two-dimensional data matrix that was used to correlate motif enrichment with groups of cell lines. To evaluate whether CIMMiner algorithm is appropriate for clustering analysis of peptide frequency data, a simulation test was devised assuming that the frequencies of tripeptide motifs in a given data set follow an independent Poisson distribution. The inventors simulated a random 3,280×59 data matrix of the dimension identical to that of tripeptide motif frequency data matrix (corresponding to the set of 3,280 tripeptides and 59 cell lines). These simulated data were centered the same way as the experimental data by transforming to mean of 0, variance of 1. For CIM in FIG. 1, tripeptides selected on all but one cell line of common origin (Arap et al., 2002) were used. Specificity of five tripeptides selectively overrepresented or underrepresented in lung tumor cell binding peptides for the 11 boxed cell lines (against the other 48 cell lines) was evaluated by using the R Package, version 2.0.0 (www.r-project.org) by performing two-sample t test (one tailed), as well as using Wilcoxon rank sum test (one tailed) and Fisher exact test (one tailed) as described (Arap et al., 2002).
Example 3
Identification of Candidate Targeted Receptors
[0049]To identify lead receptors targeted by tripeptide motifs, the Molecular Target Database (www.dtp.nci.nih.gov) was screened to identify proteins, expression levels of which in individual cell lines of the NCI-60 correlated with frequencies of individual tripeptides from FIG. 1 in the corresponding cell lines. The inventors used the COMPARE software (dtp.nci.nih.gov/docs/compare/compare.html) to calculate pairwise Pearson correlations between tripeptide frequencies in cell lines and the protein expression patterns in the database. Minimum Pearson correlation coefficient of 0.2 served as cutoff for the selection of lead receptors, as it provided a reasonable number of candidate molecular targets for which NCI-60 expression profiles and tripeptide frequency distribution profiles correlated. To initially restrict the candidate targets analyzed to broad-specificity receptors, only putative cell surface molecules (Table 1) were included, expression of which in the NCI-60 was found to correlate with the frequency profile of at least 25% of the tripeptides.
Example 4
Protein Database Screening for Peptide Motif Similarity
[0050]To identify natural prototype ligands of candidate receptors that are mimicked by selected peptides, the inventors screened all 7-mer peptides selected in the screen by using online ClustalW software (www.ebi.ac.uk/clustalw/) to identify extended (four or longer amino acids) motifs shared between multiple peptides containing the broad-specificity tripeptides (FIG. 1). Nonredundant databases of human proteins were searched by the BLAST software (www.ncbi.nlm.nih.gov/BLAST/) for proteins containing the cell-targeting 4-mers under the condition that at least the tripeptide part of the motif is identical to the part of the BLAST match.
Example 5
Validation of Epidermal Growth Factor Receptor as One of the Peptide Targets
[0051]To isolate peptides binding to epidermal growth factor receptor (EGFR), phage clones selected on SKOV3 in rounds 2 and 3 of the screening were individually amplified and pooled, and 109 transduction units of the mixed phage were incubated overnight at 4° C. with 10 μg of purified human EGFR (Sigma, St. Louis, Mo.), or BSA control immobilized on plastic. Unbound phages were extensively washed off with PBS, and then the bound phages were recovered by infecting host K91 Escherichia coli directly on the plate, and tetracycline-resistant clones were selected, quantified, and sequenced. To identify EGFR ligand-matching motifs among phage-displayed SKOV3-binding peptides, custom-designed Peri 5.8.1-based software was used to run peptide sequences against biological EGFR ligand sequences. Each 7-mer peptide sequence was aligned in each orientation against the EGFR ligand sequences from the NH2 to COOH terminus in one-amino-acid shifts. The peptide/protein similarity scores for each residue were calculated based on a BLOSUM62 matrix modified to identify peptide matches of at least three amino acids in any position being identical and one being similar to the corresponding amino acid positions in the EGFR ligands (FIG. 2A).
Example 6
Isolation of Peptides Binding to Surface of the NCI-60 Cancer Cells
[0052]As an initial attempt to profile cell surface of the tumor cell panel, a large (2×108 unique sequences) cyclic random peptide library was screened with the basic structure CX7C (C, cysteine; X any residue) on every cell line of the NCI-60. Phage selection was done in the excess of a competing Arg-Gly-Asp (RGD) synthetic integrin-binding peptide (Arap et al., 1009) to minimize the recovery of RGD-containing peptides. This strategy was designed to facilitate the recovery of ligands binding to nonintegrin families of cell surface receptors because RGD tends to become dominant in the screening due to the high levels of integrin expression in adherent cells (unpublished observation). Preferential cell binding of specific cell-targeting peptides results in enrichment, defined by the increased recovery frequency of these peptide motifs in each subsequent round of the screen (Kolonin et al., 2001; Pasqualini et al., 2001). Thus, the inventors set out to profile the expression of nonintegrin cell surface molecules among the cell lines of the NCI-60 according to the differential selection of motifs enriched in the screen.
Example 7
Hierarchical Cluster Analysis of Peptides Binding to the NCI-60 Cells
[0053]To analyze the spectrum of the peptides resulting from the screening and compare those among different cell lines of the panel, a combinatorial statistical approach was adopted based on the premise that three residue motifs (tripeptides) provide a sufficient structure for protein-peptide interactions in the context of phage display (Arap et al., 2002). For each NCI-60 cell line, CX7C peptide-encoding DNA inserts from 96 phage clones recovered after three rounds of selection were sequenced. A computer-assisted survey of all tripeptides within the library-derived sequences selected on each cell line by analyzing a database of 26,031 tripeptides contained within the 5,270 CX7C-encoded 7-mer peptides isolated (an average of eighty-nine 7-mer peptide sequences analyzed per each NCI-60 cell line) was performed. Thus, each cell line was assigned a unique set of tripeptides that was identified during the selection for cell surface binders, and the frequencies of each motif among all peptides for a given cell line were calculated.
[0054]To classify cell lines according to their association with particular motifs, which might provide inference on the targeted surface molecules, a hierarchical clustering analysis of the 3,280 nonredundant tripeptides was done based on the frequency of association with the NCI-60 cell lines. For the construction of a CIM, the inventors adapted a hierarchical clustering algorithm and a pseudo-color visualization matrix initially designed to address differential gene expression among the cells of the panel (Scherf et al., 2000; Zaharevitz et al., 2002; Blower et al., 2002; Rabow et al., 2002). CIMMiner (Weinstein et al., 1997) was used for inference of the variation in peptide binding specificity across the cell lines by comparing relative frequencies of tripeptides found in 7-mer peptides binding to each cell. Clustering of peptide motifs with similar cell selectivity revealed that the peptide distribution of the combinatorial library within the NCI-60 set was nonrandom. Computer simulations of the permutated data set show that the observed pattern could not be generated by random chance, thus indicating that the discontinuous tripeptide frequency data is applicable for cluster analysis.
[0055]The selective spectra of peptide motifs interacting with the clustered cell lines suggest the existence of shared targeted surface receptor(s) expressed in these lines. In this study, the inventors chose to focus on putative peptide-targeted receptors with broad cell line specificity, which would be more informative for an initial peptide binding/receptor expression correlation analysis. the inventors therefore excluded from the data set motifs selected only on a single or few cell lines. Instead, the inventors focused on 38 tripeptides that showed a semiubiquitous distribution among the NCI-60 lines (FIG. 1). A CIM constructed according to the isolation frequency of these broader-specificity tripeptides from each cell line revealed several apparent clusters of cell lines that displayed distinct profiles of association with certain classes of peptide motifs. For example, the majority of lung cancer-derived cell lines segregated as a separate group, suggesting that some of the receptors targeted may be conserved among cell lines derived from a common origin (FIG. 1). Thus, although the analysis was severely restricted by limiting it to semiubiquitous tripeptides, clustering of some of them (predominantly with cell lines derived from the same tumor type) is consistent with their relative tissue specificity. To evaluate individual motifs for selectivity, a distinct cluster of five tripeptides associated with lung tumor-derived cell lines (FIG. 1, boxed) were identified. The inventors compared tripeptide frequencies for the 11 cell lines within this cluster with their frequencies for the rest of NCI-60 lines by using statistical tests (Fisher exact, Wilcoxon rank-sum, and t test). Consistently, the GGS motif was isolated for the clustered lines significantly (P<0.05) more frequently than for the other NCI-60 cell lines.
[0056]Notably, the distribution of cell lines in the dendrogram (FIG. 1) was partially consistent with the reported association of cells derived from tumors with common tissue origin (Scherf et al., 2000; Nishizuka et al., 2003). This suggests that some of the receptors, such as the one presumably recognized by the lung tumor-specific tripeptide GGS (FIG. 1), may be up-regulated only in certain cancer origins. However, the tumor cell phylogeny was recapitulated only to an extent; the majority of the observed clusters contained cell lines derived from unrelated tumor types (FIG. 1). The limited grouping of lines derived from tumors of common origin is perhaps not surprising: the relationship between different cell lines in the study is based on peptide binding to putative cell surface molecules, many of which may be tumor induced rather than characteristic of the tissue of origin. If so, the analysis of broad-specificity motif distribution may be well suitable for identification of specific surface molecules that are generally up-regulated by tumors and thus may constitute broad drug targets against cancer.
Example 8
Identification of Candidate Receptor Targets for Peptide Motifs
[0057]The inventors proceeded to identify the targets for the 38 broad-specificity tripeptides, most of which presumably bind to receptors expressed by multiple NCI-60 cell lines. The NCI Molecular Targets Database that contains detailed information on the expression and activity of 1,218 human proteins measured by nonarray methods was used (Holbeck, 2004). By using the COMPARE algorithm (Zaharevitz et al., 2002), the inventors correlated the selectivity profiles of the 38 tripeptide motifs with the expression profiles of the characterized molecular targets. It was observed that several of the qualifying proteins, expression of which correlated with enrichment profiles of certain motifs, represented tyrosine kinase receptors, such as those for ligands belonging to families of EGFs, fibroblast growth factors (FGF), nerve growth factors (NGF), and ephrins (Table 1). When transferred to molecular target correlation data, the order of the 38-tripeptide motif set in the dendrogram (FIG. 1) revealed clusters of tripeptides for which cell line association profile correlated with expression profiles of EGF, FGF, NGF, or ephrin receptors (Table 1).
[0058]The peptide distribution-correlating tyrosine kinase receptors, belonging to EGFR, FGFR, NGFR, and ephrin receptor families (Table 1), are often up-regulated in many types of cancer (Vogelstein and Kinzler, 2004). To determine if the cell-binding peptides may target these tyrosine kinases, the inventors employed the notion that receptor-binding peptide motifs often mimic natural ligands for these receptors (Giordano et al., 2001; Arap et al., 2002; Kolonin et al., 2002). Thus, the selected motifs mimic ligands for the candidate tyrosine kinases were tested by determining whether tripeptides listed in Table 1 are embedded into longer peptides that may be responsible for cell surface binding. The inventors analyzed the CX7C (SEQ ID NO:1) phage inserts containing the 38 tripeptides by using the ClustalW software and compiled extended motifs containing the tripeptides shared among multiple peptides selected during the screen (data not shown). To identify candidate prototype human ligands, epitopes of which could be mimicked, each of the ClustalW-extended motifs were screened against the nonredundant database of human proteins by using the BLAST software (National Center for Biotechnology Information). As a result of this analysis, the inventors found the motifs containing 34 of 38 tripeptides (89%) to be identical or very similar to segments of proven or putative ligands for the tyrosine kinase receptors listed (Table 1).
Example 9
Validation of EGFR as a Targeted Receptor
[0059]To show that the approach taken can lead to actual targetable tumor cell surface proteins, the inventors chose to test if the EGFR is bound by any of the tripeptide motifs distributed in the panel in a profile correlating with EGFR expression. Consistently, 24 of 38 tripeptides surveyed displayed NCI-60 cell line association pattern consistent with that of EGFR expression (Table 1). Of these tripeptides, 22 were isolated in the screens on ovarian cancer cell lines SKOV3 and OVCAR4 (data not shown). Because EGFR is well known to be associated with ovarian cancer (Vogelstein and Kinzler, 2004), the inventors deemed these cell lines to be likely expressers of targetable EGFR, which would account for the selection of EGFR ligand-mimicking motifs. To validate EGFR binding by the selected motifs, the SKOV3-binding phage sublibrary (pooled clones recovered in rounds 2 and 3) were screened against immobilized human EGFR. After two rounds of selection, phage displaying the EGFR-binding peptides were analyzed: the majority were comprised by different 7-mer peptides (FIG. 2A) that contained 17 of 22 SKOV3-selected tripeptide motifs distributed in the panel in a profile correlating with EGFR expression (Table 1). Phage displaying these peptides had specific affinity to EGFR, as determined by subjecting the same sublibrary to immobilized BSA control binding (FIG. 2B). Remarkably, computer-assisted analysis of sequences (FIG. 2A) revealed that 12 of the 7-mer EGFR-binding peptides contained amino acid motifs similar to those present in some of the biological EGFR ligands (Vogelstein and Kinzler, 2004). These peptides, containing eight of the candidate tripeptides (RVS, AGS, AGL, GVR, GGR, GGL, GSV, and GVS), were found highly similar to fragments of EGF, amphiregulin, heparin-binding EGF-like growth factor, and epiregulin (FIG. 2A). Similarity search using the same algorithm on the same twelve 7-mers did not reveal any matches to two other EGFR ligands, transforming growth factor-α and β-cellulin, or randomly chosen control ligands of tyrosine kinase receptors from the three other candidate families listed in Table 1: ephrin A, NGF-β, and FGF6 (data not shown). Taken together, these data suggest that at least some of the peptides selected on the NCI-60 cells target EGFR, whereas others may bind to different tyrosine kinases, possibly including those from TRK, ephrin, or FGF receptor families.
[0060]Expression profiles of the candidate receptor targets for peptides identified in the screen illustrate the concept that in cancer, at least some tumor-associated cell surface molecules seem up-regulated regardless of cancer tissue origin. As such, this is the case for the EGFR and other tyrosine kinases possibly targeted by peptide ligands selected on the NCI-60 cell panel. This may also be the case for many other receptors with a role in tumorigenesis, expression profiles of which may not correlate with the overall proteomic profile of the original tumor tissue. In fact, these observations may account for the relatively limited success in correlating drug toxicity profiles with the genomic and/or proteomic profiles of the NCI-60 panel (Walloyist et al., 2003). On the other hand, some of the receptors, such as EphA5 presumably targeted by GGS tripeptide and its derivatives predominantly selective for lung tumor-derived cell lines (FIG. 1), seem to be at least partially specific for the progenitor cancer type.
[0061]The candidate ligand-receptor leads identified in this study can be characterized further for the development of targeted agents selective for tumors. Moreover, the peptides identified by the approach described here may map receptor interaction domains of biological (native) ligands. Similarity of peptides to the corresponding receptor-binding ligands has already been used for validation of the IL-11Ra receptor as a target of an interleukin-11 mimic peptide homing to blood vessels in the prostate (Arap et al., 2002; Zurita et al., 2004). The inventors and others have modeled the usage of peptides homing to receptors expressed by tumors (Pasqualini et al., 2000) or non-malignant tissues (Kolonin et al., 2002; Kolonin et al., 2004) for directing the delivery of cytotoxics, proapoptotic peptides, metalloprotease inhibitors, cytokines, fluorophores, and genes (Arap et al., 1998; Kolonin et al., 2001). Thus, the approach provides a straightforward way to identify drug-accessible tumor cell surface receptors and to discover peptide ligands that can serve as mimetic prototype drugs. Unlike genomic or proteomic-based approaches that rely on differential expression levels of transcripts or protein products, this discovery platform directly addresses functional protein-protein interactions at the level of physical binding. In contrast to protein array systems, it is possible to select binding peptides even if the ligand-receptor interaction is mediated by conformational (rather than linear) epitopes. Ligand-directed screening of combinatorial libraries on tumor cell surfaces can lead to improved selection of functionally relevant peptides that can be developed for targeting "druggable" molecular targets.
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TABLE-US-00001 TABLE 1 Candidate ligand-receptor interactions mimicked* RLS ErbB2, ErbB4 FGF2, 4 EGF-TM7 RGV RGS ErbB4 FGF2 EphA2, A3, A4, A8, B1 EGF-TM7, FGF-12b, FGF-5, NGF-beta RAV ErbB2 MEGF7, NGF-beta. NTF 6 alpha RAS TRKA FGF-20, NRG-3 GAG EGFR FGF1, 2, 3 MEGF4. FGF6, NGF-beta AVS EGFR, ErbB2, FGF1 TRKB, C EphA2, A3, A4, A7, B1, TRK1 ErbB4 B2, B3, B5 LLS Amphlregulin LLR TRKA EphA4 LRV EGFR, ErbB2, FGF3 TRKA, B, C EphA2, A3, A7 FGF-12b, Eph-B3 ErbB4 LRS ErbB3 MEGF4, MEGF5 MEGFS, NRG-3, NGF-beta RVS EGFR, Erb B2, FGF1, 2 TRKB EphA7 MEGF10, amphiregulin ErbB4 RSS FGF3 TRKA EphAS EGF-TM7, FGF-S, NRG-3 AGS EGFR TRKA MEGF6, brain NGF AGR MEGF2, MEGF4, FGF6, NTF-5, NTF-6 AGL EGFR, ErbB2, FGF1, 3 EphAS, A6, A8 MEGF12 ErbB3 AGG EphA5 HB-EGF, Ephr-B3 GVR EGFR, ErbB2, FGF1, 2 TRKB EphA7 MEGF4, MEGF6 MEGF8, FGF-5, ErbB4 bFGF, brain NGF GVL FGF1, 2 EphA2, A3, A5, A6, B3 NGF2, Ephrin-B3, GAV MEGFS, MEGF6, NGF-beta GLV ErbB4 FGF4 EphA5 ESF-TM7, betaceilulin, NTF 3, Eph-B3, GLR ErbB4 MEGF5, EGFL5, FGF-12b, FGF-16, NRG-3 LVS FGF1, 4 EphA5, A6 EGFL5. FGF23, GDNF, Eph-B3 ARG ErbB2 FGF2, 4 TRKA EphAI FGF-12b, FGF23, NGF-beta. GDNF. NTF 6 ASL FGF1, 2 TRKC EGF-TM7, FGFR1 AAV TRKB EphA2, A3, A4, A7, B3, • B5 AAS FGF1, 2 TRKC • GGS EphA5 Eph-B3, Eph A4 GGR EGFR.ErbB2 FGF2 EGF-TM7, HB-EGF, FGF23, Ephrin-B3 GLG ErbB2, ErbB3 FGF2, 3, 4 EphA1, A6 heparin binding growth factor 8 GGL ErbB2 HB-EGF, MEGF5, EGFL5, NRG-3 GSS EGFR, ErbB2 FGF3 TRKA, C EphA5 MEGFS GSG EGFR EphA5 GSV EGFR, ErbB2, FGF4 TRKB EphA7, B2 MEGF5, NRG-3, Ephrin-B3 ErbB4 GRV EGFR MEGFS, EGF-TM7, FGF23, NTF5 GRL EGFR.ErbB2 EphAS, B1, B2, B4 betacellulin, EGFL5, NGF2, NTF5, EphB3, EphA4 GPS EGFR, ErbB2, FGF3 TRKB EpnA2, A3, A4, A7, B2, MEGFS, EGFL5, EGF-like EMR3, SPGF ERB4 B5 GVS EGFR FGF4 TRKA MEGF-1, MEGF5, NRG-3, NTF-6, NTF-5 *NOTE: Candidate peptide motif receptors are the human cell surface proteins (identified by COMPARE) expressed in profiles correlating with the selectivity of the corresponding tripeptides. Candidate peptide-mimicked receptor ligands are human proteins (identified by automated BLAST) that contained the corresponding tripeptides. Tripeptides in the column are ordered as in FIG. 1. Receptors of the same family and their corresponding candidate biological ligands identified based on tripeptide similarity are coded by the same color [EGFR, blue; FGFR, green; TRK receptor (NGFR), purple; ephrin receptor, red]. Tripeptides that both have a selectivity correlating with EGFR family receptor expression and are found within EGFR ligands (boldface). Tripeptides that were confirmed to reside within EGFR-binding SKOV3-slected peptides (FIG. 2; blue).
Example 10
Molecular Fingerprinting of Cancer Cell Lines
[0062]Proteomics can be defined as the systematic analysis of the proteins in biological samples that aims to document the overall distribution of proteins in tumor cells or tumor-associated cells, identify and characterize individual proteins of interest and to elucidate their relationships and functional roles. Ultimately, high-throughput profiling of protein expression will lead to the "proteome", a protein-based fingerprint, for each tissue in humans and other species. As technologies related to proteomics advance, new approaches for systematic molecular analysis of cancer at the protein level are surfacing. However, methods for systematic protein expression profiling may also easily overlook potential targets for intervention. These methods often do not take anatomical context into account. Therefore, for the generation of molecular map of accessible receptors that can be used for targeting therapeutics, information derived from conventional protein profiling approaches should be enhanced by integration with data from functional screenings ex vivo and in vivo. Studies by the inventors and others have advanced the concept of cancer proteomics: the molecular phenotyping of tumor cells and cells forming blood vessels at the protein-protein interaction level. Exploiting the molecular diversity of cell surface receptors expressed in cancer will eventually result in a ligand-receptor functional map for targeted delivery.
[0063]A major goal in drug development has long been to generate targeted therapies. This approach would improve drug therapeutic indexes by limiting the systemic exposure of other tissues to untoward or toxic effects. Thus, the promise for the identification of selectively expressed tumor-associated receptors and the ligands that home to these receptors is translation of this knowledge into the development of targeted therapeutics. Generally, coupling of homing peptides yields targeted compounds that are more effective and less toxic than the parental compound. So far, peptides selected by homing to tumor vasculature have been used as carriers to guide the delivery of cytotoxic drugs, pro-apoptotic peptides, metalloprotease inhibitors, cytokines, fluorofores, and genes in transgenic and xenograft mouse models of human disease.
[0064]Recognition of molecular diversity in human cancer is essential for the development of targeted therapies. The methods developed have two main applications. First, they may identify ligands targeting human cancer. Second, the determination of molecular profiles of biomarkers in specific types of tumors may enable identification of differentially expressed cancer markers. Thus, the approach may lead to construction of a molecular profile of human tumors. Early identification of targets, optimized regimens tailored to molecular profile of individual cancer patients, combined with the identification of new vascular addresses may result in revisiting or salvaging of drug candidates that are ineffective or too toxic. Ultimately, it may be possible to guide imaging or therapeutic compounds to tumor targets in cancer patients.
[0065]By fingerprinting lung cancer cells the inventors have confirmed the expression of a previously characterized molecular target, EGFR, in multiple cancer origins, which demonstrates the power of the approach. Recently, the inventors used this approach to identify a new cancer origin-selective molecular target, Ephrin A5 receptor, which the inventors have preliminary validated in the context of human lung cancer cell lines and tissues.
Example 11
Motifs Targeting NCI-60 Cells in Correlation with EGFR Expression Pattern are Found Within Peptides Similar to Domains of Biological EGFR Ligands and Bind to EGFR
[0066]To show that the approach taken can lead to actual targetable tumor cell surface proteins, the inventors chose to test if the EGF receptor (EGFR) is bound by any of the tripeptide motifs distributed in the panel in a profile correlating with EGFR expression. Consistently, 24 out of 38 tripeptides surveyed displayed NCI-60 cell line association pattern consistent with that of EGFR expression (Kolonin et al., 2001). Of these, tripeptides, 22 were isolated in the screens on ovarian cancer cell lines SKOV3 and OVCAR4 (data not shown). Since EGFR is well known to be associated with ovarian cancer (Vogelstein, 2004; Maihle and Lafky, 2002), the inventors deemed these cell lines to be likely expressers of targetable EGFR, which would account for the selection of EGFR ligand-mimicking motifs. To validate EGFR binding by the selected motifs, the SKOV3-binding phage sub-library (pooled clones recovered in rounds 2 and 3) were screened against immobilized human EGFR. After 2 rounds of selection, phage displaying the EGFR-binding peptides were analyzed: the majority were comprised by different seven-mer peptides (FIG. 3A) that contained 17 out of 22 SKOV3-selected tripeptide motifs distributed in the panel in a profile correlating with EGFR expression.
[0067]Phage displaying these peptides had specific affinity to EGFR, as determined by subjecting the same sub-library to immobilized bovine serum albumin (BSA) control binding (FIG. 2B). Remarkably, computer-assisted analysis of sequences (FIG. 2A) revealed that 12 of the seven-mer EGFR-binding peptides contained amino acid motifs similar to those present in some of the biological EGFR ligands. These peptides, containing eight of the candidate tripeptides (RVS, AGS, AGL, GVR, GGR, GGL, GSV, and GVS) were found highly similar to fragments of EGF, Amphiregulin, heparin-binding EGF-like growth factor, and Epiregulin (FIG. 2A). Similarity search using the same algorithm on the same 12 seven-mers did not reveal any matches to two other EGFR ligands, TGF-α and betacellulin, or randomly chosen control ligands of tyrosine kinase receptors from the three other candidate families listed in Table 2 (Kolonin et al. 2001): Ephrin A, NGF-β, and FGF6. Taken together, these data suggest that at least some of the peptides selected on the NCI-60 cells target EGFR, while others may bind to different tyrosine kinases, possibly including those from TRK, Ephrin, or FGF receptor families.
[0068]A phage-displayed combinatorial library was systematically screened for peptides capable of targeting the cell lines in the NCI-60 panel. By statistical analysis of peptide motif sequences, each NCI-60 cell line was assigned a unique set of peptide motifs that were isolated during the selection for cell surface binders. It was shown that tumor cells can be grouped by profiles of their phage display-derived peptide ligands directed to differentially expressed cell surface receptors.
[0069]An approach for peptide-targeted receptor identification was designed. Profiles of peptide motif preference for specific lines of the NCI-60 were correlated with expression profiles of known breast cancer-related targets. Some of the peptide motifs were found within proteins known to bind the receptors that had NCI-60 expression profiles matching cell line recognition profiles of the peptides, and that are implicated in cancer.
[0070]Candidate targeted cell surface molecules were identified, which included a number of tyrosine kinase receptors. As a proof of principle, EGFR, a receptor known to be upregulated in various cancers, was validated as a target of tripeptides RVS, AGS, AGL, GVR, GGR, GGL, GSV, and GVS, which were The results described uncover a previously overlooked phenomenon. The data support the notion that many tumor cell surface-exposed receptors are expressed irrespective of tumor origin, thus suggesting they could be explored as broad tumor targets.
Example 12
Ephrin A5 Receptor as a Lung Cancer Cell Surface Marker
[0071]The peptide distribution-correlating tyrosine kinase receptors, belonging to EGFR, FGFR, NGFR and Ephrin receptor families are often up-regulated in many types of cancer. On the other hand, some of the receptors, such as EphA5 presumably targeted by GGS tripeptide and its derivatives predominantly selective for lung tumor-derived cell lines appear to be at least partially specific for the progenitor cancer type. Since this approach clearly allowed identification of cell surface receptors ubiquitously upregulated in various cancers, the inventors took a step further to attempt identification of cancer type-specific receptors.
[0072]Having chosen lung cancer for the initial procedure establishment, the inventors identified a distinct cluster of five tripeptides associated with lung tumor-derived cell lines. The inventors compared tripeptide frequencies for the 11 cell lines within this cluster with their frequencies for the rest of NCI-60 lines by using statistical tests (Fisher exact, Wilcoxon rank-sum, and t-test). Consistently, the inventors observed that motif GGS was isolated for the clustered lines significantly (P<0.05) more frequently than for the other NCI-60 cell lines (Table 2).
TABLE-US-00002 TABLE 2 Association of specific tripeptides with lung cancer-derived cell lines: P value Mean motif count (±SEM) P value Wilcoxon P value inside vs. outside t-test, rank-sum Fisher exact Motif cluster 1-sided test, 1-sided test, 1-sided GGS 2.2 (±0.5) vs. 1.2 (±0.2) 0.0422 0.0407 0.0043 GGR 1.3 (±0.3) vs. 1.5 (±0.2) 0.6991 0.6466 0.6739 GLG 0.7 (±0.4) vs. 0.7 (±0.2) 0.5375 0.6888 0.5150 GGL 1.2 (±0.2) vs. 1.3 (±0.2) 0.6457 0.4174 0.5485 GSS 2.2 (±0.4) vs. 1.1 (±0.2) 0.0422 0.0026 0.0008
[0073]To determine statistical significance of association or dissociation between exemplary tripeptides and cell lines, normalized frequencies of five tripeptides predominantly associated (GGS, GGR, GLG, and GGL) or dissociated (GSS) with the cluster containing the majority of lung tumor-derived cell lines (FIG. 1, boxed) were compared for cell lines inside the cluster and outside the cluster. Selective association of tripeptide GGS with the clustered cell lines was found significant according to t-test, Fisher exact test and Wilcoxon rank-sum test (all tests one-tailed).
[0074]Based on the automated BLAST analysis (Table 2) the inventors identified proteins of the ephrin family candidate prototypes of the GGS-containing peptides: ephrins-B3 and A4 contain the GGS, consistent with a functional mimickry. Ephrins (A and B) and their receptors (EphA and EphB) represent a large class of cell-cell communication molecules with well-defined developmental functions. Their role in healthy adult tissues and in human disease is still largely unknown, although diverse roles in carcinogenesis have been postulated and a number of Eph receptors have been found overexpressed by various cancers (Hafner et al., 2004). Based on the COMPARE analysis of GGS distribution within NCI-60 (Kolonin et al., 2001, Table 2), the receptor expressed in the corresponding pattern is EphA5. The EphA5 expression (FIG. 4 has been explored using cDNA microarray analysis and is reported at the DTP server (dtp.nci.nih.gov/mtweb/servlet/moltidsearch?moltid=MT894), however, no studies of EphA5 function in cancer have been published. Intriguingly EphA5 is not expressed in normal lung and normally is only thought to have brain-specific functions.
Example 13
Validation of Ephrin-Mimic Peptides in Lung Cancer
[0075]To validate phage containing the motif GGS as a ligand of Eph receptors, the inventors tested phage binding to the EphA5 immobilized receptor. The inventors started testing eight peptides (CAGLSGGTC, CSGIGSGGC, CSSGGVLGC, CSWGSGGSC, CTLVLGGSC, CRFESSGGC, CHVSGGSGC, CTGGSLGAC) containing the enriched motif GGS, all of them displayed by phage clones obtained from the screening on different cell lines known to express the EphA5 receptor (FIG. 3A). From this first round of selection, 5 clones (CAGLSGGTC, CSGIGSGGC, CSSGGVLGC, CRFESSGGC and CSWGSGGSC) showed good binding to the receptor relative to the control (BSA) and were further analyzed by their ability to specifically bind to EphA5 but not to the control EphA4 receptor (FIG. 3B). Phage displaying the peptide sequences CSGIGSGGC and CRFESSGGC showed binding specificity and were chosen for characterization. The inventors investigated the binding of the selected phage to the lung cancer cells Hop92 and H460. These cells are known to express EphA5 receptor on its surface, as confirmed by immunofluorescence analysis (FIG. 5). The ovarian cancer cell line OVCAR-3, negative for EphA5 expression, was used as control.
[0076]Next, the inventors used the BRASIL method (biopanning and rapid analysis of selective interactive ligands) to analyze binding of selected phage to lung cancer cells. The inventors observed specific binding of phage displaying the sequences CSGIGSGGC and CRFESSGGC to Hop92 and H460, confirming the data obtained from the screening on the immobilized EphA5 receptor (FIG. 6).
[0077]Finally, by using banked sections or patient tissues from the MD Anderson Cancer Center, the inventors showed that EphA5 protein is overexpressed by human lung adenocarcinoma epithelium.
[0078]Immunohistochemistry (polyclonal anti-prohibitin antibody) on formalin-fixed paraffin sections of human non-small cell lung cancer (NSLC) or normal prostate with EphA5 or EphA4-specific antibodies. Immunostaining demonstrates selective EphA5 upregulation of EphA5 protein expression in NSLC lung adenocarcinoma epithelium, but not stroma, as compared with the control prostate tissue.
[0079]Taken together, these data suggest that the two selected phage displaying the motif GGS are ligands of EphA5 receptor. Upregulation of EphA5 in gliomas has been reported, without any functional connections, and, up to date, there has been no reports of investigation of this tyrosine kinase receptor in lung cancer. Therefore, EphA5 protein overexpression in lung cancer cells (FIG. 4) in light of candidate ephrin mimics (GGS peptides) targeting these cells provides an original evidence for EphA5 being a lung cancer marker and has potential functional implications.
[0080]It is contemplated by the inventors that the cancer-associated motifs identified here can be used for the development of approaches for targeted imaging or therapy of breast tumors in patients. Their receptors, including EGFR, EphA5, and other cell surface molecules, can be further explored for their oncogenic properties and the potential to serve as universal or origin/grade-selective targets of cancer.
Example 14
Cell Internalization of Ephrin-Mimic Peptides
