MEMORANDUM FOR: THE RECORD
MKULTRA, Subproject 2?
1. The purpose ofoject ts to provide funns to carryisolation and characterization of the Intoxicating substancescertain varieties oforymbosa.
on this material which have lead to the developirent of method* which can now be applied to large samples of seed, thereby allowing the production of sufficient quantities of the .active material* for definitive biological testing and characterization. | mitted the attached proposal to carry out this work as directed by TSS/^H
3. The Geschickter Fund for Medical Research,ill serve as cutout for transfer of funds to the investigator. The estl-
the WOrk0 for one -vear- r" be . Percent service charge for the Geschickter Therefore, the total cost of this investigation for one year will not
ccordance with the Memorandum of Understanding w'th
the University shall retain title to any permanentin'lieu of higher overhead rates.
5. The Geschickter Fund has made arrangements for theof unexpended monies receivedrant from the Fund and fn*^ that ,he Universtty submit toummaryfor all monles-received therefrom. '
. SUi*Uy agreed that documentation and account-ngfor travel expenses under-the grant which are reimbursable bv the University shall conform with the accepted practices of that institution.
E2 IHPDK: CL BJ
overt clearance under Project MKULTRA
and has agreed to comply with the terms of the Memorandum
APPROVED FOR OBLIGATION OF FUNDS:
trch Director Date: |J$
Distribution: Original only
Chief, Branch II TSS/(J ivision
APPROVED FOR RELEASE
Requoat for renewal of support for the project; Investigation of the seed of Rlvea Corymboaa(ololuqul).
Summary of work, November
Physical examination of the seed used In this work reveals that two "types" have been under Investigation. Taxonomioally all the seed have been called Rivea Corymbosa although one variety (the seed are the larger of the two varieties) originated in Mexico and one variety originated In Cuba. The literature on the subject of ololiuqul, as faran ascertain Indicates that its usesychic drug has boon restricted to Mexico. This data alone would Indicate the probability that the Cuban variety lacks some physiologically active component which the Mexican variety contains. Experimental work in this laboratory has been largely restricted to the Cuban variety (small seed sinceery small amount of the Mexican variety has been available. The chemical work, although not designed to compare the composition of the two varioties, has Indicated some difference in the two. Also physiological tests on humans are indicativeifference In the two varieties. This work la much too inconclusive to bo muchthan speculation at this time.
In addition to the isolation of glucose and hydro-quinone as constituents of ololiuqul as reported In the last progress report, two crystalline fractions have been Isolated which seem neither to be alkaloid or glycoside. Due to the small quantity of aeed available the amount of these crystalline fractions ls extremely small and little more than qualitative tests have been made on them. Experimental techniques, especially in extraction and separation, have been perfected which will be used to isolate pure components of the drug which, just today, has become available In sufficient quantity to make the Investigation profitable.
Plans for future Investigation:
Now thatounds of the Cuban varietyhe Mexican variety are available, the following lineswill be actively
Determine conclusively If therehemical difference in the two varieties of seed.
Obtain aa many "pure" components froa each variety, using previously perfected techniques, as Is possible.
Submit for physiological testing each "pure" component.
each "pure" component to chemicaldetermine tho type of compound, whether it is a
known compound and its chemical composition if it
SOURCES AND METHODS INVOLVED
proposed budget, Novomborovember7
Equipment (Including larger scale
extraction and separation equipment)
Analyses and testa 0
Travel expenses 0
Salaries (one graduate assistant laboratory
help and director's
SOURCES AND7Original document.