Zuercher, US
David Zuercher, Boise, ID US
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20100138204 | CELL-BASED MODELS AND METHODS FOR SIMULATING LYMPHOCYTE DIFFERENTIATION AND OTHER BIOLOGICAL EVENTS - Systems and methods are disclosed herein that enable computer-implemented modeling of lymphocyte differentiation and developmental processes. Cell-based models and methods for simulating natural and transgenic lymphocyte differentiation are also disclosed. In some embodiments, systems and methods are provided for cell-centric simulation of lymphocyte differentiation with accommodating virtual thymic and/or bone marrow environment feedback. In one embodiment, a computer-implemented method of modeling lymphocyte differentiation can include receiving configurable simulation information and initializing an ontogeny engine to an initial step boundary in accordance with the configurable simulation information. The method can also include advancing the ontogeny engine, until a halting condition is encountered, from a current step boundary to a next step boundary in accordance with the configurable simulation information and the current step boundary. The initial step boundary can define at least one virtual early lymphoid progenitor cell. The advancing can include performing a stepCells function. | 06-03-2010 |
David G. Zuercher, Boise, ID US
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20090070087 | Virtual tissue with emergent behavior and modeling method for producing the tissue - A multi-cellular virtual tissue having the emergent properties of self-repair, adaptive response to an altered environment, or tissue differentiation, and a method of generating the tissue by computer modeling are disclosed. The tissue is formed of a plurality of virtual cells, each having a heritable virtual genome containing a set of virtual genes relating to each of (a1) intercellular adhesion, (a2) cell division, (a3) cell growth, (a4) intercellular signaling, and (a5) the state of one cell relative to an adjacent cell. In forming the tissue, the sequential operation and actions of the genes are guided by (1) chemical-interaction rules that govern the extra-genetic behavior of one or more molecules placed or produced in the environment, (2) action rules that specify a cell's adhesion, growth, or cell-division condition, in response to molecules produced by a cell's genes relating to intercellular adhesion, cell growth, or cell division, respectively, and (3) physical-interaction rules that govern how a cell will move in response to its own growth or division or the growth or division of neighboring cells. | 03-12-2009 |
20100153082 | SYSTEMS AND METHODS FOR CELL-CENTRIC SIMULATION OF BIOLOGICAL EVENTS AND CELL BASED-MODELS PRODUCED THEREFROM - Systems and methods are provided herein that enable computer-implemented modeling of a biological event. Cell-based models produced from such systems and methods are also disclosed. In some embodiments, systems and methods are provided for cell-centric simulation with accommodating environment feedback. In one embodiment, a computer-implemented method of modeling a biological event can include receiving configurable simulation information and initializing an ontogeny engine to an initial step boundary in accordance with the configurable simulation information. The method can also include advancing the ontogeny engine from a current step boundary to a next step boundary in accordance with the configurable simulation information and the current step boundary. The advancing can include performing a metabolizeCell function. The method can further include continuing the advancing until a halting condition is encountered. In some embodiments, simulation of biological events includes modeling biological processes, such as development of ECM, multicellular tissue and differentiation of pluripotent cells. | 06-17-2010 |
20100305929 | SYSTEMS AND METHODS FOR CELL-CENTRIC SIMULATION AND CELL-BASED MODELS PRODUCED THEREFROM - Systems and methods are provided herein that enable computer-implemented modeling of a biological event. Cell-based models produced from such systems and methods are also disclosed. In some embodiments, systems and methods are provided for cell-centric simulation with accommodating environment feedback. In one embodiment, a computer-implemented method of modeling a biological event can include receiving configurable simulation information and initializing an ontogeny engine to an initial step boundary in accordance with the configurable simulation information. The method can also include advancing the ontogeny engine from a current step boundary to a next step boundary in accordance with the configurable simulation information and the current step boundary. The advancing can include performing a stepCells function. The method can further include continuing the advancing until a halting condition is encountered. In some embodiments, simulation of biological events includes modeling biological processes, such as development of multicellular tissue and differentiation of pluripotent cells. | 12-02-2010 |
Douglas Zuercher, Morgan Hill, CA US
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20110116186 | Adjusting Recording Density in a Circumferential Direction - Approaches for adjusting the recording density of a recording medium in a circumferential direction are disclosed. A hard-disk drive includes one or more electronic components configured to divide a track, of a plurality of concentric tracks on a magnetic-recording disk, into a plurality of portions, and write data to each of the plurality of portions at a recording density that is independent of the recording density used for any of the other portions. Data may be written to a first portion of a track at a different frequency than to a second portion of the same track. The frequency at which data is written may be adjusted for different portions of the same track to allow the frequency to be reduced at certain portions shown to have relatively higher soft error rate while increasing the frequency for other portions to achieve a desired average error rate for the track. | 05-19-2011 |