[0081]The ability of ephrin-mimic peptides to mediate cell internaization was assessed. The A549 cell line was used as a representative human lung cancer-derived cells expressing the EphA5 receptor on the cell surface. Each phage clone or control insertless phage was incubated with cells for 4h at 37 ° C. Both CSGIGSGGC (SEQ ID NO:2) and CRFESSGGC (SEQ ID NO:3)-phage were internalized into A549 cells while only background fluorescence was obtained when nontargeted control phage was used (see FIG. 8).
Example 15
Activation of Cells by Ephrin-Mimic Peptide
[0082]Activation of the EphA5 receptor by the peptides CSGIGSGGC (SEQ ID NO: 2) and CRFESSGGC (SEQ ID NO:3) lead to proliferation and/or survival of lung cancer cells. In the absence of sera, this peptides increased lung cancer cells proliferation by 4-fold (FIG. 9A-B). This effect was confirmed in two different human cell lines, which express the EphA5 receptor.
TABLE-US-00003 TABLE 3 Peptides and Motifs Associated with NCI-60 cell lines. (SEQ ID NO:) Motif Peptide Cell Line RLS LRLSSIP (6) CCRF-CEM Leukemia RGV ARGVLLM (7) CCRF-CEM Leukemia RGS RGSHLVP (8) CCRF-CEM Leukemia DVETRGS (9) CCRF-CEM Leukemia RAV SRAVIDM (10) CCRF-CEM Leukemia RAS CCRF-CEM Leukemia GAG CCRF-CEM Leukemia AVS CCRF-CEM Leukemia LLS GLLSLXL (11) CCRF-CEM Leukemia TSLLSFR (12) CCRF-CEM Leukemia LLR CCRF-CEM Leukemia LRV CCRF-CEM Leukemia LRS CCRF-CEM Leukemia RVS RRVSLVA (13) CCRF-CEM Leukemia SRFRVSI (14) CCRF-CEM Leukemia RSS CCRF-CEM Leukemia AGS AGSLSVF (15) CCRF-CEM Leukemia AGR AGRICEG (16) CCRF-CEM Leukemia QVAGRER (17) CCRF-CEM Leukemia VEYAAGR (18) CCRF-CEM Leukemia AGL YNRSAGL (19) CCRF-CEM Leukemia AGG AVLVAGG (20) CCRF-CEM Leukemia LAGGVPG (21) CCRF-CEM Leukemia GVR DWWAGVR (22) CCRF-CEM Leukemia EPDGVRS (23) CCRF-CEM Leukemia EQLSGVR (24) CCRF-CEM Leukemia GVL GVLARVT (25) CCRF-CEM Leukemia ARGVLLM (26) CCRF-CEM Leukemia GAV GGAVLVA (27) CCRF-CEM Leukemia RERGAVQ (28) CCRF-CEM Leukemia GLV RALGLVS (29) CCRF-CEM Leukemia GLR SLGLRNQ (30) CCRF-CEM Leukemia LVS RALGLVS (31) CCRF-CEM Leukemia GAYRLVS (32) CCRF-CEM Leukemia ARG FDARGGL (33) CCRF-CEM Leukemia MFARGWE (34) CCRF-CEM Leukemia ARGVLLM (35) CCRF-CEM Leukemia ASL CCRF-CEM Leukemia AAV CCRF-CEM Leukemia AAS CCRF-CEM Leukemia GGS GGGSDGV (36) CCRF-CEM Leukemia GGR LGGRADF (37) CCRF-CEM Leukemia CCRF-CEM Leukemia GLG CCRF-CEM Leukemia GGL EVGGGLT (38) CCRF-CEM Leukemia FDARGGL (39) CCRF-CEM Leukemia GSS CCRF-CEM Leukemia GSG CCRF-CEM Leukemia GSV CCRF-CEM Leukemia GRV TGRVVRR (40) CCRF-CEM Leukemia GRL CCRF-CEM Leukemia GPS MGMSGPS (41) CCRF-CEM Leukemia GVS CCRF-CEM Leukemia RLS HL-60-Leukemia RGV AVRGVAR (42) HL-60-Leukemia DRGVPGL (43) HL-60-Leukemia RGS LSFSRGS (44) HL-60-Leukemia RGSVRVL (45) HL-60-Leukemia PVRGSVD (46) HL-60-Leukemia QVMMRGS (47) HL-60-Leukemia NGRGSGW (48) HL-60-Leukemia RAV RAVGRVA (49) HL-60-Leukemia RAS RASCALT (50) HL-60-Leukemia GAG ADIGAGG (51) HL-60-Leukemia FMGAGFA (52) HL-60-Leukemia AVS AGVFAVS (53) HL-60-Leukemia LLS HL-60-Leukemia LLR VMLLRPE (54) HL-60-Leukemia LLRGLEL (55) HL-60-Leukemia LPLLRGI (56) HL-60-Leukemia LRV DPRGLRV (57) HL-60-Leukemia LRS HL-60-Leukemia RVS LVRVSGR (58) HL-60-Leukemia SGSRVSL (59) HL-60-Leukemia RSS HL-60-Leukemia AGS AGSIALR (60) HL-60-Leukemia AGR MLASAGR (61) HL-60-Leukemia AGL HL-60-Leukemia AGG ADIGAGG (62) HL-60-Leukemia FAGGSTD (63) HL-60-Leukemia GVR HL-60-Leukemia GVL HL-60-Leukemia GAV TGFGAVG (64) HL-60-Leukemia HL-60-Leukemia GLV HL-60-Leukemia GLR FGLRNSR (65) HL-60-Leukemia DPRGLRV (66) HL-60-Leukemia LVS LVSSGSK (67) HL-60-Leukemia LVSSSEP (68) HL-60-Leukemia ARG HL-60-Leukemia ASL HL-60-Leukemia AAV AAVWAAD (69) HL-60-Leukemia AAS HL-60-Leukemia GGS FAGGSTD (70) HL-60-Leukemia GGR HL-60-Leukemia GLG HL-60-Leukemia GGL TFGKGGL (71) HL-60-Leukemia GSS KSGSSVL (72) HL-60-Leukemia HL-60-Leukemia GSG WGSGRGN (73) HL-60-Leukemia GSV RGSVRVL (74) HL-60-Leukemia PVRGSVD (75) HL-60-Leukemia TEGSVTV (76) HL-60-Leukemia GRV RAVGRVA (77) HL-60-Leukemia DVSGRVP (78) HL-60-Leukemia LGQCGRV (79) HL-60-Leukemia GRL GRLRLTD (80) HL-60-Leukemia LELGRLL (81) HL-60-Leukemia IGRLLPL (82) HL-60-Leukemia SDENGRL (83) HL-60-Leukemia GPS HL-60-Leukemia GVS HL-60-Leukemia RLS K-562-Leukemia RGV ELHPRGV (84) K-562-Leukemia FDRGVEA (85) K-562-Leukemia RGS EAVSRGS (86) K-562-Leukemia WTKRGSV (87) K-562-Leukemia RAV K-562-Leukemia RAS ERASQTA (88) K-562-Leukemia GAG K-562-Leukemia AVS EAVSRGS (89) K-562-Leukemia LLS AATLLSF (90) K-562-Leukemia LLSASLV (91) K-562-Leukemia RRHGLLS (92) K-562-Leukemia LLR RYSTLLR (93) K-562-Leukemia LRV FTLRVDK (94) K-562-Leukemia LRS K-562-Leukemia RVS SHRVSDS (95) K-562-Leukemia K-562-Leukemia RSS NRSSAKF (96) K-562-Leukemia LRRSSFS (97) K-562-Leukemia AGS AIRAGSD (98) K-562-Leukemia VLFSAGS (99) K-562-Leukemia AGR K-562-Leukemia AGL K-562-Leukemia AGG K-562-Leukemia GVR K-562-Leukemia GVL GVLHSIA (100) K-562-Leukemia GAV RQTTGAV (101) K-562-Leukemia GLV CQGLVLQ (102) K-562-Leukemia GLR PPPWGLR (103) K-562-Leukemia LVS K-562-Leukemia ARG SNARGPR (104) K-562-Leukemia ASL LLSASLV (105) K-562-Leukemia AAV AAVFVRS (106) K-562-Leukemia AAS K-562-Leukemia GGS FFGGSRA (107) K-562-Leukemia GGSQCDT (108) K-562-Leukemia VWGVGGS (109) K-562-Leukemia GGR FAWGGRG (110) K-562-Leukemia GLG GLGIMGP (111) K-562-Leukemia GGL K-562-Leukemia GSS SSGSSNG (112) K-562-Leukemia GSG K-562-Leukemia GSV WTKRGSV (113) K-562-Leukemia GRV K-562-Leukemia GRL K-562-Leukemia GPS K-562-Leukemia GVS GVSTGFT (114) K-562-Leukemia RLS Molt-4-Leukemia RGV CHARGVT (115) Molt-4-Leukemia RGS WGRGSVA (116) Molt-4-Leukemia RAV Molt-4-Leukemia RAS Molt-4-Leukemia GAG LRSGAGS (117) Molt-4-Leukemia AVS RAAVSAI (118) Molt-4-Leukemia AVSGRGW (119) Molt-4-Leukemia LLS LLSFLGR (120) Molt-4-Leukemia LLR Molt-4-Leukemia LRV Molt-4-Leukemia LRS GFYWLRS (121) Molt-4-Leukemia RVS RGARVSA (122) Molt-4-Leukemia RSS GGRSSHP (123) Molt-4-Leukemia RSSIAPS (124) Molt-4-Leukemia AGS LAGSGSH (125) Molt-4-Leukemia LRSGAGS (126) Molt-4-Leukemia AGR ASVRAGR (127) Molt-4-Leukemia AGL Molt-4-Leukemia AGG Molt-4-Leukemia GVR IGVRGFF (128) Molt-4-Leukemia GVL ANGVLEL (129) Molt-4-Leukemia Molt-4-Leukemia GAV WFGAVGL (130) Molt-4-Leukemia GLV GLVRGTA (131) Molt-4-Leukemia GLVRGTA Molt-4-Leukemia EGLVSVV (132) Molt-4-Leukemia GLR DLGLRPV (133) Molt-4-Leukemia LVS ALVSRRG (134) Molt-4-Leukemia EVLVSGD (135) Molt-4-Leukemia EGLVSVV (136) Molt-4-Leukemia ARG CHARGVT (137) Molt-4-Leukemia ASL Molt-4-Leukemia AAV RAAVSAI (138) Molt-4-Leukemia AAS Molt-4-Leukemia GGS HRGGSQS (139) Molt-4-Leukemia GGR GGRSSHP (140) Molt-4-Leukemia SQSGGRH (141) Molt-4-Leukemia GLG ARAIGLG (142) Molt-4-Leukemia GGL STEGGGL (143) Molt-4-Leukemia GSS Molt-4-Leukemia GSG LAGSGSH (144) Molt-4-Leukemia GSV DGSVLVE (145) Molt-4-Leukemia WGRGSVA (146) Molt-4-Leukemia GRV ATGRVLG (147) Molt-4-Leukemia ATGRVLG (148) Molt-4-Leukemia FFGRVGI (149) Molt-4-Leukemia RIGRVWA (150) Molt-4-Leukemia GRL RGRLEVP (151) Molt-4-Leukemia GPS Molt-4-Leukemia GVS Molt-4-Leukemia RLS RRLSYRD (152) RPMI-8226-Leukemia SRLSYRG (153) RPMI-8226-Leukemia RGV FSSKRGV (154) RPMI-8226-Leukemia RGS RGSAQNF (155) RPMI-8226-Leukemia LRSGRGS (156) RPMI-8226-Leukemia LRSGRGS RPMI-8226-Leukemia LRSGRGS RPMI-8226-Leukemia YRGSSGK (157) RPMI-8226-Leukemia RAV RPMI-8226-Leukemia RAS FWISRAS (158) RPMI-8226-Leukemia GAG GAGSISD (159) RPMI-8226-Leukemia RAMGGAG (160) RPMI-8226-Leukemia AVS RPMI-8226-Leukemia LLS LLSTSIR (161) RPMI-8226-Leukemia LLR LLLRSGG (162) RPMI-8226-Leukemia LLRSAAP (163) RPMI-8226-Leukemia LRV RPMI-8226-Leukemia LRS LLLRSGG (164) RPMI-8226-Leukemia GRYSLRS (165) RPMI-8226-Leukemia LRSGRGS (166) RPMI-8226-Leukemia LRYDLRS (167) RPMI-8226-Leukemia LRYNLRS (168) RPMI-8226-Leukemia LLRSAAP (169) RPMI-8226-Leukemia SKYRLRS (170) RPMI-8226-Leukemia RVS VHRVSGG (171) RPMI-8226-Leukemia RSS RPMI-8226-Leukemia AGS GAGSISD (172) RPMI-8226-Leukemia AGR FAGRVPS (173) RPMI-8226-Leukemia AGL AGLSGSQ (174) RPMI-8226-Leukemia TDLAGLH (175) RPMI-8226-Leukemia
AGG LAAGGEL (176) RPMI-8226-Leukemia GAGGMAR (177) RPMI-8226-Leukemia RAAGGSR (178) RPMI-8226-Leukemia GVR LYGVRYG (179) RPMI-8226-Leukemia PRYGVRA (180) RPMI-8226-Leukemia GVL RPMI-8226-Leukemia GAV GAVDGSR (181) RPMI-8226-Leukemia GLV ADFFGLV (182) RPMI-8226-Leukemia GLR KYYGLRR (183) RPMI-8226-Leukemia SRYGLRR (184) RPMI-8226-Leukemia LVS RPMI-8226-Leukemia ARG RPMI-8226-Leukemia ASL RPMI-8226-Leukemia AAV RPMI-8226-Leukemia AAS PAASRLL (185) RPMI-8226-Leukemia RLRAASY (186) RPMI-8226-Leukemia RPMI-8226-Leukemia GGS GGSRLLL (187) RPMI-8226-Leukemia RAAGGSR (188) RPMI-8226-Leukemia GGSVRHV (189) RPMI-8226-Leukemia GGR GGRSWVN (190) RPMI-8226-Leukemia GLG GLGNRPT (191) RPMI-8226-Leukemia HGLGSGT (192) RPMI-8226-Leukemia GGL RPMI-8226-Leukemia GSS GSSLHLL (193) RPMI-8226-Leukemia YRGSSGK (194) RPMI-8226-Leukemia GSG EGSGVDC (195) RPMI-8226-Leukemia HGLGSGT (196) RPMI-8226-Leukemia GSV SGSVNRG (197) RPMI-8226-Leukemia GGSVRHV (198) RPMI-8226-Leukemia GRV FAGRVPS (199) RPMI-8226-Leukemia GRL AMRPGRL (200) RPMI-8226-Leukemia GRLYYYR (201) RPMI-8226-Leukemia GPS PAFGPSR (202) RPMI-8226-Leukemia GVS HSGVSHG (203) RPMI-8226-Leukemia RLS VYYRLSA (204) SR Leukemia RGV SR Leukemia RGS GRGSFES (205) SR Leukemia RRGSSRN (206) SR Leukemia RAV HSRAVAP (207) SR Leukemia RAS RASFRAG (208) SR Leukemia LMGRASG (209) SR Leukemia WRASAFT (210) SR Leukemia GAG GAGRTVM (211) SR Leukemia AVS PLAVSMV (212) SR Leukemia LLS SR Leukemia LLR FLLRSSF (213) SR Leukemia WRLLRRQ (214) SR Leukemia LRV SR Leukemia LRS FLLRSSF (215) SR Leukemia LRSRLGF (216) SR Leukemia RVS GRRVSLV (217) SR Leukemia RSS FLLRSSF (218) SR Leukemia NRSSGRR (219) SR Leukemia VLGMRSS (220) SR Leukemia THRNRSS (221) SR Leukemia AGS LAGSTRR (222) SR Leukemia AGR AGRTGVG (223) SR Leukemia EFAVAGR (224) SR Leukemia GAGRTVM (225) SR Leukemia REEFAGR (226) SR Leukemia AGL SR Leukemia AGG AGGPTKY (227) SR Leukemia FHVAGGS (228) SR Leukemia WSAGGPH (229) SR Leukemia GVR SR Leukemia GVL SR Leukemia GAV RGAVAFE (230) SR Leukemia SGGAVHF (231) SR Leukemia GAVRARL (232) SR Leukemia GLV GLVRGFP (233) SR Leukemia GAHGLVR (234) SR Leukemia SSRMGLV (235) SR Leukemia YVGLVVS (236) SR Leukemia GLR GLRKAGF (237) SR Leukemia AVDGLRL (238) SR Leukemia FGLRSRL (239) SR Leukemia LVS SR Leukemia ARG SR Leukemia ERARGYP (240) SR Leukemia GSARGML (241) SR Leukemia ASL ASLRYYV (242) SR Leukemia NAASLPS (243) SR Leukemia WLDASLM (244) SR Leukemia AAV SR Leukemia AAS NAASLPS (245) SR Leukemia GGS FHVAGGS (246) SR Leukemia GEHLGGS (247) SR Leukemia GGR SR Leukemia GLG SR Leukemia GGL SGGLHEG (248) SR Leukemia RLS SRLSYRS (249) A549-Lung RGV GGLRGVR (250) A549-Lung VAWRGVS (251) A549-Lung SVEGRGV (252) A549-Lung RGS FWRGSVP (253) A549-Lung RAV A549-Lung RAS EFTRRAS (254) A549-Lung WGWRASS (255) A549-Lung GAG A549-Lung AVS A549-Lung LLS A549-Lung LLR A549-Lung LRV A549-Lung LRS RFYHLRS (256) A549-Lung SRYSLRS (257) A549-Lung RVS A549-Lung RSS RRSSKQA (258) A549-Lung DWGRSSF (259) A549-Lung RFTRSSG (260) A549-Lung VFQRSSG (261) A549-Lung AGS AGSQSWE (262) A549-Lung AGR A549-Lung AGL A549-Lung AGG EHPAGGM (263) A549-Lung GVR GVRTAGP (264) A549-Lung GGLRGVR (265) A549-Lung LYGGVRY (266) A549-Lung GVL PVGGVLL (267) A549-Lung GAV GAVVKPI (268) A549-Lung SVGAVGG (269) A549-Lung GLV GLVSVEA (270) A549-Lung GLR GGLRGVR (271) A549-Lung LVS DIALVSP (272) A549-Lung GLVSVEA (273) A549-Lung ARG A549-Lung ASL A549-Lung AAV A549-Lung AAS ARNAASP (274) A549-Lung GGS AEGGSGH (275) A549-Lung GGSFSGL (276) A549-Lung GGR VTGGRVD (277) A549-Lung GLG A549-Lung GGL GGLRGVR (278) A549-Lung A549-Lung GSS GSSWVVD (279) A549-Lung GSSRTFR (280) A549-Lung GSSRQFV (281) A549-Lung WVGSSKF (282) A549-Lung GSG AEGGSGH (283) A549-Lung EVIGSGI (284) A549-Lung GSV FWRGSVP (285) A549-Lung VGSVSVN (286) A549-Lung GRV VTGGRVD (287) A549-Lung GRVTVAV (288) A549-Lung GRL RVGRLGG (289) A549-Lung GPS NYMGPSA (290) A549-Lung GWHGPSH (291) A549-Lung GVS GGVSPVD (292) A549-Lung GVSKVRA (293) A549-Lung GGVAGVS (294) A549-Lung VAWRGVS (295) A549-Lung RLS VIGSRLS (296) EKVX-Lung RGV HLRGRGV (297) EKVX-Lung RGS EVRSRGS (298) EKVX-Lung RGSRLPA (299) EKVX-Lung RAV DVRAVSS (300) EKVX-Lung RAS EKVX-Lung GAG EKVX-Lung AVS DVRAVSS (301) EKVX-Lung LLS EKVX-Lung LLR EKVX-Lung LRV EKVX-Lung LRS APLRSGR (302) EKVX-Lung SLRSGIV (303) EKVX-Lung RVS EKVX-Lung RSS DGGRRSS (304) EKVX-Lung AGS QAGSFLR (305) EKVX-Lung DAGSDRR (306) EKVX-Lung AGR AGRRFGG (307) EKVX-Lung AGL AGLSGGT (308) EKVX-Lung AGG AGGGPPA (309) EKVX-Lung AGGGPPA (310) EKVX-Lung FFPAGGP (311) EKVX-Lung PRAGGRW (312) EKVX-Lung GVR DVPGVRF (313) EKVX-Lung GVL FGVLFRS (314) EKVX-Lung SRYGVLV (315) EKVX-Lung GAV EKVX-Lung GLV LRGGLVS (316) EKVX-Lung GLR KSGLRPA (317) EKVX-Lung LVS ALVSFSV (318) EKVX-Lung LRGGLVS (319) EKVX-Lung ARG HKLARGR (320) EKVX-Lung ASL ASLPPRA (321) EKVX-Lung AAV EKVX-Lung AAS EKVX-Lung GGS TGGSLGA (322) EKVX-Lung GGGSWLI (323) EKVX-Lung GGR DGGRRSS (324) EKVX-Lung SVLGGRL (325) EKVX-Lung PRAGGRW (326) EKVX-Lung GLG YWFIGLG (327) EKVX-Lung GGL GGLSVDL (328) EKVX-Lung LRGGLVS (329) EKVX-Lung GSS SGVGSSL (330) EKVX-Lung GSG GSGILDL (331) EKVX-Lung GSV SLGSVGS (332) EKVX-Lung GRV EKVX-Lung GRL VGRGRLH (333) EKVX-Lung SVLGGRL (334) EKVX-Lung MSAFGRL (335) EKVX-Lung GPS EKVX-Lung GVS SGVSGLS (336) EKVX-Lung RLS Hop-62-Lung RGV GDSRRGV (337) Hop-62-Lung GKALRGV (338) Hop-62-Lung RGS PKAGRGS (339) Hop-62-Lung RAV FDRAVAN (340) Hop-62-Lung LLRRAVF (341) Hop-62-Lung RAS FRASSEV (342) Hop-62-Lung PDRASDG (343) Hop-62-Lung FRASLQY (344) Hop-62-Lung GAG Hop-62-Lung AVS Hop-62-Lung LLS Hop-62-Lung LLR HVGLLRA (345) Hop-62-Lung QVLLRSF (346) Hop-62-Lung LLRRAVF (347) Hop-62-Lung LRV FLRVGEL (348) Hop-62-Lung LRS QVLLRSF (349) Hop-62-Lung RVS RRVSCDL (350) Hop-62-Lung RSS RSSGLGF (351) Hop-62-Lung SSGPRSS (352) Hop-62-Lung YSQRSSL (353) Hop-62-Lung Hop-62-Lung AGS Hop-62-Lung AGR DAGRTID (354) Hop-62-Lung AAGREFR (355) Hop-62-Lung PKAGRGS (356) Hop-62-Lung VRAAGRV (357) Hop-62-Lung Hop-62-Lung AGL Hop-62-Lung AGG HGYRAGG (358) Hop-62-Lung WGATAGG (359) Hop-62-Lung YYAGGLK (360) Hop-62-Lung GVR LEGVRLF (361) Hop-62-Lung GVRPFPR (362) Hop-62-Lung GVL GTFGVLG (363) Hop-62-Lung VWAGVLL (364) Hop-62-Lung GAV GAVLFRV (365) Hop-62-Lung GLV GLVGFTG (366) Hop-62-Lung GLVSAFY (367) Hop-62-Lung GLR ARAMGLR (368) Hop-62-Lung LVS GLVSAFY (369) Hop-62-Lung SWRPLVS (370) Hop-62-Lung ARG Hop-62-Lung
ASL FRASLQY (371) Hop-62-Lung AAV HSESAAV (372) Hop-62-Lung LFAVAAV (373) Hop-62-Lung AAS VAASESH (374) Hop-62-Lung GGS Hop-62-Lung GGR HPSMGGR (375) Hop-62-Lung GLG GLGVSGV (376) Hop-62-Lung KRESGLG (377) Hop-62-Lung RSSGLGF (378) Hop-62-Lung VGLGHWP (379) Hop-62-Lung GGL YYAGGLK (380) Hop-62-Lung GSS NYGSSFH (381) Hop-62-Lung FGLGSSR (382) Hop-62-Lung SSRPGSS (383) Hop-62-Lung GSG Hop-62-Lung GSV VGSVGLG (384) Hop-62-Lung GRV VRAAGRV (385) Hop-62-Lung GRL HNGRLEV (386) Hop-62-Lung VGRLAKG (387) Hop-62-Lung GPS VMGGPSL (388) Hop-62-Lung GVS GLGVSGV (389) Hop-62-Lung SGVSVEG (390) Hop-62-Lung RLS GESGRLS (391) Hop-92-Lung RGV GSGRGVA (392) Hop-92-Lung RGVVSAK (393) Hop-92-Lung RGVVSGV (394) Hop-92-Lung RGS AVGRGSG (395) Hop-92-Lung SLRGSEG (396) Hop-92-Lung PATRGSV (397) Hop-92-Lung RAV SLTRAVR (398) Hop-92-Lung VARAVPC (399) Hop-92-Lung RAS EGARASD (400) Hop-92-Lung GAG Hop-92-Lung AVS MGSAVSL (401) Hop-92-Lung LLS Hop-92-Lung LLR GGALLRG (402) Hop-92-Lung LRV Hop-92-Lung LRS Hop-92-Lung RVS PNRRVSA (403) Hop-92-Lung QDRVSRS (404) Hop-92-Lung RSS SERSSLG (405) Hop-92-Lung LVRSSGL (406) Hop-92-Lung AGS Hop-92-Lung AGR Hop-92-Lung AGL INWAGLS (407) Hop-92-Lung WAGLSPS (408) Hop-92-Lung AGG GRLLAGG (409) Hop-92-Lung GVR Hop-92-Lung GVL Hop-92-Lung GAV Hop-92-Lung GLV SYGLVLP (410) Hop-92-Lung SGGLVLT (411) Hop-92-Lung HAAHGLV (412) Hop-92-Lung GLR GLRTRQV (413) Hop-92-Lung LVS LVSGYNG (414) Hop-92-Lung ARG AGIARGG (415) Hop-92-Lung ASL Hop-92-Lung AAV Hop-92-Lung AAS Hop-92-Lung GGS HVSGGSG (416) Hop-92-Lung GGSSEFR (417) Hop-92-Lung GGSGIGS (418) Hop-92-Lung SWGSGGS (419) Hop-92-Lung TLVLGGS (420) Hop-92-Lung GGR AVRGGRP (421) Hop-92-Lung GGRAIGA (422) Hop-92-Lung GLG Hop-92-Lung GGL SGGLVLT (423) Hop-92-Lung GSS RTGSSDL (424) Hop-92-Lung LGSSRVL (425) Hop-92-Lung GGSSEFR (426) Hop-92-Lung GSG AVGRGSG (427) Hop-92-Lung HVSGGSG (428) Hop-92-Lung SGIGSGG (429) Hop-92-Lung SWGSGGS (430) Hop-92-Lung WVGSGSP (431) Hop-92-Lung GSV GSGGSVH (432) Hop-92-Lung GNYGSVL (433) Hop-92-Lung VGSVVGR (434) Hop-92-Lung PATRGSV (435) Hop-92-Lung GRV PRGGRVA (436) Hop-92-Lung GRVHLMP (437) Hop-92-Lung GRL GESGRLS (438) Hop-92-Lung GRLLAGG (439) Hop-92-Lung GRLWWHT (440) Hop-92-Lung GRLWSRV (441) Hop-92-Lung GPS AGPSAWL (442) Hop-92-Lung GVS SGVSRGQ (443) Hop-92-Lung RLS H226-Lung RGV RGVSLKG (444) H226-Lung RGS H226-Lung RAV QMQGRAV (445) H226-Lung RAS H226-Lung GAG H226-Lung AVS H226-Lung LLS H226-Lung LLR H226-Lung LRV H226-Lung LRS RGLRSVN (446) H226-Lung RVS H226-Lung RSS RSSLGLP (447) H226-Lung AGS LEAGSQL (448) H226-Lung AGR H226-Lung AGL H226-Lung AGG AGGQSER (449) H226-Lung GVR H226-Lung GVL GGVLYLE (450) H226-Lung GAV H226-Lung GLV H226-Lung GLR RGLRSVN (451) H226-Lung LVS H226-Lung ARG VARGQMQ (452) H226-Lung ASL H226-Lung AAV H226-Lung AAS H226-Lung GGS GGSRNRW (453) H226-Lung GGR GGGRSGV (454) H226-Lung GLG GLGGWVA (455) H226-Lung GGL AVWGGLG (456) H226-Lung GGLSECV (457) H226-Lung GSS H226-Lung GSG H226-Lung GSV AKLGSVY (458) H226-Lung GRV QGRVNVK (459) H226-Lung GRL GRLWGFW (460) H226-Lung GPS H226-Lung GVS RGVSLKG (461) H226-Lung GSLGVSL (462) H226-Lung RLS LLRLSLA (463) H23-Lung RGV H23-Lung RGS RRGSGGL (464) H23-Lung VRGSVRA (465) H23-Lung RAV H23-Lung RAS H23-Lung GAG H23-Lung AVS H23-Lung LLS H23-Lung LLR LLRLSLA (466) H23-Lung LRV PLRVDNL (467) H23-Lung LRVGIGY (468) H23-Lung QGYALRV (469) H23-Lung LRS PLRSFDS (470) H23-Lung RVS ARVSGRV (471) H23-Lung RSS PFPARSS (472) H23-Lung AGS AGSPLAK (473) H23-Lung FVDIAGS (474) H23-Lung AGR SYFRAGR (475) H23-Lung AGL AGLGHEG (476) H23-Lung AGG AGGSLGS (477) H23-Lung GVR YGIGVRL (478) H23-Lung GVL RANGVLV (479) H23-Lung GAV H23-Lung GLV H23-Lung GLR H23-Lung LVS H23-Lung ARG H23-Lung ASL LASLGVG (480) H23-Lung AAV RAAVGAR (481) H23-Lung AAS H23-Lung GGS GCDGGSA (482) H23-Lung GGSGELG (483) H23-Lung LGGSGRR (484) H23-Lung AGGSLGS (485) H23-Lung GGR IGGREIT (486) H23-Lung GLG GEHGLGA (487) H23-Lung GGL RRGSGGL (488) H23-Lung GSS RSGSSVY (489) H23-Lung GSG GLEGSGG (490) H23-Lung LGGSGRR (491) H23-Lung GSV TTGSVIV (492) H23-Lung VRGSVRA (493) H23-Lung GRV HGRVHRL (494) H23-Lung ARVSGRV (495) H23-Lung GRL H23-Lung GPS H23-Lung GVS SGHGVSA (496) H23-Lung RLS AVWRLSH (497) H322-Lung RGV RGVFYGK (498) H322-Lung RGVGWAK (499) H322-Lung RGS SRGSTAG (500) H322-Lung RAV H322-Lung RAS H322-Lung GAG SEDEGAG (501) H322-Lung STSLGAG (502) H322-Lung AVS H322-Lung LLS H322-Lung LLR DLLRYLA (503) H322-Lung LRV LRVRYAV (504) H322-Lung LRS LRSSGAT (505) H322-Lung LSMLRSA (506) H322-Lung RVS REAERVS (507) H322-Lung RSS LRSSGAT (508) H322-Lung AGS TAGSSRL (509) H322-Lung AGR AAGRAGC (510) H322-Lung AGL GAGLSTS (511) H322-Lung AGG H322-Lung GVR PSVGVRA (512) H322-Lung GVL H322-Lung GAV VGAVYFL (513) H322-Lung GLV H322-Lung GLR LGLRAFV (514) H322-Lung LVS TELVSWS (515) H322-Lung ARG CGARGAA (516) H322-Lung ASL H322-Lung AAV H322-Lung AAS H322-Lung GGS GGSRAAE (517) H322-Lung VNLGGSW (518) H322-Lung GGR LIGPGGR (519) H322-Lung GLG H322-Lung GGL LGGLSPH (520) H322-Lung WSGGLNV (521) H322-Lung GSS TAGSSRL (522) H322-Lung SDVSGSS (523) H322-Lung WGSSTVR (524) H322-Lung GSG H322-Lung GSV NLADGSV (525) H322-Lung SSGSVDS (526) H322-Lung GRV GRVPGFE (527) H322-Lung GRVVGEA (528) H322-Lung GRL H322-Lung GPS SRFGPSV (529) H322-Lung GVS ARVGVSP (530) H322-Lung RLS H460-Lung RGV PGKRGVQ (531) H460-Lung RGVASRS (532) H460-Lung RGS ERGSPSR (533) H460-Lung RAV LIRAVSA (534) H460-Lung RAVEMGT (535) H460-Lung RAS H460-Lung GAG WGAGFWM (536) H460-Lung AVS LIRAVSA (537) H460-Lung LLS H460-Lung LLR H460-Lung LRV H460-Lung LRS DRYMLRS (538) H460-Lung RVS H460-Lung RSS PRSSYNE (539) H460-Lung PRSSLVV (540) H460-Lung AGS H460-Lung AGR H460-Lung AGL RRFWAGL (541) H460-Lung AGG PVHSAGG (542) H460-Lung GVR H460-Lung GVL FGGSGVL (543) H460-Lung SSGGVLG (544) H460-Lung
GAV H460-Lung GLV GLVGGSS (545) H460-Lung LSSGLVS (546) H460-Lung GLR H460-Lung LVS LSSGLVS (547) H460-Lung WFSWLVS (548) H460-Lung ARG H460-Lung ASL GASLTGD (549) H460-Lung WSSTASL (550) H460-Lung AAV H460-Lung AAS H460-Lung GGS FGGSGVL (551) H460-Lung GLVGGSS (552) H460-Lung GGR H460-Lung GLG H460-Lung GGL GGLSPHR (553) H460-Lung GSS GLVGGSS (554) H460-Lung SVLGSSL (555) H460-Lung GSG FGGSGVL (556) H460-Lung GSV H460-Lung GRV DVRGRVW (557) H460-Lung AEPRGRV (558) H460-Lung GRL H460-Lung GPS SIGPSTN (559) H460-Lung GVS GVSIRQL (560) H460-Lung RLS H522-Lung RGV H522-Lung RGS H522-Lung RAV H522-Lung RAS H522-Lung GAG H522-Lung AVS AVSKRLP (561) H522-Lung RLAVSGY (562) H522-Lung H522-Lung LLS H522-Lung LLR H522-Lung LRV H522-Lung LRS RREGLRS (563) H522-Lung SRYWLRS (564) H522-Lung H522-Lung RVS H522-Lung RSS H522-Lung AGS H522-Lung AGR AVYRAGR (565) H522-Lung H522-Lung AGL H522-Lung AGG H522-Lung GVR H522-Lung GVL H522-Lung GAV H522-Lung GLV H522-Lung GLR RHFGLRE (566) H522-Lung RREGLRS (567) H522-Lung H522-Lung LVS H522-Lung ARG H522-Lung ASL GQGAASL (568) H522-Lung AAV H522-Lung AAS GQGAASL (569) H522-Lung H522-Lung GGS H522-Lung GGR H522-Lung GLG H522-Lung GGL H522-Lung GSS H522-Lung GSG H522-Lung GSV YGSVALR (570) H522-Lung H522-Lung GRV H522-Lung GRL H522-Lung GPS H522-Lung GVS H522-Lung RLS COLO-205-Colon RGV ARRGVLG (571) COLO-205-Colon LRIARGV (572) COLO-205-Colon RGS YRGSMVG (573) COLO-205-Colon GLRGSVW (574) COLO-205-Colon RAV GPFRAVP (575) COLO-205-Colon RAS COLO-205-Colon GAG COLO-205-Colon AVS COLO-205-Colon LLS COLO-205-Colon LLR COLO-205-Colon LRV COLO-205-Colon LRS AHYTLRS (576) COLO-205-Colon SELRSIR (577) COLO-205-Colon SVYALRS (578) COLO-205-Colon RVS COLO-205-Colon RSS COLO-205-Colon AGS COLO-205-Colon AGR COLO-205-Colon AGL COLO-205-Colon AGG COLO-205-Colon GVR COLO-205-Colon GVL ARRGVLG (579) COLO-205-Colon GAV PGAVLTV (580) COLO-205-Colon GLV GLVGRRA (581) COLO-205-Colon GLVRCVL (582) COLO-205-Colon YDGLVSG (583) COLO-205-Colon GLVTAPL (584) COLO-205-Colon RGLVRVV (585) COLO-205-Colon GLR GLRGSVW (586) COLO-205-Colon NSFGLRY (587) COLO-205-Colon LVS YDGLVSG (588) COLO-205-Colon ARG AARGLEA (589) COLO-205-Colon DNDGARG (590) COLO-205-Colon LRIARGV (591) COLO-205-Colon ASL COLO-205-Colon AAV MSNLAAV (592) COLO-205-Colon AAS COLO-205-Colon GGS COLO-205-Colon GGR COLO-205-Colon GLG COLO-205-Colon GGL COLO-205-Colon GSS YSGSSDF (593) COLO-205-Colon GSG COLO-205-Colon GSV GSVLGDY (594) COLO-205-Colon GLRGSVW (595) COLO-205-Colon GRV DLDGRVV (596) COLO-205-Colon GRL WVSGRLG (597) COLO-205-Colon GPS GPSSMTF (598) COLO-205-Colon GVS DGVSSDY (599) COLO-205-Colon FTSGVSW (600) COLO-205-Colon RLS HCC-2998-Colon RGV HCC-2998-Colon RGS HCC-2998-Colon RAV HCC-2998-Colon RAS VLTRAST (601) HCC-2998-Colon LRASLLW (602) HCC-2998-Colon GAG HCC-2998-Colon AVS HCC-2998-Colon LLS WLLSARL (603) HCC-2998-Colon LLR LLRPGTV (604) HCC-2998-Colon LRV HCC-2998-Colon LRS HCC-2998-Colon RVS HCC-2998-Colon RSS HCC-2998-Colon AGS HCC-2998-Colon AGR HCC-2998-Colon AGL HCC-2998-Colon AGG AAGGLLV (605) HCC-2998-Colon GVR HCC-2998-Colon GVL HCC-2998-Colon GAV HCC-2998-Colon GLV HCC-2998-Colon GLR HCC-2998-Colon LVS HCC-2998-Colon ARG HCC-2998-Colon ASL LRASLLW (606) HCC-2998-Colon AAV HCC-2998-Colon AAS HCC-2998-Colon GGS HCC-2998-Colon GGR HCC-2998-Colon GLG LWGLGWL (607) HCC-2998-Colon RRSGLGD (608) HCC-2998-Colon WWGLGWL (609) HCC-2998-Colon GGL AAGGLLV (610) HCC-2998-Colon GSS HCC-2998-Colon GSG HCC-2998-Colon GSV HCC-2998-Colon GRV HCC-2998-Colon GRL HCC-2998-Colon GPS HCC-2998-Colon GVS HCC-2998-Colon RLS HCT-116 Colon RGV GLRGVVK (611) HCT-116 Colon RGS AVEGRGS (612) HCT-116 Colon NAVRGSA (613) HCT-116 Colon RAV HCT-116 Colon RAS HCT-116 Colon GAG HCT-116 Colon AVS HCT-116 Colon LLS HCT-116 Colon LLR LLRSSLG (614) HCT-116 Colon MYLRLLR (615) HCT-116 Colon LRV HCT-116 Colon LRS LLRSSLG (616) HCT-116 Colon DEGLRSR (617) HCT-116 Colon RVS YWQHRVS (618) HCT-116 Colon RSS ARSSHRA (619) HCT-116 Colon LLRSSLG (620) HCT-116 Colon AGS HCT-116 Colon AGR AGRSCNL (621) HCT-116 Colon AGRPRAT (622) HCT-116 Colon AGL HCT-116 Colon AGG HCT-116 Colon GVR GGVRIAA (623) HCT-116 Colon GVRYLRT (624) HCT-116 Colon GVL HCT-116 Colon GAV HCT-116 Colon GLV PLAVGLV (625) HCT-116 Colon GLR GLRGVVK (626) HCT-116 Colon DEGLRSR (627) HCT-116 Colon LVS QLVSGSL (628) HCT-116 Colon ARG HCT-116 Colon ASL GWSASLG (629) HCT-116 Colon AAV IAAVWRS (630) HCT-116 Colon AAS HCT-116 Colon GGS GGSSLDA (631) HCT-116 Colon LGGSRDL (632) HCT-116 Colon GGR LIGGRNA (633) HCT-116 Colon GLG HCT-116 Colon GGL LDRSGGL (634) HCT-116 Colon GSS GGSSLDA (635) HCT-116 Colon GSSYSGP (636) HCT-116 Colon GSG TVGSGCL (637) HCT-116 Colon GSV LSGSVLQ (638) HCT-116 Colon GRV ASGRVAN (639) HCT-116 Colon GRL KVVGRLG (640) HCT-116 Colon GRLVWGL (641) HCT-116 Colon NEFLGRL (642) HCT-116 Colon GPS LCDAGPS (643) HCT-116 Colon GVS FRAGVSH (644) HCT-116 Colon RLS AGDSRLS (645) HCT-15 Colon RGV HCT-15 Colon RGS HCT-15 Colon RAV DWRRRAV (646) HCT-15 Colon RAS WTERASA (647) HCT-15 Colon GAG HCT-15 Colon AVS HCT-15 Colon LLS RLLSAFG (648) HCT-15 Colon LLR GFASLLR (649) HCT-15 Colon LRV GALRVPW (650) HCT-15 Colon GALRVPW HCT-15 Colon GALRVPW HCT-15 Colon LRS SLRSDGA (651) HCT-15 Colon DTLRSQW (652) HCT-15 Colon LRSVGSW (653) HCT-15 Colon RVS HCT-15 Colon RSS ISPRSSG (654) HCT-15 Colon WRVRSSG (655) HCT-15 Colon AGS HCT-15 Colon AGR AAGRIRP (656) HCT-15 Colon RAAGRVG (657) HCT-15 Colon AGL AGLQHAV (658) HCT-15 Colon AGG AGGWWVG (659) HCT-15 Colon GVR GVRGAAR (660) HCT-15 Colon GVL GVLPVVT (661) HCT-15 Colon GVLPVVT HCT-15 Colon GAV HCT-15 Colon GLV GLVSSLP (662) HCT-15 Colon SRHGLVR (663) HCT-15 Colon SDRGLVV (664) HCT-15 Colon SDRGLVV (665) HCT-15 Colon GLR HCT-15 Colon LVS GLVSSLP (666) HCT-15 Colon
LVSVWSR (667) HCT-15 Colon ARG GSWARGY (668) HCT-15 Colon ASL GFASLLR (669) HCT-15 Colon AAV HAAVMSL (670) HCT-15 Colon AAS HCT-15 Colon GGS HCT-15 Colon GGR DGGRRTD (671) HCT-15 Colon GRPLGGR (672) HCT-15 Colon GRVTGGR (673) HCT-15 Colon GLG HCT-15 Colon GGL RGGLPRG (674) HCT-15 Colon YGQYGGL (675) HCT-15 Colon GSS GSSRPSI (676) HCT-15 Colon PGSSFVG (677) HCT-15 Colon GSSRVRW (678) HCT-15 Colon GSG HCT-15 Colon GSV HCT-15 Colon GRV RAAGRVG (679) HCT-15 Colon GRVTGGR (680) HCT-15 Colon YVRIGRV (681) HCT-15 Colon GRL MITRGRL (682) HCT-15 Colon GPS HCT-15 Colon GVS SVVGVST (683) HCT-15 Colon WSGVSRL (684) HCT-15 Colon RLS RRLSYFH (685) HT-29 Colon PRLSWVL (686) HT-29 Colon RLSALTD (687) HT-29 Colon RGV GRGVGTD (688) HT-29 Colon LKVRGVL (689) HT-29 Colon SSTRGVY (690) HT-29 Colon QVRRGVV (691) HT-29 Colon GRGVTIW (692) HT-29 Colon RGS RGSVASA (693) HT-29 Colon HFIRGSV (694) HT-29 Colon RGSWAGV (695) HT-29 Colon VRGSRWR (696) HT-29 Colon RAV LERAVRT (697) HT-29 Colon RAS GYSRASD (698) HT-29 Colon SRASGHG (699) HT-29 Colon GHYRASV (700) HT-29 Colon DWVCRAS (701) HT-29 Colon GAG GAGRGTP (702) HT-29 Colon LSLAGAG (703) HT-29 Colon AVS ASAVSGR (704) HT-29 Colon FSGDAVS (705) HT-29 Colon LLS LKLLSVP (706) HT-29 Colon LLR HT-29 Colon LRV GTLRVGS (707) HT-29 Colon LRS EHYRLRS (708) HT-29 Colon LRSWLLF (709) HT-29 Colon RRPGLRS (710) HT-29 Colon SKYNLRS (711) HT-29 Colon WQVALRS (712) HT-29 Colon LRSDPRS (713) HT-29 Colon VPLRSSA (714) HT-29 Colon RVS HT-29 Colon RSS GRSSGME (715) HT-29 Colon VPLRSSA (716) HT-29 Colon AGS AGSGFPF (717) HT-29 Colon AGR GAGRGTP (718) HT-29 Colon AGRIASK (719) HT-29 Colon AGL WGVAGLG (720) HT-29 Colon LAGLVSG (721) HT-29 Colon AGG DAGGMDL (722) HT-29 Colon AGGRWNL (723) HT-29 Colon GVR GCGGVRD (724) HT-29 Colon SGVRLTG (725) HT-29 Colon GVL LKVRGVL (726) HT-29 Colon GAV GLGAVGW (727) HT-29 Colon PGAVPGA (728) HT-29 Colon RIGAVWY (729) HT-29 Colon GLV FSGLVVA (730) HT-29 Colon PGGLVPG (731) HT-29 Colon LAGLVSG (732) HT-29 Colon LGLVSTT (733) HT-29 Colon GLR GLRLGVT (734) HT-29 Colon RRPGLRS (735) HT-29 Colon LVS LAGLVSG (736) HT-29 Colon LGLVSTT (737) HT-29 Colon RQLVSPA (738) HT-29 Colon ARG LRARGGH (739) HT-29 Colon ASL ELWASLG (740) HT-29 Colon DTLASLR (741) HT-29 Colon VVASLPH (742) HT-29 Colon AAV HT-29 Colon AAS VLRAASR (743) HT-29 Colon AASGSYY (744) HT-29 Colon GGS GGSALFG (745) HT-29 Colon GRGGSGY (746) HT-29 Colon GGR YGSGGRG (747) HT-29 Colon GTLGGRV (748) HT-29 Colon AGGRWNL (749) HT-29 Colon HGGRARL (750) HT-29 Colon RGGRSPS (751) HT-29 Colon RKPGGGR (752) HT-29 Colon EGGRTHW (753) HT-29 Colon GLG GEVGLGV (754) HT-29 Colon GLGAVGW (755) HT-29 Colon GGL PGGLVPG (756) HT-29 Colon VRGGLTG (757) HT-29 Colon RQKCGGL (758) HT-29 Colon RYGVGGL (759) HT-29 Colon GSS EMGSSRG (760) HT-29 Colon GSG AGSGFPF (761) HT-29 Colon GRGGSGY (762) HT-29 Colon GSV GSVSAGA (763) HT-29 Colon RGSVASA (764) HT-29 Colon DLGSVQH (765) HT-29 Colon HFIRGSV (766) HT-29 Colon GSVLGAL (767) HT-29 Colon GRV GTLGGRV (768) HT-29 Colon LGRVHVW (769) HT-29 Colon LVGRVKL (770) HT-29 Colon RWRSGRV (771) HT-29 Colon GRL RNPGRLA (772) HT-29 Colon PRGRLFD (773) HT-29 Colon GRLAVVA (774) HT-29 Colon LAQGRLA (775) HT-29 Colon GGMNGRL (776) HT-29 Colon GPS RSTLGPS (777) HT-29 Colon GVS GVSALSL (778) HT-29 Colon RLS SRLSYYA (779) KM-12C Colon SRLSYYA KM-12C Colon RGV ARGVSAP (780) KM-12C Colon GRGVLAF (781) KM-12C Colon RGS MRGSGRN (782) KM-12C Colon RAV RDGRAVR (783) KM-12C Colon GRAVWMV (784) KM-12C Colon RAS KM-12C Colon GAG KM-12C Colon AVS KM-12C Colon LLS KM-12C Colon LLR KM-12C Colon LRV LRVPGGP (785) KM-12C Colon LRS AYYSLRS (786) KM-12C Colon AYYSLRS KM-12C Colon VLRSALQ (787) KM-12C Colon VYYALRS (788) KM-12C Colon VYYALRS KM-12C Colon VYYALRS KM-12C Colon VYYALRS KM-12C Colon VYYALRS KM-12C Colon VYYALRS KM-12C Colon VYYALRS KM-12C Colon RVS RYRVSVY (789) KM-12C Colon RSS KM-12C Colon AGS KM-12C Colon AGR KM-12C Colon AGL KM-12C Colon AGG AGGIWIR (790) KM-12C Colon GVR WQVSGVR (791) KM-12C Colon GVL GRGVLAF (792) KM-12C Colon GAV KM-12C Colon GLV KM-12C Colon GLR KM-12C Colon LVS HAELVSL (793) KM-12C Colon ARG ARGVSAP (794) KM-12C Colon RVARGDR (795) KM-12C Colon VMWVARG (796) KM-12C Colon ASL KM-12C Colon AAV AAVTVVR (797) KM-12C Colon AAS KM-12C Colon GGS KM-12C Colon GGR KM-12C Colon GLG KM-12C Colon GGL TREGGLD (798) KM-12C Colon LGGGGLL (799) KM-12C Colon GSS KM-12C Colon GSG GSGHSFA (800) KM-12C Colon MRGSGRN (801) KM-12C Colon GSV RVGSVQW (802) KM-12C Colon EGTSGSV (803) KM-12C Colon GRV GRVPTVV (804) KM-12C Colon KM-12C Colon GRL ADGRLRY (805) KM-12C Colon GPS KM-12C Colon GVS ARGVSAP (806) KM-12C Colon RLS SW620-Colon RGV RGVKLGD (807) SW620-Colon RGS LRGSYVL (808) SW620-Colon RRGSLMF (809) SW620-Colon RGSVGPS (810) SW620-Colon RAV SW620-Colon RAS SRASDVT (811) SW620-Colon GAG SW620-Colon AVS SW620-Colon LLS AAKTLLS (812) SW620-Colon LLR SW620-Colon LRV SW620-Colon LRS RSYPLRS (813) SW620-Colon RVS YLGRRVS (814) SW620-Colon RSS RSSPVWT (815) SW620-Colon AGS DLRRAGS (816) SW620-Colon AGR SW620-Colon AGL GVAGLRW (817) SW620-Colon AGG RIDAGGG (818) SW620-Colon GVAGGAT (819) SW620-Colon GVR SW620-Colon GVL SW620-Colon GAV TAGGAVG (820) SW620-Colon WRLGAVG (821) SW620-Colon GLV SGLVAMV (822) SW620-Colon GLR VGLRDWG (823) SW620-Colon GVAGLRW (824) SW620-Colon LVS SW620-Colon ARG ARGIVRV (825) SW620-Colon ASL ASLHHRR (826) SW620-Colon AAV SW620-Colon AAS GAAASGY (827) SW620-Colon GGS SW620-Colon GGR SW620-Colon GLG LAIRGLG (828) SW620-Colon GGL GGLSNVV (829) SW620-Colon PPGGLKW (830) SW620-Colon GSS SW620-Colon GSG SW620-Colon GSV EGSVDAH (831) SW620-Colon RGSVGPS (832) SW620-Colon GRV SW620-Colon GRL LVYSGRL (833) SW620-Colon VEEGRLR (834) SW620-Colon GPS RGSVGPS (835) SW620-Colon GVS SPGVSGR (836) SW620-Colon RGV RVGRGVL (837) SF-268 CNS RGS SF-268 CNS RAV WIWRAVS (838) SF-268 CNS RAS SF-268 CNS GAG VTDGAGQ (839) SF-268 CNS AVS LGTAVSS (840) SF-268 CNS WIWRAVS (841) SF-268 CNS DTPSAVS (842) SF-268 CNS LLS GLLSAGI (843) SF-268 CNS LLR YLLRALG (844) SF-268 CNS LRV SF-268 CNS LRS LRSGSLG (845) SF-268 CNS PLRSVWS (846) SF-268 CNS RVS SF-268 CNS RSS ARSSIVR (847) SF-268 CNS AGS SF-268 CNS AGR SF-268 CNS AGL SF-268 CNS AGG AGGRLGL (848) SF-268 CNS AGGWRGR (849) SF-268 CNS GVR LVGRGVR (850) SF-268 CNS GVL DVVGVLK (851) SF-268 CNS RVGRGVL (852) SF-268 CNS GAV GAVTGYP (853) SF-268 CNS
GLV WGLVRHA (854) SF-268 CNS GLR LGLRGGA (855) SF-268 CNS LVS SF-268 CNS ARG SF-268 CNS ASL IGASLLG (856) SF-268 CNS AAV AAVETGV (857) SF-268 CNS AAS SF-268 CNS GGS GLGGGGS (858) SF-268 CNS GGR EVLWGGR (859) SF-268 CNS AGGRLGL (860) SF-268 CNS GGRSKKV (861) SF-268 CNS GLG GLGGGGS (862) SF-268 CNS GGL SGGGGLG (863) SF-268 CNS GAYGGLL (864) SF-268 CNS GGLSRSN (865) SF-268 CNS GSS FGSSNRS (866) SF-268 CNS GSG SF-268 CNS GSV GSVSDRF (867) SF-268 CNS GRV SF-268 CNS GRL AGGRLGL (868) SF-268 CNS GPS WFKGPSV (869) SF-268 CNS GVS SF-268 CNS RLS SF-295 CNS RGV LSERRGV (870) SF-295 CNS ARGVAEY (871) SF-295 CNS SF-295 CNS RGS FDRGSLT (872) SF-295 CNS SF-295 CNS RAV SF-295 CNS RAS GRLRASL (873) SF-295 CNS SF-295 CNS GAG RDGRGAG (874) SF-295 CNS SF-295 CNS AVS GAVSVLA (875) SF-295 CNS TRGDAVS (876) SF-295 CNS SF-295 CNS LLS LLSPRGT (877) SF-295 CNS SF-295 CNS LLR LLRSHGV (878) SF-295 CNS SF-295 CNS LRV PLRVLKR (879) SF-295 CNS GRLRLRV (880) SF-295 CNS SF-295 CNS LRS LLRSHGV (881) SF-295 CNS VLRSGEL (882) SF-295 CNS VLRSIPS (883) SF-295 CNS VLRSIPS SF-295 CNS SF-295 CNS RVS GSMHRVS (884) SF-295 CNS YSIMRVS (885) SF-295 CNS SF-295 CNS RSS SF-295 CNS AGS RAGSRVQ (886) SF-295 CNS SF-295 CNS AGR RRDAGRM (887) SF-295 CNS GAGRGDR (888) SF-295 CNS SF-295 CNS AGL RWAGLVA (889) SF-295 CNS SF-295 CNS AGG QTLSAGG (890) SF-295 CNS LAGGWGS (891) SF-295 CNS SF-295 CNS GVR RHGVRSK (892) SF-295 CNS SF-295 CNS GVL SF-295 CNS GAV GAVSVLA (893) SF-295 CNS SF-295 CNS GLV RWAGLVA (894) SF-295 CNS SF-295 CNS GLR GRGLRTD (895) SF-295 CNS TLGGLRT (896) SF-295 CNS SF-295 CNS LVS ALVSVAG (897) SF-295 CNS SF-295 CNS ARG ARGVAEY (898) SF-295 CNS SF-295 CNS ASL GGASLTQ (899) SF-295 CNS GRLRASL (900) SF-295 CNS SNHTASL (901) SF-295 CNS SF-295 CNS AAV YADGAAV (902) SF-295 CNS SF-295 CNS AAS SF-295 CNS GGS SF-295 CNS GGR SF-295 CNS GLG LGGLGIH (903) SF-295 CNS SF-295 CNS GGL GGFTGGL (904) SF-295 CNS HIGLGGL (905) SF-295 CNS TRLGGLT (906) SF-295 CNS SF-295 CNS GSS SF-295 CNS GSG SF-295 CNS GSV VMPGSVV (907) SF-295 CNS SF-295 CNS GRV SF-295 CNS GRL GRLRASL (908) SF-295 CNS GRLYLGI (909) SF-295 CNS GRLRLRV (910) SF-295 CNS SF-295 CNS SF-295 CNS GPS SHCGPSN (911) SF-295 CNS SHCGPSN SF-295 CNS SF-295 CNS GVS SF-295 CNS RLS VRLSGRA (912) SNB-19 CNS RLSTFAG (913) SNB-19 CNS RGV SNB-19 CNS RGS ARGSLRV (914) SNB-19 CNS FSPRGSV (915) SNB-19 CNS RAV GGRLRAV (916) SNB-19 CNS RAS SNB-19 CNS GAG SNB-19 CNS AVS VLSAVSS (917) SNB-19 CNS LLS SNB-19 CNS LLR SNB-19 CNS LRV ARGSLRV (918) SNB-19 CNS LRS LRSYAWS (919) SNB-19 CNS RVS KGRVSAG (920) SNB-19 CNS RSS SNB-19 CNS AGS SNB-19 CNS AGR SNB-19 CNS AGL AGLTIGI (921) SNB-19 CNS AGG AWRHAGG (922) SNB-19 CNS WARAGGF (923) SNB-19 CNS GVR SNB-19 CNS GVL MGVLTAE (924) SNB-19 CNS FAGYGVL (925) SNB-19 CNS GAV RIFHGAV (926) SNB-19 CNS GLV EGLVVFE (927) SNB-19 CNS GLR REVPGLR (928) SNB-19 CNS LVS LVSVNGA (929) SNB-19 CNS HSLVSQP (930) SNB-19 CNS ARG ARGSLRV (931) SNB-19 CNS ASL SSVASLV (932) SNB-19 CNS AAV AAVWQMK (933) SNB-19 CNS QRAAVIV (934) SNB-19 CNS AAS SNB-19 CNS GGS PGGSDAA (935) SNB-19 CNS GGR GGRLRAV (936) SNB-19 CNS GLG SNB-19 CNS GGL LPCGGLA (937) SNB-19 CNS GSS GSSHDAL (938) SNB-19 CNS TQYYGSS (939) SNB-19 CNS GSG SNB-19 CNS GSV FSPRGSV (940) SNB-19 CNS GRV KGRVSAG (941) SNB-19 CNS QGRVNVK (942) SNB-19 CNS GRL GGRLRAV (943) SNB-19 CNS YDGRLAR (944) SNB-19 CNS GPS SNB-19 CNS GVS SNB-19 CNS RLS SNB-75 CNS RGV PQGRGVK (945) SNB-75 CNS RGS MVLRGSY (946) SNB-75 CNS RAV GGWARAV (947) SNB-75 CNS VRAVCLM (948) SNB-75 CNS RAS TRASRRG (949) SNB-75 CNS GAG LGAGEGD (950) SNB-75 CNS AVS IGAVSGW (951) SNB-75 CNS LLS LLSRRVG (952) SNB-75 CNS LELLSVV (953) SNB-75 CNS RLLSEGY (954) SNB-75 CNS LLR QLPGLLR (955) SNB-75 CNS YGESLLR (956) SNB-75 CNS LRV LRVYGEG (957) SNB-75 CNS LRS SNB-75 CNS RVS YRVSSGS (958) SNB-75 CNS RSS RSSSSTR (959) SNB-75 CNS AGS WAGSNYS (960) SNB-75 CNS AGR CAGRARR (961) SNB-75 CNS AGL IAGLAVV (962) SNB-75 CNS DGEGAGL (963) SNB-75 CNS AGG ALAGGGL (964) SNB-75 CNS GVR GVRRSLL (965) SNB-75 CNS GVL ADWGVLE (966) SNB-75 CNS GAV IGAVSGW (967) SNB-75 CNS GLV ASGLVVT (968) SNB-75 CNS GLR IGLRGEN (969) SNB-75 CNS LVS SNB-75 CNS ARG RRARGAC (970) SNB-75 CNS ASL YAASLMG (971) SNB-75 CNS AAV LTAAVMV (972) SNB-75 CNS AAS YAASLMG (973) SNB-75 CNS GGS RARTGGS (974) SNB-75 CNS VSGDGGS (975) SNB-75 CNS GGR FGGRSLS (976) SNB-75 CNS SLGGRTF (977) SNB-75 CNS GLG ARRGLGL (978) SNB-75 CNS GGL ALAGGGL (979) SNB-75 CNS FRALGGL (980) SNB-75 CNS FTRGGLS (981) SNB-75 CNS GSS SGSSVRY (982) SNB-75 CNS GSG SNB-75 CNS GSV WGSVAGI (983) SNB-75 CNS SGGDGSV (984) SNB-75 CNS GRV SNB-75 CNS GRL NEGRLGI (985) SNB-75 CNS YSGRLVM (986) SNB-75 CNS GPS DGPSGCS (987) SNB-75 CNS GVS SNB-75 CNS RLS U251 CNS RGV U251 CNS RGS RGSRTGP (988) U251 CNS RAV U251 CNS RAS U251 CNS GAG U251 CNS AVS U251 CNS LLS U251 CNS LLR U251 CNS LRV U251 CNS LRS U251 CNS RVS U251 CNS RSS U251 CNS AGS U251 CNS AGR U251 CNS AGL U251 CNS AGG U251 CNS GVR U251 CNS GVL U251 CNS GAV U251 CNS GLV U251 CNS GLR U251 CNS LVS U251 CNS ARG U251 CNS ASL U251 CNS AAV U251 CNS AAS U251 CNS GGS U251 CNS GGR U251 CNS GLG U251 CNS GGL U251 CNS GSS GSSACGA (989) U251 CNS GSG U251 CNS GSV U251 CNS GRV U251 CNS GRL U251 CNS GPS U251 CNS GVS U251 CNS RLS VRLSGRA (990) SF-539 CNS RLSTFAG (991) SF-539 CNS RGV SF-539 CNS RGS ARGSLRV (992) SF-539 CNS FSPRGSV (993) SF-539 CNS RAV GGRLRAV (994) SF-539 CNS RAS SF-539 CNS
