Wife of former president Bill Clinton, senator from New York, candidate for the Democratic nomination for the presidency in the 2008 election, and current Secretary of State. She's been a national political figure for twenty years, and she has handled all sorts of policy initiatives and topics in that time. She is also the only former First Lady to make such a name for herself independent of that title.

The governor of Alaska and John McCain's Vice Presidential candidate in the 2008 election. The first Republican female Vice Presidential nominee and a major, if divisive, figure in politics today.

The first female justice in the Supreme Court. She was a major force in the court during her tenure, as her status in the middle often helped decide major cases.

George W. Bush's National Security Advisor and second Secretary of State. The first African-American woman to hold the latter post and a major figure in international affairs in the last ten years.

The first female Vice-Presidential candidate for a major political party. Also a member of the House of Representatives. Went on to work in Hillary Clinton's 2008 presidential campaign.