Yes.  You can use one binary (copy of the software).  On a Unix system,
make multiple entries in /etc/services and /etc/inetd.conf, and use the
-DATABASE option with each entry in /etc/inetd.conf to specify the desired
database for that port. 

Here are some sample entries from /etc/services and /etc/inetd.conf

/etc/services:
ns              105/tcp         # CCSO nameserver
ns-clio         106/tcp
ns-eha          107/tcp

/etc/inetd.conf:
ns              stream  tcp     nowait  root    /usr/local/etc/qi qi
ns-clio         stream  tcp     nowait  root    /usr/local/etc/qi qi \
 -DATABASE=/usr/users/nameserv/db/clio
ns-eha          stream  tcp     nowait  root    /usr/local/etc/qi qi \
 -DATABASE=/usr/users/nameserv/db/eha

        (ns-clio and ns-eha are each one line, no breaks.)

(Samples contributed by Steve Madsen  <smadsen@cs.muohio.edu>)