GAG SF-539 CNS AVS VLSAVSS (995) SF-539 CNS LLS SF-539 CNS LLR SF-539 CNS LRV ARGSLRV (996) SF-539 CNS LRS LRSYAWS (997) SF-539 CNS RVS KGRVSAG (998) SF-539 CNS RSS SF-539 CNS AGS SF-539 CNS AGR SF-539 CNS AGL AGLTIGI (999) SF-539 CNS AGG AWRHAGG (1000) SF-539 CNS WARAGGF (1001) SF-539 CNS GVR SF-539 CNS GVL MGVLTAE (1002) SF-539 CNS FAGYGVL (1003) SF-539 CNS GAV RIFHGAV (1004) SF-539 CNS GLV EGLVVFE (1005) SF-539 CNS GLR REVPGLR (1006) SF-539 CNS LVS LVSVNGA (1007) SF-539 CNS HSLVSQP (1008) SF-539 CNS ARG ARGSLRV (1009) SF-539 CNS ASL SSVASLV (1010) SF-539 CNS AAV AAVWQMK (1011) SF-539 CNS QRAAVIV (1012) SF-539 CNS AAS SF-539 CNS GGS SF-539 CNS GGR GGRLRAV (1013) SF-539 CNS GLG SF-539 CNS GGL LPCGGLA (1014) SF-539 CNS GSS GSSHDAL (1015) SF-539 CNS TQYYGSS (1016) SF-539 CNS GSG SF-539 CNS GSV FSPRGSV (1017) SF-539 CNS GRV KGRVSAG (1018) SF-539 CNS QGRVNVK (1019) SF-539 CNS GRL GGRLRAV (1020) SF-539 CNS YDGRLAR (1021) SF-539 CNS GPS SF-539 CNS GVS SF-539 CNS RLS SRLSYWQ (1022) LOX-IMVI Melanoma RGV FVGSRGV (1023) LOX-IMVI Melanoma SVDRGVI (1024) LOX-IMVI Melanoma RGS GRGSGGF (1025) LOX-IMVI Melanoma RAV LOX-IMVI Melanoma RAS LOX-IMVI Melanoma GAG IFGAGLR (1026) LOX-IMVI Melanoma AVS GWVAVSC (1027) LOX-IMVI Melanoma LLS LLSGVIL (1028) LOX-IMVI Melanoma GSTLLSR (1029) LOX-IMVI Melanoma LLR LOX-IMVI Melanoma LRV LOX-IMVI Melanoma LRS QWYSLRS (1030) LOX-IMVI Melanoma RVS TWIGRVS (1031) LOX-IMVI Melanoma RSS LOX-IMVI Melanoma AGS SVVLAGS (1032) LOX-IMVI Melanoma AGR LOX-IMVI Melanoma AGL IFGAGLR (1033) LOX-IMVI Melanoma AGG SAGGWCA (1034) LOX-IMVI Melanoma GVR RDGVRVG (1035) LOX-IMVI Melanoma VSRIGVR (1036) LOX-IMVI Melanoma GVRSMPV (1037) LOX-IMVI Melanoma GVL GGVLGSD (1038) LOX-IMVI Melanoma WGVLQLE (1039) LOX-IMVI Melanoma GAV HGGPGAV (1040) LOX-IMVI Melanoma GLV DSGLVGG (1041) LOX-IMVI Melanoma GLR IFGAGLR (1042) LOX-IMVI Melanoma RMGFGLR (1043) LOX-IMVI Melanoma LVS LOX-IMVI Melanoma ARG LOX-IMVI Melanoma ASL LOX-IMVI Melanoma AAV WLDAAVK (1044) LOX-IMVI Melanoma AAS IAASYRG (1045) LOX-IMVI Melanoma GGS ATIPGGS (1046) LOX-IMVI Melanoma DGGSLVV (1047) LOX-IMVI Melanoma FGGSGRG (1048) LOX-IMVI Melanoma GGR SPTGGRR (1049) LOX-IMVI Melanoma TWSTGGR (1050) LOX-IMVI Melanoma GLG LOX-IMVI Melanoma GGL SRSCGGL (1051) LOX-IMVI Melanoma GSS LOX-IMVI Melanoma GSG CPGSGII (1052) LOX-IMVI Melanoma FGGSGRG (1053) LOX-IMVI Melanoma GSV SGSVVQR (1054) LOX-IMVI Melanoma GRV TWIGRVS (1055) LOX-IMVI Melanoma GRL LOX-IMVI Melanoma GPS GPSWATV (1056) LOX-IMVI Melanoma GVS LOX-IMVI Melanoma RLS MALME-3M Melanoma RGV MALME-3M Melanoma RGS ARRGSGL (1057) MALME-3M Melanoma RAV RAVGYNA (1058) MALME-3M Melanoma LRAVEFL (1059) MALME-3M Melanoma RAS MALME-3M Melanoma GAG MALME-3M Melanoma AVS MALME-3M Melanoma LLS FEDLLSL (1060) MALME-3M Melanoma RWLSLLS (1061) MALME-3M Melanoma LLR MALME-3M Melanoma LRV HAPGLRV (1062) MALME-3M Melanoma LRS LRSSMML (1063) MALME-3M Melanoma RPKLRSV (1064) MALME-3M Melanoma RVS SRVSFHE (1065) MALME-3M Melanoma RSS LRSSMML (1066) MALME-3M Melanoma SSGGRSS (1067) MALME-3M Melanoma AGS MALME-3M Melanoma AGR VAGRVGI (1068) MALME-3M Melanoma AGL AGLALTV (1069) MALME-3M Melanoma AGG MALME-3M Melanoma GVR IGVRGAV (1070) MALME-3M Melanoma GVL LVRDGVL (1071) MALME-3M Melanoma GAV IGVRGAV (1072) MALME-3M Melanoma GLV HGLVTHN (1073) MALME-3M Melanoma GLR HAPGLRV (1074) MALME-3M Melanoma LVS MALME-3M Melanoma ARG VSSTARG (1075) MALME-3M Melanoma ASL MALME-3M Melanoma AAV RAAVIHT (1076) MALME-3M Melanoma AAS AASTRSL (1077) MALME-3M Melanoma GGS GWGGGSA (1078) MALME-3M Melanoma SSRGGSS (1079) MALME-3M Melanoma GGR SSGGRSS (1080) MALME-3M Melanoma GLG MALME-3M Melanoma GGL MALME-3M Melanoma GSS SSRGGSS (1081) MALME-3M Melanoma GSG ARRGSGL (1082) MALME-3M Melanoma GSV MALME-3M Melanoma GRV VAGRVGI (1083) MALME-3M Melanoma GRL EGRLMLA (1084) MALME-3M Melanoma GPS MALME-3M Melanoma GVS MALME-3M Melanoma RLS RLSSAPS (1085) M14 Melanoma RRLSYHS (1086) M14 Melanoma FLHMRLS (1087) M14 Melanoma RGV LARGVPP (1088) M14 Melanoma RGS LSRGSVA (1089) M14 Melanoma VWLRGST (1090) M14 Melanoma RAV M14 Melanoma RAS RGGQRAS (1091) M14 Melanoma GAG M14 Melanoma AVS AVSGRSL (1092) M14 Melanoma LLS GLLSSFS (1093) M14 Melanoma LLR RMGLLRQ (1094) M14 Melanoma LRV M14 Melanoma LRS RLHYLRS (1095) M14 Melanoma GGYWLRS (1096) M14 Melanoma RVS M14 Melanoma RSS NRSSHCG (1097) M14 Melanoma QRSSDLT (1098) M14 Melanoma AGS M14 Melanoma AGR AAGRSRI (1099) M14 Melanoma AGL M14 Melanoma AGG GRAGGNG (1100) M14 Melanoma GVR ANASGVR (1101) M14 Melanoma GVL WAHGVLS (1102) M14 Melanoma GAV M14 Melanoma GLV M14 Melanoma GLR SLYGLRW (1103) M14 Melanoma LVS M14 Melanoma ARG GNGGARG (1104) M14 Melanoma LARGVPP (1105) M14 Melanoma NWDARGR (1106) M14 Melanoma ASL ASLPVLD (1107) M14 Melanoma PPGASLY (1108) M14 Melanoma AAV AAVGGRV (1109) M14 Melanoma AAS AASSWAV (1110) M14 Melanoma GGS AFKTGGS (1111) M14 Melanoma GGR FEGGRSG (1112) M14 Melanoma RTWGGRM (1113) M14 Melanoma SARQGGR (1114) M14 Melanoma AAVGGRV (1115) M14 Melanoma GLG M14 Melanoma GGL M14 Melanoma GSS ARHGSSV (1116) M14 Melanoma SNFYGSS (1117) M14 Melanoma GSG GSGQLIP (1118) M14 Melanoma GSV LSRGSVA (1119) M14 Melanoma GRV AEYGRVL (1120) M14 Melanoma RGRVLLP (1121) M14 Melanoma AAVGGRV (1122) M14 Melanoma GRL RGRLALL (1123) M14 Melanoma SGPGRLP (1124) M14 Melanoma TSGRLWV (1125) M14 Melanoma GPS M14 Melanoma GVS MVYSGVS (1126) M14 Melanoma RLS WRLSREG (1127) SK-MEL-2 Melanoma LLRRLSW (1128) SK-MEL-2 Melanoma RGV AARGVMV (1129) SK-MEL-2 Melanoma RGS ALARGSG (1130) SK-MEL-2 Melanoma NLRGSRS (1131) SK-MEL-2 Melanoma RAV RAVWRAS (1132) SK-MEL-2 Melanoma RAS RAVWRAS SK-MEL-2 Melanoma GAG GAGSFSS (1133) SK-MEL-2 Melanoma AVS SK-MEL-2 Melanoma LLS LLSSRRC (1134) SK-MEL-2 Melanoma LLSLDPG (1135) SK-MEL-2 Melanoma SSLLSSL (1136) SK-MEL-2 Melanoma LLR LLRPAHG (1137) SK-MEL-2 Melanoma LLRRLSW (1138) SK-MEL-2 Melanoma LRV SK-MEL-2 Melanoma LRS CMLRSAT (1139) SK-MEL-2 Melanoma SKAVLRS (1140) SK-MEL-2 Melanoma RVS SRVSNPS (1141) SK-MEL-2 Melanoma RSS CRRSSLL (1142) SK-MEL-2 Melanoma AGS GAGSFSS (1143) SK-MEL-2 Melanoma AGR SAAGRTF (1144) SK-MEL-2 Melanoma PAGRMLS (1145) SK-MEL-2 Melanoma AGL IAMAGLR (1146) SK-MEL-2 Melanoma AGG AGGFRFI (1147) SK-MEL-2 Melanoma GVR SGVRPVI (1148) SK-MEL-2 Melanoma GVL GVLSDRS (1149) SK-MEL-2 Melanoma GAV GAVTSAD (1150) SK-MEL-2 Melanoma GAVTSAD (1151) SK-MEL-2 Melanoma GAVNTPA (1152) SK-MEL-2 Melanoma GLV GGLVKRL (1153) SK-MEL-2 Melanoma EVASGLV (1154) SK-MEL-2 Melanoma GLR IAMAGLR (1155) SK-MEL-2 Melanoma GTHSGLR (1156) SK-MEL-2 Melanoma LVS LVSTSNR (1157) SK-MEL-2 Melanoma FSLVSFV (1158) SK-MEL-2 Melanoma ALVSSHV (1159) SK-MEL-2 Melanoma ARG AARGVMV (1160) SK-MEL-2 Melanoma ALARGSG (1161) SK-MEL-2 Melanoma ASL SK-MEL-2 Melanoma AAV LRYWAAV (1162) SK-MEL-2 Melanoma AAS FTRGAAS (1163) SK-MEL-2 Melanoma EWHAASG (1164) SK-MEL-2 Melanoma GGS FGGSMAP (1165) SK-MEL-2 Melanoma GGSLKWV (1166) SK-MEL-2 Melanoma GGR RGLQGGR (1167) SK-MEL-2 Melanoma TCGGRSY (1168) SK-MEL-2 Melanoma GLG GEALGLG (1169) SK-MEL-2 Melanoma PRGLGVG (1170) SK-MEL-2 Melanoma VGLGNSA (1171) SK-MEL-2 Melanoma GGL GGLVKRL (1172) SK-MEL-2 Melanoma GSS SK-MEL-2 Melanoma GSG GSGRALA (1173) SK-MEL-2 Melanoma GSV SK-MEL-2 Melanoma GRV SK-MEL-2 Melanoma GRL SRSGRLN (1174) SK-MEL-2 Melanoma GPS SK-MEL-2 Melanoma GVS SAGVSDS (1175) SK-MEL-2 Melanoma RLS PRLSDKS (1176) SK-MEL-28 Melanoma RGV GRGDRGV (1177) SK-MEL-28 Melanoma RGVSGRL (1178) SK-MEL-28 Melanoma RGS INRGSRE (1179) SK-MEL-28 Melanoma
LRGSRQF (1180) SK-MEL-28 Melanoma LRGSVGR (1181) SK-MEL-28 Melanoma RAV GLWYRAV (1182) SK-MEL-28 Melanoma RVRAVLG (1183) SK-MEL-28 Melanoma RAVLELW (1184) SK-MEL-28 Melanoma RAS LVRASNG (1185) SK-MEL-28 Melanoma GAG SK-MEL-28 Melanoma AVS SK-MEL-28 Melanoma LLS SK-MEL-28 Melanoma LLR ASGTLLR (1186) SK-MEL-28 Melanoma LRV SK-MEL-28 Melanoma LRS SK-MEL-28 Melanoma RVS GSGVRVS (1187) SK-MEL-28 Melanoma RSS VGSTRSS (1188) SK-MEL-28 Melanoma AGS RAGSRYI (1189) SK-MEL-28 Melanoma AGR SK-MEL-28 Melanoma AGL SK-MEL-28 Melanoma AGG SK-MEL-28 Melanoma GVR VGVRFSR (1190) SK-MEL-28 Melanoma GSGVRVS (1191) SK-MEL-28 Melanoma GVL IGVLASA (1192) SK-MEL-28 Melanoma GAV SK-MEL-28 Melanoma GLV GLVARVR (1193) SK-MEL-28 Melanoma GLR SK-MEL-28 Melanoma LVS SK-MEL-28 Melanoma ARG SK-MEL-28 Melanoma ASL SK-MEL-28 Melanoma AAV SK-MEL-28 Melanoma AAS SK-MEL-28 Melanoma GGS LLGIGGS (1194) SK-MEL-28 Melanoma QLGGSFR (1195) SK-MEL-28 Melanoma GGR LFRWGGR (1196) SK-MEL-28 Melanoma GLG SK-MEL-28 Melanoma GGL RFSGGLQ (1197) SK-MEL-28 Melanoma GSS VGSSHGL (1198) SK-MEL-28 Melanoma GSG SVRVGSG (1199) SK-MEL-28 Melanoma GSV GVNGSVS (1200) SK-MEL-28 Melanoma LRGSVGR (1201) SK-MEL-28 Melanoma GRV HVKNGRV (1202) SK-MEL-28 Melanoma GRL FQRSGRL (1203) SK-MEL-28 Melanoma HGRLAFG (1204) SK-MEL-28 Melanoma RGVSGRL (1205) SK-MEL-28 Melanoma GPS SK-MEL-28 Melanoma GVS RGVSGRL (1206) SK-MEL-28 Melanoma RLS SK-MEL-5 Melanoma RGV FGIGRGV (1207) SK-MEL-5 Melanoma RGS SK-MEL-5 Melanoma RAV SK-MEL-5 Melanoma RAS SK-MEL-5 Melanoma GAG SK-MEL-5 Melanoma AVS GVVQAVS (1208) SK-MEL-5 Melanoma LSAVSVK (1209) SK-MEL-5 Melanoma LLS LYLLSSA (1210) SK-MEL-5 Melanoma LIGGLLS (1211) SK-MEL-5 Melanoma LLR LLRRGIG (1212) SK-MEL-5 Melanoma LRV SK-MEL-5 Melanoma LRS FLRSLSL (1213) SK-MEL-5 Melanoma RVS VRVSGLT (1214) SK-MEL-5 Melanoma RSS SK-MEL-5 Melanoma AGS AGSVDLV (1215) SK-MEL-5 Melanoma AGR GFVAGRT (1216) SK-MEL-5 Melanoma AGL SK-MEL-5 Melanoma AGG SK-MEL-5 Melanoma GVR SK-MEL-5 Melanoma GVL SK-MEL-5 Melanoma GAV TRGAVFG (1217) SK-MEL-5 Melanoma GLV IYGGLVI (1218) SK-MEL-5 Melanoma GLR PTGEGLR (1219) SK-MEL-5 Melanoma LVS SK-MEL-5 Melanoma ARG SK-MEL-5 Melanoma ASL KVSVASL (1220) SK-MEL-5 Melanoma RYSMASL (1221) SK-MEL-5 Melanoma AAV SK-MEL-5 Melanoma AAS ANAASSP (1222) SK-MEL-5 Melanoma GGS PGGSRHA (1223) SK-MEL-5 Melanoma GGSPGVW (1224) SK-MEL-5 Melanoma GGR SK-MEL-5 Melanoma GLG SK-MEL-5 Melanoma GGL IYGGLVI (1225) SK-MEL-5 Melanoma LIGGLLS (1226) SK-MEL-5 Melanoma GSS SK-MEL-5 Melanoma GSG ACGSGLD (1227) SK-MEL-5 Melanoma GSV AGSVDLV (1228) SK-MEL-5 Melanoma TLGSVRV (1229) SK-MEL-5 Melanoma GRV HVRGRVA (1230) SK-MEL-5 Melanoma IDLGRVN (1231) SK-MEL-5 Melanoma GRL GRLDAFG (1232) SK-MEL-5 Melanoma GPS WVGPSGG (1233) SK-MEL-5 Melanoma GVS SK-MEL-5 Melanoma RLS DLRLSFP (1234) UACC 257 Melanoma SARLSHV (1235) UACC 257 Melanoma RGV VMDRGVA (1236) UACC 257 Melanoma RGS RGSLLWA (1237) UACC 257 Melanoma RGSPLTK (1238) UACC 257 Melanoma RAV UACC 257 Melanoma RAS RASIGIE (1239) UACC 257 Melanoma VHSLRAS (1240) UACC 257 Melanoma GAG UACC 257 Melanoma AVS UACC 257 Melanoma LLS AWLLSGR (1241) UACC 257 Melanoma LLR UACC 257 Melanoma LRV UACC 257 Melanoma LRS LWLRSRE (1242) UACC 257 Melanoma RVS VTRIRVS (1243) UACC 257 Melanoma RSS NSQRSSV (1244) UACC 257 Melanoma AGS AATRAGS (1245) UACC 257 Melanoma AGR UACC 257 Melanoma AGL UACC 257 Melanoma AGG UACC 257 Melanoma GVR TDGVRAF (1246) UACC 257 Melanoma GVL FAASGVL (1247) UACC 257 Melanoma GVLEGRR (1248) UACC 257 Melanoma GAV EADPGAV (1249) UACC 257 Melanoma DGAVILH (1250) UACC 257 Melanoma RDGAVNL (1251) UACC 257 Melanoma GLV UACC 257 Melanoma GLR GLRPHGA (1252) UACC 257 Melanoma TSRGLRL (1253) UACC 257 Melanoma LVS RMLVSSF (1254) UACC 257 Melanoma ARG DVIARGW (1255) UACC 257 Melanoma UACC 257 Melanoma ASL UACC 257 Melanoma AAV TLTAAVF (1256) UACC 257 Melanoma GWLNAAV (1257) UACC 257 Melanoma AAS FAASGVL (1258) UACC 257 Melanoma GGS GGSKGSA (1259) UACC 257 Melanoma AVALGGS (1260) UACC 257 Melanoma GGR HGGRYRH (1261) UACC 257 Melanoma SGVGGRY (1262) UACC 257 Melanoma GLG UACC 257 Melanoma GGL SGGLAVA (1263) UACC 257 Melanoma GSS UACC 257 Melanoma GSG UACC 257 Melanoma GSV UACC 257 Melanoma GRV UACC 257 Melanoma GRL GRLAKSI (1264) UACC 257 Melanoma GPS AGPSRGP (1265) UACC 257 Melanoma UACC 257 Melanoma GVS UACC 257 Melanoma RLS GLMRLSH (1266) UACC62 Melanoma VRVGRLS (1267) UACC62 Melanoma TGRLSAA (1268) UACC62 Melanoma RGV SLRGVRV (1269) UACC62 Melanoma DNCERGV (1270) UACC62 Melanoma TTQLRGV (1271) UACC62 Melanoma RGS GVIGRGS (1272) UACC62 Melanoma LAGMRGS (1273) UACC62 Melanoma RAV VRPRAVL (1274) UACC62 Melanoma PPRAVTN (1275) UACC62 Melanoma RAS WRARASP (1276) UACC62 Melanoma GAG UACC62 Melanoma AVS UACC62 Melanoma LLS FGRLLSP (1277) UACC62 Melanoma LLR PSLLRGF (1278) UACC62 Melanoma LRV RDLRVHL (1279) UACC62 Melanoma LRVSNPR (1280) UACC62 Melanoma LRVDQLY (1281) UACC62 Melanoma LRS HRLRSMS (1282) UACC62 Melanoma RVS LRVSNPR (1283) UACC62 Melanoma RSS UACC62 Melanoma AGS PGFMAGS (1284) UACC62 Melanoma AGR AGRGISQ (1285) UACC62 Melanoma RAGRDAP (1286) UACC62 Melanoma RAGRGFE (1287) UACC62 Melanoma AGL UACC62 Melanoma AGG HQAGGVT (1288) UACC62 Melanoma GVR SLRGVRV (1289) UACC62 Melanoma GVL DWVGVLM (1290) UACC62 Melanoma GTLGVLS (1291) UACC62 Melanoma GVLLWRP (1292) UACC62 Melanoma GAV UACC62 Melanoma GLV UACC62 Melanoma GLR GLREAHV (1293) UACC62 Melanoma LVS UACC62 Melanoma ARG AARGELR (1294) UACC62 Melanoma ASL AASLRGT (1295) UACC62 Melanoma AAV PVGAAVA (1296) UACC62 Melanoma AAS AASLRGT (1297) UACC62 Melanoma GGS UACC62 Melanoma GGR UACC62 Melanoma GLG UACC62 Melanoma GGL UACC62 Melanoma GSS UACC62 Melanoma GSG SNPGSGS (1298) UACC62 Melanoma GSV UACC62 Melanoma GRV GRVRETP (1299) UACC62 Melanoma UACC62 Melanoma GRL FGRLLSP (1300) UACC62 Melanoma VRVGRLS (1301) UACC62 Melanoma TGRLSAA (1302) UACC62 Melanoma VGRLQTT (1303) UACC62 Melanoma GPS DGPSCVI (1304) UACC62 Melanoma UACC62 Melanoma GVS UACC62 Melanoma RLS IGROV1 Ovarian RGV IGROV1 Ovarian RGS IGROV1 Ovarian RAV RFSSRAV (1305) IGROV1 Ovarian RAS HAGSRAS (1306) IGROV1 Ovarian GAG GAGLGVS (1307) IGROV1 Ovarian LLGAGTP (1308) IGROV1 Ovarian AVS IGROV1 Ovarian LLS LLSILKA (1309) IGROV1 Ovarian GLLSGGT (1310) IGROV1 Ovarian LLR IGROV1 Ovarian LRV LSVLRVL (1311) IGROV1 Ovarian LRS SRYTLRS (1312) IGROV1 Ovarian RVS IGROV1 Ovarian RSS LFHTRSS (1313) IGROV1 Ovarian VARSSFR (1314) IGROV1 Ovarian AGS CTAGSVS (1315) IGROV1 Ovarian RAAGSAG (1316) IGROV1 Ovarian HAGSRAS (1317) IGROV1 Ovarian AGR IGROV1 Ovarian AGL GAGLGVS (1318) IGROV1 Ovarian PTGAGLL (1319) IGROV1 Ovarian ASYAGLV (2) IGROV1 Ovarian (1320) AGG AGGFGVL (1321) IGROV1 Ovarian NMAGGQE (1322) IGROV1 Ovarian LRAGGSY (1323) IGROV1 Ovarian YLAGGKA (1324) IGROV1 Ovarian GVR PYYNGVR (1325) IGROV1 Ovarian GVL AGGFGVL (1326) IGROV1 Ovarian LIGGVLH (1327) IGROV1 Ovarian GAV IGROV1 Ovarian GLV DGLVPVA (1328) IGROV1 Ovarian GLVASMP (1329) IGROV1 Ovarian ASYAGLV (2) IGROV1 Ovarian (1330) GLR IGROV1 Ovarian LVS LVRLVSL (1331) IGROV1 Ovarian ARG IGROV1 Ovarian ASL VLASLSG (1332) IGROV1 Ovarian AAV IGROV1 Ovarian AAS IGROV1 Ovarian GGS GSITGGS (1333) IGROV1 Ovarian LRAGGSY (1334) IGROV1 Ovarian TGGSLLG (1335) IGROV1 Ovarian DEGGSRW (1336) IGROV1 Ovarian GGR IGROV1 Ovarian GLG GAGLGVS (1337) IGROV1 Ovarian GGL IGROV1 Ovarian GSS WGSSAVK (1338) IGROV1 Ovarian QGSSNSV (1339) IGROV1 Ovarian GSG IGROV1 Ovarian GSV CTAGSVS (1340) IGROV1 Ovarian
SVTGSVG (1341) IGROV1 Ovarian GRV SPGRVAD (1342) IGROV1 Ovarian GRL IGROV1 Ovarian GPS DAVRGPS (1343) IGROV1 Ovarian GVS GAGLGVS (1344) IGROV1 Ovarian GVSGTVS (1345) IGROV1 Ovarian SGVSISC (1346) IGROV1 Ovarian RLS RRLSYHS (65) OVCAR-3 Ovarian (1347) RGV OVCAR-3 Ovarian RGS OVCAR-3 Ovarian RAV OVCAR-3 Ovarian RAS OVCAR-3 Ovarian GAG OVCAR-3 Ovarian AVS OVCAR-3 Ovarian LLS OVCAR-3 Ovarian LLR OVCAR-3 Ovarian LRV OVCAR-3 Ovarian LRS RREGLRS (10) OVCAR-3 Ovarian (1348) RVS ERVSAAV (1349) OVCAR-3 Ovarian RSS OVCAR-3 Ovarian AGS AGSMMEF (1350) OVCAR-3 Ovarian AGR OVCAR-3 Ovarian AGL OVCAR-3 Ovarian AGG OVCAR-3 Ovarian GVR OVCAR-3 Ovarian GVL RHGPGVL (1351) OVCAR-3 Ovarian GAV OVCAR-3 Ovarian GLV OVCAR-3 Ovarian GLR GLRRDNG (1352) OVCAR-3 Ovarian RREGLRS (10) OVCAR-3 Ovarian (1353) LVS OVCAR-3 Ovarian ARG OVCAR-3 Ovarian ASL OVCAR-3 Ovarian AAV ERVSAAV (1354) OVCAR-3 Ovarian AAS VAASVRE (1355) OVCAR-3 Ovarian GGS OVCAR-3 Ovarian GGR OVCAR-3 Ovarian GLG OVCAR-3 Ovarian GGL OVCAR-3 Ovarian GSS OVCAR-3 Ovarian GSG OVCAR-3 Ovarian GSV PWYDGSV (1356) OVCAR-3 Ovarian GRV GRVTLES (1357) OVCAR-3 Ovarian GRL OVCAR-3 Ovarian GPS OVCAR-3 Ovarian GVS OVCAR-3 Ovarian RLS GRLSRAP (1358) OVCAR-4 Ovarian SRLSYCN (1359) OVCAR-4 Ovarian RGV OVCAR-4 Ovarian RGS QARGSWL (1360) OVCAR-4 Ovarian FVPRGSY (1361) OVCAR-4 Ovarian RAV AALLRAV (1362) OVCAR-4 Ovarian RAS LAGRASE (1363) OVCAR-4 Ovarian GAG AAGAGWR (1364) OVCAR-4 Ovarian ADLGAGW (1365) OVCAR-4 Ovarian ADLGAGW (1366) OVCAR-4 Ovarian GGAGRGA (1367) OVCAR-4 Ovarian AVS DVWVAVS (1368) OVCAR-4 Ovarian LLS OVCAR-4 Ovarian LLR AALLRAV (1369) OVCAR-4 Ovarian LRV NLRVGAE (1370) OVCAR-4 Ovarian LRS NCYSLRS (1371) OVCAR-4 Ovarian RVS LAGSRVS (1372) OVCAR-4 Ovarian RSS OVCAR-4 Ovarian AGS SGPAGSF (1373) OVCAR-4 Ovarian LAGSRVS (1374) OVCAR-4 Ovarian AGR GGAGRGA (1375) OVCAR-4 Ovarian LAGRASE (1376) OVCAR-4 Ovarian VAGRLQM (1377) OVCAR-4 Ovarian AGL WGAGLDA (1378) OVCAR-4 Ovarian WGAGLDA (1379) OVCAR-4 Ovarian AGG AGRGAGG (1380) OVCAR-4 Ovarian GVR EAGVRLN (1381) OVCAR-4 Ovarian GVL OVCAR-4 Ovarian GAV MQLRGAV (1382) OVCAR-4 Ovarian GLV GGPGLVM (1383) OVCAR-4 Ovarian QGLVRGG (1384) OVCAR-4 Ovarian GLR PGLRGPA (1385) OVCAR-4 Ovarian PGLRGPA (1386) OVCAR-4 Ovarian LVS GRMLVSG (1387) OVCAR-4 Ovarian ARG ESARGAL (1388) OVCAR-4 Ovarian QARGSWL (1389) OVCAR-4 Ovarian ASL OVCAR-4 Ovarian AAV OVCAR-4 Ovarian AAS OVCAR-4 Ovarian GGS GGGSGGG (1390) OVCAR-4 Ovarian NNVGGSS (1391) OVCAR-4 Ovarian GGR GGRVLGQ (1392) OVCAR-4 Ovarian GGRVRGG (1393) OVCAR-4 Ovarian GGRVRGG (1394) OVCAR-4 Ovarian WYGGRGN (1395) OVCAR-4 Ovarian GLG CVGLGCH (1396) OVCAR-4 Ovarian GGL OVCAR-4 Ovarian GSS NNVGGSS (1397) OVCAR-4 Ovarian GSG FMTYGSG (1398) OVCAR-4 Ovarian GGGSGGG (1399) OVCAR-4 Ovarian WDQGSGY (1400) OVCAR-4 Ovarian GSV GSVLMRG (1401) OVCAR-4 Ovarian GRV GGRVLGQ (1402) OVCAR-4 Ovarian GGRVRGG (1403) OVCAR-4 Ovarian GGRVRGG (1404) OVCAR-4 Ovarian YMYHGRV (1405) OVCAR-4 Ovarian GRL GRLSRAP (1406) OVCAR-4 Ovarian VAGRLQM (1407) OVCAR-4 Ovarian APGRLGP (1408) OVCAR-4 Ovarian APGRLGP (1409) OVCAR-4 Ovarian GPS RDLAGPS (1410) OVCAR-4 Ovarian GVS OVCAR-4 Ovarian RLS RLSGAGD (1411) OVCAR-5 Ovarian RGV LQRGVAR (1412) OVCAR-5 Ovarian RGS OVCAR-5 Ovarian RAV RAVGRQL (1413) OVCAR-5 Ovarian SRAVIRL (1414) OVCAR-5 Ovarian RAS VRASSKR (1415) OVCAR-5 Ovarian GAG DGAGSLR (1416) OVCAR-5 Ovarian SVSGAGS (1417) OVCAR-5 Ovarian AVS OVCAR-5 Ovarian LLS TTLLSRQ (1418) OVCAR-5 Ovarian VAELLSM (1419) OVCAR-5 Ovarian LLR OVCAR-5 Ovarian LRV LPGRLRV (1420) OVCAR-5 Ovarian LRS LKAGLRS (1421) OVCAR-5 Ovarian RVS HRVSESV (1422) OVCAR-5 Ovarian RSS YYGERSS (1423) OVCAR-5 Ovarian AGS DGAGSLR (1424) OVCAR-5 Ovarian SVSGAGS (1425) OVCAR-5 Ovarian AGSVYSV (1426) OVCAR-5 Ovarian AGR OVCAR-5 Ovarian AGL SAGLLPS (1427) OVCAR-5 Ovarian LKAGLRS (1428) OVCAR-5 Ovarian AGG RRAGGSV (1429) OVCAR-5 Ovarian GVR SWAGVRF (1430) OVCAR-5 Ovarian GVL OVCAR-5 Ovarian GAV IYPGAVL (1431) OVCAR-5 Ovarian GLV OVCAR-5 Ovarian GLR LKAGLRS (1432) OVCAR-5 Ovarian LVS SLVSPRT (1433) OVCAR-5 Ovarian ARG OVCAR-5 Ovarian ASL OVCAR-5 Ovarian AAV HAAVEPS (1434) OVCAR-5 Ovarian TAAAVLL (1435) OVCAR-5 Ovarian AAS OVCAR-5 Ovarian GGS FHFGGSG (1436) OVCAR-5 Ovarian GEGGSGG (1437) OVCAR-5 Ovarian RRAGGSV (1438) OVCAR-5 Ovarian GGR ALPGGGR (1439) OVCAR-5 Ovarian YVGGRLR (1440) OVCAR-5 Ovarian GLG GKGMGLG (1441) OVCAR-5 Ovarian SLGLGGL (1442) OVCAR-5 Ovarian GGL DGGLNDC (1443) OVCAR-5 Ovarian LGGLGLS (1444) OVCAR-5 Ovarian GSS OVCAR-5 Ovarian GSG FHFGGSG (1445) OVCAR-5 Ovarian GEGGSGG (1446) OVCAR-5 Ovarian GSV RRAGGSV (1447) OVCAR-5 Ovarian SGAGSVS (1448) OVCAR-5 Ovarian AGSVYSV (1449) OVCAR-5 Ovarian GRV GRVTWRS (1450) OVCAR-5 Ovarian GRL LPGRLRV (1451) OVCAR-5 Ovarian YVGGRLR (1452) OVCAR-5 Ovarian GPS GPSSAVE (1453) OVCAR-5 Ovarian GVS OVCAR-5 Ovarian RLS RRLSYRE (28) OVCAR-8 Ovarian (1454) RGV OVCAR-8 Ovarian RGS OVCAR-8 Ovarian RAV HTRAVSE (1455) OVCAR-8 Ovarian NVSRAVG (1456) OVCAR-8 Ovarian RAS PRHRASQ (1457) OVCAR-8 Ovarian GAG LGAGMIA (1458) OVCAR-8 Ovarian AVS AVSLVVL (1459) OVCAR-8 Ovarian HTRAVSE (1460) OVCAR-8 Ovarian LLS OVCAR-8 Ovarian LLR OVCAR-8 Ovarian LRV ELGLRVP (1461) OVCAR-8 Ovarian LRS OVCAR-8 Ovarian RVS OVCAR-8 Ovarian RSS GRSSVSD (1462) OVCAR-8 Ovarian AGS YAGSGQL (2) OVCAR-8 Ovarian (1463) AGR AGRFGAR (1464) OVCAR-8 Ovarian AGL AIMGAGL (1465) OVCAR-8 Ovarian AGG OVCAR-8 Ovarian GVR THVGGVR (1466) OVCAR-8 Ovarian GVL GVLTRGN (1467) OVCAR-8 Ovarian GAV OVCAR-8 Ovarian GLV OVCAR-8 Ovarian GLR ELGLRVP (1468) OVCAR-8 Ovarian GLGLRLG (1469) OVCAR-8 Ovarian LVS IDLVSPG (1470) OVCAR-8 Ovarian ARG OVCAR-8 Ovarian ASL OVCAR-8 Ovarian AAV OVCAR-8 Ovarian AAS OVCAR-8 Ovarian GGS GGSTVPQ (1471) OVCAR-8 Ovarian GGR OVCAR-8 Ovarian GLG GLGLRLG (1472) OVCAR-8 Ovarian GGL TATGGLL (1473) OVCAR-8 Ovarian GSS GSNGSSH (3) OVCAR-8 Ovarian (1474) GSG LQGSGAY (2) OVCAR-8 Ovarian (1475) LQHLGSG (1476) OVCAR-8 Ovarian GSV OVCAR-8 Ovarian GRV OVCAR-8 Ovarian GRL OVCAR-8 Ovarian GPS GPSVLDI (1477) OVCAR-8 Ovarian GVS GATGVSS (1478) OVCAR-8 Ovarian RLS TRLSFRH (1479) SK-OV-3-3 Ovarian RGV FLRGVEL (1480) SK-OV-3-3 Ovarian RGS NSVRGSR (1481) SK-OV-3-3 Ovarian RAV NRAVLSA (1482) SK-OV-3-3 Ovarian RAS LIGRASM (1483) SK-OV-3-3 Ovarian GAG RVGAGAF (1484) SK-OV-3-3 Ovarian AVS WISAVSK (1485) SK-OV-3-3 Ovarian SAVSESP (1486) SK-OV-3-3 Ovarian LLS SK-OV-3-3 Ovarian LLR SK-OV-3-3 Ovarian LRV RVGTLRV (4) SK-OV-3-3 Ovarian (1487) LRS SK-OV-3-3 Ovarian RVS RVSGDGK (1488) SK-OV-3-3 Ovarian RSGRVSN (1489) SK-OV-3-3 Ovarian RVSNEAL (1490) SK-OV-3-3 Ovarian RVSSDPI (1491) SK-OV-3-3 Ovarian RSS VRSSGVL (1492) SK-OV-3-3 Ovarian AGS SGWFAGS (1493) SK-OV-3-3 Ovarian AGR SK-OV-3-3 Ovarian AGL AGLGLLD (1494) SK-OV-3-3 Ovarian SAAGLAR (1495) SK-OV-3-3 Ovarian AGG SK-OV-3-3 Ovarian GVR FAGAGVR (1496) SK-OV-3-3 Ovarian VRLTGVR (4) SK-OV-3-3 Ovarian (1497) GVL VRSSGVL (1498) SK-OV-3-3 Ovarian GAV RPWGAVA (1499) SK-OV-3-3 Ovarian GLV PVSDGLV (1500) SK-OV-3-3 Ovarian GLR NKGGLRQ (1501) SK-OV-3-3 Ovarian LVS GGFLLVS (1502) SK-OV-3-3 Ovarian LVPLVSG (1503) SK-OV-3-3 Ovarian ARG ARGGESA (1504) SK-OV-3-3 Ovarian MSARGIL (1505) SK-OV-3-3 Ovarian ASL ASLVARN (1506) SK-OV-3-3 Ovarian
AAV RVEAAVP (1507) SK-OV-3-3 Ovarian AAS RALGAAS (1508) SK-OV-3-3 Ovarian GGS SK-OV-3-3 Ovarian GGR ASEGGRA (1509) SK-OV-3-3 Ovarian IGGRWVV (1510) SK-OV-3-3 Ovarian GLG AGLGLLD (1511) SK-OV-3-3 Ovarian GGL LGGLSER (1512) SK-OV-3-3 Ovarian NKGGLRQ (1513) SK-OV-3-3 Ovarian GSS LVGSSRV (1514) SK-OV-3-3 Ovarian YTGSSPS (1515) SK-OV-3-3 Ovarian GSG SK-OV-3-3 Ovarian GSV GSVLPVL (1516) SK-OV-3-3 Ovarian KGDGSVR (1517) SK-OV-3-3 Ovarian GSVSHRR (1518) SK-OV-3-3 Ovarian RLWGSVV (1519) SK-OV-3-3 Ovarian GRV MQGRVIV (1520) SK-OV-3-3 Ovarian RSGRVSN (1521) SK-OV-3-3 Ovarian GRL LEVGRLF (1522) SK-OV-3-3 Ovarian GPS SQFGPSF (3) SK-OV-3-3 Ovarian (1523) GVS ATLDGVS (1524) SK-OV-3-3 Ovarian RLS RLSWTVL (1525) PC3 Prostate RGV LRFRRGV (1526) PC3 Prostate RGS ARGRFSQ (1527) PC3 Prostate VLRGSTP (1528) PC3 Prostate RAV PC3 Prostate RAS ARLRASR (1529) PC3 Prostate GAG RIGAGHR (1530) PC3 Prostate AVS PC3 Prostate LLS WLLSSEI (1531) PC3 Prostate LLR PC3 Prostate LRV GGLRVGG (1532) PC3 Prostate GLRVYEP (1533) PC3 Prostate LRS YLRSAGM (1534) PC3 Prostate RVS RVSRAGG (1535) PC3 Prostate RSS PC3 Prostate AGS PC3 Prostate AGR AGRPGGY (1536) PC3 Prostate AGL YGALAGL (1537) PC3 Prostate AGG AVSRAGG (1538) PC3 Prostate SHTAGGG (1539) PC3 Prostate AGGVRDL (1540) PC3 Prostate RPAGGRT (1541) PC3 Prostate GVR GGVRLGG (1542) PC3 Prostate AGGVRDL (1543) PC3 Prostate GVL GVLGCDG (1544) PC3 Prostate GAV CGAVAEW (1545) PC3 Prostate GLV GDCGLVG (1546) PC3 Prostate GLR GGLRVGG (1547) PC3 Prostate GLRVYEP (1548) PC3 Prostate LVS PC3 Prostate ARG ARGRGSQ (1549) PC3 Prostate ASL PC3 Prostate AAV PC3 Prostate AAS PC3 Prostate GGS PC3 Prostate GGR GGRELKA (1550) PC3 Prostate GGGRRAL (1551) PC3 Prostate RPAGGRT (1552) PC3 Prostate GLG PC3 Prostate GGL GGLKVWR (1553) PC3 Prostate GGLRVGG (1554) PC3 Prostate GGLPVQM (1555) PC3 Prostate RQDGGLY (1556) PC3 Prostate GSS YATLGSS (1557) PC3 Prostate GSG SGSGCVF (1558) PC3 Prostate VSGSGTA (1559) PC3 Prostate GSV VGSVKAS (1560) PC3 Prostate ATGSGSV (1561) PC3 Prostate GRV PC3 Prostate GRL PTSGRLV (1562) PC3 Prostate GPS LACRGPS (1563) PC3 Prostate RGPSQVL (1564) PC3 Prostate GVS PC3 Prostate RLS TLGRLSS (1565) DU-145 Prostate RGV AGDRGVA (1566) DU-145 Prostate RGS DU-145 Prostate RAV LPRRAVF (1567) DU-145 Prostate RAS RASCVWR (6) DU-145 Prostate (1568) FSKMRAS (1569) DU-145 Prostate GAG DYVGAGT (1570) DU-145 Prostate AVS DU-145 Prostate LLS DU-145 Prostate LLR ARLLRGG (1571) DU-145 Prostate LLRSVGY (1572) DU-145 Prostate LRV DU-145 Prostate LRS HLRSGFS (1573) DU-145 Prostate LLRSVGY (1574) DU-145 Prostate RVS DU-145 Prostate RSS DU-145 Prostate AGS DU-145 Prostate AGR AGRPDGV (1575) DU-145 Prostate AGL DENRAGL (1576) DU-145 Prostate AGG AWAGGDM (1577) DU-145 Prostate LNAGGSG (1578) DU-145 Prostate GVR DU-145 Prostate GVL DU-145 Prostate GAV NMGAVGS (1579) DU-145 Prostate PIGAVMN (1580) DU-145 Prostate GLV LTGGLVF (1581) DU-145 Prostate CGEGLVV (1582) DU-145 Prostate GLR SDLGLRR (1583) DU-145 Prostate LVS HADVLVS (1584) DU-145 Prostate ARG FSNARGY (1585) DU-145 Prostate ASL DU-145 Prostate AAV AAVWWAA (1586) DU-145 Prostate AAS DU-145 Prostate GGS LNAGGSG (1587) DU-145 Prostate GGSAWWG (1588) DU-145 Prostate VYGWGGS (1589) DU-145 Prostate GGR GGRLLRA (1590) DU-145 Prostate LGGRTIS (1591) DU-145 Prostate GLG YLGLGGL (1592) DU-145 Prostate GGL SITRGGL (1593) DU-145 Prostate LTGGLVF (1594) DU-145 Prostate LGGLGLY (1595) DU-145 Prostate GSS GSSELSR (1596) DU-145 Prostate GSG GSGGANL (1597) DU-145 Prostate VDGSGDD (1598) DU-145 Prostate GSV RSLGSVG (1599) DU-145 Prostate GRV GRVKPGA (1600) DU-145 Prostate GRL GGRLLRA (1601) DU-145 Prostate GRLWYVA (1602) DU-145 Prostate TLGRLSS (1603) DU-145 Prostate GPS DU-145 Prostate GVS GVSGLSR (1604) DU-145 Prostate YGVSRLL (1605) DU-145 Prostate RLS SRLSYRA (1606) 786-0 Renal RGV IHRGVWG (1607) 786-0 Renal RGS YFRARGS (1608) 786-0 Renal RAV 786-0 Renal RAS 786-0 Renal GAG GAGRFPH (1609) 786-0 Renal SGAGAAF (1610) 786-0 Renal VDVGGAG (1611) 786-0 Renal AVS ASAGAVS (1612) 786-0 Renal LLS 786-0 Renal LLR 786-0 Renal LRV 786-0 Renal LRS ARYSLRS (1613) 786-0 Renal RLRSYVA (1614) 786-0 Renal SRKGLRS (1615) 786-0 Renal RVS SVTGRVS (1616) 786-0 Renal RSS 786-0 Renal AGS AGSAFWA (1617) 786-0 Renal DQQEAGS (1618) 786-0 Renal FAAGAGS (1619) 786-0 Renal AGR GAGRFPH (1620) 786-0 Renal AGL 786-0 Renal AGG GAGGVDV (1621) 786-0 Renal GVR 786-0 Renal GVL 786-0 Renal GAV ASAGAVS (1622) 786-0 Renal GLV RRDGLVE (1623) 786-0 Renal GLR SRKGLRS (1624) 786-0 Renal LVS GDATLVS (1625) 786-0 Renal GDATLVS (1626) 786-0 Renal ARG YFRARGS (1627) 786-0 Renal ASL 786-0 Renal AAV 786-0 Renal AAS 786-0 Renal GGS 786-0 Renal GGR 786-0 Renal GLG DRGLGMS (1628) 786-0 Renal GGL 786-0 Renal GSS 786-0 Renal GSG GSGYFIT (1629) 786-0 Renal GSV 786-0 Renal GRV SVTGRVS (1630) 786-0 Renal GRL 786-0 Renal GPS VGPSVHL (1631) 786-0 Renal GVS 786-0 Renal RLS A498 Renal RGV EGVRGVF (1632) A498 Renal GDRGVRG (1633) A498 Renal MRGVARK (1634) A498 Renal RGS A498 Renal RAV KRAVGRM (1635) A498 Renal RAS DRASSWA (1636) A498 Renal GAG LQGAGIH (1637) A498 Renal AVS A498 Renal LLS A498 Renal LLR WLLRGFG (1638) A498 Renal LRV A498 Renal LRS ASPPLRS (1639) A498 Renal RVS RVSSETF (1640) A498 Renal RSS A498 Renal AGS ARAGSTF (1641) A498 Renal AGR TFAGRSL (1642) A498 Renal AGL A498 Renal AGG YAAGGST (1643) A498 Renal GVR EGVRGVF (1644) A498 Renal GDRGVRG (1645) A498 Renal GVL PGVLREP (1646) A498 Renal GAV A498 Renal GLV A498 Renal GLR GLRDGVE (1647) A498 Renal LVS A498 Renal ARG FPARGED (1648) A498 Renal ASL MLGSASL (1649) A498 Renal AAV A498 Renal AAS A498 Renal GGS HGGSNDR (1650) A498 Renal YAAGGST (1651) A498 Renal GGR QGGRSGV (1652) A498 Renal WTVGGRV (1653) A498 Renal GLG A498 Renal GGL A498 Renal GSS VKGSSMR (1654) A498 Renal GSG A498 Renal GSV A498 Renal GRV FVGRVGE (1655) A498 Renal GRVGRDG (1656) A498 Renal SVSRGRV (1657) A498 Renal WTVGGRV (1658) A498 Renal GRL GFGRLLW (1659) A498 Renal GPS AAYWGPS (1660) A498 Renal GVS MDGVSTE (1661) A498 Renal VYWWGVS (1662) A498 Renal RLS RLSMASR (1663) ACHN Renal GRLSFGV (1664) ACHN Renal RGV GLSRGVL (1665) ACHN Renal RGS LRGSHVA (1666) ACHN Renal NMGRGSL (1667) ACHN Renal SVVRRGS (1668) ACHN Renal RAV ACHN Renal RAS ACHN Renal GAG VMGAGVQ (1669) ACHN Renal AVS ACHN Renal LLS ACHN Renal LLR PLLRQQL (1670) ACHN Renal LRV SNGLRVV (1671) ACHN Renal LRS LRSMAVM (1672) ACHN Renal VDLRSAF (1673) ACHN Renal RVS FRVSLGY (1674) ACHN Renal RSS RSSYAPP (1675) ACHN Renal AGS FPGSAGS (1676) ACHN Renal AGR FAGRAPR (1677) ACHN Renal AGL ACHN Renal AGG FIAGGVG (1678) ACHN Renal LIHAGGQ (1679) ACHN Renal RAGGGAP (1680) ACHN Renal TWHAGGI (1681) ACHN Renal GVR GVRSITL (1682) ACHN Renal GVL GLSRGVL (1683) ACHN Renal
GAV RVVGAVL (1684) ACHN Renal GLV ACHN Renal GLR FGLRMSN (1685) ACHN Renal LGLRGWT (1686) ACHN Renal AFFMGLR (1687) ACHN Renal SNGLRVV (1688) ACHN Renal LVS ACHN Renal ARG ARGTMTG (1689) ACHN Renal RPARGAF (1690) ACHN Renal ASL ASLPMLH (1691) ACHN Renal AAV ACHN Renal AAS ACHN Renal GGS GGSVEGQ (1692) ACHN Renal GGR LGGRQES (1693) ACHN Renal NGGRVLS (1694) ACHN Renal GLG ACHN Renal GGL PIGGLFG (1695) ACHN Renal AECCGGL (1696) ACHN Renal SEQRGGL (1697) ACHN Renal GSS DRFGSSA (1698) ACHN Renal GSG GHGSGSR (1699) ACHN Renal GSV GGSVEGQ (1700) ACHN Renal GSVVSSW (1701) ACHN Renal GRV NGGRVLS (1702) ACHN Renal GRL GRLMPGG (1703) ACHN Renal TWGRLGL (1704) ACHN Renal AVHSGRL (1705) ACHN Renal GRLSFGV (1706) ACHN Renal GPS PQGPSSV (1707) ACHN Renal GVS ACHN Renal RLS AGWRLSQ (1708) CAIK-1 Renal RGV CAIK-1 Renal RGS RVDRGSL (1709) CAIK-1 Renal RAV RAVCEWD (1710) CAIK-1 Renal RAVERVA (1711) CAIK-1 Renal RAS AVFRASR (1712) CAIK-1 Renal GAG GAGSSVW (1713) CAIK-1 Renal GAGSSVW (1714) CAIK-1 Renal AVS CAIK-1 Renal LLS CAIK-1 Renal LLR WLLRSWS (1715) CAIK-1 Renal LRV RKEALRV (1716) CAIK-1 Renal RLRVSVR (1717) CAIK-1 Renal LRS LRPGLRS (1718) CAIK-1 Renal QRYHLRS (13) CAIK-1 Renal (1719) WLLRSWS (1720) CAIK-1 Renal RVS GRERVSH (2) CAIK-1 Renal (1721) RVSVRLR (1722) CAIK-1 Renal RSS CAIK-1 Renal AGS GAGSSVW (1723) CAIK-1 Renal GAGSSVW (1724) CAIK-1 Renal AGR CAIK-1 Renal AGL AGLWPWN (1725) CAIK-1 Renal AGG CAIK-1 Renal GVR GVRGGGD (1726) CAIK-1 Renal GVL CAIK-1 Renal GAV CAIK-1 Renal GLV GLVRRVV (1727) CAIK-1 Renal GLR LRPGLRS (1728) CAIK-1 Renal LVS CAIK-1 Renal ARG CAIK-1 Renal ASL CAIK-1 Renal AAV CAIK-1 Renal AAS WAHAASY (1729) CAIK-1 Renal GGS CAIK-1 Renal GGR DGGGRVG (1730) CAIK-1 Renal VGVMGGR (1731) CAIK-1 Renal VYGGRSE (1732) CAIK-1 Renal GLG TICLGLG (1733) CAIK-1 Renal GGL CAIK-1 Renal GSS GAGSSVW (1734) CAIK-1 Renal GAGSSVW (1735) CAIK-1 Renal GSG CAIK-1 Renal GSV DHVSGSV (1736) CAIK-1 Renal GRV DGGGRVG (1737) CAIK-1 Renal GRL GEGRLCG (1738) CAIK-1 Renal GVAIGRL (1739) CAIK-1 Renal GPS CAIK-1 Renal GVS FGVSQVH (1740) CAIK-1 Renal GGVSRMR (1741) CAIK-1 Renal RLS GRIRLSF (1742) RXF393 Renal RGV RGVNYRS (1743) RXF393 Renal TEGTRGV (1744) RXF393 Renal RGS GYARGSG (1745) RXF393 Renal GVWLRGS (1746) RXF393 Renal RAV AARAVWG (1747) RXF393 Renal RAS RASYYGV (1748) RXF393 Renal GAG GAGVEYF (1749) RXF393 Renal AVS RXF393 Renal LLS LLLLSGS (1750) RXF393 Renal VLLSAGL (1751) RXF393 Renal LLR TGLLRLY (1752) RXF393 Renal LRV RXF393 Renal LRS LRSSLVS (1753) RXF393 Renal RVS RXF393 Renal RSS LRSSLVS (1754) RXF393 Renal PRSSGPM (1755) RXF393 Renal AGS RXF393 Renal AGR TAGRLEV (1756) RXF393 Renal AGL AGLEDLG (1757) RXF393 Renal MPAGLGV (1758) RXF393 Renal VLLSAGL (1759) RXF393 Renal AGG RXF393 Renal GVR GVRWNWS (1760) RXF393 Renal TRDGVRW (1761) RXF393 Renal GVL RXF393 Renal GAV RXF393 Renal GLV RAHGLVC (1762) RXF393 Renal GLR LGSSGLR (1763) RXF393 Renal LVS LLVSLSS (1764) RXF393 Renal LRSSLVS (1765) RXF393 Renal LVSTRWA (1766) RXF393 Renal LVSYSAV (1767) RXF393 Renal ARG GYARGSG (1768) RXF393 Renal ASL LGASLLV (1769) RXF393 Renal AAV GTGAAVF (1770) RXF393 Renal AAVGTAL (1771) RXF393 Renal AAS VSAASSV (1772) RXF393 Renal GGS RGGSPPV (1773) RXF393 Renal GGR VPPSGGR (1774) RXF393 Renal GLG GLGSCAP (1775) RXF393 Renal MPAGLGV (1776) RXF393 Renal GGL RXF393 Renal GSS MPGSSRP (1777) RXF393 Renal GSSLSRP (1778) RXF393 Renal RLGSSGL (1779) RXF393 Renal GSG GYARGSG (1780) RXF393 Renal GSV RXF393 Renal GRV RXF393 Renal GRL SGRLWVG (1781) RXF393 Renal TAGRLEV (1782) RXF393 Renal GPS GPSFDAK (1783) RXF393 Renal GVS ACTGVSR (1784) RXF393 Renal RLS SN12C Renal RGV LGMGRGV (1785) SN12C Renal RGS MLGRGSV (1786) SN12C Renal RAV SN12C Renal RAS PRASSTG (1787) SN12C Renal RASCFWD (1788) SN12C Renal RASCFWD (1789) SN12C Renal GAG SN12C Renal AVS SN12C Renal LLS FLLLSHR (1790) SN12C Renal LLSVTSX (1791) SN12C Renal LLR PLLREVG (1792) SN12C Renal LRV LRVGHAG (1793) SN12C Renal NELRVCR (1794) SN12C Renal LRS MRYELRS (1795) SN12C Renal RVS RVSVWWA (1796) SN12C Renal FAQRRVS (1797) SN12C Renal RSS SHHRSSI (1798) SN12C Renal AGS CMAGSQD (1799) SN12C Renal RYGTAGS (1800) SN12C Renal SAGSHPA (1801) SN12C Renal PNSAGSV (1802) SN12C Renal AGR KMRIAGR (1803) SN12C Renal MERVAGR (1804) SN12C Renal AGL WAGLSRP (1805) SN12C Renal AGG SN12C Renal GVR GAHGVRL (1806) SN12C Renal RVPTGVR (1807) SN12C Renal GVL SN12C Renal GAV RGAVREM (1808) SN12C Renal GLV SN12C Renal GLR FDPGGLR (1809) SN12C Renal LVS ILSDLVS (1810) SN12C Renal ARG LLNPARG (1811) SN12C Renal ASL SN12C Renal AAV WWAAVPG (1812) SN12C Renal AAS KAASTED (1813) SN12C Renal SYMGAAS (1814) SN12C Renal GGS GGSIDCC (1815) SN12C Renal GPGGSKR (1816) SN12C Renal AFGGGSM (1817) SN12C Renal GGR PEGGRRP (1818) SN12C Renal GLG SN12C Renal GGL GGLEQDG (1819) SN12C Renal FDPGGLR (1820) SN12C Renal GSS LFGSSVS (1821) SN12C Renal WDGSSVS (1822) SN12C Renal GSG SN12C Renal GSV PNSAGSV (1823) SN12C Renal MLGRGSV (1824) SN12C Renal GRV SN12C Renal GRL TRRGRLD (1825) SN12C Renal GPS SN12C Renal GVS GVSISDG (1826) SN12C Renal GVSIYDL (1827) SN12C Renal RLS ARLSLEL (1828) TK-10 Renal RLRLSSW (1829) TK-10 Renal RRLSSIA (1830) TK-10 Renal SRLSYRT (1831) TK-10 Renal RGV TK-10 Renal RGS ARGSWRE (1832) TK-10 Renal RAV VRLRAVF (1833) TK-10 Renal RAS RASRIGL (1834) TK-10 Renal GAG GAGTSEG (1835) TK-10 Renal AVS TK-10 Renal LLS LLSTVWV (1836) TK-10 Renal ELRRLLS (1837) TK-10 Renal LLR LLRGLRP (1838) TK-10 Renal SLLRRLE (1839) TK-10 Renal LRV LRVSRGL (1840) TK-10 Renal TLGLRVP (1841) TK-10 Renal FVARLRV (1842) TK-10 Renal LRS GVYWLRS (1843) TK-10 Renal SFWWLRS (1844) TK-10 Renal TRYSLRS (1845) TK-10 Renal RVS LRVSRGL (1846) TK-10 Renal RSS RSSSGSG (1847) TK-10 Renal TRSSLTH (1848) TK-10 Renal TGRSSFW (1849) TK-10 Renal AGS TK-10 Renal AGR NAGRGAS (1850) TK-10 Renal AGL HAGLLVV (1851) TK-10 Renal AGG TK-10 Renal GVR HTYGVRF (1852) TK-10 Renal GVL TK-10 Renal GAV GAVRSVM (1853) TK-10 Renal VLVEGAV (1854) TK-10 Renal GLV TK-10 Renal GLR LLRGLRP (1855) TK-10 Renal TLGLRVP (1856) TK-10 Renal LVS TK-10 Renal ARG ARGSWRE (1857) TK-10 Renal ASL TK-10 Renal AAV GLWAAVL (1858) TK-10 Renal AAS GWTMAAS (1859) TK-10 Renal GGS LYMGGSH (1860) TK-10 Renal GGR GVGGRQS (1861) TK-10 Renal GLG RRGLGDA (1862) TK-10 Renal GGL TGGLHWY (1863) TK-10 Renal GSS GSGSSSR (1864) TK-10 Renal GSSTLQW (1865) TK-10 Renal GSG RSSSGSG (1866) TK-10 Renal GSV DELGSVQ (1867) TK-10 Renal GRV TK-10 Renal GRL GRLRPFS (1868) TK-10 Renal PRLGRLL (1869) TK-10 Renal GPS TK-10 Renal GVS VGVSQEW (1870) TK-10 Renal DGVSPLW (1871) TK-10 Renal RLS UO31 Renal RGV UO31 Renal
RGS PRGSLFA (1872) UO31 Renal VIVRGSL (1873) UO31 Renal RAV GDRAVGL (1874) UO31 Renal VHKRAVL (1875) UO31 Renal RAS UO31 Renal GAG GGAGSRR (1876) UO31 Renal AVS UO31 Renal LLS RLETLLS (1877) UO31 Renal LLR LLRAGVR (1878) UO31 Renal LRV PAILRVR (1879) UO31 Renal GDLRVSV (1880) UO31 Renal LRS UO31 Renal RVS GDLRVSV (1881) UO31 Renal RSS UO31 Renal AGS GGAGSRR (1882) UO31 Renal AGSVTEQ (1883) UO31 Renal SSSLAGS (1884) UO31 Renal AGR RSWNAGR (1885) UO31 Renal AGL AGLPHRF (1886) UO31 Renal RNSRAGL (1887) UO31 Renal AGG RRSGAGG (1888) UO31 Renal AGGPSSY (1889) UO31 Renal GVR TGVRNSP (1890) UO31 Renal LLRAGVR (1891) UO31 Renal GVL UO31 Renal GAV UO31 Renal GLV UO31 Renal GLR UO31 Renal LVS ALVSTIL (1892) UO31 Renal ARG ARGRDEG (1893) UO31 Renal ASL ASLSVVI (1894) UO31 Renal AAV UO31 Renal AAS UO31 Renal GGS GGSRGYR (1895) UO31 Renal YWGGSVP (1896) UO31 Renal GGR GGRPVER (1897) UO31 Renal GGRSQEG (1898) UO31 Renal PGGGRGR (1899) UO31 Renal GLG UO31 Renal GGL UO31 Renal GSS FSLGSSP (1900) UO31 Renal GSG UO31 Renal GSV GSVFGTP (1901) UO31 Renal AGSVTEQ (1902) UO31 Renal YWGGSVP (1903) UO31 Renal GRV LSGRVIV (1904) UO31 Renal LSTPGRV (1905) UO31 Renal GRL UO31 Renal GPS AGGPSSY (1906) UO31 Renal UO31 Renal GVS UO31 Renal RLS MCF-7 Breast RGV MCF-7 Breast RGS RVMRGSL (1907) MCF-7 Breast RAV MCF-7 Breast RAS RASCVWA (1908) MCF-7 Breast GAG MCF-7 Breast AVS MCF-7 Breast LLS QLLSQVY (1909) MCF-7 Breast LLR MCF-7 Breast LRV MCF-7 Breast LRS ERYYLRS (1910) MCF-7 Breast GLVKLRS (1911) MCF-7 Breast RVS MCF-7 Breast RSS MCF-7 Breast AGS GRLAAGS (1912) MCF-7 Breast AGR MCF-7 Breast AGL MCF-7 Breast AGG MCF-7 Breast GVR MCF-7 Breast GVL MCF-7 Breast GAV MCF-7 Breast GLV GLVKLRS (1913) MCF-7 Breast GLR MCF-7 Breast LVS LWFELVS (1914) MCF-7 Breast ARG MCF-7 Breast ASL MCF-7 Breast AAV MCF-7 Breast AAS IGAASWF (1915) MCF-7 Breast GGS MCF-7 Breast GGR GGRRGTS (1916) MCF-7 Breast RDLGGRW (1917) MCF-7 Breast GLG MCF-7 Breast GGL WRGGLDR (1918) MCF-7 Breast GSS GRWTGSS (1919) MCF-7 Breast SYWVGSS (1920) MCF-7 Breast GSG MCF-7 Breast GSV MCF-7 Breast GRV MCF-7 Breast GRL GRLAAGS (1921) MCF-7 Breast GPS MCF-7 Breast GVS AKAGVSR (1922) MCF-7 Breast RLS LRLSGHD (1923) NCI/ADR-RES Breast RGV RGVGAKA (1924) NCI/ADR-RES Breast LRGVYVA (1925) NCI/ADR-RES Breast RGS NCI/ADR-RES Breast RAV NCI/ADR-RES Breast RAS NCI/ADR-RES Breast GAG NCI/ADR-RES Breast AVS GTPAVSY (1926) NCI/ADR-RES Breast LLS FLLSRSA (1927) NCI/ADR-RES Breast AGLLSDV (1928) NCI/ADR-RES Breast LLR NCI/ADR-RES Breast LRV LRVGXPG (1929) NCI/ADR-RES Breast LRS NCI/ADR-RES Breast RVS RVSGSPV (1930) NCI/ADR-RES Breast RSS RSSIDVG (1931) NCI/ADR-RES Breast AGS NCI/ADR-RES Breast AGR AGRRLRD (1932) NCI/ADR-RES Breast AGL WRLAGLG (1933) NCI/ADR-RES Breast PTVSAGL (1934) NCI/ADR-RES Breast AGLLSDV (1935) NCI/ADR-RES Breast AGG NCI/ADR-RES Breast GVR NCI/ADR-RES Breast GVL TLGVLVT (1936) NCI/ADR-RES Breast GAV NCI/ADR-RES Breast GLV NCI/ADR-RES Breast GLR NCI/ADR-RES Breast LVS GDRRLVS (1937) NCI/ADR-RES Breast LMLVSGK (1938) NCI/ADR-RES Breast ARG DVHARGD (1939) NCI/ADR-RES Breast ASL NCI/ADR-RES Breast AAV NCI/ADR-RES Breast AAS NCI/ADR-RES Breast GGS REGGSDT (1940) NCI/ADR-RES Breast GGR GGRRVVV (1941) NCI/ADR-RES Breast NVGGGRF (1942) NCI/ADR-RES Breast GLG GLGALRW (1943) NCI/ADR-RES Breast LGLSGLG (1944) NCI/ADR-RES Breast RGLGRPV (1945) NCI/ADR-RES Breast GGL NCI/ADR-RES Breast GSS GSSGLLA (1946) NCI/ADR-RES Breast LGSSSHI (1947) NCI/ADR-RES Breast GSG IGSGVGV (1948) NCI/ADR-RES Breast GSV KGSVLML (1949) NCI/ADR-RES Breast VPSGSVR (1950) NCI/ADR-RES Breast GRV NCI/ADR-RES Breast GRL GYLGRLP (1951) NCI/ADR-RES Breast AVYVGRL (1952) NCI/ADR-RES Breast GPS NCI/ADR-RES Breast GVS NCI/ADR-RES Breast RLS LGGRLSL (1953) MDA-MB-231 Breast RGV RGVGKTK (1954) MDA-MB-231 Breast LGGARGV (1955) MDA-MB-231 Breast HAWDRGV (1956) MDA-MB-231 Breast DWGSRGV (1957) MDA-MB-231 Breast RGS PYRRGSC (1958) MDA-MB-231 Breast ALNRGSR (3) MDA-MB-231 Breast (1959) RAV MDA-MB-231 Breast RAS MDA-MB-231 Breast GAG TFRGAGV (1960) MDA-MB-231 Breast AVS MDA-MB-231 Breast LLS LLSAARF (1961) MDA-MB-231 Breast LLR MDA-MB-231 Breast LRV MDA-MB-231 Breast LRS MRPGLRS (1962) MDA-MB-231 Breast RVS PRVSALV (1963) MDA-MB-231 Breast VRVSLNS (1964) MDA-MB-231 Breast RSS GRSSAGP (1965) MDA-MB-231 Breast AGS LHAGSSV (1966) MDA-MB-231 Breast VVMIAGS (1967) MDA-MB-231 Breast AGR DTPAGRL (1968) MDA-MB-231 Breast VGAGRFT (1969) MDA-MB-231 Breast AGL MDA-MB-231 Breast AGG AGGTDRT (1970) MDA-MB-231 Breast FISAGGW (1971) MDA-MB-231 Breast TIPAGGG (1972) MDA-MB-231 Breast VGRAGGL (1973) MDA-MB-231 Breast GVR MDA-MB-231 Breast GVL MDA-MB-231 Breast GAV MDA-MB-231 Breast GLV NPGLVWN (1974) MDA-MB-231 Breast LGLVHWV (1975) MDA-MB-231 Breast GLR MRPGLRS (1976) MDA-MB-231 Breast LVS MDA-MB-231 Breast ARG ARGNVRF (1977) MDA-MB-231 Breast LGGARGV (1978) MDA-MB-231 Breast ASL FRAASLL (1979) MDA-MB-231 Breast AAV MDA-MB-231 Breast AAS AASVGVA (1980) MDA-MB-231 Breast FRAASLL (1981) MDA-MB-231 Breast GGS PVFRGGS (1982) MDA-MB-231 Breast SGGSVGF (1983) MDA-MB-231 Breast VRANGGS (1984) MDA-MB-231 Breast GGR FHIWGGR (1985) MDA-MB-231 Breast LGGRLSL (1986) MDA-MB-231 Breast SGGRFVP (1987) MDA-MB-231 Breast GLG MDA-MB-231 Breast GGL GGGLPVD (1988) MDA-MB-231 Breast LSLRGGL (1989) MDA-MB-231 Breast VGRAGGL (1990) MDA-MB-231 Breast GSS ANGSSKK (1991) MDA-MB-231 Breast DFTLGSS (1992) MDA-MB-231 Breast LHAGSSV (1993) MDA-MB-231 Breast GSG MDA-MB-231 Breast GSV NSGSVVS (1994) MDA-MB-231 Breast SGGSVGF (1995) MDA-MB-231 Breast WSISGSV (1996) MDA-MB-231 Breast GRV MDA-MB-231 Breast GRL DTPAGRL (1997) MDA-MB-231 Breast LGGRLSL (1998) MDA-MB-231 Breast GPS MDA-MB-231 Breast GVS AVGVSAA (1999) MDA-MB-231 Breast SGVSNPG (2000) MDA-MB-231 Breast FGVSGGS (2001) MDA-MB-231 Breast ESATGVS (2002) MDA-MB-231 Breast AAIVGVS (2003) MDA-MB-231 Breast RLS MDA-MB-435-Breast RGV MDA-MB-435-Breast RGS LRSGRGS (2004) MDA-MB-435-Breast LRSGRGS (2005) MDA-MB-435-Breast RGRGSTL (2006) MDA-MB-435-Breast RGSPAAA (2007) MDA-MB-435-Breast SRGSYGS (2008) MDA-MB-435-Breast MDA-MB-435-Breast RAV MDA-MB-435-Breast RAS MDA-MB-435-Breast GAG GVGGGAG (2009) MDA-MB-435-Breast MDA-MB-435-Breast AVS MDA-MB-435-Breast LLS MDA-MB-435-Breast LLR MDA-MB-435-Breast LRV MDA-MB-435-Breast LRS LRSGRGS (49) MDA-MB-435-Breast (2010) RVS MDA-MB-435-Breast RSS MDA-MB-435-Breast AGS MDA-MB-435-Breast AGR MDA-MB-435-Breast AGL MDA-MB-435-Breast AGG AGGGGYH (2011) MDA-MB-435-Breast GAGGGVG (2012) MDA-MB-435-Breast YRALAGG (2) MDA-MB-435-Breast (2013) MDA-MB-435-Breast GVR MDA-MB-435-Breast GVL MDA-MB-435-Breast GAV MDA-MB-435-Breast GLV MDA-MB-435-Breast GLR MDA-MB-435-Breast LVS MDA-MB-435-Breast ARG MDA-MB-435-Breast ASL LYVDASL (2014) MDA-MB-435-Breast AAV MDA-MB-435-Breast AAS MDA-MB-435-Breast GGS MDA-MB-435-Breast
GGR MDA-MB-435-Breast GLG MDA-MB-435-Breast GGL MDA-MB-435-Breast GSS MDA-MB-435-Breast GSG GEGSGSA (2015) MDA-MB-435-Breast GSV MDA-MB-435-Breast GRV MDA-MB-435-Breast GRL MDA-MB-435-Breast GPS MDA-MB-435-Breast GVS MDA-MB-435-Breast RLS BT-549 Breast RGV RVRGVLD (2016) BT-549 Breast SMRGVLS (2017) BT-549 Breast EAGPRGV (2018) BT-549 Breast RGS CRGSIGA (2019) BT-549 Breast PLQRGSG (2020) BT-549 Breast RGSRWSS (2021) BT-549 Breast RGSYVER (2022) BT-549 Breast RAV TYCDRAV (2023) BT-549 Breast RAS LGVRASP (2024) BT-549 Breast WRASPGM (2025) BT-549 Breast PRASDIL (2026) BT-549 Breast GAG RVGAGWP (2027) BT-549 Breast AVS BT-549 Breast LLS LLSRAQA (2028) BT-549 Breast LLR BT-549 Breast LRV SALRVGL (2029) BT-549 Breast VGLRVRF (2030) BT-549 Breast LRS YGLRSLV (2031) BT-549 Breast RVS TRVSGSG (2032) BT-549 Breast RSS VRRSSKF (2033) BT-549 Breast AGS BT-549 Breast AGR BT-549 Breast AGL TFAGLAQ (2034) BT-549 Breast AGG BT-549 Breast GVR LGVRASP (2035) BT-549 Breast LGVRLAS (2036) BT-549 Breast PWGAGVR (2037) BT-549 Breast GVL GVLTIGA (2038) BT-549 Breast RVRGVLD (2039) BT-549 Breast IGWGVLG (2040) BT-549 Breast SMRGVLS (2041) BT-549 Breast GAV GAVLTSC (2042) BT-549 Breast GLV GLVSTLI (2043) BT-549 Breast GLVGWGI (2044) BT-549 Breast GLR VGLRCSV (2045) BT-549 Breast VGLRVRF (2046) BT-549 Breast YGLRSLV (2047) BT-549 Breast LVS GLVSTLI (2048) BT-549 Breast ARG PRGMARG (2049) BT-549 Breast ASL BT-549 Breast AAV BT-549 Breast AAS BT-549 Breast GGS RGGSDEA (2050) BT-549 Breast GGR AEDSGGR (2051) BT-549 Breast GGRCGAE (2052) BT-549 Breast GLG BT-549 Breast GGL GGLMPRY (2053) BT-549 Breast GSS GSSVSLG (2054) BT-549 Breast GSG GSGRQLP (2055) BT-549 Breast RKGSGTA (2056) BT-549 Breast TRVSGSG (2057) BT-549 Breast GSV GSGSVRT (2058) BT-549 Breast GRV DDGRVHR (2059) BT-549 Breast DLVGRVR (2060) BT-549 Breast GRL WGRLEST (2061) BT-549 Breast GPS MGPSARW (2062) BT-549 Breast GVS ISGVSDD (2063) BT-549 Breast RLS GHSERLS (2064) T-47D Breast RGV ERGVFVY (2065) T-47D Breast TRGVIGG (2066) T-47D Breast RGS RGSFGLG (2067) T-47D Breast RAV PFHRRAV (2068) T-47D Breast RAS T-47D Breast GAG VGIGAGG (2) T-47D Breast (2069) AVS AVSLAWQ (2070) T-47D Breast FPAVSTE (2071) T-47D Breast LLS T-47D Breast LLR T-47D Breast LRV T-47D Breast LRS SGARLRS (2072) T-47D Breast RVS T-47D Breast RSS SHRSSTG (2073) T-47D Breast AGS SRLRAGS (2074) T-47D Breast AGR SFAGRIL (2075) T-47D Breast AGL T-47D Breast AGG RVAAGGL (2076) T-47D Breast VGIGAGG (2077) T-47D Breast VGIGAGG (2078) T-47D Breast GVR T-47D Breast GVL T-47D Breast GAV QKPGAVG (2079) T-47D Breast LGYYGAV (2080) T-47D Breast GLV LPLGLVS (2081) T-47D Breast LGLVFTR (2082) T-47D Breast GLR T-47D Breast LVS LPLGLVS (2083) T-47D Breast NSKPLVS (2084) T-47D Breast ARG TNRFARG (2085) T-47D Breast ASL LASLARP (2086) T-47D Breast AAV LGGAAVR (2087) T-47D Breast AAS AASPHPG (2088) T-47D Breast GGS LSKGGSE (2089) T-47D Breast GGR T-47D Breast GLG GLGRSVN (2090) T-47D Breast PGLGYAL (2091) T-47D Breast RGSFGLG (2092) T-47D Breast GGL GRDWGGL (2093) T-47D Breast RVAAGGL (2094) T-47D Breast GSS TVGSSLG (2095) T-47D Breast GSG T-47D Breast GSV T-47D Breast GRV GRVDPVD (2096) T-47D Breast GRL SLYRGRL (2097) T-47D Breast GPS T-47D Breast GVS VALGVSS (2098) T-47D Breast RLS VSVTRLS (2099) HS 578 T Breast RGV HS 578 T Breast RGS AGATRGS (2100) HS 578 T Breast RRGSVAE (2101) HS 578 T Breast FRFVRGS (2102) HS 578 T Breast TRGSGAG (2103) HS 578 T Breast RAV GARAVAP (2104) HS 578 T Breast RAS HS 578 T Breast GAG TRGSGAG (2105) HS 578 T Breast AVS EAVSGRR (2106) HS 578 T Breast LLS HS 578 T Breast LLR HS 578 T Breast LRV HS 578 T Breast LRS HS 578 T Breast RVS PVRRVSS (2107) HS 578 T Breast IRVSAVV (2108) HS 578 T Breast RSS HVRSSYA (2109) HS 578 T Breast RVRSSLA (2110) HS 578 T Breast AGS TAAGSSF (2111) HS 578 T Breast GAGSGRT (2112) HS 578 T Breast PAVAGST (2113) HS 578 T Breast AGR AGRHLDA (2114) HS 578 T Breast DRQLAGR (2115) HS 578 T Breast AGL HS 578 T Breast AGG HS 578 T Breast GVR LGVREVG (2116) HS 578 T Breast VAVGVRS (2117) HS 578 T Breast GVL SFGVLSG (2118) HS 578 T Breast GAV TSGAVAP (2119) HS 578 T Breast GLV HS 578 T Breast GLR GLREVQD (2120) HS 578 T Breast LVS SLVSERA (2121) HS 578 T Breast SVHLVSG (2122) HS 578 T Breast ARG TQVEARG (2123) HS 578 T Breast ASL HS 578 T Breast AAV HS 578 T Breast AAS HS 578 T Breast GGS HS 578 T Breast GGR GGRPTVT (2124) HS 578 T Breast VVGGRRT (2125) HS 578 T Breast GLG HS 578 T Breast GGL GVGGLSS (2126) HS 578 T Breast GSS TAAGSSF (2127) HS 578 T Breast GSG TRGSGAG (2128) HS 578 T Breast GSV RRGSVAE (2129) HS 578 T Breast GSVLHVS (2130) HS 578 T Breast GRV SGRVFRF (2131) HS 578 T Breast GRL HS 578 T Breast GPS HS 578 T Breast GVS WSATGVS (2132) HS 578 T Breast
REFERENCES
[0083]The following references, to the extent that they provide exemplary procedural or other details supplementary to those set forth herein, are specifically incorporated herein by reference. [0084]Arap et al., Nature Med. 8, 121-127, 2002. [0085]Arap et al., Science, 279:377-80, 1998. [0086]Blower et al., Pharmacogenomics J., 2:259-271, 2002. [0087]Brown, Oncol. Res., 1997; 9:213-5, 1997. [0088]Giordano et al., Nat. Med., 7:1249-1253, 2001. [0089]Hafner et al., Clin. Chem., 50:490-499, 2004. [0090]Holbeck, Eur. J. Cancer, 40:785-793, 2004. [0091]Kolonin et al., Cancer Res., 66(1):1-7, 2006. [0092]Kolonin et al., Curr. Opin. Chem. Biol., 5:308-13, 2001. [0093]Kolonin et al., Nat. Med., 6:625-632, 2004. [0094]Kolonin et al., Proc. Natl. Acad. Sci. USA, 99:13055-13060, 2002. [0095]Maihle and Lafky, Trends Cell Biol., 12:160-161, 2002. [0096]Monks et al., J. Natl. Cancer Inst., 1991; 83:757-66, 1991. [0097]Myers et al., Electrophoresis, 18:647-653, 1997. [0098]Nishizuka et al., Proc. Natl. Acad. Sci. USA, 100:14229-14234, 2003. [0099]Pasqualini and Ruoslahti, Nature, 380:364-366, 1996. [0100]Pasqualini et al., Cancer Res., 60:722-727, 2000. [0101]Pasqualini et al., In: Phage Display, A Laboratory Manual, Barbas et al. (Eds.), NY, Cold Spring Harbor Laboratory Press, 22:1-24, 2001. [0102]Rabow et al., J. Med. Chem., 45:818-40, 2002. [0103]Scherf et al., Nat. Genet., 24:236-244, 2000. [0104]Szakacs et al., Cancer Cell, 6:129-37, 2004. [0105]Vogelstein and Kinzler, Nat. Med., 10:789-799, 2004. [0106]Walloyist et al., Bioinformatics, 19:2212-24, 2003. [0107]Wallqvist et al., Mol. Cancer Ther., 1:311-20, 2002. [0108]Weinstein et al., Science, 275:343-349, 1997. [0109]Zaharevitz et al., J. Mol. Graph. Model, 30:297-303, 2002. [0110]Zurita et al., Cancer Res., 2004:64:435-9, 2004.
Sequence CWU
1
214019PRTArtificial SequenceSynthetic peptide 1Cys Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Cys1 529PRTArtificial SequenceArtificial peptide 2Cys
Ser Gly Ile Gly Ser Gly Gly Cys1 539PRTArtificial
SequenceArtificial peptide 3Cys Arg Phe Glu Ser Ser Gly Gly Cys1
547PRTArtificial SequenceArtificial peptide 4Ser Gly Ile Gly Ser Gly
Gly1 557PRTArtificial SequenceArtificial peptide 5Arg Phe
Glu Ser Ser Gly Gly1 567PRTArtificial SequenceArtificial
peptide 6Leu Arg Leu Ser Ser Ile Pro1 577PRTArtificial
SequenceArtificial peptide 7Ala Arg Gly Val Leu Leu Met1
587PRTArtificial SequenceArtificial peptide 8Arg Gly Ser His Leu Val Pro1
597PRTArtificial SequenceArtificial peptide 9Asp Val Glu
Thr Arg Gly Ser1 5107PRTArtificial SequenceArtificial
peptide 10Ser Arg Ala Val Ile Asp Met1 5117PRTArtificial
SequenceArtificial peptide 11Gly Leu Leu Ser Leu Xaa Leu1
5127PRTArtificial SequenceArtificial peptide 12Thr Ser Leu Leu Ser Phe
Arg1 5137PRTArtificial SequenceArtificial peptide 13Arg Arg
Val Ser Leu Val Ala1 5147PRTArtificial SequenceArtificial
peptide 14Ser Arg Phe Arg Val Ser Ile1 5157PRTArtificial
SequenceArtificial peptide 15Ala Gly Ser Leu Ser Val Phe1
5167PRTArtificial SequenceArtificial peptide 16Ala Gly Arg Ile Cys Glu
Gly1 5177PRTArtificial SequenceArtificial peptide 17Gln Val
Ala Gly Arg Glu Arg1 5187PRTArtificial SequenceArtificial
peptide 18Val Glu Tyr Ala Ala Gly Arg1 5197PRTArtificial
SequenceArtificial peptide 19Tyr Asn Arg Ser Ala Gly Leu1
5207PRTArtificial SequenceArtificial peptide 20Ala Val Leu Val Ala Gly
Gly1 5217PRTArtificial SequenceArtificial peptide 21Leu Ala
Gly Gly Val Pro Gly1 5227PRTArtificial SequenceArtificial
peptide 22Asp Trp Trp Ala Gly Val Arg1 5237PRTArtificial
SequenceArtificial peptide 23Glu Pro Asp Gly Val Arg Ser1
5247PRTArtificial SequenceArtificial peptide 24Glu Gln Leu Ser Gly Val
Arg1 5257PRTArtificial SequenceArtificial peptide 25Gly Val
Leu Ala Arg Val Thr1 5267PRTArtificial SequenceArtificial
peptide 26Ala Arg Gly Val Leu Leu Met1 5277PRTArtificial
SequenceArtificial peptide 27Gly Gly Ala Val Leu Val Ala1
5287PRTArtificial SequenceArtificial peptide 28Arg Glu Arg Gly Ala Val
Gln1 5297PRTArtificial SequenceArtificial peptide 29Arg Ala
Leu Gly Leu Val Ser1 5307PRTArtificial SequenceArtificial
peptide 30Ser Leu Gly Leu Arg Asn Gln1 5317PRTArtificial
SequenceArtificial peptide 31Arg Ala Leu Gly Leu Val Ser1
5327PRTArtificial SequenceArtificial peptide 32Gly Ala Tyr Arg Leu Val
Ser1 5337PRTArtificial SequenceArtificial peptide 33Phe Asp
Ala Arg Gly Gly Leu1 5347PRTArtificial SequenceArtificial
peptide 34Met Phe Ala Arg Gly Trp Glu1 5357PRTArtificial
SequenceArtificial peptide 35Ala Arg Gly Val Leu Leu Met1
5367PRTArtificial SequenceArtificial peptide 36Gly Gly Gly Ser Asp Gly
Val1 5377PRTArtificial SequenceArtificial peptide 37Leu Gly
Gly Arg Ala Asp Phe1 5387PRTArtificial SequenceArtificial
peptide 38Glu Val Gly Gly Gly Leu Thr1 5397PRTArtificial
SequenceArtificial peptide 39Phe Asp Ala Arg Gly Gly Leu1
5407PRTArtificial SequenceArtificial peptide 40Thr Gly Arg Val Val Arg
Arg1 5417PRTArtificial SequenceArtificial peptide 41Met Gly
Met Ser Gly Pro Ser1 5427PRTArtificial SequenceArtificial
peptide 42Ala Val Arg Gly Val Ala Arg1 5437PRTArtificial
SequenceArtificial peptide 43Asp Arg Gly Val Pro Gly Leu1
5447PRTArtificial SequenceArtificial peptide 44Leu Ser Phe Ser Arg Gly
Ser1 5457PRTArtificial SequenceArtificial peptide 45Arg Gly
Ser Val Arg Val Leu1 5467PRTArtificial SequenceArtificial
peptide 46Pro Val Arg Gly Ser Val Asp1 5477PRTArtificial
SequenceArtificial peptide 47Gln Val Met Met Arg Gly Ser1
5487PRTArtificial SequenceArtificial peptide 48Asn Gly Arg Gly Ser Gly
Trp1 5497PRTArtificial SequenceArtificial peptide 49Arg Ala
Val Gly Arg Val Ala1 5507PRTArtificial SequenceArtificial
peptide 50Arg Ala Ser Cys Ala Leu Thr1 5517PRTArtificial
SequenceArtificial peptide 51Ala Asp Ile Gly Ala Gly Gly1
5527PRTArtificial SequenceArtificial peptide 52Phe Met Gly Ala Gly Phe
Ala1 5537PRTArtificial SequenceArtificial peptide 53Ala Gly
Val Phe Ala Val Ser1 5547PRTArtificial SequenceArtificial
peptide 54Val Met Leu Leu Arg Pro Glu1 5557PRTArtificial
SequenceArtificial peptide 55Leu Leu Arg Gly Leu Glu Leu1
5567PRTArtificial SequenceArtificial peptide 56Leu Pro Leu Leu Arg Gly
Ile1 5577PRTArtificial SequenceArtificial peptide 57Asp Pro
Arg Gly Leu Arg Val1 5587PRTArtificial SequenceArtificial
peptide 58Leu Val Arg Val Ser Gly Arg1 5597PRTArtificial
SequenceArtificial peptide 59Ser Gly Ser Arg Val Ser Leu1
5607PRTArtificial SequenceArtificial peptide 60Ala Gly Ser Ile Ala Leu
Arg1 5617PRTArtificial SequenceArtificial peptide 61Met Leu
Ala Ser Ala Gly Arg1 5627PRTArtificial SequenceArtificial
peptide 62Ala Asp Ile Gly Ala Gly Gly1 5637PRTArtificial
SequenceArtificial peptide 63Phe Ala Gly Gly Ser Thr Asp1
5647PRTArtificial SequenceArtificial peptide 64Thr Gly Phe Gly Ala Val
Gly1 5657PRTArtificial SequenceArtificial peptide 65Phe Gly
Leu Arg Asn Ser Arg1 5667PRTArtificial SequenceArtificial
peptide 66Asp Pro Arg Gly Leu Arg Val1 5677PRTArtificial
SequenceArtificial peptide 67Leu Val Ser Ser Gly Ser Lys1
5687PRTArtificial SequenceArtificial peptide 68Leu Val Ser Ser Ser Glu
Pro1 5697PRTArtificial SequenceArtificial peptide 69Ala Ala
Val Trp Ala Ala Asp1 5707PRTArtificial SequenceArtificial
peptide 70Phe Ala Gly Gly Ser Thr Asp1 5717PRTArtificial
SequenceArtificial peptide 71Thr Phe Gly Lys Gly Gly Leu1
5727PRTArtificial SequenceArtificial peptide 72Lys Ser Gly Ser Ser Val
Leu1 5737PRTArtificial SequenceArtificial peptide 73Trp Gly
Ser Gly Arg Gly Asn1 5747PRTArtificial SequenceArtificial
peptide 74Arg Gly Ser Val Arg Val Leu1 5757PRTArtificial
SequenceArtificial peptide 75Pro Val Arg Gly Ser Val Asp1
5767PRTArtificial SequenceArtificial peptide 76Thr Glu Gly Ser Val Thr
Val1 5777PRTArtificial SequenceArtificial peptide 77Arg Ala
Val Gly Arg Val Ala1 5787PRTArtificial SequenceArtificial
peptide 78Asp Val Ser Gly Arg Val Pro1 5797PRTArtificial
SequenceArtificial peptide 79Leu Gly Gln Cys Gly Arg Val1
5807PRTArtificial SequenceArtificial peptide 80Gly Arg Leu Arg Leu Thr
Asp1 5817PRTArtificial SequenceArtificial peptide 81Leu Glu
Leu Gly Arg Leu Leu1 5827PRTArtificial SequenceArtificial
peptide 82Ile Gly Arg Leu Leu Pro Leu1 5837PRTArtificial
SequenceArtificial peptide 83Ser Asp Glu Asn Gly Arg Leu1
5847PRTArtificial SequenceArtificial peptide 84Glu Leu His Pro Arg Gly
Val1 5857PRTArtificial SequenceArtificial peptide 85Phe Asp
Arg Gly Val Glu Ala1 5867PRTArtificial SequenceArtificial
peptide 86Glu Ala Val Ser Arg Gly Ser1 5877PRTArtificial
SequenceArtificial peptide 87Trp Thr Lys Arg Gly Ser Val1
5887PRTArtificial SequenceArtificial peptide 88Glu Arg Ala Ser Gln Thr
Ala1 5897PRTArtificial SequenceArtificial peptide 89Glu Ala
Val Ser Arg Gly Ser1 5907PRTArtificial SequenceArtificial
peptide 90Ala Ala Thr Leu Leu Ser Phe1 5917PRTArtificial
SequenceArtificial peptide 91Leu Leu Ser Ala Ser Leu Val1
5927PRTArtificial SequenceArtificial peptide 92Arg Arg His Gly Leu Leu
Ser1 5937PRTArtificial SequenceSynthetic peptide 93Arg Tyr
Ser Thr Leu Leu Arg1 5947PRTArtificial SequenceSynthetic
peptide 94Phe Thr Leu Arg Val Asp Lys1 5957PRTArtificial
SequenceSynthetic peptide 95Ser His Arg Val Ser Asp Ser1
5967PRTArtificial SequenceSynthetic peptide 96Asn Arg Ser Ser Ala Lys
Phe1 5977PRTArtificial SequenceSynthetic peptide 97Leu Arg
Arg Ser Ser Phe Ser1 5987PRTArtificial SequenceSynthetic
peptide 98Ala Ile Arg Ala Gly Ser Asp1 5997PRTArtificial
SequenceSynthetic peptide 99Val Leu Phe Ser Ala Gly Ser1
51007PRTArtificial SequenceSynthetic peptide 100Gly Val Leu His Ser Ile
Ala1 51017PRTArtificial SequenceSynthetic peptide 101Arg
Gln Thr Thr Gly Ala Val1 51027PRTArtificial
SequenceSynthetic peptide 102Cys Gln Gly Leu Val Leu Gln1
51037PRTArtificial SequenceSynthetic peptide 103Pro Pro Pro Trp Gly Leu
Arg1 51047PRTArtificial SequenceSynthetic peptide 104Ser
Asn Ala Arg Gly Pro Arg1 51057PRTArtificial
SequenceSynthetic peptide 105Leu Leu Ser Ala Ser Leu Val1
51067PRTArtificial SequenceSynthetic peptide 106Ala Ala Val Phe Val Arg
Ser1 51077PRTArtificial SequenceSynthetic peptide 107Phe
Phe Gly Gly Ser Arg Ala1 51087PRTArtificial
SequenceSynthetic peptide 108Gly Gly Ser Gln Cys Asp Thr1
51097PRTArtificial SequenceSynthetic peptide 109Val Trp Gly Val Gly Gly
Ser1 51107PRTArtificial SequenceSynthetic peptide 110Phe
Ala Trp Gly Gly Arg Gly1 51117PRTArtificial
SequenceSynthetic peptide 111Gly Leu Gly Ile Met Gly Pro1
51127PRTArtificial SequenceSynthetic peptide 112Ser Ser Gly Ser Ser Asn
Gly1 51137PRTArtificial SequenceSynthetic peptide 113Trp
Thr Lys Arg Gly Ser Val1 51147PRTArtificial
SequenceSynthetic peptide 114Gly Val Ser Thr Gly Phe Thr1
51157PRTArtificial SequenceSynthetic peptide 115Cys His Ala Arg Gly Val
Thr1 51167PRTArtificial SequenceSynthetic peptide 116Trp
Gly Arg Gly Ser Val Ala1 51177PRTArtificial
SequenceSynthetic peptide 117Leu Arg Ser Gly Ala Gly Ser1
51187PRTArtificial SequenceSynthetic peptide 118Arg Ala Ala Val Ser Ala
Ile1 51197PRTArtificial SequenceSynthetic peptide 119Ala
Val Ser Gly Arg Gly Trp1 51207PRTArtificial
SequenceSynthetic peptide 120Leu Leu Ser Phe Leu Gly Arg1
51217PRTArtificial SequenceSynthetic peptide 121Gly Phe Tyr Trp Leu Arg
Ser1 51227PRTArtificial SequenceSynthetic peptide 122Arg
Gly Ala Arg Val Ser Ala1 51237PRTArtificial
SequenceSynthetic peptide 123Gly Gly Arg Ser Ser His Pro1
51247PRTArtificial SequenceSynthetic peptide 124Arg Ser Ser Ile Ala Pro
Ser1 51257PRTArtificial SequenceSynthetic peptide 125Leu
Ala Gly Ser Gly Ser His1 51267PRTArtificial
SequenceSynthetic peptide 126Leu Arg Ser Gly Ala Gly Ser1
51277PRTArtificial SequenceSynthetic peptide 127Ala Ser Val Arg Ala Gly
Arg1 51287PRTArtificial SequenceSynthetic peptide 128Ile
Gly Val Arg Gly Phe Phe1 51297PRTArtificial
SequenceSynthetic peptide 129Ala Asn Gly Val Leu Glu Leu1
51307PRTArtificial SequenceSynthetic peptide 130Trp Phe Gly Ala Val Gly
Leu1 51317PRTArtificial SequenceSynthetic peptide 131Gly
Leu Val Arg Gly Thr Ala1 51327PRTArtificial
SequenceSynthetic peptide 132Glu Gly Leu Val Ser Val Val1
51337PRTArtificial SequenceSynthetic peptide 133Asp Leu Gly Leu Arg Pro
Val1 51347PRTArtificial SequenceSynthetic peptide 134Ala
Leu Val Ser Arg Arg Gly1 51357PRTArtificial
SequenceSynthetic peptide 135Glu Val Leu Val Ser Gly Asp1
51367PRTArtificial SequenceSynthetic peptide 136Glu Gly Leu Val Ser Val
Val1 51377PRTArtificial SequenceSynthetic peptide 137Cys
His Ala Arg Gly Val Thr1 51387PRTArtificial
SequenceSynthetic peptide 138Arg Ala Ala Val Ser Ala Ile1
51397PRTArtificial SequenceSynthetic peptide 139His Arg Gly Gly Ser Gln
Ser1 51407PRTArtificial SequenceSynthetic peptide 140Gly
Gly Arg Ser Ser His Pro1 51417PRTArtificial
SequenceSynthetic peptide 141Ser Gln Ser Gly Gly Arg His1
51427PRTArtificial SequenceSynthetic peptide 142Ala Arg Ala Ile Gly Leu
Gly1 51437PRTArtificial SequenceSynthetic peptide 143Ser
Thr Glu Gly Gly Gly Leu1 51447PRTArtificial
SequenceSynthetic peptide 144Leu Ala Gly Ser Gly Ser His1
51457PRTArtificial SequenceSynthetic peptide 145Asp Gly Ser Val Leu Val
Glu1 51467PRTArtificial SequenceSynthetic peptide 146Trp
Gly Arg Gly Ser Val Ala1 51477PRTArtificial
SequenceSynthetic peptide 147Ala Thr Gly Arg Val Leu Gly1
51487PRTArtificial SequenceSynthetic peptide 148Ala Thr Gly Arg Val Leu
Gly1 51497PRTArtificial SequenceSynthetic peptide 149Phe
Phe Gly Arg Val Gly Ile1 51507PRTArtificial
SequenceSynthetic peptide 150Arg Ile Gly Arg Val Trp Ala1
51517PRTArtificial SequenceSynthetic peptide 151Arg Gly Arg Leu Glu Val
Pro1 51527PRTArtificial SequenceSynthetic peptide 152Arg
Arg Leu Ser Tyr Arg Asp1 51537PRTArtificial
SequenceSynthetic peptide 153Ser Arg Leu Ser Tyr Arg Gly1
51547PRTArtificial SequenceSynthetic peptide 154Phe Ser Ser Lys Arg Gly
Val1 51557PRTArtificial SequenceSynthetic peptide 155Arg
Gly Ser Ala Gln Asn Phe1 51567PRTArtificial
SequenceSynthetic peptide 156Leu Arg Ser Gly Arg Gly Ser1
51577PRTArtificial SequenceSynthetic peptide 157Tyr Arg Gly Ser Ser Gly
Lys1 51587PRTArtificial SequenceSynthetic peptide 158Phe
Trp Ile Ser Arg Ala Ser1 51597PRTArtificial
SequenceSynthetic peptide 159Gly Ala Gly Ser Ile Ser Asp1
51607PRTArtificial SequenceSynthetic peptide 160Arg Ala Met Gly Gly Ala
Gly1 51617PRTArtificial SequenceSynthetic peptide 161Leu
Leu Ser Thr Ser Ile Arg1 51627PRTArtificial
SequenceSynthetic peptide 162Leu Leu Leu Arg Ser Gly Gly1
51637PRTArtificial SequenceSynthetic peptide 163Leu Leu Arg Ser Ala Ala
Pro1 51647PRTArtificial SequenceSynthetic peptide 164Leu
Leu Leu Arg Ser Gly Gly1 51657PRTArtificial
SequenceSynthetic peptide 165Gly Arg Tyr Ser Leu Arg Ser1
51667PRTArtificial SequenceSynthetic peptide 166Leu Arg Ser Gly Arg Gly
Ser1 51677PRTArtificial SequenceSynthetic peptide 167Leu
Arg Tyr Asp Leu Arg Ser1 51687PRTArtificial
SequenceSynthetic peptide 168Leu Arg Tyr Asn Leu Arg Ser1
51697PRTArtificial SequenceSynthetic peptide 169Leu Leu Arg Ser Ala Ala
Pro1 51707PRTArtificial SequenceSynthetic peptide 170Ser
Lys Tyr Arg Leu Arg Ser1 51717PRTArtificial
SequenceSynthetic peptide 171Val His Arg Val Ser Gly Gly1
51727PRTArtificial SequenceSynthetic peptide 172Gly Ala Gly Ser Ile Ser
Asp1 51737PRTArtificial SequenceSynthetic peptide 173Phe
Ala Gly Arg Val Pro Ser1 51747PRTArtificial
SequenceSynthetic peptide 174Ala Gly Leu Ser Gly Ser Gln1
51757PRTArtificial SequenceSynthetic peptide 175Thr Asp Leu Ala Gly Leu
His1 51767PRTArtificial SequenceSynthetic peptide 176Leu
Ala Ala Gly Gly Glu Leu1 51777PRTArtificial
SequenceSynthetic peptide 177Gly Ala Gly Gly Met Ala Arg1
51787PRTArtificial SequenceSynthetic peptide 178Arg Ala Ala Gly Gly Ser
Arg1 51797PRTArtificial SequenceSynthetic peptide 179Leu
Tyr Gly Val Arg Tyr Gly1 51807PRTArtificial
SequenceSynthetic peptide 180Pro Arg Tyr Gly Val Arg Ala1
51817PRTArtificial SequenceSynthetic peptide 181Gly Ala Val Asp Gly Ser
Arg1 51827PRTArtificial SequenceSynthetic peptide 182Ala
Asp Phe Phe Gly Leu Val1 51837PRTArtificial
SequenceSynthetic peptide 183Lys Tyr Tyr Gly Leu Arg Arg1
51847PRTArtificial SequenceSynthetic peptide 184Ser Arg Tyr Gly Leu Arg
Arg1 51857PRTArtificial SequenceSynthetic peptide 185Pro
Ala Ala Ser Arg Leu Leu1 51867PRTArtificial
SequenceSynthetic peptide 186Arg Leu Arg Ala Ala Ser Tyr1
51877PRTArtificial SequenceSynthetic peptide 187Gly Gly Ser Arg Leu Leu
Leu1 51887PRTArtificial SequenceSynthetic peptide 188Arg
Ala Ala Gly Gly Ser Arg1 51897PRTArtificial
SequenceSynthetic peptide 189Gly Gly Ser Val Arg His Val1
51907PRTArtificial SequenceSynthetic peptide 190Gly Gly Arg Ser Trp Val
Asn1 51917PRTArtificial SequenceSynthetic peptide 191Gly
Leu Gly Asn Arg Pro Thr1 51927PRTArtificial
SequenceSynthetic peptide 192His Gly Leu Gly Ser Gly Thr1
51937PRTArtificial SequenceSynthetic peptide 193Gly Ser Ser Leu His Leu
Leu1 51947PRTArtificial SequenceSynthetic peptide 194Tyr
Arg Gly Ser Ser Gly Lys1 51957PRTArtificial
SequenceSynthetic peptide 195Glu Gly Ser Gly Val Asp Cys1
51967PRTArtificial SequenceSynthetic peptide 196His Gly Leu Gly Ser Gly
Thr1 51977PRTArtificial SequenceSynthetic peptide 197Ser
Gly Ser Val Asn Arg Gly1 51987PRTArtificial
SequenceSynthetic peptide 198Gly Gly Ser Val Arg His Val1
51997PRTArtificial SequenceSynthetic peptide 199Phe Ala Gly Arg Val Pro
Ser1 52007PRTArtificial SequenceSynthetic peptide 200Ala
Met Arg Pro Gly Arg Leu1 52017PRTArtificial
SequenceSynthetic peptide 201Gly Arg Leu Tyr Tyr Tyr Arg1
52027PRTArtificial SequenceSynthetic peptide 202Pro Ala Phe Gly Pro Ser
Arg1 52037PRTArtificial SequenceSynthetic peptide 203His
Ser Gly Val Ser His Gly1 52047PRTArtificial
SequenceSynthetic peptide 204Val Tyr Tyr Arg Leu Ser Ala1
52057PRTArtificial SequenceSynthetic peptide 205Gly Arg Gly Ser Phe Glu
Ser1 52067PRTArtificial SequenceSynthetic peptide 206Arg
Arg Gly Ser Ser Arg Asn1 52077PRTArtificial
SequenceSynthetic peptide 207His Ser Arg Ala Val Ala Pro1
52087PRTArtificial SequenceSynthetic peptide 208Arg Ala Ser Phe Arg Ala
Gly1 52097PRTArtificial SequenceSynthetic peptide 209Leu
Met Gly Arg Ala Ser Gly1 52107PRTArtificial
SequenceSynthetic peptide 210Trp Arg Ala Ser Ala Phe Thr1
52117PRTArtificial SequenceSynthetic peptide 211Gly Ala Gly Arg Thr Val
Met1 52127PRTArtificial SequenceSynthetic peptide 212Pro
Leu Ala Val Ser Met Val1 52137PRTArtificial
SequenceSynthetic peptide 213Phe Leu Leu Arg Ser Ser Phe1
52147PRTArtificial SequenceSynthetic peptide 214Trp Arg Leu Leu Arg Arg
Gln1 52157PRTArtificial SequenceSynthetic peptide 215Phe
Leu Leu Arg Ser Ser Phe1 52167PRTArtificial
SequenceSynthetic peptide 216Leu Arg Ser Arg Leu Gly Phe1
52177PRTArtificial SequenceSynthetic peptide 217Gly Arg Arg Val Ser Leu
Val1 52187PRTArtificial SequenceSynthetic peptide 218Phe
Leu Leu Arg Ser Ser Phe1 52197PRTArtificial
SequenceSynthetic peptide 219Asn Arg Ser Ser Gly Arg Arg1
52207PRTArtificial SequenceSynthetic peptide 220Val Leu Gly Met Arg Ser
Ser1 52217PRTArtificial SequenceSynthetic peptide 221Thr
His Arg Asn Arg Ser Ser1 52227PRTArtificial
SequenceSynthetic peptide 222Leu Ala Gly Ser Thr Arg Arg1
52237PRTArtificial SequenceSynthetic peptide 223Ala Gly Arg Thr Gly Val
Gly1 52247PRTArtificial SequenceSynthetic peptide 224Glu
Phe Ala Val Ala Gly Arg1 52257PRTArtificial
SequenceSynthetic peptide 225Gly Ala Gly Arg Thr Val Met1
52267PRTArtificial SequenceSynthetic peptide 226Arg Glu Glu Phe Ala Gly
Arg1 52277PRTArtificial SequenceSynthetic peptide 227Ala
Gly Gly Pro Thr Lys Tyr1 52287PRTArtificial
SequenceSynthetic peptide 228Phe His Val Ala Gly Gly Ser1
52297PRTArtificial SequenceSynthetic peptide 229Trp Ser Ala Gly Gly Pro
His1 52307PRTArtificial SequenceSynthetic peptide 230Arg
Gly Ala Val Ala Phe Glu1 52317PRTArtificial
SequenceSynthetic peptide 231Ser Gly Gly Ala Val His Phe1
52327PRTArtificial SequenceSynthetic peptide 232Gly Ala Val Arg Ala Arg
Leu1 52337PRTArtificial SequenceSynthetic peptide 233Gly
Leu Val Arg Gly Phe Pro1 52347PRTArtificial
SequenceSynthetic peptide 234Gly Ala His Gly Leu Val Arg1
52357PRTArtificial SequenceSynthetic peptide 235Ser Ser Arg Met Gly Leu
Val1 52367PRTArtificial SequenceSynthetic peptide 236Tyr
Val Gly Leu Val Val Ser1 52377PRTArtificial
SequenceSynthetic peptide 237Gly Leu Arg Lys Ala Gly Phe1
52387PRTArtificial SequenceSynthetic peptide 238Ala Val Asp Gly Leu Arg
Leu1 52397PRTArtificial SequenceSynthetic peptide 239Phe
Gly Leu Arg Ser Arg Leu1 52407PRTArtificial
SequenceSynthetic peptide 240Glu Arg Ala Arg Gly Tyr Pro1
52417PRTArtificial SequenceSynthetic peptide 241Gly Ser Ala Arg Gly Met
Leu1 52427PRTArtificial SequenceSynthetic peptide 242Ala
Ser Leu Arg Tyr Tyr Val1 52437PRTArtificial
SequenceSynthetic peptide 243Asn Ala Ala Ser Leu Pro Ser1
52447PRTArtificial SequenceSynthetic peptide 244Trp Leu Asp Ala Ser Leu
Met1 52457PRTArtificial SequenceSynthetic peptide 245Asn
Ala Ala Ser Leu Pro Ser1 52467PRTArtificial
SequenceSynthetic peptide 246Phe His Val Ala Gly Gly Ser1
52477PRTArtificial SequenceSynthetic peptide 247Gly Glu His Leu Gly Gly
Ser1 52487PRTArtificial SequenceSynthetic peptide 248Ser
Gly Gly Leu His Glu Gly1 52497PRTArtificial
SequenceSynthetic peptide 249Ser Arg Leu Ser Tyr Arg Ser1
52507PRTArtificial SequenceSynthetic peptide 250Gly Gly Leu Arg Gly Val
Arg1 52517PRTArtificial SequenceSynthetic peptide 251Val
Ala Trp Arg Gly Val Ser1 52527PRTArtificial
SequenceSynthetic peptide 252Ser Val Glu Gly Arg Gly Val1
52537PRTArtificial SequenceSynthetic peptide 253Phe Trp Arg Gly Ser Val
Pro1 52547PRTArtificial SequenceSynthetic peptide 254Glu
Phe Thr Arg Arg Ala Ser1 52557PRTArtificial
SequenceSynthetic peptide 255Trp Gly Trp Arg Ala Ser Ser1
52567PRTArtificial SequenceSynthetic peptide 256Arg Phe Tyr His Leu Arg
Ser1 52577PRTArtificial SequenceSynthetic peptide 257Ser
Arg Tyr Ser Leu Arg Ser1 52587PRTArtificial
SequenceSynthetic peptide 258Arg Arg Ser Ser Lys Gln Ala1
52597PRTArtificial SequenceSynthetic peptide 259Asp Trp Gly Arg Ser Ser
Phe1 52607PRTArtificial SequenceSynthetic peptide 260Arg
Phe Thr Arg Ser Ser Gly1 52617PRTArtificial
SequenceSynthetic peptide 261Val Phe Gln Arg Ser Ser Gly1
52627PRTArtificial SequenceSynthetic peptide 262Ala Gly Ser Gln Ser Trp
Glu1 52637PRTArtificial SequenceSynthetic peptide 263Glu
His Pro Ala Gly Gly Met1 52647PRTArtificial
SequenceSynthetic peptide 264Gly Val Arg Thr Ala Gly Pro1
52657PRTArtificial SequenceSynthetic peptide 265Gly Gly Leu Arg Gly Val
Arg1 52667PRTArtificial SequenceSynthetic peptide 266Leu
Tyr Gly Gly Val Arg Tyr1 52677PRTArtificial
SequenceSynthetic peptide 267Pro Val Gly Gly Val Leu Leu1
52687PRTArtificial SequenceSynthetic peptide 268Gly Ala Val Val Lys Pro
Ile1 52697PRTArtificial SequenceSynthetic peptide 269Ser
Val Gly Ala Val Gly Gly1 52707PRTArtificial
SequenceSynthetic peptide 270Gly Leu Val Ser Val Glu Ala1
52717PRTArtificial SequenceSynthetic peptide 271Gly Gly Leu Arg Gly Val
Arg1 52727PRTArtificial SequenceSynthetic peptide 272Asp
Ile Ala Leu Val Ser Pro1 52737PRTArtificial
SequenceSynthetic peptide 273Gly Leu Val Ser Val Glu Ala1
52747PRTArtificial SequenceSynthetic peptide 274Ala Arg Asn Ala Ala Ser
Pro1 52757PRTArtificial SequenceSynthetic peptide 275Ala
Glu Gly Gly Ser Gly His1 52767PRTArtificial
SequenceSynthetic peptide 276Gly Gly Ser Phe Ser Gly Leu1
52777PRTArtificial SequenceSynthetic peptide 277Val Thr Gly Gly Arg Val
Asp1 52787PRTArtificial SequenceSynthetic peptide 278Gly
Gly Leu Arg Gly Val Arg1 52797PRTArtificial
SequenceSynthetic peptide 279Gly Ser Ser Trp Val Val Asp1
52807PRTArtificial SequenceSynthetic peptide 280Gly Ser Ser Arg Thr Phe
Arg1 52817PRTArtificial SequenceSynthetic peptide 281Gly
Ser Ser Arg Gln Phe Val1 52827PRTArtificial
SequenceSynthetic peptide 282Trp Val Gly Ser Ser Lys Phe1
52837PRTArtificial SequenceSynthetic peptide 283Ala Glu Gly Gly Ser Gly
His1 52847PRTArtificial SequenceSynthetic peptide 284Glu
Val Ile Gly Ser Gly Ile1 52857PRTArtificial
SequenceSynthetic peptide 285Phe Trp Arg Gly Ser Val Pro1
52867PRTArtificial SequenceSynthetic peptide 286Val Gly Ser Val Ser Val
Asn1 52877PRTArtificial SequenceSynthetic peptide 287Val
Thr Gly Gly Arg Val Asp1 52887PRTArtificial
SequenceSynthetic peptide 288Gly Arg Val Thr Val Ala Val1
52897PRTArtificial SequenceSynthetic peptide 289Arg Val Gly Arg Leu Gly
Gly1 52907PRTArtificial SequenceSynthetic peptide 290Asn
Tyr Met Gly Pro Ser Ala1 52917PRTArtificial
SequenceSynthetic peptide 291Gly Trp His Gly Pro Ser His1
52927PRTArtificial SequenceSynthetic peptide 292Gly Gly Val Ser Pro Val
Asp1 52937PRTArtificial SequenceSynthetic peptide 293Gly
Val Ser Lys Val Arg Ala1 52947PRTArtificial
SequenceSynthetic peptide 294Gly Gly Val Ala Gly Val Ser1
52957PRTArtificial SequenceSynthetic peptide 295Val Ala Trp Arg Gly Val
Ser1 52967PRTArtificial SequenceSynthetic peptide 296Val
Ile Gly Ser Arg Leu Ser1 52977PRTArtificial
SequenceSynthetic peptide 297His Leu Arg Gly Arg Gly Val1
52987PRTArtificial SequenceSynthetic peptide 298Glu Val Arg Ser Arg Gly
Ser1 52997PRTArtificial SequenceSynthetic peptide 299Arg
Gly Ser Arg Leu Pro Ala1 53007PRTArtificial
SequenceSynthetic peptide 300Asp Val Arg Ala Val Ser Ser1
53017PRTArtificial SequenceSynthetic peptide 301Asp Val Arg Ala Val Ser
Ser1 53027PRTArtificial SequenceSynthetic peptide 302Ala
Pro Leu Arg Ser Gly Arg1 53037PRTArtificial
SequenceSynthetic peptide 303Ser Leu Arg Ser Gly Ile Val1
53047PRTArtificial SequenceSynthetic peptide 304Asp Gly Gly Arg Arg Ser
Ser1 53057PRTArtificial SequenceSynthetic peptide 305Gln
Ala Gly Ser Phe Leu Arg1 53067PRTArtificial
SequenceSynthetic peptide 306Asp Ala Gly Ser Asp Arg Arg1
53077PRTArtificial SequenceSynthetic peptide 307Ala Gly Arg Arg Phe Gly
Gly1 53087PRTArtificial SequenceSynthetic peptide 308Ala
Gly Leu Ser Gly Gly Thr1 53097PRTArtificial
SequenceSynthetic peptide 309Ala Gly Gly Gly Pro Pro Ala1
53107PRTArtificial SequenceSynthetic peptide 310Ala Gly Gly Gly Pro Pro
Ala1 53117PRTArtificial SequenceSynthetic peptide 311Phe
Phe Pro Ala Gly Gly Pro1 53127PRTArtificial
SequenceSynthetic peptide 312Pro Arg Ala Gly Gly Arg Trp1
53137PRTArtificial SequenceSynthetic peptide 313Asp Val Pro Gly Val Arg
Phe1 53147PRTArtificial SequenceSynthetic peptide 314Phe
Gly Val Leu Phe Arg Ser1 53157PRTArtificial
SequenceSynthetic peptide 315Ser Arg Tyr Gly Val Leu Val1
53167PRTArtificial SequenceSynthetic peptide 316Leu Arg Gly Gly Leu Val
Ser1 53177PRTArtificial SequenceSynthetic peptide 317Lys
Ser Gly Leu Arg Pro Ala1 53187PRTArtificial
SequenceSynthetic peptide 318Ala Leu Val Ser Phe Ser Val1
53197PRTArtificial SequenceSynthetic peptide 319Leu Arg Gly Gly Leu Val
Ser1 53207PRTArtificial SequenceSynthetic peptide 320His
Lys Leu Ala Arg Gly Arg1 53217PRTArtificial
SequenceSynthetic peptide 321Ala Ser Leu Pro Pro Arg Ala1
53227PRTArtificial SequenceSynthetic peptide 322Thr Gly Gly Ser Leu Gly
Ala1 53237PRTArtificial SequenceSynthetic peptide 323Gly
Gly Gly Ser Trp Leu Ile1 53247PRTArtificial
SequenceSynthetic peptide 324Asp Gly Gly Arg Arg Ser Ser1
53257PRTArtificial SequenceSynthetic peptide 325Ser Val Leu Gly Gly Arg
Leu1 53267PRTArtificial SequenceSynthetic peptide 326Pro
Arg Ala Gly Gly Arg Trp1 53277PRTArtificial
SequenceSynthetic peptide 327Tyr Trp Phe Ile Gly Leu Gly1
53287PRTArtificial SequenceSynthetic peptide 328Gly Gly Leu Ser Val Asp
Leu1 53297PRTArtificial SequenceSynthetic peptide 329Leu
Arg Gly Gly Leu Val Ser1 53307PRTArtificial
SequenceSynthetic peptide 330Ser Gly Val Gly Ser Ser Leu1
53317PRTArtificial SequenceSynthetic peptide 331Gly Ser Gly Ile Leu Asp
Leu1 53327PRTArtificial SequenceSynthetic peptide 332Ser
Leu Gly Ser Val Gly Ser1 53337PRTArtificial
SequenceSynthetic peptide 333Val Gly Arg Gly Arg Leu His1
53347PRTArtificial SequenceSynthetic peptide 334Ser Val Leu Gly Gly Arg
Leu1 53357PRTArtificial SequenceSynthetic peptide 335Met
Ser Ala Phe Gly Arg Leu1 53367PRTArtificial
SequenceSynthetic peptide 336Ser Gly Val Ser Gly Leu Ser1
53377PRTArtificial SequenceSynthetic peptide 337Gly Asp Ser Arg Arg Gly
Val1 53387PRTArtificial SequenceSynthetic peptide 338Gly
Lys Ala Leu Arg Gly Val1 53397PRTArtificial
SequenceSynthetic peptide 339Pro Lys Ala Gly Arg Gly Ser1
53407PRTArtificial SequenceSynthetic peptide 340Phe Asp Arg Ala Val Ala
Asn1 53417PRTArtificial SequenceSynthetic peptide 341Leu
Leu Arg Arg Ala Val Phe1 53427PRTArtificial
SequenceSynthetic peptide 342Phe Arg Ala Ser Ser Glu Val1
53437PRTArtificial SequenceSynthetic peptide 343Pro Asp Arg Ala Ser Asp
Gly1 53447PRTArtificial SequenceSynthetic peptide 344Phe
Arg Ala Ser Leu Gln Tyr1 53457PRTArtificial
SequenceSynthetic peptide 345His Val Gly Leu Leu Arg Ala1
53467PRTArtificial SequenceSynthetic peptide 346Gln Val Leu Leu Arg Ser
Phe1 53477PRTArtificial SequenceSynthetic peptide 347Leu
Leu Arg Arg Ala Val Phe1 53487PRTArtificial
SequenceSynthetic peptide 348Phe Leu Arg Val Gly Glu Leu1
53497PRTArtificial SequenceSynthetic peptide 349Gln Val Leu Leu Arg Ser
Phe1 53507PRTArtificial SequenceSynthetic peptide 350Arg
Arg Val Ser Cys Asp Leu1 53517PRTArtificial
SequenceSynthetic peptide 351Arg Ser Ser Gly Leu Gly Phe1
53527PRTArtificial SequenceSynthetic peptide 352Ser Ser Gly Pro Arg Ser
Ser1 53537PRTArtificial SequenceSynthetic peptide 353Tyr
Ser Gln Arg Ser Ser Leu1 53547PRTArtificial
SequenceSynthetic peptide 354Asp Ala Gly Arg Thr Ile Asp1
53557PRTArtificial SequenceSynthetic peptide 355Ala Ala Gly Arg Glu Phe
Arg1 53567PRTArtificial SequenceSynthetic peptide 356Pro
Lys Ala Gly Arg Gly Ser1 53577PRTArtificial
SequenceSynthetic peptide 357Val Arg Ala Ala Gly Arg Val1
53587PRTArtificial SequenceSynthetic peptide 358His Gly Tyr Arg Ala Gly
Gly1 53597PRTArtificial SequenceSynthetic peptide 359Trp
Gly Ala Thr Ala Gly Gly1 53607PRTArtificial
SequenceSynthetic peptide 360Tyr Tyr Ala Gly Gly Leu Lys1
53617PRTArtificial SequenceSynthetic peptide 361Leu Glu Gly Val Arg Leu
Phe1 53627PRTArtificial SequenceSynthetic peptide 362Gly
Thr Phe Gly Val Leu Gly1 53637PRTArtificial
SequenceSynthetic peptide 363Gly Thr Phe Gly Val Leu Gly1
53647PRTArtificial SequenceSynthetic peptide 364Val Trp Ala Gly Val Leu
Leu1 53657PRTArtificial SequenceSynthetic peptide 365Gly
Ala Val Leu Phe Arg Val1 53667PRTArtificial
SequenceSynthetic peptide 366Gly Leu Val Gly Phe Thr Gly1
53677PRTArtificial SequenceSynthetic peptide 367Gly Leu Val Ser Ala Phe
Tyr1 53687PRTArtificial SequenceSynthetic peptide 368Ala
Arg Ala Met Gly Leu Arg1 53697PRTArtificial
SequenceSynthetic peptide 369Gly Leu Val Ser Ala Phe Tyr1
53707PRTArtificial SequenceSynthetic peptide 370Ser Trp Arg Pro Leu Val
Ser1 53717PRTArtificial SequenceSynthetic peptide 371Phe
Arg Ala Ser Leu Gln Tyr1 53727PRTArtificial
SequenceSynthetic peptide 372His Ser Glu Ser Ala Ala Val1
53737PRTArtificial SequenceSynthetic peptide 373Leu Phe Ala Val Ala Ala
Val1 53747PRTArtificial SequenceSynthetic peptide 374Val
Ala Ala Ser Glu Ser His1 53757PRTArtificial
SequenceSynthetic peptide 375His Pro Ser Met Gly Gly Arg1
53767PRTArtificial SequenceSynthetic peptide 376Gly Leu Gly Val Ser Gly
Val1 53777PRTArtificial SequenceSynthetic peptide 377Lys
Arg Glu Ser Gly Leu Gly1 53787PRTArtificial
SequenceSynthetic peptide 378Arg Ser Ser Gly Leu Gly Phe1
53797PRTArtificial SequenceSynthetic peptide 379Val Gly Leu Gly His Trp
Pro1 53807PRTArtificial SequenceSynthetic peptide 380Tyr
Tyr Ala Gly Gly Leu Lys1 53817PRTArtificial
SequenceSynthetic peptide 381Asn Tyr Gly Ser Ser Phe His1
53827PRTArtificial SequenceSynthetic peptide 382Phe Gly Leu Gly Ser Ser
Arg1 53837PRTArtificial SequenceSynthetic peptide 383Ser
Ser Arg Pro Gly Ser Ser1 53847PRTArtificial
SequenceSynthetic peptide 384Val Gly Ser Val Gly Leu Gly1
53857PRTArtificial SequenceSynthetic peptide 385Val Arg Ala Ala Gly Arg
Val1 53867PRTArtificial SequenceSynthetic peptide 386His
Asn Gly Arg Leu Glu Val1 53877PRTArtificial
SequenceSynthetic peptide 387Val Gly Arg Leu Ala Lys Gly1
53887PRTArtificial SequenceSynthetic peptide 388Val Met Gly Gly Pro Ser
Leu1 53897PRTArtificial SequenceSynthetic peptide 389Gly
Leu Gly Val Ser Gly Val1 53907PRTArtificial
SequenceSynthetic peptide 390Ser Gly Val Ser Val Glu Gly1
53917PRTArtificial SequenceSynthetic peptide 391Gly Glu Ser Gly Arg Leu
Ser1 53927PRTArtificial SequenceSynthetic peptide 392Gly
Ser Gly Arg Gly Val Ala1 53937PRTArtificial
SequenceSynthetic peptide 393Arg Gly Val Val Ser Ala Lys1
53947PRTArtificial SequenceSynthetic peptide 394Arg Gly Val Val Ser Gly
Val1 53957PRTArtificial SequenceSynthetic peptide 395Ala
Val Gly Arg Gly Ser Gly1 53967PRTArtificial
SequenceSynthetic peptide 396Ser Leu Arg Gly Ser Glu Gly1
53977PRTArtificial SequenceSynthetic peptide 397Pro Ala Thr Arg Gly Ser
Val1 53987PRTArtificial SequenceSynthetic peptide 398Ser
Leu Thr Arg Ala Val Arg1 53997PRTArtificial
SequenceSynthetic peptide 399Val Ala Arg Ala Val Pro Cys1
54007PRTArtificial SequenceSynthetic peptide 400Glu Gly Ala Arg Ala Ser
Asp1 54017PRTArtificial SequenceSynthetic peptide 401Met
Gly Ser Ala Val Ser Leu1 54027PRTArtificial
SequenceSynthetic peptide 402Gly Gly Ala Leu Leu Arg Gly1
54037PRTArtificial SequenceSynthetic peptide 403Pro Asn Arg Arg Val Ser
Ala1 54047PRTArtificial SequenceSynthetic peptide 404Gln
Asp Arg Val Ser Arg Ser1 54057PRTArtificial
SequenceSynthetic peptide 405Ser Glu Arg Ser Ser Leu Gly1
54067PRTArtificial SequenceSynthetic peptide 406Leu Val Arg Ser Ser Gly
Leu1 54077PRTArtificial SequenceSynthetic peptide 407Ile
Asn Trp Ala Gly Leu Ser1 54087PRTArtificial
SequenceSynthetic peptide 408Trp Ala Gly Leu Ser Pro Ser1
54097PRTArtificial SequenceSynthetic peptide 409Gly Arg Leu Leu Ala Gly
Gly1 54107PRTArtificial SequenceSynthetic peptide 410Ser
Tyr Gly Leu Val Leu Pro1 54117PRTArtificial
SequenceSynthetic peptide 411Ser Gly Gly Leu Val Leu Thr1
54127PRTArtificial SequenceSynthetic peptide 412His Ala Ala His Gly Leu
Val1 54137PRTArtificial SequenceSynthetic peptide 413Gly
Leu Arg Thr Arg Gln Val1 54147PRTArtificial
SequenceSynthetic peptide 414Leu Val Ser Gly Tyr Asn Gly1
54157PRTArtificial SequenceSynthetic peptide 415Ala Gly Ile Ala Arg Gly
Gly1 54167PRTArtificial SequenceSynthetic peptide 416His
Val Ser Gly Gly Ser Gly1 54177PRTArtificial
SequenceSynthetic peptide 417Gly Gly Ser Ser Glu Phe Arg1
54187PRTArtificial SequenceSynthetic peptide 418Gly Gly Ser Gly Ile Gly
Ser1 54197PRTArtificial SequenceSynthetic peptide 419Ser
Trp Gly Ser Gly Gly Ser1 54207PRTArtificial
SequenceSynthetic peptide 420Thr Leu Val Leu Gly Gly Ser1
54217PRTArtificial SequenceSynthetic peptide 421Ala Val Arg Gly Gly Arg
Pro1 54227PRTArtificial SequenceSynthetic peptide 422Gly
Gly Arg Ala Ile Gly Ala1 54237PRTArtificial
SequenceSynthetic peptide 423Ser Gly Gly Leu Val Leu Thr1
54247PRTArtificial SequenceSynthetic peptide 424Arg Thr Gly Ser Ser Asp
Leu1 54257PRTArtificial SequenceSynthetic peptide 425Leu
Gly Ser Ser Arg Val Leu1 54267PRTArtificial
SequenceSynthetic peptide 426Gly Gly Ser Ser Glu Phe Arg1
54277PRTArtificial SequenceSynthetic peptide 427Ala Val Gly Arg Gly Ser
Gly1 54287PRTArtificial SequenceSynthetic peptide 428His
Val Ser Gly Gly Ser Gly1 54297PRTArtificial
SequenceSynthetic peptide 429Ser Gly Ile Gly Ser Gly Gly1
54307PRTArtificial SequenceSynthetic peptide 430Ser Trp Gly Ser Gly Gly
Ser1 54317PRTArtificial SequenceSynthetic peptide 431Trp
Val Gly Ser Gly Ser Pro1 54327PRTArtificial
SequenceSynthetic peptide 432Gly Ser Gly Gly Ser Val His1
54337PRTArtificial SequenceSynthetic peptide 433Gly Asn Tyr Gly Ser Val
Leu1 54347PRTArtificial SequenceSynthetic peptide 434Val
Gly Ser Val Val Gly Arg1 54357PRTArtificial
SequenceSynthetic peptide 435Pro Ala Thr Arg Gly Ser Val1
54367PRTArtificial SequenceSynthetic peptide 436Pro Arg Gly Gly Arg Val
Ala1 54377PRTArtificial SequenceSynthetic peptide 437Gly
Arg Val His Leu Met Pro1 54387PRTArtificial
SequenceSynthetic peptide 438Gly Glu Ser Gly Arg Leu Ser1
54397PRTArtificial SequenceSynthetic peptide 439Gly Arg Leu Leu Ala Gly
Gly1 54407PRTArtificial SequenceSynthetic peptide 440Gly
Arg Leu Trp Trp His Thr1 54417PRTArtificial
SequenceSynthetic peptide 441Gly Arg Leu Trp Ser Arg Val1
54427PRTArtificial SequenceSynthetic peptide 442Ala Gly Pro Ser Ala Trp
Leu1 54437PRTArtificial SequenceSynthetic peptide 443Ser
Gly Val Ser Arg Gly Gln1 54447PRTArtificial
SequenceSynthetic peptide 444Arg Gly Val Ser Leu Lys Gly1
54457PRTArtificial SequenceSynthetic peptide 445Gln Met Gln Gly Arg Ala
Val1 54467PRTArtificial SequenceSynthetic peptide 446Arg
Gly Leu Arg Ser Val Asn1 54477PRTArtificial
SequenceSynthetic peptide 447Arg Ser Ser Leu Gly Leu Pro1
54487PRTArtificial SequenceSynthetic peptide 448Leu Glu Ala Gly Ser Gln
Leu1 54497PRTArtificial SequenceSynthetic peptide 449Ala
Gly Gly Gln Ser Glu Arg1 54507PRTArtificial
SequenceSynthetic peptide 450Gly Gly Val Leu Tyr Leu Glu1
54517PRTArtificial SequenceSynthetic peptide 451Arg Gly Leu Arg Ser Val
Asn1 54527PRTArtificial SequenceSynthetic peptide 452Val
Ala Arg Gly Gln Met Gln1 54537PRTArtificial
SequenceSynthetic peptide 453Gly Gly Ser Arg Asn Arg Trp1
54547PRTArtificial SequenceSynthetic peptide 454Gly Gly Gly Arg Ser Gly
Val1 54557PRTArtificial SequenceSynthetic peptide 455Gly
Leu Gly Gly Trp Val Ala1 54567PRTArtificial
SequenceSynthetic peptide 456Ala Val Trp Gly Gly Leu Gly1
54577PRTArtificial SequenceSynthetic peptide 457Gly Gly Leu Ser Glu Cys
Val1 54587PRTArtificial SequenceSynthetic peptide 458Ala
Lys Leu Gly Ser Val Tyr1 54597PRTArtificial
SequenceSynthetic peptide 459Gln Gly Arg Val Asn Val Lys1
54607PRTArtificial SequenceSynthetic peptide 460Gly Arg Leu Trp Gly Phe
Trp1 54617PRTArtificial SequenceSynthetic peptide 461Arg
Gly Val Ser Leu Lys Gly1 54627PRTArtificial
SequenceSynthetic peptide 462Gly Ser Leu Gly Val Ser Leu1
54637PRTArtificial SequenceSynthetic peptide 463Leu Leu Arg Leu Ser Leu
Ala1 54647PRTArtificial SequenceSynthetic peptide 464Arg
Arg Gly Ser Gly Gly Leu1 54657PRTArtificial
SequenceSynthetic peptide 465Val Arg Gly Ser Val Arg Ala1
54667PRTArtificial SequenceSynthetic peptide 466Leu Leu Arg Leu Ser Leu
Ala1 54677PRTArtificial SequenceSynthetic peptide 467Pro
Leu Arg Val Asp Asn Leu1 54687PRTArtificial
SequenceSynthetic peptide 468Leu Arg Val Gly Ile Gly Tyr1
54697PRTArtificial SequenceSynthetic peptide 469Gln Gly Tyr Ala Leu Arg
Val1 54707PRTArtificial SequenceSynthetic peptide 470Pro
Leu Arg Ser Phe Asp Ser1 54717PRTArtificial
SequenceSynthetic peptide 471Ala Arg Val Ser Gly Arg Val1
54727PRTArtificial SequenceSynthetic peptide 472Pro Phe Pro Ala Arg Ser
Ser1 54737PRTArtificial SequenceSynthetic peptide 473Ala
Gly Ser Pro Leu Ala Lys1 54747PRTArtificial
SequenceSynthetic peptide 474Phe Val Asp Ile Ala Gly Ser1
54757PRTArtificial SequenceSynthetic peptide 475Ser Tyr Phe Arg Ala Gly
Arg1 54767PRTArtificial SequenceSynthetic peptide 476Ala
Gly Leu Gly His Glu Gly1 54777PRTArtificial
SequenceSynthetic peptide 477Ala Gly Gly Ser Leu Gly Ser1
54787PRTArtificial SequenceSynthetic peptide 478Tyr Gly Ile Gly Val Arg
Leu1 54797PRTArtificial SequenceSynthetic peptide 479Arg
Ala Asn Gly Val Leu Val1 54807PRTArtificial
SequenceSynthetic peptide 480Leu Ala Ser Leu Gly Val Gly1
54817PRTArtificial SequenceSynthetic peptide 481Arg Ala Ala Val Gly Ala
Arg1 54827PRTArtificial SequenceSynthetic peptide 482Gly
Cys Asp Gly Gly Ser Ala1 54837PRTArtificial
SequenceSynthetic peptide 483Gly Gly Ser Gly Glu Leu Gly1
54847PRTArtificial SequenceSynthetic peptide 484Leu Gly Gly Ser Gly Arg
Arg1 54857PRTArtificial SequenceSynthetic peptide 485Ala
Gly Gly Ser Leu Gly Ser1 54867PRTArtificial
SequenceSynthetic peptide 486Ile Gly Gly Arg Glu Ile Thr1
54877PRTArtificial SequenceSynthetic peptide 487Gly Glu His Gly Leu Gly
Ala1 54887PRTArtificial SequenceSynthetic peptide 488Arg
Arg Gly Ser Gly Gly Leu1 54897PRTArtificial
SequenceSynthetic peptide 489Arg Ser Gly Ser Ser Val Tyr1
54907PRTArtificial SequenceSynthetic peptide 490Gly Leu Glu Gly Ser Gly
Gly1 54917PRTArtificial SequenceSynthetic peptide 491Leu
Gly Gly Ser Gly Arg Arg1 54927PRTArtificial
SequenceSynthetic peptide 492Thr Thr Gly Ser Val Ile Val1
54937PRTArtificial SequenceSynthetic peptide 493Val Arg Gly Ser Val Arg
Ala1 54947PRTArtificial SequenceSynthetic peptide 494His
Gly Arg Val His Arg Leu1 54957PRTArtificial
SequenceSynthetic peptide 495Ala Arg Val Ser Gly Arg Val1
54967PRTArtificial SequenceSynthetic peptide 496Ser Gly His Gly Val Ser
Ala1 54977PRTArtificial SequenceSynthetic peptide 497Ala
Val Trp Arg Leu Ser His1 54987PRTArtificial
SequenceSynthetic peptide 498Arg Gly Val Phe Tyr Gly Lys1
54997PRTArtificial SequenceSynthetic peptide 499Arg Gly Val Gly Trp Ala
Lys1 55007PRTArtificial SequenceSynthetic peptide 500Ser
Arg Gly Ser Thr Ala Gly1 55017PRTArtificial
SequenceSynthetic peptide 501Ser Glu Asp Glu Gly Ala Gly1
55027PRTArtificial SequenceSynthetic peptide 502Ser Thr Ser Leu Gly Ala
Gly1 55037PRTArtificial SequenceSynthetic peptide 503Asp
Leu Leu Arg Tyr Leu Ala1 55047PRTArtificial
SequenceSynthetic peptide 504Leu Arg Val Arg Tyr Ala Val1
55057PRTArtificial SequenceSynthetic peptide 505Leu Arg Ser Ser Gly Ala
Thr1 55067PRTArtificial SequenceSynthetic peptide 506Leu
Ser Met Leu Arg Ser Ala1 55077PRTArtificial
SequenceSynthetic peptide 507Arg Glu Ala Glu Arg Val Ser1
55087PRTArtificial SequenceSynthetic peptide 508Leu Arg Ser Ser Gly Ala
Thr1 55097PRTArtificial SequenceSynthetic peptide 509Thr
Ala Gly Ser Ser Arg Leu1 55107PRTArtificial
SequenceSynthetic peptide 510Ala Ala Gly Arg Ala Gly Cys1
55117PRTArtificial SequenceSynthetic peptide 511Gly Ala Gly Leu Ser Thr
Ser1 55127PRTArtificial SequenceSynthetic peptide 512Pro
Ser Val Gly Val Arg Ala1 55137PRTArtificial
SequenceSynthetic peptide 513Val Gly Ala Val Tyr Phe Leu1
55147PRTArtificial SequenceSynthetic peptide 514Leu Gly Leu Arg Ala Phe
Val1 55157PRTArtificial SequenceSynthetic peptide 515Thr
Glu Leu Val Ser Trp Ser1 55167PRTArtificial
SequenceSynthetic peptide 516Cys Gly Ala Arg Gly Ala Ala1
55177PRTArtificial SequenceSynthetic peptide 517Gly Gly Ser Arg Ala Ala
Glu1 55187PRTArtificial SequenceSynthetic peptide 518Val
Asn Leu Gly Gly Ser Trp1 55197PRTArtificial
SequenceSynthetic peptide 519Leu Ile Gly Pro Gly Gly Arg1
55207PRTArtificial SequenceSynthetic peptide 520Leu Gly Gly Leu Ser Pro
His1 55217PRTArtificial SequenceSynthetic peptide 521Trp
Ser Gly Gly Leu Asn Val1 55227PRTArtificial
SequenceSynthetic peptide 522Thr Ala Gly Ser Ser Arg Leu1
55237PRTArtificial SequenceSynthetic peptide 523Ser Asp Val Ser Gly Ser
Ser1 55247PRTArtificial SequenceSynthetic peptide 524Trp
Gly Ser Ser Thr Val Arg1 55257PRTArtificial
SequenceSynthetic peptide 525Asn Leu Ala Asp Gly Ser Val1
55267PRTArtificial SequenceSynthetic peptide 526Ser Ser Gly Ser Val Asp
Ser1 55277PRTArtificial SequenceSynthetic peptide 527Gly
Arg Val Pro Gly Phe Glu1 55287PRTArtificial
SequenceSynthetic peptide 528Gly Arg Val Val Gly Glu Ala1
55297PRTArtificial SequenceSynthetic peptide 529Ser Arg Phe Gly Pro Ser
Val1 55307PRTArtificial SequenceSynthetic peptide 530Ala
Arg Val Gly Val Ser Pro1 55317PRTArtificial
SequenceSynthetic peptide 531Pro Gly Lys Arg Gly Val Gln1
55327PRTArtificial SequenceSynthetic peptide 532Arg Gly Val Ala Ser Arg
Ser1 55337PRTArtificial SequenceSynthetic peptide 533Glu
Arg Gly Ser Pro Ser Arg1 55347PRTArtificial
SequenceSynthetic peptide 534Leu Ile Arg Ala Val Ser Ala1
55357PRTArtificial SequenceSynthetic peptide 535Arg Ala Val Glu Met Gly
Thr1 55367PRTArtificial SequenceSynthetic peptide 536Trp
Gly Ala Gly Phe Trp Met1 55377PRTArtificial
SequenceSynthetic peptide 537Leu Ile Arg Ala Val Ser Ala1
55387PRTArtificial SequenceSynthetic peptide 538Asp Arg Tyr Met Leu Arg
Ser1 55397PRTArtificial SequenceSynthetic peptide 539Pro
Arg Ser Ser Tyr Asn Glu1 55407PRTArtificial
SequenceSynthetic peptide 540Pro Arg Ser Ser Leu Val Val1
55417PRTArtificial SequenceSynthetic peptide 541Arg Arg Phe Trp Ala Gly
Leu1 55427PRTArtificial SequenceSynthetic peptide 542Pro
Val His Ser Ala Gly Gly1 55437PRTArtificial
SequenceSynthetic peptide 543Phe Gly Gly Ser Gly Val Leu1
55447PRTArtificial SequenceSynthetic peptide 544Ser Ser Gly Gly Val Leu
Gly1 55457PRTArtificial SequenceSynthetic peptide 545Gly
Leu Val Gly Gly Ser Ser1 55467PRTArtificial
SequenceSynthetic peptide 546Leu Ser Ser Gly Leu Val Ser1
55477PRTArtificial SequenceSynthetic peptide 547Leu Ser Ser Gly Leu Val
Ser1 55487PRTArtificial SequenceSynthetic peptide 548Trp
Phe Ser Trp Leu Val Ser1 55497PRTArtificial
SequenceSynthetic peptide 549Gly Ala Ser Leu Thr Gly Asp1
55507PRTArtificial SequenceSynthetic peptide 550Trp Ser Ser Thr Ala Ser
Leu1 55517PRTArtificial SequenceSynthetic peptide 551Phe
Gly Gly Ser Gly Val Leu1 55527PRTArtificial
SequenceSynthetic peptide 552Gly Leu Val Gly Gly Ser Ser1
55537PRTArtificial SequenceSynthetic peptide 553Gly Gly Leu Ser Pro His
Arg1 55547PRTArtificial SequenceSynthetic peptide 554Gly
Leu Val Gly Gly Ser Ser1 55557PRTArtificial
SequenceSynthetic peptide 555Ser Val Leu Gly Ser Ser Leu1
55567PRTArtificial SequenceSynthetic peptide 556Phe Gly Gly Ser Gly Val
Leu1 55577PRTArtificial SequenceSynthetic peptide 557Asp
Val Arg Gly Arg Val Trp1 55587PRTArtificial
SequenceSynthetic peptide 558Ala Glu Pro Arg Gly Arg Val1
55597PRTArtificial SequenceSynthetic peptide 559Ser Ile Gly Pro Ser Thr
Asn1 55607PRTArtificial SequenceSynthetic peptide 560Gly
Val Ser Ile Arg Gln Leu1 55617PRTArtificial
SequenceSynthetic peptide 561Ala Val Ser Lys Arg Leu Pro1
55627PRTArtificial SequenceSynthetic peptide 562Arg Leu Ala Val Ser Gly
Tyr1 55637PRTArtificial SequenceSynthetic peptide 563Arg
Arg Glu Gly Leu Arg Ser1 55647PRTArtificial
SequenceSynthetic peptide 564Ser Arg Tyr Trp Leu Arg Ser1
55657PRTArtificial SequenceSynthetic peptide 565Ala Val Tyr Arg Ala Gly
Arg1 55667PRTArtificial SequenceSynthetic peptide 566Arg
His Phe Gly Leu Arg Glu1 55677PRTArtificial
SequenceSynthetic peptide 567Arg Arg Glu Gly Leu Arg Ser1
55687PRTArtificial SequenceSynthetic peptide 568Gly Gln Gly Ala Ala Ser
Leu1 55697PRTArtificial SequenceSynthetic peptide 569Gly
Gln Gly Ala Ala Ser Leu1 55707PRTArtificial
SequenceSynthetic peptide 570Tyr Gly Ser Val Ala Leu Arg1
55717PRTArtificial SequenceSynthetic peptide 571Ala Arg Arg Gly Val Leu
Gly1 55727PRTArtificial SequenceSynthetic peptide 572Leu
Arg Ile Ala Arg Gly Val1 55737PRTArtificial
SequenceSynthetic peptide 573Tyr Arg Gly Ser Met Val Gly1
55747PRTArtificial SequenceSynthetic peptide 574Gly Leu Arg Gly Ser Val
Trp1 55757PRTArtificial SequenceSynthetic peptide 575Gly
Pro Phe Arg Ala Val Pro1 55767PRTArtificial
SequenceSynthetic peptide 576Ala His Tyr Thr Leu Arg Ser1
55777PRTArtificial SequenceSynthetic peptide 577Ser Glu Leu Arg Ser Ile
Arg1 55787PRTArtificial SequenceSynthetic peptide 578Ser
Val Tyr Ala Leu Arg Ser1 55797PRTArtificial
SequenceSynthetic peptide 579Ala Arg Arg Gly Val Leu Gly1
55807PRTArtificial SequenceSynthetic peptide 580Pro Gly Ala Val Leu Thr
Val1 55817PRTArtificial SequenceSynthetic peptide 581Gly
Leu Val Gly Arg Arg Ala1 55827PRTArtificial
SequenceSynthetic peptide 582Gly Leu Val Arg Cys Val Leu1
55837PRTArtificial SequenceSynthetic peptide 583Tyr Asp Gly Leu Val Ser
Gly1 55847PRTArtificial SequenceSynthetic peptide 584Gly
Leu Val Thr Ala Pro Leu1 55857PRTArtificial
SequenceSynthetic peptide 585Arg Gly Leu Val Arg Val Val1
55867PRTArtificial SequenceSynthetic peptide 586Gly Leu Arg Gly Ser Val
Trp1 55877PRTArtificial SequenceSynthetic peptide 587Asn
Ser Phe Gly Leu Arg Tyr1 55887PRTArtificial
SequenceSynthetic peptide 588Tyr Asp Gly Leu Val Ser Gly1
55897PRTArtificial SequenceSynthetic peptide 589Ala Ala Arg Gly Leu Glu
Ala1 55907PRTArtificial SequenceSynthetic peptide 590Asp
Asn Asp Gly Ala Arg Gly1 55917PRTArtificial
SequenceSynthetic peptide 591Leu Arg Ile Ala Arg Gly Val1
55927PRTArtificial SequenceSynthetic peptide 592Met Ser Asn Leu Ala Ala
Val1 55937PRTArtificial SequenceSynthetic peptide 593Tyr
Ser Gly Ser Ser Asp Phe1 55947PRTArtificial
SequenceSynthetic peptide 594Gly Ser Val Leu Gly Asp Tyr1
55957PRTArtificial SequenceSynthetic peptide 595Gly Leu Arg Gly Ser Val
Trp1 55967PRTArtificial SequenceSynthetic peptide 596Asp
Leu Asp Gly Arg Val Val1 55977PRTArtificial
SequenceSynthetic peptide 597Trp Val Ser Gly Arg Leu Gly1
55987PRTArtificial SequenceSynthetic peptide 598Gly Pro Ser Ser Met Thr
Phe1 55997PRTArtificial SequenceSynthetic peptide 599Asp
Gly Val Ser Ser Asp Tyr1 56007PRTArtificial
SequenceSynthetic peptide 600Phe Thr Ser Gly Val Ser Trp1
56017PRTArtificial SequenceSynthetic peptide 601Val Leu Thr Arg Ala Ser
Thr1 56027PRTArtificial SequenceSynthetic peptide 602Leu
Arg Ala Ser Leu Leu Trp1 56037PRTArtificial
SequenceSynthetic peptide 603Trp Leu Leu Ser Ala Arg Leu1
56047PRTArtificial SequenceSynthetic peptide 604Leu Leu Arg Pro Gly Thr
Val1 56057PRTArtificial SequenceSynthetic peptide 605Ala
Ala Gly Gly Leu Leu Val1 56067PRTArtificial
SequenceSynthetic peptide 606Leu Arg Ala Ser Leu Leu Trp1
56077PRTArtificial SequenceSynthetic peptide 607Leu Trp Gly Leu Gly Trp
Leu1 56087PRTArtificial SequenceSynthetic peptide 608Arg
Arg Ser Gly Leu Gly Asp1 56097PRTArtificial
SequenceSynthetic peptide 609Trp Trp Gly Leu Gly Trp Leu1
56107PRTArtificial SequenceSynthetic peptide 610Ala Ala Gly Gly Leu Leu
Val1 56117PRTArtificial SequenceSynthetic peptide 611Gly
Leu Arg Gly Val Val Lys1 56127PRTArtificial
SequenceSynthetic peptide 612Ala Val Glu Gly Arg Gly Ser1
56137PRTArtificial SequenceSynthetic peptide 613Asn Ala Val Arg Gly Ser
Ala1 56147PRTArtificial SequenceSynthetic peptide 614Leu
Leu Arg Ser Ser Leu Gly1 56157PRTArtificial
SequenceSynthetic peptide 615Met Tyr Leu Arg Leu Leu Arg1
56167PRTArtificial SequenceSynthetic peptide 616Leu Leu Arg Ser Ser Leu
Gly1 56177PRTArtificial SequenceSynthetic peptide 617Asp
Glu Gly Leu Arg Ser Arg1 56187PRTArtificial
SequenceSynthetic peptide 618Tyr Trp Gln His Arg Val Ser1
56197PRTArtificial SequenceSynthetic peptide 619Ala Arg Ser Ser His Arg
Ala1 56207PRTArtificial SequenceSynthetic peptide 620Leu
Leu Arg Ser Ser Leu Gly1 56217PRTArtificial
SequenceSynthetic peptide 621Ala Gly Arg Ser Cys Asn Leu1
56227PRTArtificial SequenceSynthetic peptide 622Ala Gly Arg Pro Arg Ala
Thr1 56237PRTArtificial SequenceSynthetic peptide 623Gly
Gly Val Arg Ile Ala Ala1 56247PRTArtificial
SequenceSynthetic peptide 624Gly Val Arg Tyr Leu Arg Thr1
56257PRTArtificial SequenceSynthetic peptide 625Pro Leu Ala Val Gly Leu
Val1 56267PRTArtificial SequenceSynthetic peptide 626Gly
Leu Arg Gly Val Val Lys1 56277PRTArtificial
SequenceSynthetic peptide 627Asp Glu Gly Leu Arg Ser Arg1
56287PRTArtificial SequenceSynthetic peptide 628Gln Leu Val Ser Gly Ser
Leu1 56297PRTArtificial SequenceSynthetic peptide 629Gly
Trp Ser Ala Ser Leu Gly1 56307PRTArtificial
SequenceSynthetic peptide 630Ile Ala Ala Val Trp Arg Ser1
56317PRTArtificial SequenceSynthetic peptide 631Gly Gly Ser Ser Leu Asp
Ala1 56327PRTArtificial SequenceSynthetic peptide 632Leu
Gly Gly Ser Arg Asp Leu1 56337PRTArtificial
SequenceSynthetic peptide 633Leu Ile Gly Gly Arg Asn Ala1
56347PRTArtificial SequenceSynthetic peptide 634Leu Asp Arg Ser Gly Gly
Leu1 56357PRTArtificial SequenceSynthetic peptide 635Gly
Gly Ser Ser Leu Asp Ala1 56367PRTArtificial
SequenceSynthetic peptide 636Gly Ser Ser Tyr Ser Gly Pro1
56377PRTArtificial SequenceSynthetic peptide 637Thr Val Gly Ser Gly Cys
Leu1 56387PRTArtificial SequenceSynthetic peptide 638Leu
Ser Gly Ser Val Leu Gln1 56397PRTArtificial
SequenceSynthetic peptide 639Ala Ser Gly Arg Val Ala Asn1
56407PRTArtificial SequenceSynthetic peptide 640Lys Val Val Gly Arg Leu
Gly1 56417PRTArtificial SequenceSynthetic peptide 641Gly
Arg Leu Val Trp Gly Leu1 56427PRTArtificial
SequenceSynthetic peptide 642Asn Glu Phe Leu Gly Arg Leu1
56437PRTArtificial SequenceSynthetic peptide 643Leu Cys Asp Ala Gly Pro
Ser1 56447PRTArtificial SequenceSynthetic peptide 644Phe
Arg Ala Gly Val Ser His1 56457PRTArtificial
SequenceSynthetic peptide 645Ala Gly Asp Ser Arg Leu Ser1
56467PRTArtificial SequenceSynthetic peptide 646Asp Trp Arg Arg Arg Ala
Val1 56477PRTArtificial SequenceSynthetic peptide 647Trp
Thr Glu Arg Ala Ser Ala1 56487PRTArtificial
SequenceSynthetic peptide 648Arg Leu Leu Ser Ala Phe Gly1
56497PRTArtificial SequenceSynthetic peptide 649Gly Phe Ala Ser Leu Leu
Arg1 56507PRTArtificial SequenceSynthetic peptide 650Gly
Ala Leu Arg Val Pro Trp1 56517PRTArtificial
SequenceSynthetic peptide 651Ser Leu Arg Ser Asp Gly Ala1
56527PRTArtificial SequenceSynthetic peptide 652Asp Thr Leu Arg Ser Gln
Trp1 56537PRTArtificial SequenceSynthetic peptide 653Leu
Arg Ser Val Gly Ser Trp1 56547PRTArtificial
SequenceSynthetic peptide 654Ile Ser Pro Arg Ser Ser Gly1
56557PRTArtificial SequenceSynthetic peptide 655Trp Arg Val Arg Ser Ser
Gly1 56567PRTArtificial SequenceSynthetic peptide 656Ala
Ala Gly Arg Ile Arg Pro1 56577PRTArtificial
SequenceSynthetic peptide 657Arg Ala Ala Gly Arg Val Gly1
56587PRTArtificial SequenceSynthetic peptide 658Ala Gly Leu Gln His Ala
Val1 56597PRTArtificial SequenceSynthetic peptide 659Ala
Gly Gly Trp Trp Val Gly1 56607PRTArtificial
SequenceSynthetic peptide 660Gly Val Arg Gly Ala Ala Arg1
56617PRTArtificial SequenceSynthetic peptide 661Gly Val Leu Pro Val Val
Thr1 56627PRTArtificial SequenceSynthetic peptide 662Gly
Leu Val Ser Ser Leu Pro1 56637PRTArtificial
SequenceSynthetic peptide 663Ser Arg His Gly Leu Val Arg1
56647PRTArtificial SequenceSynthetic peptide 664Ser Asp Arg Gly Leu Val
Val1 56657PRTArtificial SequenceSynthetic peptide 665Ser
Asp Arg Gly Leu Val Val1 56667PRTArtificial
SequenceSynthetic peptide 666Gly Leu Val Ser Ser Leu Pro1
56677PRTArtificial SequenceSynthetic peptide 667Leu Val Ser Val Trp Ser
Arg1 56687PRTArtificial SequenceSynthetic peptide 668Gly
Ser Trp Ala Arg Gly Tyr1 56697PRTArtificial
SequenceSynthetic peptide 669Gly Phe Ala Ser Leu Leu Arg1
56707PRTArtificial SequenceSynthetic peptide 670His Ala Ala Val Met Ser
Leu1 56717PRTArtificial SequenceSynthetic peptide 671Asp
Gly Gly Arg Arg Thr Asp1 56727PRTArtificial
SequenceSynthetic peptide 672Gly Arg Pro Leu Gly Gly Arg1
56737PRTArtificial SequenceSynthetic peptide 673Gly Arg Val Thr Gly Gly
Arg1 56747PRTArtificial SequenceSynthetic peptide 674Arg
Gly Gly Leu Pro Arg Gly1 56757PRTArtificial
SequenceSynthetic peptide 675Tyr Gly Gln Tyr Gly Gly Leu1
56767PRTArtificial SequenceSynthetic peptide 676Gly Ser Ser Arg Pro Ser
Ile1 56777PRTArtificial SequenceSynthetic peptide 677Pro
Gly Ser Ser Phe Val Gly1 56787PRTArtificial
SequenceSynthetic peptide 678Gly Ser Ser Arg Val Arg Trp1
56797PRTArtificial SequenceSynthetic peptide 679Arg Ala Ala Gly Arg Val
Gly1 56807PRTArtificial SequenceSynthetic peptide 680Gly
Arg Val Thr Gly Gly Arg1 56817PRTArtificial
SequenceSynthetic peptide 681Tyr Val Arg Ile Gly Arg Val1
56827PRTArtificial SequenceSynthetic peptide 682Met Ile Thr Arg Gly Arg
Leu1 56837PRTArtificial SequenceSynthetic peptide 683Ser
Val Val Gly Val Ser Thr1 56847PRTArtificial
SequenceSynthetic peptide 684Trp Ser Gly Val Ser Arg Leu1
56857PRTArtificial SequenceSynthetic peptide 685Arg Arg Leu Ser Tyr Phe
His1 56867PRTArtificial SequenceSynthetic peptide 686Pro
Arg Leu Ser Trp Val Leu1 56877PRTArtificial
SequenceSynthetic peptide 687Arg Leu Ser Ala Leu Thr Asp1
56887PRTArtificial SequenceSynthetic peptide 688Gly Arg Gly Val Gly Thr
Asp1 56897PRTArtificial SequenceSynthetic peptide 689Leu
Lys Val Arg Gly Val Leu1 56907PRTArtificial
SequenceSynthetic peptide 690Ser Ser Thr Arg Gly Val Tyr1
56917PRTArtificial SequenceSynthetic peptide 691Gln Val Arg Arg Gly Val
Val1 56927PRTArtificial SequenceSynthetic peptide 692Gly
Arg Gly Val Thr Ile Trp1 56937PRTArtificial
SequenceSynthetic peptide 693Arg Gly Ser Val Ala Ser Ala1
56947PRTArtificial SequenceSynthetic peptide 694His Phe Ile Arg Gly Ser
Val1 56957PRTArtificial SequenceSynthetic peptide 695Arg
Gly Ser Trp Ala Gly Val1 56967PRTArtificial
SequenceSynthetic peptide 696Val Arg Gly Ser Arg Trp Arg1
56977PRTArtificial SequenceSynthetic peptide 697Leu Glu Arg Ala Val Arg
Thr1 56987PRTArtificial SequenceSynthetic peptide 698Gly
Tyr Ser Arg Ala Ser Asp1 56997PRTArtificial
SequenceSynthetic peptide 699Ser Arg Ala Ser Gly His Gly1
57007PRTArtificial SequenceSynthetic peptide 700Gly His Tyr Arg Ala Ser
Val1 57017PRTArtificial SequenceSynthetic peptide 701Asp
Trp Val Cys Arg Ala Ser1 57027PRTArtificial
SequenceSynthetic peptide 702Gly Ala Gly Arg Gly Thr Pro1
57037PRTArtificial SequenceSynthetic peptide 703Leu Ser Leu Ala Gly Ala
Gly1 57047PRTArtificial SequenceSynthetic peptide 704Ala
Ser Ala Val Ser Gly Arg1 57057PRTArtificial
SequenceSynthetic peptide 705Phe Ser Gly Asp Ala Val Ser1
57067PRTArtificial SequenceSynthetic peptide 706Leu Lys Leu Leu Ser Val
Pro1 57077PRTArtificial SequenceSynthetic peptide 707Gly
Thr Leu Arg Val Gly Ser1 57087PRTArtificial
SequenceSynthetic peptide 708Glu His Tyr Arg Leu Arg Ser1
57097PRTArtificial SequenceSynthetic peptide 709Leu Arg Ser Trp Leu Leu
Phe1 57107PRTArtificial SequenceSynthetic peptide 710Arg
Arg Pro Gly Leu Arg Ser1 57117PRTArtificial
SequenceSynthetic peptide 711Ser Lys Tyr Asn Leu Arg Ser1
57127PRTArtificial SequenceSynthetic peptide 712Trp Gln Val Ala Leu Arg
Ser1 57137PRTArtificial SequenceSynthetic peptide 713Leu
Arg Ser Asp Pro Arg Ser1 57147PRTArtificial
SequenceSynthetic peptide 714Val Pro Leu Arg Ser Ser Ala1
57157PRTArtificial SequenceSynthetic peptide 715Gly Arg Ser Ser Gly Met
Glu1 57167PRTArtificial SequenceSynthetic peptide 716Val
Pro Leu Arg Ser Ser Ala1 57177PRTArtificial
SequenceSynthetic peptide 717Ala Gly Ser Gly Phe Pro Phe1
57187PRTArtificial SequenceSynthetic peptide 718Gly Ala Gly Arg Gly Thr
Pro1 57197PRTArtificial SequenceSynthetic peptide 719Ala
Gly Arg Ile Ala Ser Lys1 57207PRTArtificial
SequenceSynthetic peptide 720Trp Gly Val Ala Gly Leu Gly1
57217PRTArtificial SequenceSynthetic peptide 721Leu Ala Gly Leu Val Ser
Gly1 57227PRTArtificial SequenceSynthetic peptide 722Asp
Ala Gly Gly Met Asp Leu1 57237PRTArtificial
SequenceSynthetic peptide 723Ala Gly Gly Arg Trp Asn Leu1
57247PRTArtificial SequenceSynthetic peptide 724Gly Cys Gly Gly Val Arg
Asp1 57257PRTArtificial SequenceSynthetic peptide 725Ser
Gly Val Arg Leu Thr Gly1 57267PRTArtificial
SequenceSynthetic peptide 726Leu Lys Val Arg Gly Val Leu1
57277PRTArtificial SequenceSynthetic peptide 727Gly Leu Gly Ala Val Gly
Trp1 57287PRTArtificial SequenceSynthetic peptide 728Pro
Gly Ala Val Pro Gly Ala1 57297PRTArtificial
SequenceSynthetic peptide 729Arg Ile Gly Ala Val Trp Tyr1
57307PRTArtificial SequenceSynthetic peptide 730Phe Ser Gly Leu Val Val
Ala1 57317PRTArtificial SequenceSynthetic peptide 731Pro
Gly Gly Leu Val Pro Gly1 57327PRTArtificial
SequenceSynthetic peptide 732Leu Ala Gly Leu Val Ser Gly1
57337PRTArtificial SequenceSynthetic peptide 733Leu Gly Leu Val Ser Thr
Thr1 57347PRTArtificial SequenceSynthetic peptide 734Gly
Leu Arg Leu Gly Val Thr1 57357PRTArtificial
SequenceSynthetic peptide 735Arg Arg Pro Gly Leu Arg Ser1
57367PRTArtificial SequenceSynthetic peptide 736Leu Ala Gly Leu Val Ser
Gly1 57377PRTArtificial SequenceSynthetic peptide 737Leu
Gly Leu Val Ser Thr Thr1 57387PRTArtificial
SequenceSynthetic peptide 738Arg Gln Leu Val Ser Pro Ala1
57397PRTArtificial SequenceSynthetic peptide 739Leu Arg Ala Arg Gly Gly
His1 57407PRTArtificial SequenceSynthetic peptide 740Glu
Leu Trp Ala Ser Leu Gly1 57417PRTArtificial
SequenceSynthetic peptide 741Asp Thr Leu Ala Ser Leu Arg1
57427PRTArtificial SequenceSynthetic peptide 742Val Val Ala Ser Leu Pro
His1 57437PRTArtificial SequenceSynthetic peptide 743Val
Leu Arg Ala Ala Ser Arg1 57447PRTArtificial
SequenceSynthetic peptide 744Ala Ala Ser Gly Ser Tyr Tyr1
57457PRTArtificial SequenceSynthetic peptide 745Gly Gly Ser Ala Leu Phe
Gly1 57467PRTArtificial SequenceSynthetic peptide 746Gly
Arg Gly Gly Ser Gly Tyr1 57477PRTArtificial
SequenceSynthetic peptide 747Tyr Gly Ser Gly Gly Arg Gly1
57487PRTArtificial SequenceSynthetic peptide 748Gly Thr Leu Gly Gly Arg
Val1 57497PRTArtificial SequenceSynthetic peptide 749Ala
Gly Gly Arg Trp Asn Leu1 57507PRTArtificial
SequenceSynthetic peptide 750His Gly Gly Arg Ala Arg Leu1
57517PRTArtificial SequenceSynthetic peptide 751Arg Gly Gly Arg Ser Pro
Ser1 57527PRTArtificial SequenceSynthetic peptide 752Arg
Lys Pro Gly Gly Gly Arg1 57537PRTArtificial
SequenceSynthetic peptide 753Glu Gly Gly Arg Thr His Trp1
57547PRTArtificial SequenceSynthetic peptide 754Gly Glu Val Gly Leu Gly
Val1 57557PRTArtificial SequenceSynthetic peptide 755Gly
Leu Gly Ala Val Gly Trp1 57567PRTArtificial
SequenceSynthetic peptide 756Pro Gly Gly Leu Val Pro Gly1
57577PRTArtificial SequenceSynthetic peptide 757Val Arg Gly Gly Leu Thr
Gly1 57587PRTArtificial SequenceSynthetic peptide 758Arg
Gln Lys Cys Gly Gly Leu1 57597PRTArtificial
SequenceSynthetic peptide 759Arg Tyr Gly Val Gly Gly Leu1
57607PRTArtificial SequenceSynthetic peptide 760Glu Met Gly Ser Ser Arg
Gly1 57617PRTArtificial SequenceSynthetic peptide 761Ala
Gly Ser Gly Phe Pro Phe1 57627PRTArtificial
SequenceSynthetic peptide 762Gly Arg Gly Gly Ser Gly Tyr1
57637PRTArtificial SequenceSynthetic peptide 763Gly Ser Val Ser Ala Gly
Ala1 57647PRTArtificial SequenceSynthetic peptide 764Arg
Gly Ser Val Ala Ser Ala1 57657PRTArtificial
SequenceSynthetic peptide 765Asp Leu Gly Ser Val Gln His1
57667PRTArtificial SequenceSynthetic peptide 766His Phe Ile Arg Gly Ser
Val1 57677PRTArtificial SequenceSynthetic peptide 767Gly
Ser Val Leu Gly Ala Leu1 57687PRTArtificial
SequenceSynthetic peptide 768Gly Thr Leu Gly Gly Arg Val1
57697PRTArtificial SequenceSynthetic peptide 769Leu Gly Arg Val His Val
Trp1 57707PRTArtificial SequenceSynthetic peptide 770Leu
Val Gly Arg Val Lys Leu1 57717PRTArtificial
SequenceSynthetic peptide 771Arg Trp Arg Ser Gly Arg Val1
57727PRTArtificial SequenceSynthetic peptide 772Arg Asn Pro Gly Arg Leu
Ala1 57737PRTArtificial SequenceSynthetic peptide 773Pro
Arg Gly Arg Leu Phe Asp1 57747PRTArtificial
SequenceSynthetic peptide 774Gly Arg Leu Ala Val Val Ala1
57757PRTArtificial SequenceSynthetic peptide 775Leu Ala Gln Gly Arg Leu
Ala1 57767PRTArtificial SequenceSynthetic peptide 776Gly
Gly Met Asn Gly Arg Leu1 57777PRTArtificial
SequenceSynthetic peptide 777Arg Ser Thr Leu Gly Pro Ser1
57787PRTArtificial SequenceSynthetic peptide 778Gly Val Ser Ala Leu Ser
Leu1 57797PRTArtificial SequenceSynthetic peptide 779Ser
Arg Leu Ser Tyr Tyr Ala1 57807PRTArtificial
SequenceSynthetic peptide 780Ala Arg Gly Val Ser Ala Pro1
57817PRTArtificial SequenceSynthetic peptide 781Gly Arg Gly Val Leu Ala
Phe1 57827PRTArtificial SequenceSynthetic peptide 782Met
Arg Gly Ser Gly Arg Asn1 57837PRTArtificial
SequenceSynthetic peptide 783Arg Asp Gly Arg Ala Val Arg1
57847PRTArtificial SequenceSynthetic peptide 784Gly Arg Ala Val Trp Met
Val1 57857PRTArtificial SequenceSynthetic peptide 785Leu
Arg Val Pro Gly Gly Pro1 57867PRTArtificial
SequenceSynthetic peptide 786Ala Tyr Tyr Ser Leu Arg Ser1
57877PRTArtificial SequenceSynthetic peptide 787Val Leu Arg Ser Ala Leu
Gln1 57887PRTArtificial SequenceSynthetic peptide 788Val
Tyr Tyr Ala Leu Arg Ser1 57897PRTArtificial
SequenceSynthetic peptide 789Arg Tyr Arg Val Ser Val Tyr1
57907PRTArtificial SequenceSynthetic peptide 790Ala Gly Gly Ile Trp Ile
Arg1 57917PRTArtificial SequenceSynthetic peptide 791Trp
Gln Val Ser Gly Val Arg1 57927PRTArtificial
SequenceSynthetic peptide 792Gly Arg Gly Val Leu Ala Phe1
57937PRTArtificial SequenceSynthetic peptide 793His Ala Glu Leu Val Ser
Leu1 57947PRTArtificial SequenceSynthetic peptide 794Ala
Arg Gly Val Ser Ala Pro1 57957PRTArtificial
SequenceSynthetic peptide 795Arg Val Ala Arg Gly Asp Arg1
57967PRTArtificial SequenceSynthetic peptide 796Val Met Trp Val Ala Arg
Gly1 57977PRTArtificial SequenceSynthetic peptide 797Ala
Ala Val Thr Val Val Arg1 57987PRTArtificial
SequenceSynthetic peptide 798Thr Arg Glu Gly Gly Leu Asp1
57997PRTArtificial SequenceSynthetic peptide 799Leu Gly Gly Gly Gly Leu
Leu1 58007PRTArtificial SequenceSynthetic peptide 800Gly
Ser Gly His Ser Phe Ala1 58017PRTArtificial
SequenceSynthetic peptide 801Met Arg Gly Ser Gly Arg Asn1
58027PRTArtificial SequenceSynthetic peptide 802Arg Val Gly Ser Val Gln
Trp1 58037PRTArtificial SequenceSynthetic peptide 803Glu
Gly Thr Ser Gly Ser Val1 58047PRTArtificial
SequenceSynthetic peptide 804Gly Arg Val Pro Thr Val Val1
58057PRTArtificial SequenceSynthetic peptide 805Ala Asp Gly Arg Leu Arg
Tyr1 58067PRTArtificial SequenceSynthetic peptide 806Ala
Arg Gly Val Ser Ala Pro1 58077PRTArtificial
SequenceSynthetic peptide 807Arg Gly Val Lys Leu Gly Asp1
58087PRTArtificial SequenceSynthetic peptide 808Leu Arg Gly Ser Tyr Val
Leu1 58097PRTArtificial SequenceSynthetic peptide 809Arg
Arg Gly Ser Leu Met Phe1 58107PRTArtificial
SequenceSynthetic peptide 810Arg Gly Ser Val Gly Pro Ser1
58117PRTArtificial SequenceSynthetic peptide 811Ser Arg Ala Ser Asp Val
Thr1 58127PRTArtificial SequenceSynthetic peptide 812Ala
Ala Lys Thr Leu Leu Ser1 58137PRTArtificial
SequenceSynthetic peptide 813Arg Ser Tyr Pro Leu Arg Ser1
58147PRTArtificial SequenceSynthetic peptide 814Tyr Leu Gly Arg Arg Val
Ser1 58157PRTArtificial SequenceSynthetic peptide 815Arg
Ser Ser Pro Val Trp Thr1 58167PRTArtificial
SequenceSynthetic peptide 816Asp Leu Arg Arg Ala Gly Ser1
58177PRTArtificial SequenceSynthetic peptide 817Gly Val Ala Gly Leu Arg
Trp1 58187PRTArtificial SequenceSynthetic peptide 818Arg
Ile Asp Ala Gly Gly Gly1 58197PRTArtificial
SequenceSynthetic peptide 819Gly Val Ala Gly Gly Ala Thr1
58207PRTArtificial SequenceSynthetic peptide 820Thr Ala Gly Gly Ala Val
Gly1 58217PRTArtificial SequenceSynthetic peptide 821Trp
Arg Leu Gly Ala Val Gly1 58227PRTArtificial
SequenceSynthetic peptide 822Ser Gly Leu Val Ala Met Val1
58237PRTArtificial SequenceSynthetic peptide 823Val Gly Leu Arg Asp Trp
Gly1 58247PRTArtificial SequenceSynthetic peptide 824Gly
Val Ala Gly Leu Arg Trp1 58257PRTArtificial
SequenceSynthetic peptide 825Ala Arg Gly Ile Val Arg Val1
58267PRTArtificial SequenceSynthetic peptide 826Ala Ser Leu His His Arg
Arg1 58277PRTArtificial SequenceSynthetic peptide 827Gly
Ala Ala Ala Ser Gly Tyr1 58287PRTArtificial
SequenceSynthetic peptide 828Leu Ala Ile Arg Gly Leu Gly1
58297PRTArtificial SequenceSynthetic peptide 829Gly Gly Leu Ser Asn Val
Val1 58307PRTArtificial SequenceSynthetic peptide 830Pro
Pro Gly Gly Leu Lys Trp1 58317PRTArtificial
SequenceSynthetic peptide 831Glu Gly Ser Val Asp Ala His1
58327PRTArtificial SequenceSynthetic peptide 832Arg Gly Ser Val Gly Pro
Ser1 58337PRTArtificial SequenceSynthetic peptide 833Leu
Val Tyr Ser Gly Arg Leu1 58347PRTArtificial
SequenceSynthetic peptide 834Val Glu Glu Gly Arg Leu Arg1
58357PRTArtificial SequenceSynthetic peptide 835Arg Gly Ser Val Gly Pro
Ser1 58367PRTArtificial SequenceSynthetic peptide 836Ser
Pro Gly Val Ser Gly Arg1 58377PRTArtificial
SequenceSynthetic peptide 837Arg Val Gly Arg Gly Val Leu1
58387PRTArtificial SequenceSynthetic peptide 838Trp Ile Trp Arg Ala Val
Ser1 58397PRTArtificial SequenceSynthetic peptide 839Val
Thr Asp Gly Ala Gly Gln1 58407PRTArtificial
SequenceSynthetic peptide 840Leu Gly Thr Ala Val Ser Ser1
58417PRTArtificial SequenceSynthetic peptide 841Trp Ile Trp Arg Ala Val
Ser1 58427PRTArtificial SequenceSynthetic peptide 842Asp
Thr Pro Ser Ala Val Ser1 58437PRTArtificial
SequenceSynthetic peptide 843Gly Leu Leu Ser Ala Gly Ile1
58447PRTArtificial SequenceSynthetic peptide 844Tyr Leu Leu Arg Ala Leu
Gly1 58457PRTArtificial SequenceSynthetic peptide 845Leu
Arg Ser Gly Ser Leu Gly1 58467PRTArtificial
SequenceSynthetic peptide 846Pro Leu Arg Ser Val Trp Ser1
58477PRTArtificial SequenceSynthetic peptide 847Ala Arg Ser Ser Ile Val
Arg1 58487PRTArtificial SequenceSynthetic peptide 848Ala
Gly Gly Arg Leu Gly Leu1 58497PRTArtificial
SequenceSynthetic peptide 849Ala Gly Gly Trp Arg Gly Arg1
58507PRTArtificial SequenceSynthetic peptide 850Leu Val Gly Arg Gly Val
Arg1 58517PRTArtificial SequenceSynthetic peptide 851Asp
Val Val Gly Val Leu Lys1 58527PRTArtificial
SequenceSynthetic peptide 852Arg Val Gly Arg Gly Val Leu1
58537PRTArtificial SequenceSynthetic peptide 853Gly Ala Val Thr Gly Tyr
Pro1 58547PRTArtificial SequenceSynthetic peptide 854Trp
Gly Leu Val Arg His Ala1 58557PRTArtificial
SequenceSynthetic peptide 855Leu Gly Leu Arg Gly Gly Ala1
58567PRTArtificial SequenceSynthetic peptide 856Ile Gly Ala Ser Leu Leu
Gly1 58577PRTArtificial SequenceSynthetic peptide 857Ala
Ala Val Glu Thr Gly Val1 58587PRTArtificial
SequenceSynthetic peptide 858Gly Leu Gly Gly Gly Gly Ser1
58597PRTArtificial SequenceSynthetic peptide 859Glu Val Leu Trp Gly Gly
Arg1 58607PRTArtificial SequenceSynthetic peptide 860Ala
Gly Gly Arg Leu Gly Leu1 58617PRTArtificial
SequenceSynthetic peptide 861Gly Gly Arg Ser Lys Lys Val1
58627PRTArtificial SequenceSynthetic peptide 862Gly Leu Gly Gly Gly Gly
Ser1 58637PRTArtificial SequenceSynthetic peptide 863Ser
Gly Gly Gly Gly Leu Gly1 58647PRTArtificial
SequenceSynthetic peptide 864Gly Ala Tyr Gly Gly Leu Leu1
58657PRTArtificial SequenceSynthetic peptide 865Gly Gly Leu Ser Arg Ser
Asn1 58667PRTArtificial SequenceSynthetic peptide 866Phe
Gly Ser Ser Asn Arg Ser1 58677PRTArtificial
SequenceSynthetic peptide 867Gly Ser Val Ser Asp Arg Phe1
58687PRTArtificial SequenceSynthetic peptide 868Ala Gly Gly Arg Leu Gly
Leu1 58697PRTArtificial SequenceSynthetic peptide 869Trp
Phe Lys Gly Pro Ser Val1 58707PRTArtificial
SequenceSynthetic peptide 870Leu Ser Glu Arg Arg Gly Val1
58717PRTArtificial SequenceSynthetic peptide 871Ala Arg Gly Val Ala Glu
Tyr1 58727PRTArtificial SequenceSynthetic peptide 872Phe
Asp Arg Gly Ser Leu Thr1 58737PRTArtificial
SequenceSynthetic peptide 873Gly Arg Leu Arg Ala Ser Leu1
58747PRTArtificial SequenceSynthetic peptide 874Arg Asp Gly Arg Gly Ala
Gly1 58757PRTArtificial SequenceSynthetic peptide 875Gly
Ala Val Ser Val Leu Ala1 58767PRTArtificial
SequenceSynthetic peptide 876Thr Arg Gly Asp Ala Val Ser1
58777PRTArtificial SequenceSynthetic peptide 877Leu Leu Ser Pro Arg Gly
Thr1 58787PRTArtificial SequenceSynthetic peptide 878Leu
Leu Arg Ser His Gly Val1 58797PRTArtificial
SequenceSynthetic peptide 879Pro Leu Arg Val Leu Lys Arg1
58807PRTArtificial SequenceSynthetic peptide 880Gly Arg Leu Arg Leu Arg
Val1 58817PRTArtificial SequenceSynthetic peptide 881Leu
Leu Arg Ser His Gly Val1 58827PRTArtificial
SequenceSynthetic peptide 882Val Leu Arg Ser Gly Glu Leu1
58837PRTArtificial SequenceSynthetic peptide 883Val Leu Arg Ser Ile Pro
Ser1 58847PRTArtificial SequenceSynthetic peptide 884Gly
Ser Met His Arg Val Ser1 58857PRTArtificial
SequenceSynthetic peptide 885Tyr Ser Ile Met Arg Val Ser1
58867PRTArtificial SequenceSynthetic peptide 886Arg Ala Gly Ser Arg Val
Gln1 58877PRTArtificial SequenceSynthetic peptide 887Arg
Arg Asp Ala Gly Arg Met1 58887PRTArtificial
SequenceSynthetic peptide 888Gly Ala Gly Arg Gly Asp Arg1
58897PRTArtificial SequenceSynthetic peptide 889Arg Trp Ala Gly Leu Val
Ala1 58907PRTArtificial SequenceSynthetic peptide 890Gln
Thr Leu Ser Ala Gly Gly1 58917PRTArtificial
SequenceSynthetic peptide 891Leu Ala Gly Gly Trp Gly Ser1
58927PRTArtificial SequenceSynthetic peptide 892Arg His Gly Val Arg Ser
Lys1 58937PRTArtificial SequenceSynthetic peptide 893Gly
Ala Val Ser Val Leu Ala1 58947PRTArtificial
SequenceSynthetic peptide 894Arg Trp Ala Gly Leu Val Ala1
58957PRTArtificial SequenceSynthetic peptide 895Gly Arg Gly Leu Arg Thr
Asp1 58967PRTArtificial SequenceSynthetic peptide 896Thr
Leu Gly Gly Leu Arg Thr1 58977PRTArtificial
SequenceSynthetic peptide 897Ala Leu Val Ser Val Ala Gly1
58987PRTArtificial SequenceSynthetic peptide 898Ala Arg Gly Val Ala Glu
Tyr1 58997PRTArtificial SequenceSynthetic peptide 899Gly
Gly Ala Ser Leu Thr Gln1 59007PRTArtificial
SequenceSynthetic peptide 900Gly Arg Leu Arg Ala Ser Leu1
59017PRTArtificial SequenceSynthetic peptide 901Ser Asn His Thr Ala Ser
Leu1 59027PRTArtificial SequenceSynthetic peptide 902Tyr
Ala Asp Gly Ala Ala Val1 59037PRTArtificial
SequenceSynthetic peptide 903Leu Gly Gly Leu Gly Ile His1
59047PRTArtificial SequenceSynthetic peptide 904Gly Gly Phe Thr Gly Gly
Leu1 59057PRTArtificial SequenceSynthetic peptide 905His
Ile Gly Leu Gly Gly Leu1 59067PRTArtificial
SequenceSynthetic peptide 906Thr Arg Leu Gly Gly Leu Thr1
59077PRTArtificial SequenceSynthetic peptide 907Val Met Pro Gly Ser Val
Val1 59087PRTArtificial SequenceSynthetic peptide 908Gly
Arg Leu Arg Ala Ser Leu1 59097PRTArtificial
SequenceSynthetic peptide 909Gly Arg Leu Tyr Leu Gly Ile1
59107PRTArtificial SequenceSynthetic peptide 910Gly Arg Leu Arg Leu Arg
Val1 59117PRTArtificial SequenceSynthetic peptide 911Ser
His Cys Gly Pro Ser Asn1 59127PRTArtificial
SequenceSynthetic peptide 912Val Arg Leu Ser Gly Arg Ala1
59137PRTArtificial SequenceSynthetic peptide 913Arg Leu Ser Thr Phe Ala
Gly1 59147PRTArtificial SequenceSynthetic peptide 914Ala
Arg Gly Ser Leu Arg Val1 59157PRTArtificial
SequenceSynthetic peptide 915Phe Ser Pro Arg Gly Ser Val1
59167PRTArtificial SequenceSynthetic peptide 916Gly Gly Arg Leu Arg Ala
Val1 59177PRTArtificial SequenceSynthetic peptide 917Val
Leu Ser Ala Val Ser Ser1 59187PRTArtificial
SequenceSynthetic peptide 918Ala Arg Gly Ser Leu Arg Val1
59197PRTArtificial SequenceSynthetic peptide 919Leu Arg Ser Tyr Ala Trp
Ser1 59207PRTArtificial SequenceSynthetic peptide 920Lys
Gly Arg Val Ser Ala Gly1 59217PRTArtificial
SequenceSynthetic peptide 921Ala Gly Leu Thr Ile Gly Ile1
59227PRTArtificial SequenceSynthetic peptide 922Ala Trp Arg His Ala Gly
Gly1 59237PRTArtificial SequenceSynthetic peptide 923Trp
Ala Arg Ala Gly Gly Phe1 59247PRTArtificial
SequenceSynthetic peptide 924Met Gly Val Leu Thr Ala Glu1
59257PRTArtificial SequenceSynthetic peptide 925Phe Ala Gly Tyr Gly Val
Leu1 59267PRTArtificial SequenceSynthetic peptide 926Arg
Ile Phe His Gly Ala Val1 59277PRTArtificial
SequenceSynthetic peptide 927Glu Gly Leu Val Val Phe Glu1
59287PRTArtificial SequenceSynthetic peptide 928Arg Glu Val Pro Gly Leu
Arg1 59297PRTArtificial SequenceSynthetic peptide 929Leu
Val Ser Val Asn Gly Ala1 59307PRTArtificial
SequenceSynthetic peptide 930His Ser Leu Val Ser Gln Pro1
59317PRTArtificial SequenceSynthetic peptide 931Ala Arg Gly Ser Leu Arg
Val1 59327PRTArtificial SequenceSynthetic peptide 932Ser
Ser Val Ala Ser Leu Val1 59337PRTArtificial
SequenceSynthetic peptide 933Ala Ala Val Trp Gln Met Lys1
59347PRTArtificial SequenceSynthetic peptide 934Gln Arg Ala Ala Val Ile
Val1 59357PRTArtificial SequenceSynthetic peptide 935Pro
Gly Gly Ser Asp Ala Ala1 59367PRTArtificial
SequenceSynthetic peptide 936Gly Gly Arg Leu Arg Ala Val1
59377PRTArtificial SequenceSynthetic peptide 937Leu Pro Cys Gly Gly Leu
Ala1 59387PRTArtificial SequenceSynthetic peptide 938Gly
Ser Ser His Asp Ala Leu1 59397PRTArtificial
SequenceSynthetic peptide 939Thr Gln Tyr Tyr Gly Ser Ser1
59407PRTArtificial SequenceSynthetic peptide 940Phe Ser Pro Arg Gly Ser
Val1 59417PRTArtificial SequenceSynthetic peptide 941Lys
Gly Arg Val Ser Ala Gly1 59427PRTArtificial
SequenceSynthetic peptide 942Gln Gly Arg Val Asn Val Lys1
59437PRTArtificial SequenceSynthetic peptide 943Gly Gly Arg Leu Arg Ala
Val1 59447PRTArtificial SequenceSynthetic peptide 944Tyr
Asp Gly Arg Leu Ala Arg1 59457PRTArtificial
SequenceSynthetic peptide 945Pro Gln Gly Arg Gly Val Lys1
59467PRTArtificial SequenceSynthetic peptide 946Met Val Leu Arg Gly Ser
Tyr1 59477PRTArtificial SequenceSynthetic peptide 947Gly
Gly Trp Ala Arg Ala Val1 59487PRTArtificial
SequenceSynthetic peptide 948Val Arg Ala Val Cys Leu Met1
59497PRTArtificial SequenceSynthetic peptide 949Thr Arg Ala Ser Arg Arg
Gly1 59507PRTArtificial SequenceSynthetic peptide 950Leu
Gly Ala Gly Glu Gly Asp1 59517PRTArtificial
SequenceSynthetic peptide 951Ile Gly Ala Val Ser Gly Trp1
59527PRTArtificial SequenceSynthetic peptide 952Leu Leu Ser Arg Arg Val
Gly1 59537PRTArtificial SequenceSynthetic peptide 953Leu
Glu Leu Leu Ser Val Val1 59547PRTArtificial
SequenceSynthetic peptide 954Arg Leu Leu Ser Glu Gly Tyr1
59557PRTArtificial SequenceSynthetic peptide 955Gln Leu Pro Gly Leu Leu
Arg1 59567PRTArtificial SequenceSynthetic peptide 956Tyr
Gly Glu Ser Leu Leu Arg1 59577PRTArtificial
SequenceSynthetic peptide 957Leu Arg Val Tyr Gly Glu Gly1
59587PRTArtificial SequenceSynthetic peptide 958Tyr Arg Val Ser Ser Gly
Ser1 59597PRTArtificial SequenceSynthetic peptide 959Arg
Ser Ser Ser Ser Thr Arg1 59607PRTArtificial
SequenceSynthetic peptide 960Trp Ala Gly Ser Asn Tyr Ser1
59617PRTArtificial SequenceSynthetic peptide 961Cys Ala Gly Arg Ala Arg
Arg1 59627PRTArtificial SequenceSynthetic peptide 962Ile
Ala Gly Leu Ala Val Val1 59637PRTArtificial
SequenceSynthetic peptide 963Asp Gly Glu Gly Ala Gly Leu1
59647PRTArtificial SequenceSynthetic peptide 964Ala Leu Ala Gly Gly Gly
Leu1 59657PRTArtificial SequenceSynthetic peptide 965Gly
Val Arg Arg Ser Leu Leu1 59667PRTArtificial
SequenceSynthetic peptide 966Ala Asp Trp Gly Val Leu Glu1
59677PRTArtificial SequenceSynthetic peptide 967Ile Gly Ala Val Ser Gly
Trp1 59687PRTArtificial SequenceSynthetic peptide 968Ala
Ser Gly Leu Val Val Thr1 59697PRTArtificial
SequenceSynthetic peptide 969Ile Gly Leu Arg Gly Glu Asn1
59707PRTArtificial SequenceSynthetic peptide 970Arg Arg Ala Arg Gly Ala
Cys1 59717PRTArtificial SequenceSynthetic peptide 971Tyr
Ala Ala Ser Leu Met Gly1 59727PRTArtificial
SequenceSynthetic peptide 972Leu Thr Ala Ala Val Met Val1
59737PRTArtificial SequenceSynthetic peptide 973Tyr Ala Ala Ser Leu Met
Gly1 59747PRTArtificial SequenceSynthetic peptide 974Arg
Ala Arg Thr Gly Gly Ser1 59757PRTArtificial
SequenceSynthetic peptide 975Val Ser Gly Asp Gly Gly Ser1
59767PRTArtificial SequenceSynthetic peptide 976Phe Gly Gly Arg Ser Leu
Ser1 59777PRTArtificial SequenceSynthetic peptide 977Ser
Leu Gly Gly Arg Thr Phe1 59787PRTArtificial
SequenceSynthetic peptide 978Ala Arg Arg Gly Leu Gly Leu1
59797PRTArtificial SequenceSynthetic peptide 979Ala Leu Ala Gly Gly Gly
Leu1 59807PRTArtificial SequenceSynthetic peptide 980Phe
Arg Ala Leu Gly Gly Leu1 59817PRTArtificial
SequenceSynthetic peptide 981Phe Thr Arg Gly Gly Leu Ser1
59827PRTArtificial SequenceSynthetic peptide 982Ser Gly Ser Ser Val Arg
Tyr1 59837PRTArtificial SequenceSynthetic peptide 983Trp
Gly Ser Val Ala Gly Ile1 59847PRTArtificial
SequenceSynthetic peptide 984Ser Gly Gly Asp Gly Ser Val1
59857PRTArtificial SequenceSynthetic peptide 985Asn Glu Gly Arg Leu Gly
Ile1 59867PRTArtificial SequenceSynthetic peptide 986Tyr
Ser Gly Arg Leu Val Met1 59877PRTArtificial
SequenceSynthetic peptide 987Asp Gly Pro Ser Gly Cys Ser1
59887PRTArtificial SequenceSynthetic peptide 988Arg Gly Ser Arg Thr Gly
Pro1 59897PRTArtificial SequenceSynthetic peptide 989Gly
Ser Ser Ala Cys Gly Ala1 59907PRTArtificial
SequenceSynthetic peptide 990Val Arg Leu Ser Gly Arg Ala1
59917PRTArtificial SequenceSynthetic peptide 991Arg Leu Ser Thr Phe Ala
Gly1 59927PRTArtificial SequenceSynthetic peptide 992Ala
Arg Gly Ser Leu Arg Val1 59937PRTArtificial
SequenceSynthetic peptide 993Phe Ser Pro Arg Gly Ser Val1
59947PRTArtificial SequenceSynthetic peptide 994Gly Gly Arg Leu Arg Ala
Val1 59957PRTArtificial SequenceSynthetic peptide 995Val
Leu Ser Ala Val Ser Ser1 59967PRTArtificial
SequenceSynthetic peptide 996Ala Arg Gly Ser Leu Arg Val1
59977PRTArtificial SequenceSynthetic peptide 997Leu Arg Ser Tyr Ala Trp
Ser1 59987PRTArtificial SequenceSynthetic peptide 998Lys
Gly Arg Val Ser Ala Gly1 59997PRTArtificial
SequenceSynthetic peptide 999Ala Gly Leu Thr Ile Gly Ile1
510007PRTArtificial SequenceSynthetic peptide 1000Ala Trp Arg His Ala Gly
Gly1 510017PRTArtificial SequenceSynthetic peptide 1001Trp
Ala Arg Ala Gly Gly Phe1 510027PRTArtificial
SequenceSynthetic peptide 1002Met Gly Val Leu Thr Ala Glu1
510037PRTArtificial SequenceSynthetic peptide 1003Phe Ala Gly Tyr Gly Val
Leu1 510047PRTArtificial SequenceSynthetic peptide 1004Arg
Ile Phe His Gly Ala Val1 510057PRTArtificial
SequenceSynthetic peptide 1005Glu Gly Leu Val Val Phe Glu1
510067PRTArtificial SequenceSynthetic peptide 1006Arg Glu Val Pro Gly Leu
Arg1 510077PRTArtificial SequenceSynthetic peptide 1007Leu
Val Ser Val Asn Gly Ala1 510087PRTArtificial
SequenceSynthetic peptide 1008His Ser Leu Val Ser Gln Pro1
510097PRTArtificial SequenceSynthetic peptide 1009Ala Arg Gly Ser Leu Arg
Val1 510107PRTArtificial SequenceSynthetic peptide 1010Ser
Ser Val Ala Ser Leu Val1 510117PRTArtificial
SequenceSynthetic peptide 1011Ala Ala Val Trp Gln Met Lys1
510127PRTArtificial SequenceSynthetic peptide 1012Gln Arg Ala Ala Val Ile
Val1 510137PRTArtificial SequenceSynthetic peptide 1013Gly
Gly Arg Leu Arg Ala Val1 510147PRTArtificial
SequenceSynthetic peptide 1014Leu Pro Cys Gly Gly Leu Ala1
510157PRTArtificial SequenceSynthetic peptide 1015Gly Ser Ser His Asp Ala
Leu1 510167PRTArtificial SequenceSynthetic peptide 1016Thr
Gln Tyr Tyr Gly Ser Ser1 510177PRTArtificial
SequenceSynthetic peptide 1017Phe Ser Pro Arg Gly Ser Val1
510187PRTArtificial SequenceSynthetic peptide 1018Lys Gly Arg Val Ser Ala
Gly1 510197PRTArtificial SequenceSynthetic peptide 1019Gln
Gly Arg Val Asn Val Lys1 510207PRTArtificial
SequenceSynthetic peptide 1020Gly Gly Arg Leu Arg Ala Val1
510217PRTArtificial SequenceSynthetic peptide 1021Tyr Asp Gly Arg Leu Ala
Arg1 510227PRTArtificial SequenceSynthetic peptide 1022Ser
Arg Leu Ser Tyr Trp Gln1 510237PRTArtificial
SequenceSynthetic peptide 1023Phe Val Gly Ser Arg Gly Val1
510247PRTArtificial SequenceSynthetic peptide 1024Ser Val Asp Arg Gly Val
Ile1 510257PRTArtificial SequenceSynthetic peptide 1025Gly
Arg Gly Ser Gly Gly Phe1 510267PRTArtificial
SequenceSynthetic peptide 1026Ile Phe Gly Ala Gly Leu Arg1
510277PRTArtificial SequenceSynthetic peptide 1027Gly Trp Val Ala Val Ser
Cys1 510287PRTArtificial SequenceSynthetic peptide 1028Leu
Leu Ser Gly Val Ile Leu1 510297PRTArtificial
SequenceSynthetic peptide 1029Gly Ser Thr Leu Leu Ser Arg1
510307PRTArtificial SequenceSynthetic peptide 1030Gln Trp Tyr Ser Leu Arg
Ser1 510317PRTArtificial SequenceSynthetic peptide 1031Thr
Trp Ile Gly Arg Val Ser1 510327PRTArtificial
SequenceSynthetic peptide 1032Ser Val Val Leu Ala Gly Ser1
510337PRTArtificial SequenceSynthetic peptide 1033Ile Phe Gly Ala Gly Leu
Arg1 510347PRTArtificial SequenceSynthetic peptide 1034Ser
Ala Gly Gly Trp Cys Ala1 510357PRTArtificial
SequenceSynthetic peptide 1035Arg Asp Gly Val Arg Val Gly1
510367PRTArtificial SequenceSynthetic peptide 1036Val Ser Arg Ile Gly Val
Arg1 510377PRTArtificial SequenceSynthetic peptide 1037Gly
Val Arg Ser Met Pro Val1 510387PRTArtificial
SequenceSynthetic peptide 1038Gly Gly Val Leu Gly Ser Asp1
510397PRTArtificial SequenceSynthetic peptide 1039Trp Gly Val Leu Gln Leu
Glu1 510407PRTArtificial SequenceSynthetic peptide 1040His
Gly Gly Pro Gly Ala Val1 510417PRTArtificial
SequenceSynthetic peptide 1041Asp Ser Gly Leu Val Gly Gly1
510427PRTArtificial SequenceSynthetic peptide 1042Ile Phe Gly Ala Gly Leu
Arg1 510437PRTArtificial SequenceSynthetic peptide 1043Arg
Met Gly Phe Gly Leu Arg1 510447PRTArtificial
SequenceSynthetic peptide 1044Trp Leu Asp Ala Ala Val Lys1
510457PRTArtificial SequenceSynthetic peptide 1045Ile Ala Ala Ser Tyr Arg
Gly1 510467PRTArtificial SequenceSynthetic peptide 1046Ala
Thr Ile Pro Gly Gly Ser1 510477PRTArtificial
SequenceSynthetic peptide 1047Asp Gly Gly Ser Leu Val Val1
510487PRTArtificial SequenceSynthetic peptide 1048Phe Gly Gly Ser Gly Arg
Gly1 510497PRTArtificial SequenceSynthetic peptide 1049Ser
Pro Thr Gly Gly Arg Arg1 510507PRTArtificial
SequenceSynthetic peptide 1050Thr Trp Ser Thr Gly Gly Arg1
510517PRTArtificial SequenceSynthetic peptide 1051Ser Arg Ser Cys Gly Gly
Leu1 510527PRTArtificial SequenceSynthetic peptide 1052Cys
Pro Gly Ser Gly Ile Ile1 510537PRTArtificial
SequenceSynthetic peptide 1053Phe Gly Gly Ser Gly Arg Gly1
510547PRTArtificial SequenceSynthetic peptide 1054Ser Gly Ser Val Val Gln
Arg1 510557PRTArtificial SequenceSynthetic peptide 1055Thr
Trp Ile Gly Arg Val Ser1 510567PRTArtificial
SequenceSynthetic peptide 1056Gly Pro Ser Trp Ala Thr Val1
510577PRTArtificial SequenceSynthetic peptide 1057Ala Arg Arg Gly Ser Gly
Leu1 510587PRTArtificial SequenceSynthetic peptide 1058Arg
Ala Val Gly Tyr Asn Ala1 510597PRTArtificial
SequenceSynthetic peptide 1059Leu Arg Ala Val Glu Phe Leu1
510607PRTArtificial SequenceSynthetic peptide 1060Phe Glu Asp Leu Leu Ser
Leu1 510617PRTArtificial SequenceSynthetic peptide 1061Arg
Trp Leu Ser Leu Leu Ser1 510627PRTArtificial
SequenceSynthetic peptide 1062His Ala Pro Gly Leu Arg Val1
510637PRTArtificial SequenceSynthetic peptide 1063Leu Arg Ser Ser Met Met
Leu1 510647PRTArtificial SequenceSynthetic peptide 1064Arg
Pro Lys Leu Arg Ser Val1 510657PRTArtificial
SequenceSynthetic peptide 1065Ser Arg Val Ser Phe His Glu1
510667PRTArtificial SequenceSynthetic peptide 1066Leu Arg Ser Ser Met Met
Leu1 510677PRTArtificial SequenceSynthetic peptide 1067Ser
Ser Gly Gly Arg Ser Ser1 510687PRTArtificial
SequenceSynthetic peptide 1068Val Ala Gly Arg Val Gly Ile1
510697PRTArtificial SequenceSynthetic peptide 1069Ala Gly Leu Ala Leu Thr
Val1 510707PRTArtificial SequenceSynthetic peptide 1070Ile
Gly Val Arg Gly Ala Val1 510717PRTArtificial
SequenceSynthetic peptide 1071Leu Val Arg Asp Gly Val Leu1
510727PRTArtificial SequenceSynthetic peptide 1072Ile Gly Val Arg Gly Ala
Val1 510737PRTArtificial SequenceSynthetic peptide 1073His
Gly Leu Val Thr His Asn1 510747PRTArtificial
SequenceSynthetic peptide 1074His Ala Pro Gly Leu Arg Val1
510757PRTArtificial SequenceSynthetic peptide 1075Val Ser Ser Thr Ala Arg
Gly1 510767PRTArtificial SequenceSynthetic peptide 1076Arg
Ala Ala Val Ile His Thr1 510777PRTArtificial
SequenceSynthetic peptide 1077Ala Ala Ser Thr Arg Ser Leu1
510787PRTArtificial SequenceSynthetic peptide 1078Gly Trp Gly Gly Gly Ser
Ala1 510797PRTArtificial SequenceSynthetic peptide 1079Ser
Ser Arg Gly Gly Ser Ser1 510807PRTArtificial
SequenceSynthetic peptide 1080Ser Ser Gly Gly Arg Ser Ser1
510817PRTArtificial SequenceSynthetic peptide 1081Ser Ser Arg Gly Gly Ser
Ser1 510827PRTArtificial SequenceSynthetic peptide 1082Ala
Arg Arg Gly Ser Gly Leu1 510837PRTArtificial
SequenceSynthetic peptide 1083Val Ala Gly Arg Val Gly Ile1
510847PRTArtificial SequenceSynthetic peptide 1084Glu Gly Arg Leu Met Leu
Ala1 510857PRTArtificial SequenceSynthetic peptide 1085Arg
Leu Ser Ser Ala Pro Ser1 510867PRTArtificial
SequenceSynthetic peptide 1086Arg Arg Leu Ser Tyr His Ser1
510877PRTArtificial SequenceSynthetic peptide 1087Phe Leu His Met Arg Leu
Ser1 510887PRTArtificial SequenceSynthetic peptide 1088Leu
Ala Arg Gly Val Pro Pro1 510897PRTArtificial
SequenceSynthetic peptide 1089Leu Ser Arg Gly Ser Val Ala1
510907PRTArtificial SequenceSynthetic peptide 1090Val Trp Leu Arg Gly Ser
Thr1 510917PRTArtificial SequenceSynthetic peptide 1091Arg
Gly Gly Gln Arg Ala Ser1 510927PRTArtificial
SequenceSynthetic peptide 1092Ala Val Ser Gly Arg Ser Leu1
510937PRTArtificial SequenceSynthetic peptide 1093Gly Leu Leu Ser Ser Phe
Ser1 510947PRTArtificial SequenceSynthetic peptide 1094Arg
Met Gly Leu Leu Arg Gln1 510957PRTArtificial
SequenceSynthetic peptide 1095Arg Leu His Tyr Leu Arg Ser1
510967PRTArtificial SequenceSynthetic peptide 1096Gly Gly Tyr Trp Leu Arg
Ser1 510977PRTArtificial SequenceSynthetic peptide 1097Asn
Arg Ser Ser His Cys Gly1 510987PRTArtificial
SequenceSynthetic peptide 1098Gln Arg Ser Ser Asp Leu Thr1
510997PRTArtificial SequenceSynthetic peptide 1099Ala Ala Gly Arg Ser Arg
Ile1 511007PRTArtificial SequenceSynthetic peptide 1100Gly
Arg Ala Gly Gly Asn Gly1 511017PRTArtificial
SequenceSynthetic peptide 1101Ala Asn Ala Ser Gly Val Arg1
511027PRTArtificial SequenceSynthetic peptide 1102Trp Ala His Gly Val Leu
Ser1 511037PRTArtificial SequenceSynthetic peptide 1103Ser
Leu Tyr Gly Leu Arg Trp1 511047PRTArtificial
SequenceSynthetic peptide 1104Gly Asn Gly Gly Ala Arg Gly1
511057PRTArtificial SequenceSynthetic peptide 1105Leu Ala Arg Gly Val Pro
Pro1 511067PRTArtificial SequenceSynthetic peptide 1106Asn
Trp Asp Ala Arg Gly Arg1 511077PRTArtificial
SequenceSynthetic peptide 1107Ala Ser Leu Pro Val Leu Asp1
511087PRTArtificial SequenceSynthetic peptide 1108Pro Pro Gly Ala Ser Leu
Tyr1 511097PRTArtificial SequenceSynthetic peptide 1109Ala
Ala Val Gly Gly Arg Val1 511107PRTArtificial
SequenceSynthetic peptide 1110Ala Ala Ser Ser Trp Ala Val1
511117PRTArtificial SequenceSynthetic peptide 1111Ala Phe Lys Thr Gly Gly
Ser1 511127PRTArtificial SequenceSynthetic peptide 1112Phe
Glu Gly Gly Arg Ser Gly1 511137PRTArtificial
SequenceSynthetic peptide 1113Arg Thr Trp Gly Gly Arg Met1
511147PRTArtificial SequenceSynthetic peptide 1114Ser Ala Arg Gln Gly Gly
Arg1 511157PRTArtificial SequenceSynthetic peptide 1115Ala
Ala Val Gly Gly Arg Val1 511167PRTArtificial
SequenceSynthetic peptide 1116Ala Arg His Gly Ser Ser Val1
511177PRTArtificial SequenceSynthetic peptide 1117Ser Asn Phe Tyr Gly Ser
Ser1 511187PRTArtificial SequenceSynthetic peptide 1118Gly
Ser Gly Gln Leu Ile Pro1 511197PRTArtificial
SequenceSynthetic peptide 1119Leu Ser Arg Gly Ser Val Ala1
511207PRTArtificial SequenceSynthetic peptide 1120Ala Glu Tyr Gly Arg Val
Leu1 511217PRTArtificial SequenceSynthetic peptide 1121Arg
Gly Arg Val Leu Leu Pro1 511227PRTArtificial
SequenceSynthetic peptide 1122Ala Ala Val Gly Gly Arg Val1
511237PRTArtificial SequenceSynthetic peptide 1123Arg Gly Arg Leu Ala Leu
Leu1 511247PRTArtificial SequenceSynthetic peptide 1124Ser
Gly Pro Gly Arg Leu Pro1 511257PRTArtificial
SequenceSynthetic peptide 1125Thr Ser Gly Arg Leu Trp Val1
511267PRTArtificial SequenceSynthetic peptide 1126Met Val Tyr Ser Gly Val
Ser1 511277PRTArtificial SequenceSynthetic peptide 1127Trp
Arg Leu Ser Arg Glu Gly1 511287PRTArtificial
SequenceSynthetic peptide 1128Leu Leu Arg Arg Leu Ser Trp1
511297PRTArtificial SequenceSynthetic peptide 1129Ala Ala Arg Gly Val Met
Val1 511307PRTArtificial SequenceSynthetic peptide 1130Ala
Leu Ala Arg Gly Ser Gly1 511317PRTArtificial
SequenceSynthetic peptide 1131Asn Leu Arg Gly Ser Arg Ser1
511327PRTArtificial SequenceSynthetic peptide 1132Arg Ala Val Trp Arg Ala
Ser1 511337PRTArtificial SequenceSynthetic peptide 1133Gly
Ala Gly Ser Phe Ser Ser1 511347PRTArtificial
SequenceSynthetic peptide 1134Leu Leu Ser Ser Arg Arg Cys1
511357PRTArtificial SequenceSynthetic peptide 1135Leu Leu Ser Leu Asp Pro
Gly1 511367PRTArtificial SequenceSynthetic peptide 1136Ser
Ser Leu Leu Ser Ser Leu1 511377PRTArtificial
SequenceSynthetic peptide 1137Leu Leu Arg Pro Ala His Gly1
511387PRTArtificial SequenceSynthetic peptide 1138Leu Leu Arg Arg Leu Ser
Trp1 511397PRTArtificial SequenceSynthetic peptide 1139Cys
Met Leu Arg Ser Ala Thr1 511407PRTArtificial
SequenceSynthetic peptide 1140Ser Lys Ala Val Leu Arg Ser1
511417PRTArtificial SequenceSynthetic peptide 1141Ser Arg Val Ser Asn Pro
Ser1 511427PRTArtificial SequenceSynthetic peptide 1142Cys
Arg Arg Ser Ser Leu Leu1 511437PRTArtificial
SequenceSynthetic peptide 1143Gly Ala Gly Ser Phe Ser Ser1
511447PRTArtificial SequenceSynthetic peptide 1144Ser Ala Ala Gly Arg Thr
Phe1 511457PRTArtificial SequenceSynthetic peptide 1145Pro
Ala Gly Arg Met Leu Ser1 511467PRTArtificial
SequenceSynthetic peptide 1146Ile Ala Met Ala Gly Leu Arg1
511477PRTArtificial SequenceSynthetic peptide 1147Ala Gly Gly Phe Arg Phe
Ile1 511487PRTArtificial SequenceSynthetic peptide 1148Ser
Gly Val Arg Pro Val Ile1 511497PRTArtificial
SequenceSynthetic peptide 1149Gly Val Leu Ser Asp Arg Ser1
511507PRTArtificial SequenceSynthetic peptide 1150Gly Ala Val Thr Ser Ala
Asp1 511517PRTArtificial SequenceSynthetic peptide 1151Gly
Ala Val Thr Ser Ala Asp1 511527PRTArtificial
SequenceSynthetic peptide 1152Gly Ala Val Asn Thr Pro Ala1
511537PRTArtificial SequenceSynthetic peptide 1153Gly Gly Leu Val Lys Arg
Leu1 511547PRTArtificial SequenceSynthetic peptide 1154Glu
Val Ala Ser Gly Leu Val1 511557PRTArtificial
SequenceSynthetic peptide 1155Ile Ala Met Ala Gly Leu Arg1
511567PRTArtificial SequenceSynthetic peptide 1156Gly Thr His Ser Gly Leu
Arg1 511577PRTArtificial SequenceSynthetic peptide 1157Leu
Val Ser Thr Ser Asn Arg1 511587PRTArtificial
SequenceSynthetic peptide 1158Phe Ser Leu Val Ser Phe Val1
511597PRTArtificial SequenceSynthetic peptide 1159Ala Leu Val Ser Ser His
Val1 511607PRTArtificial SequenceSynthetic peptide 1160Ala
Ala Arg Gly Val Met Val1 511617PRTArtificial
SequenceSynthetic peptide 1161Ala Leu Ala Arg Gly Ser Gly1
511627PRTArtificial SequenceSynthetic peptide 1162Leu Arg Tyr Trp Ala Ala
Val1 511637PRTArtificial SequenceSynthetic peptide 1163Phe
Thr Arg Gly Ala Ala Ser1 511647PRTArtificial
SequenceSynthetic peptide 1164Glu Trp His Ala Ala Ser Gly1
511657PRTArtificial SequenceSynthetic peptide 1165Phe Gly Gly Ser Met Ala
Pro1 511667PRTArtificial SequenceSynthetic peptide 1166Gly
Gly Ser Leu Lys Trp Val1 511677PRTArtificial
SequenceSynthetic peptide 1167Arg Gly Leu Gln Gly Gly Arg1
511687PRTArtificial SequenceSynthetic peptide 1168Thr Cys Gly Gly Arg Ser
Tyr1 511697PRTArtificial SequenceSynthetic peptide 1169Gly
Glu Ala Leu Gly Leu Gly1 511707PRTArtificial
SequenceSynthetic peptide 1170Pro Arg Gly Leu Gly Val Gly1
511717PRTArtificial SequenceSynthetic peptide 1171Val Gly Leu Gly Asn Ser
Ala1 511727PRTArtificial SequenceSynthetic peptide 1172Gly
Gly Leu Val Lys Arg Leu1 511737PRTArtificial
SequenceSynthetic peptide 1173Gly Ser Gly Arg Ala Leu Ala1
511747PRTArtificial SequenceSynthetic peptide 1174Ser Arg Ser Gly Arg Leu
Asn1 511757PRTArtificial SequenceSynthetic peptide 1175Ser
Ala Gly Val Ser Asp Ser1 511767PRTArtificial
SequenceSynthetic peptide 1176Pro Arg Leu Ser Asp Lys Ser1
511777PRTArtificial SequenceSynthetic peptide 1177Gly Arg Gly Asp Arg Gly
Val1 511787PRTArtificial SequenceSynthetic peptide 1178Arg
Gly Val Ser Gly Arg Leu1 511797PRTArtificial
SequenceSynthetic peptide 1179Ile Asn Arg Gly Ser Arg Glu1
511807PRTArtificial SequenceSynthetic peptide 1180Leu Arg Gly Ser Arg Gln
Phe1 511817PRTArtificial SequenceSynthetic peptide 1181Leu
Arg Gly Ser Val Gly Arg1 511827PRTArtificial
SequenceSynthetic peptide 1182Gly Leu Trp Tyr Arg Ala Val1
511837PRTArtificial SequenceSynthetic peptide 1183Arg Val Arg Ala Val Leu
Gly1 511847PRTArtificial SequenceSynthetic peptide 1184Arg
Ala Val Leu Glu Leu Trp1 511857PRTArtificial
SequenceSynthetic peptide 1185Leu Val Arg Ala Ser Asn Gly1
511867PRTArtificial SequenceSynthetic peptide 1186Ala Ser Gly Thr Leu Leu
Arg1 511877PRTArtificial SequenceSynthetic peptide 1187Gly
Ser Gly Val Arg Val Ser1 511887PRTArtificial
SequenceSynthetic peptide 1188Val Gly Ser Thr Arg Ser Ser1
511897PRTArtificial SequenceSynthetic peptide 1189Arg Ala Gly Ser Arg Tyr
Ile1 511907PRTArtificial SequenceSynthetic peptide 1190Val
Gly Val Arg Phe Ser Arg1 511917PRTArtificial
SequenceSynthetic peptide 1191Gly Ser Gly Val Arg Val Ser1
511927PRTArtificial SequenceSynthetic peptide 1192Ile Gly Val Leu Ala Ser
Ala1 511937PRTArtificial SequenceSynthetic peptide 1193Gly
Leu Val Ala Arg Val Arg1 511947PRTArtificial
SequenceSynthetic peptide 1194Leu Leu Gly Ile Gly Gly Ser1
511957PRTArtificial SequenceSynthetic peptide 1195Gln Leu Gly Gly Ser Phe
Arg1 511967PRTArtificial SequenceSynthetic peptide 1196Leu
Phe Arg Trp Gly Gly Arg1 511977PRTArtificial
SequenceSynthetic peptide 1197Arg Phe Ser Gly Gly Leu Gln1
511987PRTArtificial SequenceSynthetic peptide 1198Val Gly Ser Ser His Gly
Leu1 511997PRTArtificial SequenceSynthetic peptide 1199Ser
Val Arg Val Gly Ser Gly1 512007PRTArtificial
SequenceSynthetic peptide 1200Gly Val Asn Gly Ser Val Ser1
512017PRTArtificial SequenceSynthetic peptide 1201Leu Arg Gly Ser Val Gly
Arg1 512027PRTArtificial SequenceSynthetic peptide 1202His
Val Lys Asn Gly Arg Val1 512037PRTArtificial
SequenceSynthetic peptide 1203Phe Gln Arg Ser Gly Arg Leu1
512047PRTArtificial SequenceSynthetic peptide 1204His Gly Arg Leu Ala Phe
Gly1 512057PRTArtificial SequenceSynthetic peptide 1205Arg
Gly Val Ser Gly Arg Leu1 512067PRTArtificial
SequenceSynthetic peptide 1206Arg Gly Val Ser Gly Arg Leu1
512077PRTArtificial SequenceSynthetic peptide 1207Phe Gly Ile Gly Arg Gly
Val1 512087PRTArtificial SequenceSynthetic peptide 1208Gly
Val Val Gln Ala Val Ser1 512097PRTArtificial
SequenceSynthetic peptide 1209Leu Ser Ala Val Ser Val Lys1
512107PRTArtificial SequenceSynthetic peptide 1210Leu Tyr Leu Leu Ser Ser
Ala1 512117PRTArtificial SequenceSynthetic peptide 1211Leu
Ile Gly Gly Leu Leu Ser1 512127PRTArtificial
SequenceSynthetic peptide 1212Leu Leu Arg Arg Gly Ile Gly1
512137PRTArtificial SequenceSynthetic peptide 1213Phe Leu Arg Ser Leu Ser
Leu1 512147PRTArtificial SequenceSynthetic peptide 1214Val
Arg Val Ser Gly Leu Thr1 512157PRTArtificial
SequenceSynthetic peptide 1215Ala Gly Ser Val Asp Leu Val1
512167PRTArtificial SequenceSynthetic peptide 1216Gly Phe Val Ala Gly Arg
Thr1 512177PRTArtificial SequenceSynthetic peptide 1217Thr
Arg Gly Ala Val Phe Gly1 512187PRTArtificial
SequenceSynthetic peptide 1218Ile Tyr Gly Gly Leu Val Ile1
512197PRTArtificial SequenceSynthetic peptide 1219Pro Thr Gly Glu Gly Leu
Arg1 512207PRTArtificial SequenceSynthetic peptide 1220Lys
Val Ser Val Ala Ser Leu1 512217PRTArtificial
SequenceSynthetic peptide 1221Arg Tyr Ser Met Ala Ser Leu1
512227PRTArtificial SequenceSynthetic peptide 1222Ala Asn Ala Ala Ser Ser
Pro1 512237PRTArtificial SequenceSynthetic peptide 1223Pro
Gly Gly Ser Arg His Ala1 512247PRTArtificial
SequenceSynthetic peptide 1224Gly Gly Ser Pro Gly Val Trp1
512257PRTArtificial SequenceSynthetic peptide 1225Ile Tyr Gly Gly Leu Val
Ile1 512267PRTArtificial SequenceSynthetic peptide 1226Leu
Ile Gly Gly Leu Leu Ser1 512277PRTArtificial
SequenceSynthetic peptide 1227Ala Cys Gly Ser Gly Leu Asp1
512287PRTArtificial SequenceSynthetic peptide 1228Ala Gly Ser Val Asp Leu
Val1 512297PRTArtificial SequenceSynthetic peptide 1229Thr
Leu Gly Ser Val Arg Val1 512307PRTArtificial
SequenceSynthetic peptide 1230His Val Arg Gly Arg Val Ala1
512317PRTArtificial SequenceSynthetic peptide 1231Ile Asp Leu Gly Arg Val
Asn1 512327PRTArtificial SequenceSynthetic peptide 1232Gly
Arg Leu Asp Ala Phe Gly1 512337PRTArtificial
SequenceSynthetic peptide 1233Trp Val Gly Pro Ser Gly Gly1
512347PRTArtificial SequenceSynthetic peptide 1234Asp Leu Arg Leu Ser Phe
Pro1 512357PRTArtificial SequenceSynthetic peptide 1235Ser
Ala Arg Leu Ser His Val1 512367PRTArtificial
SequenceSynthetic peptide 1236Val Met Asp Arg Gly Val Ala1
512377PRTArtificial SequenceSynthetic peptide 1237Arg Gly Ser Leu Leu Trp
Ala1 512387PRTArtificial SequenceSynthetic peptide 1238Arg
Gly Ser Pro Leu Thr Lys1 512397PRTArtificial
SequenceSynthetic peptide 1239Arg Ala Ser Ile Gly Ile Glu1
512407PRTArtificial SequenceSynthetic peptide 1240Val His Ser Leu Arg Ala
Ser1 512417PRTArtificial SequenceSynthetic peptide 1241Ala
Trp Leu Leu Ser Gly Arg1 512427PRTArtificial
SequenceSynthetic peptide 1242Leu Trp Leu Arg Ser Arg Glu1
512437PRTArtificial SequenceSynthetic peptide 1243Val Thr Arg Ile Arg Val
Ser1 512447PRTArtificial SequenceSynthetic peptide 1244Asn
Ser Gln Arg Ser Ser Val1 512457PRTArtificial
SequenceSynthetic peptide 1245Ala Ala Thr Arg Ala Gly Ser1
512467PRTArtificial SequenceSynthetic peptide 1246Thr Asp Gly Val Arg Ala
Phe1 512477PRTArtificial SequenceSynthetic peptide 1247Phe
Ala Ala Ser Gly Val Leu1 512487PRTArtificial
SequenceSynthetic peptide 1248Gly Val Leu Glu Gly Arg Arg1
512497PRTArtificial SequenceSynthetic peptide 1249Glu Ala Asp Pro Gly Ala
Val1 512507PRTArtificial SequenceSynthetic peptide 1250Asp
Gly Ala Val Ile Leu His1 512517PRTArtificial
SequenceSynthetic peptide 1251Arg Asp Gly Ala Val Asn Leu1
512527PRTArtificial SequenceSynthetic peptide 1252Gly Leu Arg Pro His Gly
Ala1 512537PRTArtificial SequenceSynthetic peptide 1253Thr
Ser Arg Gly Leu Arg Leu1 512547PRTArtificial
SequenceSynthetic peptide 1254Arg Met Leu Val Ser Ser Phe1
512557PRTArtificial SequenceSynthetic peptide 1255Asp Val Ile Ala Arg Gly
Trp1 512567PRTArtificial SequenceSynthetic peptide 1256Thr
Leu Thr Ala Ala Val Phe1 512577PRTArtificial
SequenceSynthetic peptide 1257Gly Trp Leu Asn Ala Ala Val1
512587PRTArtificial SequenceSynthetic peptide 1258Phe Ala Ala Ser Gly Val
Leu1 512597PRTArtificial SequenceSynthetic peptide 1259Gly
Gly Ser Lys Gly Ser Ala1 512607PRTArtificial
SequenceSynthetic peptide 1260Ala Val Ala Leu Gly Gly Ser1
512617PRTArtificial SequenceSynthetic peptide 1261His Gly Gly Arg Tyr Arg
His1 512627PRTArtificial SequenceSynthetic peptide 1262Ser
Gly Val Gly Gly Arg Tyr1 512637PRTArtificial
SequenceSynthetic peptide 1263Ser Gly Gly Leu Ala Val Ala1
512647PRTArtificial SequenceSynthetic peptide 1264Gly Arg Leu Ala Lys Ser
Ile1 512657PRTArtificial SequenceSynthetic peptide 1265Ala
Gly Pro Ser Arg Gly Pro1 512667PRTArtificial
SequenceSynthetic peptide 1266Gly Leu Met Arg Leu Ser His1
512677PRTArtificial SequenceSynthetic peptide 1267Val Arg Val Gly Arg Leu
Ser1 512687PRTArtificial SequenceSynthetic peptide 1268Thr
Gly Arg Leu Ser Ala Ala1 512697PRTArtificial
SequenceSynthetic peptide 1269Ser Leu Arg Gly Val Arg Val1
512707PRTArtificial SequenceSynthetic peptide 1270Asp Asn Cys Glu Arg Gly
Val1 512717PRTArtificial SequenceSynthetic peptide 1271Thr
Thr Gln Leu Arg Gly Val1 512727PRTArtificial
SequenceSynthetic peptide 1272Gly Val Ile Gly Arg Gly Ser1
512737PRTArtificial SequenceSynthetic peptide 1273Leu Ala Gly Met Arg Gly
Ser1 512747PRTArtificial SequenceSynthetic peptide 1274Val
Arg Pro Arg Ala Val Leu1 512757PRTArtificial
SequenceSynthetic peptide 1275Pro Pro Arg Ala Val Thr Asn1
512767PRTArtificial SequenceSynthetic peptide 1276Trp Arg Ala Arg Ala Ser
Pro1 512777PRTArtificial SequenceSynthetic peptide 1277Phe
Gly Arg Leu Leu Ser Pro1 512787PRTArtificial
SequenceSynthetic peptide 1278Pro Ser Leu Leu Arg Gly Phe1
512797PRTArtificial SequenceSynthetic peptide 1279Arg Asp Leu Arg Val His
Leu1 512807PRTArtificial SequenceSynthetic peptide 1280Leu
Arg Val Ser Asn Pro Arg1 512817PRTArtificial
SequenceSynthetic peptide 1281Leu Arg Val Asp Gln Leu Tyr1
512827PRTArtificial SequenceSynthetic peptide 1282His Arg Leu Arg Ser Met
Ser1 512837PRTArtificial SequenceSynthetic peptide 1283Leu
Arg Val Ser Asn Pro Arg1 512847PRTArtificial
SequenceSynthetic peptide 1284Pro Gly Phe Met Ala Gly Ser1
512857PRTArtificial SequenceSynthetic peptide 1285Ala Gly Arg Gly Ile Ser
Gln1 512867PRTArtificial SequenceSynthetic peptide 1286Arg
Ala Gly Arg Asp Ala Pro1 512877PRTArtificial
SequenceSynthetic peptide 1287Arg Ala Gly Arg Gly Phe Glu1
512887PRTArtificial SequenceSynthetic peptide 1288His Gln Ala Gly Gly Val
Thr1 512897PRTArtificial SequenceSynthetic peptide 1289Ser
Leu Arg Gly Val Arg Val1 512907PRTArtificial
SequenceSynthetic peptide 1290Asp Trp Val Gly Val Leu Met1
512917PRTArtificial SequenceSynthetic peptide 1291Gly Thr Leu Gly Val Leu
Ser1 512927PRTArtificial SequenceSynthetic peptide 1292Gly
Val Leu Leu Trp Arg Pro1 512937PRTArtificial
SequenceSynthetic peptide 1293Gly Leu Arg Glu Ala His Val1
512947PRTArtificial SequenceSynthetic peptide 1294Ala Ala Arg Gly Glu Leu
Arg1 512957PRTArtificial SequenceSynthetic peptide 1295Ala
Ala Ser Leu Arg Gly Thr1 512967PRTArtificial
SequenceSynthetic peptide 1296Pro Val Gly Ala Ala Val Ala1
512977PRTArtificial SequenceSynthetic peptide 1297Ala Ala Ser Leu Arg Gly
Thr1 512987PRTArtificial SequenceSynthetic peptide 1298Ser
Asn Pro Gly Ser Gly Ser1 512997PRTArtificial
SequenceSynthetic peptide 1299Gly Arg Val Arg Glu Thr Pro1
513007PRTArtificial SequenceSynthetic peptide 1300Phe Gly Arg Leu Leu Ser
Pro1 513017PRTArtificial SequenceSynthetic peptide 1301Val
Arg Val Gly Arg Leu Ser1 513027PRTArtificial
SequenceSynthetic peptide 1302Thr Gly Arg Leu Ser Ala Ala1
513037PRTArtificial SequenceSynthetic peptide 1303Val Gly Arg Leu Gln Thr
Thr1 513047PRTArtificial SequenceSynthetic peptide 1304Asp
Gly Pro Ser Cys Val Ile1 513057PRTArtificial
SequenceSynthetic peptide 1305Arg Phe Ser Ser Arg Ala Val1
513067PRTArtificial SequenceSynthetic peptide 1306His Ala Gly Ser Arg Ala
Ser1 513077PRTArtificial SequenceSynthetic peptide 1307Gly
Ala Gly Leu Gly Val Ser1 513087PRTArtificial
SequenceSynthetic peptide 1308Leu Leu Gly Ala Gly Thr Pro1
513097PRTArtificial SequenceSynthetic peptide 1309Leu Leu Ser Ile Leu Lys
Ala1 513107PRTArtificial SequenceSynthetic peptide 1310Gly
Leu Leu Ser Gly Gly Thr1 513117PRTArtificial
SequenceSynthetic peptide 1311Leu Ser Val Leu Arg Val Leu1
513127PRTArtificial SequenceSynthetic peptide 1312Ser Arg Tyr Thr Leu Arg
Ser1 513137PRTArtificial SequenceSynthetic peptide 1313Leu
Phe His Thr Arg Ser Ser1 513147PRTArtificial
SequenceSynthetic peptide 1314Val Ala Arg Ser Ser Phe Arg1
513157PRTArtificial SequenceSynthetic peptide 1315Cys Thr Ala Gly Ser Val
Ser1 513167PRTArtificial SequenceSynthetic peptide 1316Arg
Ala Ala Gly Ser Ala Gly1 513177PRTArtificial
SequenceSynthetic peptide 1317His Ala Gly Ser Arg Ala Ser1
513187PRTArtificial SequenceSynthetic peptide 1318Gly Ala Gly Leu Gly Val
Ser1 513197PRTArtificial SequenceSynthetic peptide 1319Pro
Thr Gly Ala Gly Leu Leu1 513207PRTArtificial
SequenceSynthetic peptide 1320Ala Ser Tyr Ala Gly Leu Val1
513217PRTArtificial SequenceSynthetic peptide 1321Ala Gly Gly Phe Gly Val
Leu1 513227PRTArtificial SequenceSynthetic peptide 1322Asn
Met Ala Gly Gly Gln Glu1 513237PRTArtificial
SequenceSynthetic peptide 1323Leu Arg Ala Gly Gly Ser Tyr1
513247PRTArtificial SequenceSynthetic peptide 1324Tyr Leu Ala Gly Gly Lys
Ala1 513257PRTArtificial SequenceSynthetic peptide 1325Pro
Tyr Tyr Asn Gly Val Arg1 513267PRTArtificial
SequenceSynthetic peptide 1326Ala Gly Gly Phe Gly Val Leu1
513277PRTArtificial SequenceSynthetic peptide 1327Leu Ile Gly Gly Val Leu
His1 513287PRTArtificial SequenceSynthetic peptide 1328Asp
Gly Leu Val Pro Val Ala1 513297PRTArtificial
SequenceSynthetic peptide 1329Gly Leu Val Ala Ser Met Pro1
513307PRTArtificial SequenceSynthetic peptide 1330Ala Ser Tyr Ala Gly Leu
Val1 513317PRTArtificial SequenceSynthetic peptide 1331Leu
Val Arg Leu Val Ser Leu1 513327PRTArtificial
SequenceSynthetic peptide 1332Val Leu Ala Ser Leu Ser Gly1
513337PRTArtificial SequenceSynthetic peptide 1333Gly Ser Ile Thr Gly Gly
Ser1 513347PRTArtificial SequenceSynthetic peptide 1334Leu
Arg Ala Gly Gly Ser Tyr1 513357PRTArtificial
SequenceSynthetic peptide 1335Thr Gly Gly Ser Leu Leu Gly1
513367PRTArtificial SequenceSynthetic peptide 1336Asp Glu Gly Gly Ser Arg
Trp1 513377PRTArtificial SequenceSynthetic peptide 1337Gly
Ala Gly Leu Gly Val Ser1 513387PRTArtificial
SequenceSynthetic peptide 1338Trp Gly Ser Ser Ala Val Lys1
513397PRTArtificial SequenceSynthetic peptide 1339Gln Gly Ser Ser Asn Ser
Val1 513407PRTArtificial SequenceSynthetic peptide 1340Cys
Thr Ala Gly Ser Val Ser1 513417PRTArtificial
SequenceSynthetic peptide 1341Ser Val Thr Gly Ser Val Gly1
513427PRTArtificial SequenceSynthetic peptide 1342Ser Pro Gly Arg Val Ala
Asp1 513437PRTArtificial SequenceSynthetic peptide 1343Asp
Ala Val Arg Gly Pro Ser1 513447PRTArtificial
SequenceSynthetic peptide 1344Gly Ala Gly Leu Gly Val Ser1
513457PRTArtificial SequenceSynthetic peptide 1345Gly Val Ser Gly Thr Val
Ser1 513467PRTArtificial SequenceSynthetic peptide 1346Ser
Gly Val Ser Ile Ser Cys1 513477PRTArtificial
SequenceSynthetic peptide 1347Arg Arg Leu Ser Tyr His Ser1
513487PRTArtificial SequenceSynthetic peptide 1348Arg Arg Glu Gly Leu Arg
Ser1 513497PRTArtificial SequenceSynthetic peptide 1349Glu
Arg Val Ser Ala Ala Val1 513507PRTArtificial
SequenceSynthetic peptide 1350Ala Gly Ser Met Met Glu Phe1
513517PRTArtificial SequenceSynthetic peptide 1351Arg His Gly Pro Gly Val
Leu1 513527PRTArtificial SequenceSynthetic peptide 1352Gly
Leu Arg Arg Asp Asn Gly1 513537PRTArtificial
SequenceSynthetic peptide 1353Arg Arg Glu Gly Leu Arg Ser1
513547PRTArtificial SequenceSynthetic peptide 1354Glu Arg Val Ser Ala Ala
Val1 513557PRTArtificial SequenceSynthetic peptide 1355Val
Ala Ala Ser Val Arg Glu1 513567PRTArtificial
SequenceSynthetic peptide 1356Pro Trp Tyr Asp Gly Ser Val1
513577PRTArtificial SequenceSynthetic peptide 1357Gly Arg Val Thr Leu Glu
Ser1 513587PRTArtificial SequenceSynthetic peptide 1358Gly
Arg Leu Ser Arg Ala Pro1 513597PRTArtificial
SequenceSynthetic peptide 1359Ser Arg Leu Ser Tyr Cys Asn1
513607PRTArtificial SequenceSynthetic peptide 1360Gln Ala Arg Gly Ser Trp
Leu1 513617PRTArtificial SequenceSynthetic peptide 1361Phe
Val Pro Arg Gly Ser Tyr1 513627PRTArtificial
SequenceSynthetic peptide 1362Ala Ala Leu Leu Arg Ala Val1
513637PRTArtificial SequenceSynthetic peptide 1363Leu Ala Gly Arg Ala Ser
Glu1 513647PRTArtificial SequenceSynthetic peptide 1364Ala
Ala Gly Ala Gly Trp Arg1 513657PRTArtificial
SequenceSynthetic peptide 1365Ala Asp Leu Gly Ala Gly Trp1
513667PRTArtificial SequenceSynthetic peptide 1366Ala Asp Leu Gly Ala Gly
Trp1 513677PRTArtificial SequenceSynthetic peptide 1367Gly
Gly Ala Gly Arg Gly Ala1 513687PRTArtificial
SequenceSynthetic peptide 1368Asp Val Trp Val Ala Val Ser1
513697PRTArtificial SequenceSynthetic peptide 1369Ala Ala Leu Leu Arg Ala
Val1 513707PRTArtificial SequenceSynthetic peptide 1370Asn
Leu Arg Val Gly Ala Glu1 513717PRTArtificial
SequenceSynthetic peptide 1371Asn Cys Tyr Ser Leu Arg Ser1
513727PRTArtificial SequenceSynthetic peptide 1372Leu Ala Gly Ser Arg Val
Ser1 513737PRTArtificial SequenceSynthetic peptide 1373Ser
Gly Pro Ala Gly Ser Phe1 513747PRTArtificial
SequenceSynthetic peptide 1374Leu Ala Gly Ser Arg Val Ser1
513757PRTArtificial SequenceSynthetic peptide 1375Gly Gly Ala Gly Arg Gly
Ala1 513767PRTArtificial SequenceSynthetic peptide 1376Leu
Ala Gly Arg Ala Ser Glu1 513777PRTArtificial
SequenceSynthetic peptide 1377Val Ala Gly Arg Leu Gln Met1
513787PRTArtificial SequenceSynthetic peptide 1378Trp Gly Ala Gly Leu Asp
Ala1 513797PRTArtificial SequenceSynthetic peptide 1379Trp
Gly Ala Gly Leu Asp Ala1 513807PRTArtificial
SequenceSynthetic peptide 1380Ala Gly Arg Gly Ala Gly Gly1
513817PRTArtificial SequenceSynthetic peptide 1381Glu Ala Gly Val Arg Leu
Asn1 513827PRTArtificial SequenceSynthetic peptide 1382Met
Gln Leu Arg Gly Ala Val1 513837PRTArtificial
SequenceSynthetic peptide 1383Gly Gly Pro Gly Leu Val Met1
513847PRTArtificial SequenceSynthetic peptide 1384Gln Gly Leu Val Arg Gly
Gly1 513857PRTArtificial SequenceSynthetic peptide 1385Pro
Gly Leu Arg Gly Pro Ala1 513867PRTArtificial
SequenceSynthetic peptide 1386Pro Gly Leu Arg Gly Pro Ala1
513877PRTArtificial SequenceSynthetic peptide 1387Gly Arg Met Leu Val Ser
Gly1 513887PRTArtificial SequenceSynthetic peptide 1388Glu
Ser Ala Arg Gly Ala Leu1 513897PRTArtificial
SequenceSynthetic peptide 1389Gln Ala Arg Gly Ser Trp Leu1
513907PRTArtificial SequenceSynthetic peptide 1390Gly Gly Gly Ser Gly Gly
Gly1 513917PRTArtificial SequenceSynthetic peptide 1391Asn
Asn Val Gly Gly Ser Ser1 513927PRTArtificial
SequenceSynthetic peptide 1392Gly Gly Arg Val Leu Gly Gln1
513937PRTArtificial SequenceSynthetic peptide 1393Gly Gly Arg Val Arg Gly
Gly1 513947PRTArtificial SequenceSynthetic peptide 1394Gly
Gly Arg Val Arg Gly Gly1 513957PRTArtificial
SequenceSynthetic peptide 1395Trp Tyr Gly Gly Arg Gly Asn1
513967PRTArtificial SequenceSynthetic peptide 1396Cys Val Gly Leu Gly Cys
His1 513977PRTArtificial SequenceSynthetic peptide 1397Asn
Asn Val Gly Gly Ser Ser1 513987PRTArtificial
SequenceSynthetic peptide 1398Phe Met Thr Tyr Gly Ser Gly1
513997PRTArtificial SequenceSynthetic peptide 1399Gly Gly Gly Ser Gly Gly
Gly1 514007PRTArtificial SequenceSynthetic peptide 1400Trp
Asp Gln Gly Ser Gly Tyr1 514017PRTArtificial
SequenceSynthetic peptide 1401Gly Ser Val Leu Met Arg Gly1
514027PRTArtificial SequenceSynthetic peptide 1402Gly Gly Arg Val Leu Gly
Gln1 514037PRTArtificial SequenceSynthetic peptide 1403Gly
Gly Arg Val Arg Gly Gly1 514047PRTArtificial
SequenceSynthetic peptide 1404Gly Gly Arg Val Arg Gly Gly1
514057PRTArtificial SequenceSynthetic peptide 1405Tyr Met Tyr His Gly Arg
Val1 514067PRTArtificial SequenceSynthetic peptide 1406Gly
Arg Leu Ser Arg Ala Pro1 514077PRTArtificial
SequenceSynthetic peptide 1407Val Ala Gly Arg Leu Gln Met1
514087PRTArtificial SequenceSynthetic peptide 1408Ala Pro Gly Arg Leu Gly
Pro1 514097PRTArtificial SequenceSynthetic peptide 1409Ala
Pro Gly Arg Leu Gly Pro1 514107PRTArtificial
SequenceSynthetic peptide 1410Arg Asp Leu Ala Gly Pro Ser1
514117PRTArtificial SequenceSynthetic peptide 1411Arg Leu Ser Gly Ala Gly
Asp1 514127PRTArtificial SequenceSynthetic peptide 1412Leu
Gln Arg Gly Val Ala Arg1 514137PRTArtificial
SequenceSynthetic peptide 1413Arg Ala Val Gly Arg Gln Leu1
514147PRTArtificial SequenceSynthetic peptide 1414Ser Arg Ala Val Ile Arg
Leu1 514157PRTArtificial SequenceSynthetic peptide 1415Val
Arg Ala Ser Ser Lys Arg1 514167PRTArtificial
SequenceSynthetic peptide 1416Asp Gly Ala Gly Ser Leu Arg1
514177PRTArtificial SequenceSynthetic peptide 1417Ser Val Ser Gly Ala Gly
Ser1 514187PRTArtificial SequenceSynthetic peptide 1418Thr
Thr Leu Leu Ser Arg Gln1 514197PRTArtificial
SequenceSynthetic peptide 1419Val Ala Glu Leu Leu Ser Met1
514207PRTArtificial SequenceSynthetic peptide 1420Leu Pro Gly Arg Leu Arg
Val1 514217PRTArtificial SequenceSynthetic peptide 1421Leu
Lys Ala Gly Leu Arg Ser1 514227PRTArtificial
SequenceSynthetic peptide 1422His Arg Val Ser Glu Ser Val1
514237PRTArtificial SequenceSynthetic peptide 1423Tyr Tyr Gly Glu Arg Ser
Ser1 514247PRTArtificial SequenceSynthetic peptide 1424Asp
Gly Ala Gly Ser Leu Arg1 514257PRTArtificial
SequenceSynthetic peptide 1425Ser Val Ser Gly Ala Gly Ser1
514267PRTArtificial SequenceSynthetic peptide 1426Ala Gly Ser Val Tyr Ser
Val1 514277PRTArtificial SequenceSynthetic peptide 1427Ser
Ala Gly Leu Leu Pro Ser1 514287PRTArtificial
SequenceSynthetic peptide 1428Leu Lys Ala Gly Leu Arg Ser1
514297PRTArtificial SequenceSynthetic peptide 1429Arg Arg Ala Gly Gly Ser
Val1 514307PRTArtificial SequenceSynthetic peptide 1430Ser
Trp Ala Gly Val Arg Phe1 514317PRTArtificial
SequenceSynthetic peptide 1431Ile Tyr Pro Gly Ala Val Leu1
514327PRTArtificial SequenceSynthetic peptide 1432Leu Lys Ala Gly Leu Arg
Ser1 514337PRTArtificial SequenceSynthetic peptide 1433Ser
Leu Val Ser Pro Arg Thr1 514347PRTArtificial
SequenceSynthetic peptide 1434His Ala Ala Val Glu Pro Ser1
514357PRTArtificial SequenceSynthetic peptide 1435Thr Ala Ala Ala Val Leu
Leu1 514367PRTArtificial SequenceSynthetic peptide 1436Phe
His Phe Gly Gly Ser Gly1 514377PRTArtificial
SequenceSynthetic peptide 1437Gly Glu Gly Gly Ser Gly Gly1
514387PRTArtificial SequenceSynthetic peptide 1438Arg Arg Ala Gly Gly Ser
Val1 514397PRTArtificial SequenceSynthetic peptide 1439Ala
Leu Pro Gly Gly Gly Arg1 514407PRTArtificial
SequenceSynthetic peptide 1440Tyr Val Gly Gly Arg Leu Arg1
514417PRTArtificial SequenceSynthetic peptide 1441Gly Lys Gly Met Gly Leu
Gly1 514427PRTArtificial SequenceSynthetic peptide 1442Ser
Leu Gly Leu Gly Gly Leu1 514437PRTArtificial
SequenceSynthetic peptide 1443Asp Gly Gly Leu Asn Asp Cys1
514447PRTArtificial SequenceSynthetic peptide 1444Leu Gly Gly Leu Gly Leu
Ser1 514457PRTArtificial SequenceSynthetic peptide 1445Phe
His Phe Gly Gly Ser Gly1 514467PRTArtificial
SequenceSynthetic peptide 1446Gly Glu Gly Gly Ser Gly Gly1
514477PRTArtificial SequenceSynthetic peptide 1447Arg Arg Ala Gly Gly Ser
Val1 514487PRTArtificial SequenceSynthetic peptide 1448Ser
Gly Ala Gly Ser Val Ser1 514497PRTArtificial
SequenceSynthetic peptide 1449Ala Gly Ser Val Tyr Ser Val1
514507PRTArtificial SequenceSynthetic peptide 1450Gly Arg Val Thr Trp Arg
Ser1 514517PRTArtificial SequenceSynthetic peptide 1451Leu
Pro Gly Arg Leu Arg Val1 514527PRTArtificial
SequenceSynthetic peptide 1452Tyr Val Gly Gly Arg Leu Arg1
514537PRTArtificial SequenceSynthetic peptide 1453Gly Pro Ser Ser Ala Val
Glu1 514547PRTArtificial SequenceSynthetic peptide 1454Arg
Arg Leu Ser Tyr Arg Glu1 514557PRTArtificial
SequenceSynthetic peptide 1455His Thr Arg Ala Val Ser Glu1
514567PRTArtificial SequenceSynthetic peptide 1456Asn Val Ser Arg Ala Val
Gly1 514577PRTArtificial SequenceSynthetic peptide 1457Pro
Arg His Arg Ala Ser Gln1 514587PRTArtificial
SequenceSynthetic peptide 1458Leu Gly Ala Gly Met Ile Ala1
514597PRTArtificial SequenceSynthetic peptide 1459Ala Val Ser Leu Val Val
Leu1 514607PRTArtificial SequenceSynthetic peptide 1460His
Thr Arg Ala Val Ser Glu1 514617PRTArtificial
SequenceSynthetic peptide 1461Glu Leu Gly Leu Arg Val Pro1
514627PRTArtificial SequenceSynthetic peptide 1462Gly Arg Ser Ser Val Ser
Asp1 514637PRTArtificial SequenceSynthetic peptide 1463Tyr
Ala Gly Ser Gly Gln Leu1 514647PRTArtificial
SequenceSynthetic peptide 1464Ala Gly Arg Phe Gly Ala Arg1
514657PRTArtificial SequenceSynthetic peptide 1465Ala Ile Met Gly Ala Gly
Leu1 514667PRTArtificial SequenceSynthetic peptide 1466Thr
His Val Gly Gly Val Arg1 514677PRTArtificial
SequenceSynthetic peptide 1467Gly Val Leu Thr Arg Gly Asn1
514687PRTArtificial SequenceSynthetic peptide 1468Glu Leu Gly Leu Arg Val
Pro1 514697PRTArtificial SequenceSynthetic peptide 1469Gly
Leu Gly Leu Arg Leu Gly1 514707PRTArtificial
SequenceSynthetic peptide 1470Ile Asp Leu Val Ser Pro Gly1
514717PRTArtificial SequenceSynthetic peptide 1471Gly Gly Ser Thr Val Pro
Gln1 514727PRTArtificial SequenceSynthetic peptide 1472Gly
Leu Gly Leu Arg Leu Gly1 514737PRTArtificial
SequenceSynthetic peptide 1473Thr Ala Thr Gly Gly Leu Leu1
514747PRTArtificial SequenceSynthetic peptide 1474Gly Ser Asn Gly Ser Ser
His1 514757PRTArtificial SequenceSynthetic peptide 1475Leu
Gln Gly Ser Gly Ala Tyr1 514767PRTArtificial
SequenceSynthetic peptide 1476Leu Gln His Leu Gly Ser Gly1
514777PRTArtificial SequenceSynthetic peptide 1477Gly Pro Ser Val Leu Asp
Ile1 514787PRTArtificial SequenceSynthetic peptide 1478Gly
Ala Thr Gly Val Ser Ser1 514797PRTArtificial
SequenceSynthetic peptide 1479Thr Arg Leu Ser Phe Arg His1
514807PRTArtificial SequenceSynthetic peptide 1480Phe Leu Arg Gly Val Glu
Leu1 514817PRTArtificial SequenceSynthetic peptide 1481Asn
Ser Val Arg Gly Ser Arg1 514827PRTArtificial
SequenceSynthetic peptide 1482Asn Arg Ala Val Leu Ser Ala1
514837PRTArtificial SequenceSynthetic peptide 1483Leu Ile Gly Arg Ala Ser
Met1 514847PRTArtificial SequenceSynthetic peptide 1484Arg
Val Gly Ala Gly Ala Phe1 514857PRTArtificial
SequenceSynthetic peptide 1485Trp Ile Ser Ala Val Ser Lys1
514867PRTArtificial SequenceSynthetic peptide 1486Ser Ala Val Ser Glu Ser
Pro1 514877PRTArtificial SequenceSynthetic peptide 1487Arg
Val Gly Thr Leu Arg Val1 514887PRTArtificial
SequenceSynthetic peptide 1488Arg Val Ser Gly Asp Gly Lys1
514897PRTArtificial SequenceSynthetic peptide 1489Arg Ser Gly Arg Val Ser
Asn1 514907PRTArtificial SequenceSynthetic peptide 1490Arg
Val Ser Asn Glu Ala Leu1 514917PRTArtificial
SequenceSynthetic peptide 1491Arg Val Ser Ser Asp Pro Ile1
514927PRTArtificial SequenceSynthetic peptide 1492Val Arg Ser Ser Gly Val
Leu1 514937PRTArtificial SequenceSynthetic peptide 1493Ser
Gly Trp Phe Ala Gly Ser1 514947PRTArtificial
SequenceSynthetic peptide 1494Ala Gly Leu Gly Leu Leu Asp1
514957PRTArtificial SequenceSynthetic peptide 1495Ser Ala Ala Gly Leu Ala
Arg1 514967PRTArtificial SequenceSynthetic peptide 1496Phe
Ala Gly Ala Gly Val Arg1 514977PRTArtificial
SequenceSynthetic peptide 1497Val Arg Leu Thr Gly Val Arg1
514987PRTArtificial SequenceSynthetic peptide 1498Val Arg Ser Ser Gly Val
Leu1 514997PRTArtificial SequenceSynthetic peptide 1499Arg
Pro Trp Gly Ala Val Ala1 515007PRTArtificial
SequenceSynthetic peptide 1500Pro Val Ser Asp Gly Leu Val1
515017PRTArtificial SequenceSynthetic peptide 1501Asn Lys Gly Gly Leu Arg
Gln1 515027PRTArtificial SequenceSynthetic peptide 1502Gly
Gly Phe Leu Leu Val Ser1 515037PRTArtificial
SequenceSynthetic peptide 1503Leu Val Pro Leu Val Ser Gly1
515047PRTArtificial SequenceSynthetic peptide 1504Ala Arg Gly Gly Glu Ser
Ala1 515057PRTArtificial SequenceSynthetic peptide 1505Met
Ser Ala Arg Gly Ile Leu1 515067PRTArtificial
SequenceSynthetic peptide 1506Ala Ser Leu Val Ala Arg Asn1
515077PRTArtificial SequenceSynthetic peptide 1507Arg Val Glu Ala Ala Val
Pro1 515087PRTArtificial SequenceSynthetic peptide 1508Arg
Ala Leu Gly Ala Ala Ser1 515097PRTArtificial
SequenceSynthetic peptide 1509Ala Ser Glu Gly Gly Arg Ala1
515107PRTArtificial SequenceSynthetic peptide 1510Ile Gly Gly Arg Trp Val
Val1 515117PRTArtificial SequenceSynthetic peptide 1511Ala
Gly Leu Gly Leu Leu Asp1 515127PRTArtificial
SequenceSynthetic peptide 1512Leu Gly Gly Leu Ser Glu Arg1
515137PRTArtificial SequenceSynthetic peptide 1513Asn Lys Gly Gly Leu Arg
Gln1 515147PRTArtificial SequenceSynthetic peptide 1514Leu
Val Gly Ser Ser Arg Val1 515157PRTArtificial
SequenceSynthetic peptide 1515Tyr Thr Gly Ser Ser Pro Ser1
515167PRTArtificial SequenceSynthetic peptide 1516Gly Ser Val Leu Pro Val
Leu1 515177PRTArtificial SequenceSynthetic peptide 1517Lys
Gly Asp Gly Ser Val Arg1 515187PRTArtificial
SequenceSynthetic peptide 1518Gly Ser Val Ser His Arg Arg1
515197PRTArtificial SequenceSynthetic peptide 1519Arg Leu Trp Gly Ser Val
Val1 515207PRTArtificial SequenceSynthetic peptide 1520Met
Gln Gly Arg Val Ile Val1 515217PRTArtificial
SequenceSynthetic peptide 1521Arg Ser Gly Arg Val Ser Asn1
515227PRTArtificial SequenceSynthetic peptide 1522Leu Glu Val Gly Arg Leu
Phe1 515237PRTArtificial SequenceSynthetic peptide 1523Ser
Gln Phe Gly Pro Ser Phe1 515247PRTArtificial
SequenceSynthetic peptide 1524Ala Thr Leu Asp Gly Val Ser1
515257PRTArtificial SequenceSynthetic peptide 1525Arg Leu Ser Trp Thr Val
Leu1 515267PRTArtificial SequenceSynthetic peptide 1526Leu
Arg Phe Arg Arg Gly Val1 515277PRTArtificial
SequenceSynthetic peptide 1527Ala Arg Gly Arg Gly Ser Gln1
515287PRTArtificial SequenceSynthetic peptide 1528Val Leu Arg Gly Ser Thr
Pro1 515297PRTArtificial SequenceSynthetic peptide 1529Ala
Arg Leu Arg Ala Ser Arg1 515307PRTArtificial
SequenceSynthetic peptide 1530Arg Ile Gly Ala Gly His Arg1
515317PRTArtificial SequenceSynthetic peptide 1531Trp Leu Leu Ser Ser Glu
Ile1 515327PRTArtificial SequenceSynthetic peptide 1532Gly
Gly Leu Arg Val Gly Gly1 515337PRTArtificial
SequenceSynthetic peptide 1533Gly Leu Arg Val Tyr Glu Pro1
515347PRTArtificial SequenceSynthetic peptide 1534Tyr Leu Arg Ser Ala Gly
Met1 515357PRTArtificial SequenceSynthetic peptide 1535Arg
Val Ser Arg Ala Gly Gly1 515367PRTArtificial
SequenceSynthetic peptide 1536Ala Gly Arg Pro Gly Gly Tyr1
515377PRTArtificial SequenceSynthetic peptide 1537Tyr Gly Ala Leu Ala Gly
Leu1 515387PRTArtificial SequenceSynthetic peptide 1538Arg
Val Ser Arg Ala Gly Gly1 515397PRTArtificial
SequenceSynthetic peptide 1539Ser His Thr Ala Gly Gly Gly1
515407PRTArtificial SequenceSynthetic peptide 1540Ala Gly Gly Val Arg Asp
Leu1 515417PRTArtificial SequenceSynthetic peptide 1541Arg
Pro Ala Gly Gly Arg Thr1 515427PRTArtificial
SequenceSynthetic peptide 1542Gly Gly Val Arg Leu Gly Gly1
515437PRTArtificial SequenceSynthetic peptide 1543Ala Gly Gly Val Arg Asp
Leu1 515447PRTArtificial SequenceSynthetic peptide 1544Gly
Val Leu Gly Cys Asp Gly1 515457PRTArtificial
SequenceSynthetic peptide 1545Cys Gly Ala Val Ala Glu Trp1
515467PRTArtificial SequenceSynthetic peptide 1546Gly Asp Cys Gly Leu Val
Gly1 515477PRTArtificial SequenceSynthetic peptide 1547Gly
Gly Leu Arg Val Gly Gly1 515487PRTArtificial
SequenceSynthetic peptide 1548Gly Leu Arg Val Tyr Glu Pro1
515497PRTArtificial SequenceSynthetic peptide 1549Ala Arg Gly Arg Gly Ser
Gln1 515507PRTArtificial SequenceSynthetic peptide 1550Gly
Gly Arg Glu Leu Lys Ala1 515517PRTArtificial
SequenceSynthetic peptide 1551Gly Gly Gly Arg Arg Ala Leu1
515527PRTArtificial SequenceSynthetic peptide 1552Arg Pro Ala Gly Gly Arg
Thr1 515537PRTArtificial SequenceSynthetic peptide 1553Gly
Gly Leu Lys Val Trp Arg1 515547PRTArtificial
SequenceSynthetic peptide 1554Gly Gly Leu Arg Val Gly Gly1
515557PRTArtificial SequenceSynthetic peptide 1555Gly Gly Leu Pro Val Gln
Met1 515567PRTArtificial SequenceSynthetic peptide 1556Arg
Gln Asp Gly Gly Leu Tyr1 515577PRTArtificial
SequenceSynthetic peptide 1557Tyr Ala Thr Leu Gly Ser Ser1
515587PRTArtificial SequenceSynthetic peptide 1558Ser Gly Ser Gly Cys Val
Phe1 515597PRTArtificial SequenceSynthetic peptide 1559Val
Ser Gly Ser Gly Thr Ala1 515607PRTArtificial
SequenceSynthetic peptide 1560Val Gly Ser Val Lys Ala Ser1
515617PRTArtificial SequenceSynthetic peptide 1561Ala Thr Gly Ser Gly Ser
Val1 515627PRTArtificial SequenceSynthetic peptide 1562Pro
Thr Ser Gly Arg Leu Val1 515637PRTArtificial
SequenceSynthetic peptide 1563Leu Ala Cys Arg Gly Pro Ser1
515647PRTArtificial SequenceSynthetic peptide 1564Arg Gly Pro Ser Gln Val
Leu1 515657PRTArtificial SequenceSynthetic peptide 1565Thr
Leu Gly Arg Leu Ser Ser1 515667PRTArtificial
SequenceSynthetic peptide 1566Ala Gly Asp Arg Gly Val Ala1
515677PRTArtificial SequenceSynthetic peptide 1567Leu Pro Arg Arg Ala Val
Phe1 515687PRTArtificial SequenceSynthetic peptide 1568Arg
Ala Ser Cys Val Trp Arg1 515697PRTArtificial
SequenceSynthetic peptide 1569Phe Ser Lys Met Arg Ala Ser1
515707PRTArtificial SequenceSynthetic peptide 1570Asp Tyr Val Gly Ala Gly
Thr1 515717PRTArtificial SequenceSynthetic peptide 1571Ala
Arg Leu Leu Arg Gly Gly1 515727PRTArtificial
SequenceSynthetic peptide 1572Leu Leu Arg Ser Val Gly Tyr1
515737PRTArtificial SequenceSynthetic peptide 1573His Leu Arg Ser Gly Phe
Ser1 515747PRTArtificial SequenceSynthetic peptide 1574Leu
Leu Arg Ser Val Gly Tyr1 515757PRTArtificial
SequenceSynthetic peptide 1575Ala Gly Arg Pro Asp Gly Val1
515767PRTArtificial SequenceSynthetic peptide 1576Asp Glu Asn Arg Ala Gly
Leu1 515777PRTArtificial SequenceSynthetic peptide 1577Ala
Trp Ala Gly Gly Asp Met1 515787PRTArtificial
SequenceSynthetic peptide 1578Leu Asn Ala Gly Gly Ser Gly1
515797PRTArtificial SequenceSynthetic peptide 1579Asn Met Gly Ala Val Gly
Ser1 515807PRTArtificial SequenceSynthetic peptide 1580Pro
Ile Gly Ala Val Met Asn1 515817PRTArtificial
SequenceSynthetic peptide 1581Leu Thr Gly Gly Leu Val Phe1
515827PRTArtificial SequenceSynthetic peptide 1582Cys Gly Glu Gly Leu Val
Val1 515837PRTArtificial SequenceSynthetic peptide 1583Ser
Asp Leu Gly Leu Arg Arg1 515847PRTArtificial
SequenceSynthetic peptide 1584His Ala Asp Val Leu Val Ser1
515857PRTArtificial SequenceSynthetic peptide 1585Phe Ser Asn Ala Arg Gly
Tyr1 515867PRTArtificial SequenceSynthetic peptide 1586Ala
Ala Val Trp Trp Ala Ala1 515877PRTArtificial
SequenceSynthetic peptide 1587Leu Asn Ala Gly Gly Ser Gly1
515887PRTArtificial SequenceSynthetic peptide 1588Gly Gly Ser Ala Trp Trp
Gly1 515897PRTArtificial SequenceSynthetic peptide 1589Val
Tyr Gly Trp Gly Gly Ser1 515907PRTArtificial
SequenceSynthetic peptide 1590Gly Gly Arg Leu Leu Arg Ala1
515917PRTArtificial SequenceSynthetic peptide 1591Leu Gly Gly Arg Thr Ile
Ser1 515927PRTArtificial SequenceSynthetic peptide 1592Tyr
Leu Gly Leu Gly Gly Leu1 515937PRTArtificial
SequenceSynthetic peptide 1593Ser Ile Thr Arg Gly Gly Leu1
515947PRTArtificial SequenceSynthetic peptide 1594Leu Thr Gly Gly Leu Val
Phe1 515957PRTArtificial SequenceSynthetic peptide 1595Leu
Gly Gly Leu Gly Leu Tyr1 515967PRTArtificial
SequenceSynthetic peptide 1596Gly Ser Ser Glu Leu Ser Arg1
515977PRTArtificial SequenceSynthetic peptide 1597Gly Ser Gly Gly Ala Asn
Leu1 515987PRTArtificial SequenceSynthetic peptide 1598Val
Asp Gly Ser Gly Asp Asp1 515997PRTArtificial
SequenceSynthetic peptide 1599Arg Ser Leu Gly Ser Val Gly1
516007PRTArtificial SequenceSynthetic peptide 1600Gly Arg Val Lys Pro Gly
Ala1 516017PRTArtificial SequenceSynthetic peptide 1601Gly
Gly Arg Leu Leu Arg Ala1 516027PRTArtificial
SequenceSynthetic peptide 1602Gly Arg Leu Trp Tyr Val Ala1
516037PRTArtificial SequenceSynthetic peptide 1603Thr Leu Gly Arg Leu Ser
Ser1 516047PRTArtificial SequenceSynthetic peptide 1604Gly
Val Ser Gly Leu Ser Arg1 516057PRTArtificial
SequenceSynthetic peptide 1605Tyr Gly Val Ser Arg Leu Leu1
516067PRTArtificial SequenceSynthetic peptide 1606Ser Arg Leu Ser Tyr Arg
Ala1 516077PRTArtificial SequenceSynthetic peptide 1607Ile
His Arg Gly Val Trp Gly1 516087PRTArtificial
SequenceSynthetic peptide 1608Tyr Phe Arg Ala Arg Gly Ser1
516097PRTArtificial SequenceSynthetic peptide 1609Gly Ala Gly Arg Phe Pro
His1 516107PRTArtificial SequenceSynthetic peptide 1610Ser
Gly Ala Gly Ala Ala Phe1 516117PRTArtificial
SequenceSynthetic peptide 1611Val Asp Val Gly Gly Ala Gly1
516127PRTArtificial SequenceSynthetic peptide 1612Ala Ser Ala Gly Ala Val
Ser1 516137PRTArtificial SequenceSynthetic peptide 1613Ala
Arg Tyr Ser Leu Arg Ser1 516147PRTArtificial
SequenceSynthetic peptide 1614Arg Leu Arg Ser Tyr Val Ala1
516157PRTArtificial SequenceSynthetic peptide 1615Ser Arg Lys Gly Leu Arg
Ser1 516167PRTArtificial SequenceSynthetic peptide 1616Ser
Val Thr Gly Arg Val Ser1 516177PRTArtificial
SequenceSynthetic peptide 1617Ala Gly Ser Ala Phe Trp Ala1
516187PRTArtificial SequenceSynthetic peptide 1618Asp Gln Gln Glu Ala Gly
Ser1 516197PRTArtificial SequenceSynthetic peptide 1619Phe
Ala Ala Gly Ala Gly Ser1 516207PRTArtificial
SequenceSynthetic peptide 1620Gly Ala Gly Arg Phe Pro His1
516217PRTArtificial SequenceSynthetic peptide 1621Gly Ala Gly Gly Val Asp
Val1 516227PRTArtificial SequenceSynthetic peptide 1622Ala
Ser Ala Gly Ala Val Ser1 516237PRTArtificial
SequenceSynthetic peptide 1623Arg Arg Asp Gly Leu Val Glu1
516247PRTArtificial SequenceSynthetic peptide 1624Ser Arg Lys Gly Leu Arg
Ser1 516257PRTArtificial SequenceSynthetic peptide 1625Gly
Asp Ala Thr Leu Val Ser1 516267PRTArtificial
SequenceSynthetic peptide 1626Gly Asp Ala Thr Leu Val Ser1
516277PRTArtificial SequenceSynthetic peptide 1627Tyr Phe Arg Ala Arg Gly
Ser1 516287PRTArtificial SequenceSynthetic peptide 1628Asp
Arg Gly Leu Gly Met Ser1 516297PRTArtificial
SequenceSynthetic peptide 1629Gly Ser Gly Tyr Phe Ile Thr1
516307PRTArtificial SequenceSynthetic peptide 1630Ser Val Thr Gly Arg Val
Ser1 516317PRTArtificial SequenceSynthetic peptide 1631Val
Gly Pro Ser Val His Leu1 516327PRTArtificial
SequenceSynthetic peptide 1632Glu Gly Val Arg Gly Val Phe1
516337PRTArtificial SequenceSynthetic peptide 1633Gly Asp Arg Gly Val Arg
Gly1 516347PRTArtificial SequenceSynthetic peptide 1634Met
Arg Gly Val Ala Arg Lys1 516357PRTArtificial
SequenceSynthetic peptide 1635Lys Arg Ala Val Gly Arg Met1
516367PRTArtificial SequenceSynthetic peptide 1636Asp Arg Ala Ser Ser Trp
Ala1 516377PRTArtificial SequenceSynthetic peptide 1637Leu
Gln Gly Ala Gly Ile His1 516387PRTArtificial
SequenceSynthetic peptide 1638Trp Leu Leu Arg Gly Phe Gly1
516397PRTArtificial SequenceSynthetic peptide 1639Ala Ser Pro Pro Leu Arg
Ser1 516407PRTArtificial SequenceSynthetic peptide 1640Arg
Val Ser Ser Glu Thr Phe1 516417PRTArtificial
SequenceSynthetic peptide 1641Ala Arg Ala Gly Ser Thr Phe1
516427PRTArtificial SequenceSynthetic peptide 1642Thr Phe Ala Gly Arg Ser
Leu1 516437PRTArtificial SequenceSynthetic peptide 1643Tyr
Ala Ala Gly Gly Ser Thr1 516447PRTArtificial
SequenceSynthetic peptide 1644Glu Gly Val Arg Gly Val Phe1
516457PRTArtificial SequenceSynthetic peptide 1645Gly Asp Arg Gly Val Arg
Gly1 516467PRTArtificial SequenceSynthetic peptide 1646Pro
Gly Val Leu Arg Glu Pro1 516477PRTArtificial
SequenceSynthetic peptide 1647Gly Leu Arg Asp Gly Val Glu1
516487PRTArtificial SequenceSynthetic peptide 1648Phe Pro Ala Arg Gly Glu
Asp1 516497PRTArtificial SequenceSynthetic peptide 1649Met
Leu Gly Ser Ala Ser Leu1 516507PRTArtificial
SequenceSynthetic peptide 1650His Gly Gly Ser Asn Asp Arg1
516517PRTArtificial SequenceSynthetic peptide 1651Tyr Ala Ala Gly Gly Ser
Thr1 516527PRTArtificial SequenceSynthetic peptide 1652Gln
Gly Gly Arg Ser Gly Val1 516537PRTArtificial
SequenceSynthetic peptide 1653Trp Thr Val Gly Gly Arg Val1
516547PRTArtificial SequenceSynthetic peptide 1654Val Lys Gly Ser Ser Met
Arg1 516557PRTArtificial SequenceSynthetic peptide 1655Phe
Val Gly Arg Val Gly Glu1 516567PRTArtificial
SequenceSynthetic peptide 1656Gly Arg Val Gly Arg Asp Gly1
516577PRTArtificial SequenceSynthetic peptide 1657Ser Val Ser Arg Gly Arg
Val1 516587PRTArtificial SequenceSynthetic peptide 1658Trp
Thr Val Gly Gly Arg Val1 516597PRTArtificial
SequenceSynthetic peptide 1659Gly Phe Gly Arg Leu Leu Trp1
516607PRTArtificial SequenceSynthetic peptide 1660Ala Ala Tyr Trp Gly Pro
Ser1 516617PRTArtificial SequenceSynthetic peptide 1661Met
Asp Gly Val Ser Thr Glu1 516627PRTArtificial
SequenceSynthetic peptide 1662Val Tyr Trp Trp Gly Val Ser1
516637PRTArtificial SequenceSynthetic peptide 1663Arg Leu Ser Met Ala Ser
Arg1 516647PRTArtificial SequenceSynthetic peptide 1664Gly
Arg Leu Ser Phe Gly Val1 516657PRTArtificial
SequenceSynthetic peptide 1665Gly Leu Ser Arg Gly Val Leu1
516667PRTArtificial SequenceSynthetic peptide 1666Leu Arg Gly Ser His Val
Ala1 516677PRTArtificial SequenceSynthetic peptide 1667Asn
Met Gly Arg Gly Ser Leu1 516687PRTArtificial
SequenceSynthetic peptide 1668Ser Val Val Arg Arg Gly Ser1
516697PRTArtificial SequenceSynthetic peptide 1669Val Met Gly Ala Gly Val
Gln1 516707PRTArtificial SequenceSynthetic peptide 1670Pro
Leu Leu Arg Gln Gln Leu1 516717PRTArtificial
SequenceSynthetic peptide 1671Ser Asn Gly Leu Arg Val Val1
516727PRTArtificial SequenceSynthetic peptide 1672Leu Arg Ser Met Ala Val
Met1 516737PRTArtificial SequenceSynthetic peptide 1673Val
Asp Leu Arg Ser Ala Phe1 516747PRTArtificial
SequenceSynthetic peptide 1674Phe Arg Val Ser Leu Gly Tyr1
516757PRTArtificial SequenceSynthetic peptide 1675Arg Ser Ser Tyr Ala Pro
Pro1 516767PRTArtificial SequenceSynthetic peptide 1676Phe
Pro Gly Ser Ala Gly Ser1 516777PRTArtificial
SequenceSynthetic peptide 1677Phe Ala Gly Arg Ala Pro Arg1
516787PRTArtificial SequenceSynthetic peptide 1678Phe Ile Ala Gly Gly Val
Gly1 516797PRTArtificial SequenceSynthetic peptide 1679Leu
Ile His Ala Gly Gly Gln1 516807PRTArtificial
SequenceSynthetic peptide 1680Arg Ala Gly Gly Gly Ala Pro1
516817PRTArtificial SequenceSynthetic peptide 1681Thr Trp His Ala Gly Gly
Ile1 516827PRTArtificial SequenceSynthetic peptide 1682Gly
Val Arg Ser Ile Thr Leu1 516837PRTArtificial
SequenceSynthetic peptide 1683Gly Leu Ser Arg Gly Val Leu1
516847PRTArtificial SequenceSynthetic peptide 1684Arg Val Val Gly Ala Val
Leu1 516857PRTArtificial SequenceSynthetic peptide 1685Phe
Gly Leu Arg Met Ser Asn1 516867PRTArtificial
SequenceSynthetic peptide 1686Leu Gly Leu Arg Gly Trp Thr1
516877PRTArtificial SequenceSynthetic peptide 1687Ala Phe Phe Met Gly Leu
Arg1 516887PRTArtificial SequenceSynthetic peptide 1688Ser
Asn Gly Leu Arg Val Val1 516897PRTArtificial
SequenceSynthetic peptide 1689Ala Arg Gly Thr Met Thr Gly1
516907PRTArtificial SequenceSynthetic peptide 1690Arg Pro Ala Arg Gly Ala
Phe1 516917PRTArtificial SequenceSynthetic peptide 1691Ala
Ser Leu Pro Met Leu His1 516927PRTArtificial
SequenceSynthetic peptide 1692Gly Gly Ser Val Glu Gly Gln1
516937PRTArtificial SequenceSynthetic peptide 1693Leu Gly Gly Arg Gln Glu
Ser1 516947PRTArtificial SequenceSynthetic peptide 1694Asn
Gly Gly Arg Val Leu Ser1 516957PRTArtificial
SequenceSynthetic peptide 1695Pro Ile Gly Gly Leu Phe Gly1
516967PRTArtificial SequenceSynthetic peptide 1696Ala Glu Cys Cys Gly Gly
Leu1 516977PRTArtificial SequenceSynthetic peptide 1697Ser
Glu Gln Arg Gly Gly Leu1 516987PRTArtificial
SequenceSynthetic peptide 1698Asp Arg Phe Gly Ser Ser Ala1
516997PRTArtificial SequenceSynthetic peptide 1699Gly His Gly Ser Gly Ser
Arg1 517007PRTArtificial SequenceSynthetic peptide 1700Gly
Gly Ser Val Glu Gly Gln1 517017PRTArtificial
SequenceSynthetic peptide 1701Gly Ser Val Val Ser Ser Trp1
517027PRTArtificial SequenceSynthetic peptide 1702Asn Gly Gly Arg Val Leu
Ser1 517037PRTArtificial SequenceSynthetic peptide 1703Gly
Arg Leu Met Pro Gly Gly1 517047PRTArtificial
SequenceSynthetic peptide 1704Thr Trp Gly Arg Leu Gly Leu1
517057PRTArtificial SequenceSynthetic peptide 1705Ala Val His Ser Gly Arg
Leu1 517067PRTArtificial SequenceSynthetic peptide 1706Gly
Arg Leu Ser Phe Gly Val1 517077PRTArtificial
SequenceSynthetic peptide 1707Pro Gln Gly Pro Ser Ser Val1
517087PRTArtificial SequenceSynthetic peptide 1708Ala Gly Trp Arg Leu Ser
Gln1 517097PRTArtificial SequenceSynthetic peptide 1709Arg
Val Asp Arg Gly Ser Leu1 517107PRTArtificial
SequenceSynthetic peptide 1710Arg Ala Val Cys Glu Trp Asp1
517117PRTArtificial SequenceSynthetic peptide 1711Arg Ala Val Glu Arg Val
Ala1 517127PRTArtificial SequenceSynthetic peptide 1712Ala
Val Phe Arg Ala Ser Arg1 517137PRTArtificial
SequenceSynthetic peptide 1713Gly Ala Gly Ser Ser Val Trp1
517147PRTArtificial SequenceSynthetic peptide 1714Gly Ala Gly Ser Ser Val
Trp1 517157PRTArtificial SequenceSynthetic peptide 1715Trp
Leu Leu Arg Ser Trp Ser1 517167PRTArtificial
SequenceSynthetic peptide 1716Arg Lys Glu Ala Leu Arg Val1
517177PRTArtificial SequenceSynthetic peptide 1717Arg Leu Arg Val Ser Val
Arg1 517187PRTArtificial SequenceSynthetic peptide 1718Leu
Arg Pro Gly Leu Arg Ser1 517197PRTArtificial
SequenceSynthetic peptide 1719Gln Arg Tyr His Leu Arg Ser1
517207PRTArtificial SequenceSynthetic peptide 1720Trp Leu Leu Arg Ser Trp
Ser1 517217PRTArtificial SequenceSynthetic peptide 1721Gly
Arg Glu Arg Val Ser His1 517227PRTArtificial
SequenceSynthetic peptide 1722Arg Val Ser Val Arg Leu Arg1
517237PRTArtificial SequenceSynthetic peptide 1723Gly Ala Gly Ser Ser Val
Trp1 517247PRTArtificial SequenceSynthetic peptide 1724Gly
Ala Gly Ser Ser Val Trp1 517257PRTArtificial
SequenceSynthetic peptide 1725Ala Gly Leu Trp Pro Trp Asn1
517267PRTArtificial SequenceSynthetic peptide 1726Gly Val Arg Gly Gly Gly
Asp1 517277PRTArtificial SequenceSynthetic peptide 1727Gly
Leu Val Arg Arg Val Val1 517287PRTArtificial
SequenceSynthetic peptide 1728Leu Arg Pro Gly Leu Arg Ser1
517297PRTArtificial SequenceSynthetic peptide 1729Trp Ala His Ala Ala Ser
Tyr1 517307PRTArtificial SequenceSynthetic peptide 1730Asp
Gly Gly Gly Arg Val Gly1 517317PRTArtificial
SequenceSynthetic peptide 1731Val Gly Val Met Gly Gly Arg1
517327PRTArtificial SequenceSynthetic peptide 1732Val Tyr Gly Gly Arg Ser
Glu1 517337PRTArtificial SequenceSynthetic peptide 1733Thr
Ile Cys Leu Gly Leu Gly1 517347PRTArtificial
SequenceSynthetic peptide 1734Gly Ala Gly Ser Ser Val Trp1
517357PRTArtificial SequenceSynthetic peptide 1735Gly Ala Gly Ser Ser Val
Trp1 517367PRTArtificial SequenceSynthetic peptide 1736Asp
His Val Ser Gly Ser Val1 517377PRTArtificial
SequenceSynthetic peptide 1737Asp Gly Gly Gly Arg Val Gly1
517387PRTArtificial SequenceSynthetic peptide 1738Gly Glu Gly Arg Leu Cys
Gly1 517397PRTArtificial SequenceSynthetic peptide 1739Gly
Val Ala Ile Gly Arg Leu1 517407PRTArtificial
SequenceSynthetic peptide 1740Phe Gly Val Ser Gln Val His1
517417PRTArtificial SequenceSynthetic peptide 1741Gly Gly Val Ser Arg Met
Arg1 517427PRTArtificial SequenceSynthetic peptide 1742Gly
Arg Ile Arg Leu Ser Phe1 517437PRTArtificial
SequenceSynthetic peptide 1743Arg Gly Val Asn Tyr Arg Ser1
517447PRTArtificial SequenceSynthetic peptide 1744Thr Glu Gly Thr Arg Gly
Val1 517457PRTArtificial SequenceSynthetic peptide 1745Gly
Tyr Ala Arg Gly Ser Gly1 517467PRTArtificial
SequenceSynthetic peptide 1746Gly Val Trp Leu Arg Gly Ser1
517477PRTArtificial SequenceSynthetic peptide 1747Ala Ala Arg Ala Val Trp
Gly1 517487PRTArtificial SequenceSynthetic peptide 1748Arg
Ala Ser Tyr Tyr Gly Val1 517497PRTArtificial
SequenceSynthetic peptide 1749Gly Ala Gly Val Glu Tyr Phe1
517507PRTArtificial SequenceSynthetic peptide 1750Leu Leu Leu Leu Ser Gly
Ser1 517517PRTArtificial SequenceSynthetic peptide 1751Val
Leu Leu Ser Ala Gly Leu1 517527PRTArtificial
SequenceSynthetic peptide 1752Thr Gly Leu Leu Arg Leu Tyr1
517537PRTArtificial SequenceSynthetic peptide 1753Leu Arg Ser Ser Leu Val
Ser1 517547PRTArtificial SequenceSynthetic peptide 1754Leu
Arg Ser Ser Leu Val Ser1 517557PRTArtificial
SequenceSynthetic peptide 1755Pro Arg Ser Ser Gly Pro Met1
517567PRTArtificial SequenceSynthetic peptide 1756Thr Ala Gly Arg Leu Glu
Val1 517577PRTArtificial SequenceSynthetic peptide 1757Ala
Gly Leu Glu Asp Leu Gly1 517587PRTArtificial
SequenceSynthetic peptide 1758Met Pro Ala Gly Leu Gly Val1
517597PRTArtificial SequenceSynthetic peptide 1759Val Leu Leu Ser Ala Gly
Leu1 517607PRTArtificial SequenceSynthetic peptide 1760Gly
Val Arg Trp Asn Trp Ser1 517617PRTArtificial
SequenceSynthetic peptide 1761Thr Arg Asp Gly Val Arg Trp1
517627PRTArtificial SequenceSynthetic peptide 1762Arg Ala His Gly Leu Val
Cys1 517637PRTArtificial SequenceSynthetic peptide 1763Leu
Gly Ser Ser Gly Leu Arg1 517647PRTArtificial
SequenceSynthetic peptide 1764Leu Leu Val Ser Leu Ser Ser1
517657PRTArtificial SequenceSynthetic peptide 1765Leu Arg Ser Ser Leu Val
Ser1 517667PRTArtificial SequenceSynthetic peptide 1766Leu
Val Ser Thr Arg Trp Ala1 517677PRTArtificial
SequenceSynthetic peptide 1767Leu Val Ser Tyr Ser Ala Val1
517687PRTArtificial SequenceSynthetic peptide 1768Gly Tyr Ala Arg Gly Ser
Gly1 517697PRTArtificial SequenceSynthetic peptide 1769Leu
Gly Ala Ser Leu Leu Val1 517707PRTArtificial
SequenceSynthetic peptide 1770Gly Thr Gly Ala Ala Val Phe1
517717PRTArtificial SequenceSynthetic peptide 1771Ala Ala Val Gly Thr Ala
Leu1 517727PRTArtificial SequenceSynthetic peptide 1772Val
Ser Ala Ala Ser Ser Val1 517737PRTArtificial
SequenceSynthetic peptide 1773Arg Gly Gly Ser Pro Pro Val1
517747PRTArtificial SequenceSynthetic peptide 1774Val Pro Pro Ser Gly Gly
Arg1 517757PRTArtificial SequenceSynthetic peptide 1775Gly
Leu Gly Ser Cys Ala Pro1 517767PRTArtificial
SequenceSynthetic peptide 1776Met Pro Ala Gly Leu Gly Val1
517777PRTArtificial SequenceSynthetic peptide 1777Met Pro Gly Ser Ser Arg
Pro1 517787PRTArtificial SequenceSynthetic peptide 1778Gly
Ser Ser Leu Ser Arg Pro1 517797PRTArtificial
SequenceSynthetic peptide 1779Arg Leu Gly Ser Ser Gly Leu1
517807PRTArtificial SequenceSynthetic peptide 1780Gly Tyr Ala Arg Gly Ser
Gly1 517817PRTArtificial SequenceSynthetic peptide 1781Ser
Gly Arg Leu Trp Val Gly1 517827PRTArtificial
SequenceSynthetic peptide 1782Thr Ala Gly Arg Leu Glu Val1
517837PRTArtificial SequenceSynthetic peptide 1783Gly Pro Ser Phe Asp Ala
Lys1 517847PRTArtificial SequenceSynthetic peptide 1784Ala
Cys Thr Gly Val Ser Arg1 517857PRTArtificial
SequenceSynthetic peptide 1785Leu Gly Met Gly Arg Gly Val1
517867PRTArtificial SequenceSynthetic peptide 1786Met Leu Gly Arg Gly Ser
Val1 517877PRTArtificial SequenceSynthetic peptide 1787Pro
Arg Ala Ser Ser Thr Gly1 517887PRTArtificial
SequenceSynthetic peptide 1788Arg Ala Ser Cys Phe Trp Asp1
517897PRTArtificial SequenceSynthetic peptide 1789Arg Ala Ser Cys Phe Trp
Asp1 517907PRTArtificial SequenceSynthetic peptide 1790Phe
Leu Leu Leu Ser His Arg1 517917PRTArtificial
SequenceSynthetic peptide 1791Leu Leu Ser Val Thr Ser Xaa1
517927PRTArtificial SequenceSynthetic peptide 1792Pro Leu Leu Arg Glu Val
Gly1 517937PRTArtificial SequenceSynthetic peptide 1793Leu
Arg Val Gly His Ala Gly1 517947PRTArtificial
SequenceSynthetic peptide 1794Asn Glu Leu Arg Val Cys Arg1
517957PRTArtificial SequenceSynthetic peptide 1795Met Arg Tyr Glu Leu Arg
Ser1 517967PRTArtificial SequenceSynthetic peptide 1796Arg
Val Ser Val Trp Trp Ala1 517977PRTArtificial
SequenceSynthetic peptide 1797Phe Ala Gln Arg Arg Val Ser1
517987PRTArtificial SequenceSynthetic peptide 1798Ser His His Arg Ser Ser
Ile1 517997PRTArtificial SequenceSynthetic peptide 1799Cys
Met Ala Gly Ser Gln Asp1 518007PRTArtificial
SequenceSynthetic peptide 1800Arg Tyr Gly Thr Ala Gly Ser1
518017PRTArtificial SequenceSynthetic peptide 1801Ser Ala Gly Ser His Pro
Ala1 518027PRTArtificial SequenceSynthetic peptide 1802Pro
Asn Ser Ala Gly Ser Val1 518037PRTArtificial
SequenceSynthetic peptide 1803Lys Met Arg Ile Ala Gly Arg1
518047PRTArtificial SequenceSynthetic peptide 1804Met Glu Arg Val Ala Gly
Arg1 518057PRTArtificial SequenceSynthetic peptide 1805Trp
Ala Gly Leu Ser Arg Pro1 518067PRTArtificial
SequenceSynthetic peptide 1806Gly Ala His Gly Val Arg Leu1
518077PRTArtificial SequenceSynthetic peptide 1807Arg Val Pro Thr Gly Val
Arg1 518087PRTArtificial SequenceSynthetic peptide 1808Arg
Gly Ala Val Arg Glu Met1 518097PRTArtificial
SequenceSynthetic peptide 1809Phe Asp Pro Gly Gly Leu Arg1
518107PRTArtificial SequenceSynthetic peptide 1810Ile Leu Ser Asp Leu Val
Ser1 518117PRTArtificial SequenceSynthetic peptide 1811Leu
Leu Asn Pro Ala Arg Gly1 518127PRTArtificial
SequenceSynthetic peptide 1812Trp Trp Ala Ala Val Pro Gly1
518137PRTArtificial SequenceSynthetic peptide 1813Lys Ala Ala Ser Thr Glu
Asp1 518147PRTArtificial SequenceSynthetic peptide 1814Ser
Tyr Met Gly Ala Ala Ser1 518157PRTArtificial
SequenceSynthetic peptide 1815Gly Gly Ser Ile Asp Cys Cys1
518167PRTArtificial SequenceSynthetic peptide 1816Gly Pro Gly Gly Ser Lys
Arg1 518177PRTArtificial SequenceSynthetic peptide 1817Ala
Phe Gly Gly Gly Ser Met1 518187PRTArtificial
SequenceSynthetic peptide 1818Pro Glu Gly Gly Arg Arg Pro1
518197PRTArtificial SequenceSynthetic peptide 1819Gly Gly Leu Glu Gln Asp
Gly1 518207PRTArtificial SequenceSynthetic peptide 1820Phe
Asp Pro Gly Gly Leu Arg1 518217PRTArtificial
SequenceSynthetic peptide 1821Leu Phe Gly Ser Ser Val Ser1
518227PRTArtificial SequenceSynthetic peptide 1822Trp Asp Gly Ser Ser Val
Ser1 518237PRTArtificial SequenceSynthetic peptide 1823Pro
Asn Ser Ala Gly Ser Val1 518247PRTArtificial
SequenceSynthetic peptide 1824Met Leu Gly Arg Gly Ser Val1
518257PRTArtificial SequenceSynthetic peptide 1825Thr Arg Arg Gly Arg Leu
Asp1 518267PRTArtificial SequenceSynthetic peptide 1826Gly
Val Ser Ile Ser Asp Gly1 518277PRTArtificial
SequenceSynthetic peptide 1827Gly Val Ser Ile Tyr Asp Leu1
518287PRTArtificial SequenceSynthetic peptide 1828Ala Arg Leu Ser Leu Glu
Leu1 518297PRTArtificial SequenceSynthetic peptide 1829Arg
Leu Arg Leu Ser Ser Trp1 518307PRTArtificial
SequenceSynthetic peptide 1830Arg Arg Leu Ser Ser Ile Ala1
518317PRTArtificial SequenceSynthetic peptide 1831Ser Arg Leu Ser Tyr Arg
Thr1 518327PRTArtificial SequenceSynthetic peptide 1832Ala
Arg Gly Ser Trp Arg Glu1 518337PRTArtificial
SequenceSynthetic peptide 1833Val Arg Leu Arg Ala Val Phe1
518347PRTArtificial SequenceSynthetic peptide 1834Arg Ala Ser Arg Ile Gly
Leu1 518357PRTArtificial SequenceSynthetic peptide 1835Gly
Ala Gly Thr Ser Glu Gly1 518367PRTArtificial
SequenceSynthetic peptide 1836Leu Leu Ser Thr Val Trp Val1
518377PRTArtificial SequenceSynthetic peptide 1837Glu Leu Arg Arg Leu Leu
Ser1 518387PRTArtificial SequenceSynthetic peptide 1838Leu
Leu Arg Gly Leu Arg Pro1 518397PRTArtificial
SequenceSynthetic peptide 1839Ser Leu Leu Arg Arg Leu Glu1
518407PRTArtificial SequenceSynthetic peptide 1840Leu Arg Val Ser Arg Gly
Leu1 518417PRTArtificial SequenceSynthetic peptide 1841Thr
Leu Gly Leu Arg Val Pro1 518427PRTArtificial
SequenceSynthetic peptide 1842Phe Val Ala Arg Leu Arg Val1
518437PRTArtificial SequenceSynthetic peptide 1843Gly Val Tyr Trp Leu Arg
Ser1 518447PRTArtificial SequenceSynthetic peptide 1844Ser
Phe Trp Trp Leu Arg Ser1 518457PRTArtificial
SequenceSynthetic peptide 1845Thr Arg Tyr Ser Leu Arg Ser1
518467PRTArtificial SequenceSynthetic peptide 1846Leu Arg Val Ser Arg Gly
Leu1 518477PRTArtificial SequenceSynthetic peptide 1847Arg
Ser Ser Ser Gly Ser Gly1 518487PRTArtificial
SequenceSynthetic peptide 1848Thr Arg Ser Ser Leu Thr His1
518497PRTArtificial SequenceSynthetic peptide 1849Thr Gly Arg Ser Ser Phe
Trp1 518507PRTArtificial SequenceSynthetic peptide 1850Asn
Ala Gly Arg Gly Ala Ser1 518517PRTArtificial
SequenceSynthetic peptide 1851His Ala Gly Leu Leu Val Val1
518527PRTArtificial SequenceSynthetic peptide 1852His Thr Tyr Gly Val Arg
Phe1 518537PRTArtificial SequenceSynthetic peptide 1853Gly
Ala Val Arg Ser Val Met1 518547PRTArtificial
SequenceSynthetic peptide 1854Val Leu Val Glu Gly Ala Val1
518557PRTArtificial SequenceSynthetic peptide 1855Leu Leu Arg Gly Leu Arg
Pro1 518567PRTArtificial SequenceSynthetic peptide 1856Thr
Leu Gly Leu Arg Val Pro1 518577PRTArtificial
SequenceSynthetic peptide 1857Ala Arg Gly Ser Trp Arg Glu1
518587PRTArtificial SequenceSynthetic peptide 1858Gly Leu Trp Ala Ala Val
Leu1 518597PRTArtificial SequenceSynthetic peptide 1859Gly
Trp Thr Met Ala Ala Ser1 518607PRTArtificial
SequenceSynthetic peptide 1860Leu Tyr Met Gly Gly Ser His1
518617PRTArtificial SequenceSynthetic peptide 1861Gly Val Gly Gly Arg Gln
Ser1 518627PRTArtificial SequenceSynthetic peptide 1862Arg
Arg Gly Leu Gly Asp Ala1 518637PRTArtificial
SequenceSynthetic peptide 1863Thr Gly Gly Leu His Trp Tyr1
518647PRTArtificial SequenceSynthetic peptide 1864Gly Ser Gly Ser Ser Ser
Arg1 518657PRTArtificial SequenceSynthetic peptide 1865Gly
Ser Ser Thr Leu Gln Trp1 518667PRTArtificial
SequenceSynthetic peptide 1866Arg Ser Ser Ser Gly Ser Gly1
518677PRTArtificial SequenceSynthetic peptide 1867Asp Glu Leu Gly Ser Val
Gln1 518687PRTArtificial SequenceSynthetic peptide 1868Gly
Arg Leu Arg Pro Phe Ser1 518697PRTArtificial
SequenceSynthetic peptide 1869Pro Arg Leu Gly Arg Leu Leu1
518707PRTArtificial SequenceSynthetic peptide 1870Val Gly Val Ser Gln Glu
Trp1 518717PRTArtificial SequenceSynthetic peptide 1871Asp
Gly Val Ser Pro Leu Trp1 518727PRTArtificial
SequenceSynthetic peptide 1872Pro Arg Gly Ser Leu Phe Ala1
518737PRTArtificial SequenceSynthetic peptide 1873Val Ile Val Arg Gly Ser
Leu1 518747PRTArtificial SequenceSynthetic peptide 1874Gly
Asp Arg Ala Val Gly Leu1 518757PRTArtificial
SequenceSynthetic peptide 1875Val His Lys Arg Ala Val Leu1
518767PRTArtificial SequenceSynthetic peptide 1876Gly Gly Ala Gly Ser Arg
Arg1 518777PRTArtificial SequenceSynthetic peptide 1877Arg
Leu Glu Thr Leu Leu Ser1 518787PRTArtificial
SequenceSynthetic peptide 1878Leu Leu Arg Ala Gly Val Arg1
518797PRTArtificial SequenceSynthetic peptide 1879Pro Ala Ile Leu Arg Val
Arg1 518807PRTArtificial SequenceSynthetic peptide 1880Gly
Asp Leu Arg Val Ser Val1 518817PRTArtificial
SequenceSynthetic peptide 1881Gly Asp Leu Arg Val Ser Val1
518827PRTArtificial SequenceSynthetic peptide 1882Gly Gly Ala Gly Ser Arg
Arg1 518837PRTArtificial SequenceSynthetic peptide 1883Ala
Gly Ser Val Thr Glu Gln1 518847PRTArtificial
SequenceSynthetic peptide 1884Ser Ser Ser Leu Ala Gly Ser1
518857PRTArtificial SequenceSynthetic peptide 1885Arg Ser Trp Asn Ala Gly
Arg1 518867PRTArtificial SequenceSynthetic peptide 1886Ala
Gly Leu Pro His Arg Phe1 518877PRTArtificial
SequenceSynthetic peptide 1887Arg Asn Ser Arg Ala Gly Leu1
518887PRTArtificial SequenceSynthetic peptide 1888Arg Arg Ser Gly Ala Gly
Gly1 518897PRTArtificial SequenceSynthetic peptide 1889Ala
Gly Gly Pro Ser Ser Tyr1 518907PRTArtificial
SequenceSynthetic peptide 1890Thr Gly Val Arg Asn Ser Pro1
518917PRTArtificial SequenceSynthetic peptide 1891Leu Leu Arg Ala Gly Val
Arg1 518927PRTArtificial SequenceSynthetic peptide 1892Ala
Leu Val Ser Thr Ile Leu1 518937PRTArtificial
SequenceSynthetic peptide 1893Ala Arg Gly Arg Asp Glu Gly1
518947PRTArtificial SequenceSynthetic peptide 1894Ala Ser Leu Ser Val Val
Ile1 518957PRTArtificial SequenceSynthetic peptide 1895Gly
Gly Ser Arg Gly Tyr Arg1 518967PRTArtificial
SequenceSynthetic peptide 1896Tyr Trp Gly Gly Ser Val Pro1
518977PRTArtificial SequenceSynthetic peptide 1897Gly Gly Arg Pro Val Glu
Arg1 518987PRTArtificial SequenceSynthetic peptide 1898Gly
Gly Arg Ser Gln Glu Gly1 518997PRTArtificial
SequenceSynthetic peptide 1899Pro Gly Gly Gly Arg Gly Arg1
519007PRTArtificial SequenceSynthetic peptide 1900Phe Ser Leu Gly Ser Ser
Pro1 519017PRTArtificial SequenceSynthetic peptide 1901Gly
Ser Val Phe Gly Thr Pro1 519027PRTArtificial
SequenceSynthetic peptide 1902Ala Gly Ser Val Thr Glu Gln1
519037PRTArtificial SequenceSynthetic peptide 1903Tyr Trp Gly Gly Ser Val
Pro1 519047PRTArtificial SequenceSynthetic peptide 1904Leu
Ser Gly Arg Val Ile Val1 519057PRTArtificial
SequenceSynthetic peptide 1905Leu Ser Thr Pro Gly Arg Val1
519067PRTArtificial SequenceSynthetic peptide 1906Ala Gly Gly Pro Ser Ser
Tyr1 519077PRTArtificial SequenceSynthetic peptide 1907Arg
Val Met Arg Gly Ser Leu1 519087PRTArtificial
SequenceSynthetic peptide 1908Arg Ala Ser Cys Val Trp Ala1
519097PRTArtificial SequenceSynthetic peptide 1909Gln Leu Leu Ser Gln Val
Tyr1 519107PRTArtificial SequenceSynthetic peptide 1910Glu
Arg Tyr Tyr Leu Arg Ser1 519117PRTArtificial
SequenceSynthetic peptide 1911Gly Leu Val Lys Leu Arg Ser1
519127PRTArtificial SequenceSynthetic peptide 1912Gly Arg Leu Ala Ala Gly
Ser1 519137PRTArtificial SequenceSynthetic peptide 1913Gly
Leu Val Lys Leu Arg Ser1 519147PRTArtificial
SequenceSynthetic peptide 1914Leu Trp Phe Glu Leu Val Ser1
519157PRTArtificial SequenceSynthetic peptide 1915Ile Gly Ala Ala Ser Trp
Phe1 519167PRTArtificial SequenceSynthetic peptide 1916Gly
Gly Arg Arg Gly Thr Ser1 519177PRTArtificial
SequenceSynthetic peptide 1917Arg Asp Leu Gly Gly Arg Trp1
519187PRTArtificial SequenceSynthetic peptide 1918Trp Arg Gly Gly Leu Asp
Arg1 519197PRTArtificial SequenceSynthetic peptide 1919Gly
Arg Trp Thr Gly Ser Ser1 519207PRTArtificial
SequenceSynthetic peptide 1920Ser Tyr Trp Val Gly Ser Ser1
519217PRTArtificial SequenceSynthetic peptide 1921Gly Arg Leu Ala Ala Gly
Ser1 519227PRTArtificial SequenceSynthetic peptide 1922Ala
Lys Ala Gly Val Ser Arg1 519237PRTArtificial
SequenceSynthetic peptide 1923Leu Arg Leu Ser Gly His Asp1
519247PRTArtificial SequenceSynthetic peptide 1924Arg Gly Val Gly Ala Lys
Ala1 519257PRTArtificial SequenceSynthetic peptide 1925Leu
Arg Gly Val Tyr Val Ala1 519267PRTArtificial
SequenceSynthetic peptide 1926Gly Thr Pro Ala Val Ser Tyr1
519277PRTArtificial SequenceSynthetic peptide 1927Phe Leu Leu Ser Arg Ser
Ala1 519287PRTArtificial SequenceSynthetic peptide 1928Ala
Gly Leu Leu Ser Asp Val1 519297PRTArtificial
SequenceSynthetic peptide 1929Leu Arg Val Gly Xaa Pro Gly1
519307PRTArtificial SequenceSynthetic peptide 1930Arg Val Ser Gly Ser Pro
Val1 519317PRTArtificial SequenceSynthetic peptide 1931Arg
Ser Ser Ile Asp Val Gly1 519327PRTArtificial
SequenceSynthetic peptide 1932Ala Gly Arg Arg Leu Arg Asp1
519337PRTArtificial SequenceSynthetic peptide 1933Trp Arg Leu Ala Gly Leu
Gly1 519347PRTArtificial SequenceSynthetic peptide 1934Pro
Thr Val Ser Ala Gly Leu1 519357PRTArtificial
SequenceSynthetic peptide 1935Ala Gly Leu Leu Ser Asp Val1
519367PRTArtificial SequenceSynthetic peptide 1936Thr Leu Gly Val Leu Val
Thr1 519377PRTArtificial SequenceSynthetic peptide 1937Gly
Asp Arg Arg Leu Val Ser1 519387PRTArtificial
SequenceSynthetic peptide 1938Leu Met Leu Val Ser Gly Lys1
519397PRTArtificial SequenceSynthetic peptide 1939Asp Val His Ala Arg Gly
Asp1 519407PRTArtificial SequenceSynthetic peptide 1940Arg
Glu Gly Gly Ser Asp Thr1 519417PRTArtificial
SequenceSynthetic peptide 1941Gly Gly Arg Arg Val Val Val1
519427PRTArtificial SequenceSynthetic peptide 1942Asn Val Gly Gly Gly Arg
Phe1 519437PRTArtificial SequenceSynthetic peptide 1943Gly
Leu Gly Ala Leu Arg Trp1 519447PRTArtificial
SequenceSynthetic peptide 1944Leu Gly Leu Ser Gly Leu Gly1
519457PRTArtificial SequenceSynthetic peptide 1945Arg Gly Leu Gly Arg Pro
Val1 519467PRTArtificial SequenceSynthetic peptide 1946Gly
Ser Ser Gly Leu Leu Ala1 519477PRTArtificial
SequenceSynthetic peptide 1947Leu Gly Ser Ser Ser His Ile1
519487PRTArtificial SequenceSynthetic peptide 1948Ile Gly Ser Gly Val Gly
Val1 519497PRTArtificial SequenceSynthetic peptide 1949Lys
Gly Ser Val Leu Met Leu1 519507PRTArtificial
SequenceSynthetic peptide 1950Val Pro Ser Gly Ser Val Arg1
519517PRTArtificial SequenceSynthetic peptide 1951Gly Tyr Leu Gly Arg Leu
Pro1 519527PRTArtificial SequenceSynthetic peptide 1952Ala
Val Tyr Val Gly Arg Leu1 519537PRTArtificial
SequenceSynthetic peptide 1953Leu Gly Gly Arg Leu Ser Leu1
519547PRTArtificial SequenceSynthetic peptide 1954Arg Gly Val Gly Lys Thr
Lys1 519557PRTArtificial SequenceSynthetic peptide 1955Leu
Gly Gly Ala Arg Gly Val1 519567PRTArtificial
SequenceSynthetic peptide 1956His Ala Trp Asp Arg Gly Val1
519577PRTArtificial SequenceSynthetic peptide 1957Asp Trp Gly Ser Arg Gly
Val1 519587PRTArtificial SequenceSynthetic peptide 1958Pro
Tyr Arg Arg Gly Ser Cys1 519597PRTArtificial
SequenceSynthetic peptide 1959Ala Leu Asn Arg Gly Ser Arg1
519607PRTArtificial SequenceSynthetic peptide 1960Thr Phe Arg Gly Ala Gly
Val1 519617PRTArtificial SequenceSynthetic peptide 1961Leu
Leu Ser Ala Ala Arg Phe1 519627PRTArtificial
SequenceSynthetic peptide 1962Met Arg Pro Gly Leu Arg Ser1
519637PRTArtificial SequenceSynthetic peptide 1963Pro Arg Val Ser Ala Leu
Val1 519647PRTArtificial SequenceSynthetic peptide 1964Val
Arg Val Ser Leu Asn Ser1 519657PRTArtificial
SequenceSynthetic peptide 1965Gly Arg Ser Ser Ala Gly Pro1
519667PRTArtificial SequenceSynthetic peptide 1966Leu His Ala Gly Ser Ser
Val1 519677PRTArtificial SequenceSynthetic peptide 1967Val
Val Met Ile Ala Gly Ser1 519687PRTArtificial
SequenceSynthetic peptide 1968Asp Thr Pro Ala Gly Arg Leu1
519697PRTArtificial SequenceSynthetic peptide 1969Val Gly Ala Gly Arg Phe
Thr1 519707PRTArtificial SequenceSynthetic peptide 1970Ala
Gly Gly Thr Asp Arg Thr1 519717PRTArtificial
SequenceSynthetic peptide 1971Phe Ile Ser Ala Gly Gly Trp1
519727PRTArtificial SequenceSynthetic peptide 1972Thr Ile Pro Ala Gly Gly
Gly1 519737PRTArtificial SequenceSynthetic peptide 1973Val
Gly Arg Ala Gly Gly Leu1 519747PRTArtificial
SequenceSynthetic peptide 1974Asn Pro Gly Leu Val Trp Asn1
519757PRTArtificial SequenceSynthetic peptide 1975Leu Gly Leu Val His Trp
Val1 519767PRTArtificial SequenceSynthetic peptide 1976Met
Arg Pro Gly Leu Arg Ser1 519777PRTArtificial
SequenceSynthetic peptide 1977Ala Arg Gly Asn Val Arg Phe1
519787PRTArtificial SequenceSynthetic peptide 1978Leu Gly Gly Ala Arg Gly
Val1 519797PRTArtificial SequenceSynthetic peptide 1979Phe
Arg Ala Ala Ser Leu Leu1 519807PRTArtificial
SequenceSynthetic peptide 1980Ala Ala Ser Val Gly Val Ala1
519817PRTArtificial SequenceSynthetic peptide 1981Phe Arg Ala Ala Ser Leu
Leu1 519827PRTArtificial SequenceSynthetic peptide 1982Pro
Val Phe Arg Gly Gly Ser1 519837PRTArtificial
SequenceSynthetic peptide 1983Ser Gly Gly Ser Val Gly Phe1
519847PRTArtificial SequenceSynthetic peptide 1984Val Arg Ala Asn Gly Gly
Ser1 519857PRTArtificial SequenceSynthetic peptide 1985Phe
His Ile Trp Gly Gly Arg1 519867PRTArtificial
SequenceSynthetic peptide 1986Leu Gly Gly Arg Leu Ser Leu1
519877PRTArtificial SequenceSynthetic peptide 1987Ser Gly Gly Arg Phe Val
Pro1 519887PRTArtificial SequenceSynthetic peptide 1988Gly
Gly Gly Leu Pro Val Asp1 519897PRTArtificial
SequenceSynthetic peptide 1989Leu Ser Leu Arg Gly Gly Leu1
519907PRTArtificial SequenceSynthetic peptide 1990Val Gly Arg Ala Gly Gly
Leu1 519917PRTArtificial SequenceSynthetic peptide 1991Ala
Asn Gly Ser Ser Lys Lys1 519927PRTArtificial
SequenceSynthetic peptide 1992Asp Phe Thr Leu Gly Ser Ser1
519937PRTArtificial SequenceSynthetic peptide 1993Leu His Ala Gly Ser Ser
Val1 519947PRTArtificial SequenceSynthetic peptide 1994Asn
Ser Gly Ser Val Val Ser1 519957PRTArtificial
SequenceSynthetic peptide 1995Ser Gly Gly Ser Val Gly Phe1
519967PRTArtificial SequenceSynthetic peptide 1996Trp Ser Ile Ser Gly Ser
Val1 519977PRTArtificial SequenceSynthetic peptide 1997Asp
Thr Pro Ala Gly Arg Leu1 519987PRTArtificial
SequenceSynthetic peptide 1998Leu Gly Gly Arg Leu Ser Leu1
519997PRTArtificial SequenceSynthetic peptide 1999Ala Val Gly Val Ser Ala
Ala1 520007PRTArtificial SequenceSynthetic peptide 2000Ser
Gly Val Ser Asn Pro Gly1 520017PRTArtificial
SequenceSynthetic peptide 2001Phe Gly Val Ser Gly Gly Ser1
520027PRTArtificial SequenceSynthetic peptide 2002Glu Ser Ala Thr Gly Val
Ser1 520037PRTArtificial SequenceSynthetic peptide 2003Ala
Ala Ile Val Gly Val Ser1 520047PRTArtificial
SequenceSynthetic peptide 2004Leu Arg Ser Gly Arg Gly Ser1
520057PRTArtificial SequenceSynthetic peptide 2005Leu Arg Ser Gly Arg Gly
Ser1 520067PRTArtificial SequenceSynthetic peptide 2006Arg
Gly Arg Gly Ser Thr Leu1 520077PRTArtificial
SequenceSynthetic peptide 2007Arg Gly Ser Pro Ala Ala Ala1
520087PRTArtificial SequenceSynthetic peptide 2008Ser Arg Gly Ser Tyr Gly
Ser1 520097PRTArtificial SequenceSynthetic peptide 2009Gly
Val Gly Gly Gly Ala Gly1 520107PRTArtificial
SequenceSynthetic peptide 2010Leu Arg Ser Gly Arg Gly Ser1
520117PRTArtificial SequenceSynthetic peptide 2011Ala Gly Gly Gly Gly Tyr
His1 520127PRTArtificial SequenceSynthetic peptide 2012Gly
Ala Gly Gly Gly Val Gly1 520137PRTArtificial
SequenceSynthetic peptide 2013Tyr Arg Ala Leu Ala Gly Gly1
520147PRTArtificial SequenceSynthetic peptide 2014Leu Tyr Val Asp Ala Ser
Leu1 520157PRTArtificial SequenceSynthetic peptide 2015Gly
Glu Gly Ser Gly Ser Ala1 520167PRTArtificial
SequenceSynthetic peptide 2016Arg Val Arg Gly Val Leu Asp1
520177PRTArtificial SequenceSynthetic peptide 2017Ser Met Arg Gly Val Leu
Ser1 520187PRTArtificial SequenceSynthetic peptide 2018Glu
Ala Gly Pro Arg Gly Val1 520197PRTArtificial
SequenceSynthetic peptide 2019Cys Arg Gly Ser Ile Gly Ala1
520207PRTArtificial SequenceSynthetic peptide 2020Pro Leu Gln Arg Gly Ser
Gly1 520217PRTArtificial SequenceSynthetic peptide 2021Arg
Gly Ser Arg Trp Ser Ser1 520227PRTArtificial
SequenceSynthetic peptide 2022Arg Gly Ser Tyr Val Glu Arg1
520237PRTArtificial SequenceSynthetic peptide 2023Thr Tyr Cys Asp Arg Ala
Val1 520247PRTArtificial SequenceSynthetic peptide 2024Leu
Gly Val Arg Ala Ser Pro1 520257PRTArtificial
SequenceSynthetic peptide 2025Trp Arg Ala Ser Pro Gly Met1
520267PRTArtificial SequenceSynthetic peptide 2026Pro Arg Ala Ser Asp Ile
Leu1 520277PRTArtificial SequenceSynthetic peptide 2027Arg
Val Gly Ala Gly Trp Pro1 520287PRTArtificial
SequenceSynthetic peptide 2028Leu Leu Ser Arg Ala Gln Ala1
520297PRTArtificial SequenceSynthetic peptide 2029Ser Ala Leu Arg Val Gly
Leu1 520307PRTArtificial SequenceSynthetic peptide 2030Val
Gly Leu Arg Val Arg Phe1 520317PRTArtificial
SequenceSynthetic peptide 2031Tyr Gly Leu Arg Ser Leu Val1
520327PRTArtificial SequenceSynthetic peptide 2032Thr Arg Val Ser Gly Ser
Gly1 520337PRTArtificial SequenceSynthetic peptide 2033Val
Arg Arg Ser Ser Lys Phe1 520347PRTArtificial
SequenceSynthetic peptide 2034Thr Phe Ala Gly Leu Ala Gln1
520357PRTArtificial SequenceSynthetic peptide 2035Leu Gly Val Arg Ala Ser
Pro1 520367PRTArtificial SequenceSynthetic peptide 2036Leu
Gly Val Arg Leu Ala Ser1 520377PRTArtificial
SequenceSynthetic peptide 2037Pro Trp Gly Ala Gly Val Arg1
520387PRTArtificial SequenceSynthetic peptide 2038Gly Val Leu Thr Ile Gly
Ala1 520397PRTArtificial SequenceSynthetic peptide 2039Arg
Val Arg Gly Val Leu Asp1 520407PRTArtificial
SequenceSynthetic peptide 2040Ile Gly Trp Gly Val Leu Gly1
520417PRTArtificial SequenceSynthetic peptide 2041Ser Met Arg Gly Val Leu
Ser1 520427PRTArtificial SequenceSynthetic peptide 2042Gly
Ala Val Leu Thr Ser Cys1 520437PRTArtificial
SequenceSynthetic peptide 2043Gly Leu Val Ser Thr Leu Ile1
520447PRTArtificial SequenceSynthetic peptide 2044Gly Leu Val Gly Trp Gly
Ile1 520457PRTArtificial SequenceSynthetic peptide 2045Val
Gly Leu Arg Cys Ser Val1 520467PRTArtificial
SequenceSynthetic peptide 2046Val Gly Leu Arg Val Arg Phe1
520477PRTArtificial SequenceSynthetic peptide 2047Tyr Gly Leu Arg Ser Leu
Val1 520487PRTArtificial SequenceSynthetic peptide 2048Gly
Leu Val Ser Thr Leu Ile1 520497PRTArtificial
SequenceSynthetic peptide 2049Pro Arg Gly Met Ala Arg Gly1
520507PRTArtificial SequenceSynthetic peptide 2050Arg Gly Gly Ser Asp Glu
Ala1 520517PRTArtificial SequenceSynthetic peptide 2051Ala
Glu Asp Ser Gly Gly Arg1 520527PRTArtificial
SequenceSynthetic peptide 2052Gly Gly Arg Cys Gly Ala Glu1
520537PRTArtificial SequenceSynthetic peptide 2053Gly Gly Leu Met Pro Arg
Tyr1 520547PRTArtificial SequenceSynthetic peptide 2054Gly
Ser Ser Val Ser Leu Gly1 520557PRTArtificial
SequenceSynthetic peptide 2055Gly Ser Gly Arg Gln Leu Pro1
520567PRTArtificial SequenceSynthetic peptide 2056Arg Lys Gly Ser Gly Thr
Ala1 520577PRTArtificial SequenceSynthetic peptide 2057Thr
Arg Val Ser Gly Ser Gly1 520587PRTArtificial
SequenceSynthetic peptide 2058Gly Ser Gly Ser Val Arg Thr1
520597PRTArtificial SequenceSynthetic peptide 2059Asp Asp Gly Arg Val His
Arg1 520607PRTArtificial SequenceSynthetic peptide 2060Asp
Leu Val Gly Arg Val Arg1 520617PRTArtificial
SequenceSynthetic peptide 2061Trp Gly Arg Leu Glu Ser Thr1
520627PRTArtificial SequenceSynthetic peptide 2062Met Gly Pro Ser Ala Arg
Trp1 520637PRTArtificial SequenceSynthetic peptide 2063Ile
Ser Gly Val Ser Asp Asp1 520647PRTArtificial
SequenceSynthetic peptide 2064Gly His Ser Glu Arg Leu Ser1
520657PRTArtificial SequenceSynthetic peptide 2065Glu Arg Gly Val Phe Val
Tyr1 520667PRTArtificial SequenceSynthetic peptide 2066Thr
Arg Gly Val Ile Gly Gly1 520677PRTArtificial
SequenceSynthetic peptide 2067Arg Gly Ser Phe Gly Leu Gly1
520687PRTArtificial SequenceSynthetic peptide 2068Pro Phe His Arg Arg Ala
Val1 520697PRTArtificial SequenceSynthetic peptide 2069Val
Gly Ile Gly Ala Gly Gly1 520707PRTArtificial
SequenceSynthetic peptide 2070Ala Val Ser Leu Ala Trp Gln1
520717PRTArtificial SequenceSynthetic peptide 2071Phe Pro Ala Val Ser Thr
Glu1 520727PRTArtificial SequenceSynthetic peptide 2072Ser
Gly Ala Arg Leu Arg Ser1 520737PRTArtificial
SequenceSynthetic peptide 2073Ser His Arg Ser Ser Thr Gly1
520747PRTArtificial SequenceSynthetic peptide 2074Ser Arg Leu Arg Ala Gly
Ser1 520757PRTArtificial SequenceSynthetic peptide 2075Ser
Phe Ala Gly Arg Ile Leu1 520767PRTArtificial
SequenceSynthetic peptide 2076Arg Val Ala Ala Gly Gly Leu1
520777PRTArtificial SequenceSynthetic peptide 2077Val Gly Ile Gly Ala Gly
Gly1 520787PRTArtificial SequenceSynthetic peptide 2078Val
Gly Ile Gly Ala Gly Gly1 520797PRTArtificial
SequenceSynthetic peptide 2079Gln Lys Pro Gly Ala Val Gly1
520807PRTArtificial SequenceSynthetic peptide 2080Leu Gly Tyr Tyr Gly Ala
Val1 520817PRTArtificial SequenceSynthetic peptide 2081Leu
Pro Leu Gly Leu Val Ser1 520827PRTArtificial
SequenceSynthetic peptide 2082Leu Gly Leu Val Phe Thr Arg1
520837PRTArtificial SequenceSynthetic peptide 2083Leu Pro Leu Gly Leu Val
Ser1 520847PRTArtificial SequenceSynthetic peptide 2084Asn
Ser Lys Pro Leu Val Ser1 520857PRTArtificial
SequenceSynthetic peptide 2085Thr Asn Arg Phe Ala Arg Gly1
520867PRTArtificial SequenceSynthetic peptide 2086Leu Ala Ser Leu Ala Arg
Pro1 520877PRTArtificial SequenceSynthetic peptide 2087Leu
Gly Gly Ala Ala Val Arg1 520887PRTArtificial
SequenceSynthetic peptide 2088Ala Ala Ser Pro His Pro Gly1
520897PRTArtificial SequenceSynthetic peptide 2089Leu Ser Lys Gly Gly Ser
Glu1 520907PRTArtificial SequenceSynthetic peptide 2090Gly
Leu Gly Arg Ser Val Asn1 520917PRTArtificial
SequenceSynthetic peptide 2091Pro Gly Leu Gly Tyr Ala Leu1
520927PRTArtificial SequenceSynthetic peptide 2092Arg Gly Ser Phe Gly Leu
Gly1 520937PRTArtificial SequenceSynthetic peptide 2093Gly
Arg Asp Trp Gly Gly Leu1 520947PRTArtificial
SequenceSynthetic peptide 2094Arg Val Ala Ala Gly Gly Leu1
520957PRTArtificial SequenceSynthetic peptide 2095Thr Val Gly Ser Ser Leu
Gly1 520967PRTArtificial SequenceSynthetic peptide 2096Gly
Arg Val Asp Pro Val Asp1 520977PRTArtificial
SequenceSynthetic peptide 2097Ser Leu Tyr Arg Gly Arg Leu1
520987PRTArtificial SequenceSynthetic peptide 2098Val Ala Leu Gly Val Ser
Ser1 520997PRTArtificial SequenceSynthetic peptide 2099Val
Ser Val Thr Arg Leu Ser1 521007PRTArtificial
SequenceSynthetic peptide 2100Ala Gly Ala Thr Arg Gly Ser1
521017PRTArtificial SequenceSynthetic peptide 2101Arg Arg Gly Ser Val Ala
Glu1 521027PRTArtificial SequenceSynthetic peptide 2102Phe
Arg Phe Val Arg Gly Ser1 521037PRTArtificial
SequenceSynthetic peptide 2103Thr Arg Gly Ser Gly Ala Gly1
521047PRTArtificial SequenceSynthetic peptide 2104Gly Ala Arg Ala Val Ala
Pro1 521057PRTArtificial SequenceSynthetic peptide 2105Thr
Arg Gly Ser Gly Ala Gly1 521067PRTArtificial
SequenceSynthetic peptide 2106Glu Ala Val Ser Gly Arg Arg1
521077PRTArtificial SequenceSynthetic peptide 2107Pro Val Arg Arg Val Ser
Ser1 521087PRTArtificial SequenceSynthetic peptide 2108Ile
Arg Val Ser Ala Val Val1 521097PRTArtificial
SequenceSynthetic peptide 2109His Val Arg Ser Ser Tyr Ala1
521107PRTArtificial SequenceSynthetic peptide 2110Arg Val Arg Ser Ser Leu
Ala1 521117PRTArtificial SequenceSynthetic peptide 2111Thr
Ala Ala Gly Ser Ser Phe1 521127PRTArtificial
SequenceSynthetic peptide 2112Gly Ala Gly Ser Gly Arg Thr1
521137PRTArtificial SequenceSynthetic peptide 2113Pro Ala Val Ala Gly Ser
Thr1 521147PRTArtificial SequenceSynthetic peptide 2114Ala
Gly Arg His Leu Asp Ala1 521157PRTArtificial
SequenceSynthetic peptide 2115Asp Arg Gln Leu Ala Gly Arg1
521167PRTArtificial SequenceSynthetic peptide 2116Leu Gly Val Arg Glu Val
Gly1 521177PRTArtificial SequenceSynthetic peptide 2117Val
Ala Val Gly Val Arg Ser1 521187PRTArtificial
SequenceSynthetic peptide 2118Ser Phe Gly Val Leu Ser Gly1
521197PRTArtificial SequenceSynthetic peptide 2119Thr Ser Gly Ala Val Ala
Pro1 521207PRTArtificial SequenceSynthetic peptide 2120Gly
Leu Arg Glu Val Gln Asp1 521217PRTArtificial
SequenceSynthetic peptide 2121Ser Leu Val Ser Glu Arg Ala1
521227PRTArtificial SequenceSynthetic peptide 2122Ser Val His Leu Val Ser
Gly1 521237PRTArtificial SequenceSynthetic peptide 2123Thr
Gln Val Glu Ala Arg Gly1 521247PRTArtificial
SequenceSynthetic peptide 2124Gly Gly Arg Pro Thr Val Thr1
521257PRTArtificial SequenceSynthetic peptide 2125Val Val Gly Gly Arg Arg
Thr1 521267PRTArtificial SequenceSynthetic peptide 2126Gly
Val Gly Gly Leu Ser Ser1 521277PRTArtificial
SequenceSynthetic peptide 2127Thr Ala Ala Gly Ser Ser Phe1
521287PRTArtificial SequenceSynthetic peptide 2128Thr Arg Gly Ser Gly Ala
Gly1 521297PRTArtificial SequenceSynthetic peptide 2129Arg
Arg Gly Ser Val Ala Glu1 521307PRTArtificial
SequenceSynthetic peptide 2130Gly Ser Val Leu His Val Ser1
521317PRTArtificial SequenceSynthetic peptide 2131Ser Gly Arg Val Phe Arg
Phe1 521327PRTArtificial SequenceSynthetic peptide 2132Trp
Ser Ala Thr Gly Val Ser1 521339PRTArtificial
SequenceSynthetic peptide 2133Cys Ala Gly Leu Ser Gly Gly Thr Cys1
521349PRTArtificial SequenceSynthetic peptide 2134Cys Ser Gly Ile
Gly Ser Gly Gly Cys1 521359PRTArtificial SequenceSynthetic
peptide 2135Cys Ser Ser Gly Gly Val Leu Gly Cys1
521369PRTArtificial SequenceSynthetic peptide 2136Cys Ser Trp Gly Ser Gly
Gly Ser Cys1 521379PRTArtificial SequenceSynthetic peptide
2137Cys Thr Leu Val Leu Gly Gly Ser Cys1
521389PRTArtificial SequenceSynthetic peptide 2138Cys Arg Phe Glu Ser Ser
Gly Gly Cys1 521399PRTArtificial SequenceSynthetic peptide
2139Cys His Val Ser Gly Gly Ser Gly Cys1
521409PRTArtificial SequenceSynthetic peptide 2140Cys Thr Gly Gly Ser Leu
Gly Ala Cys1 5
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