20110141607 | Write Quality of HDD Heads Experiencing Temporary Fly-Height Problems - Approaches for improving the write quality of a hard-disk drive (HDD) head experiencing temporary fly-height problem. When the hard-disk drive is idle and heads are parked on the ramp, fluid, such as a lubricant or the condensation of vapor, may collect between the surface of a platter and the head or a slider, thereby causing the head to temporarily fly higher than normal. An HDD may include electronic component(s) configured to (a) determine whether it is likely that fluid is interposed between the surface of a magnetic-recording disk and the slider or the head, and (b) temporarily adjust one or more of (i) a thermal fly height control setting of the head and (ii) a write parameter of the head to compensate for the head flying higher than normal as a result of the fluid being interposed between the surface of the disk and the slider or the head. | 06-16-2011 |
Douglas M. Zuercher, Morgan Hill, CA US
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20100079903 | ADAPTIVE DATA RECOVERY PROCEDURE BASED ON RADIAL POSITIONING - Data recovery information characterizes data recovery procedure (DRP) steps to be performed within a hard disk drive (HDD) in response to a miss. Particular data recovery information corresponds to a radial position of the actuator and, therefore, the position of the magnetic recording read/write head relative to the associated storage media at the location at which the miss occurred. The data recovery information is based on the physical shape of a write pole and on how the physical shape of the pole inherently affects operational data error associated with the head. Because of the foregoing characteristics of such data recovery information, a more efficient and performant data recovery procedure is performed based thereon. | 04-01-2010 |
Eric Zuercher, Tucson, AZ US
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20080308358 | Wheel chair lift with protective skirt sensors - A wheel chair lift device includes a lift car selectively elevated above a base, along with protective skirting covering the region below the lift car. Exposed portions of the protective skirting subject to lateral inward deformation are provided with skirt deformation sensors for detecting abnormal inward deformation of such skirt portions. The skirt deformation sensors include a spring or other elongated deformable member that extends generally parallel and proximate to the portion of the skirt being sensed. A sensor detects that the elongated member has been laterally displaced from its usual longitudinal axis and generates an electrical signal. In response to such electrical signal, the lift device stops further movement of the lift car. | 12-18-2008 |
20110174579 | PORTABLE WHEEL CHAIR LIFT - A portable wheel chair lift device includes a lift car, a support base, and a lifting mechanism coupled thereto to selectively raise or lower the lift car while allowing the floor of the lift car to be fully-lowered to the ground surface. The lift car floor can be folded and collapsed to a reduced width allowing transport through narrow passages. Transport casters are removably mounted to the bottom of the lift car to facilitate transport. The lift device includes a height adjustment control within the lift car to repeatably raise the lift car to the height of a stage. | 07-21-2011 |
20130112504 | LOW PROFILE WHEELCHAIR LIFT WITH DIRECT-ACTING HYDRAULIC CYLINDERS - A wheel chair lift device includes a pair of upside-down, vertically-oriented hydraulic cylinders having their closed ends attached to opposing sides of a lift car, and their piston rods secured to a base resting on the floor. The cylinders extend into the hollow internal channels of two fixed vertical guide members as the lift car is lowered. The vertical guide members may be received within the side walls of the lift car as the lift is lowered to the ground. Rollers on the lift car engage the vertical exterior walls of the vertical guide members to stabilize the lift car. No moving parts are exposed apart from the lift car itself. | 05-09-2013 |
20130112505 | WHEELCHAIR LIFT DEVICE WITH PINNED FLOOR STRUTS - A wheel chair lift device includes a pair of hydraulic cylinders for elevating a lift car above a base resting on the floor. Pivotally-connected floor struts extend between side walls of the lift car to support the lift car floor while allowing the side walls of the lift car to remain vertical to avoid pinching the gates of the lift car. | 05-09-2013 |
20130112506 | HEIGHT ADJUSTMENT SYSTEM FOR WHEELCHAIR LIFT - A wheel chair lift device includes a base, a lift car, and a lift mechanism for raising and lowering the lift car relative to the base. A maximum height system includes a light source, optical sensor, magnetic-backed reflector, and a placement tool for engaging a reference port on the lift car. Operation of the light source and optical sensor are confirmed before the lift car is elevated. | 05-09-2013 |
Eric J. Zuercher, Tucson, AZ US
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20140209601 | Breather Valve Assemblies - Breather valve assemblies featuring resilient, deformable members that buckle when a pressure-moveable member is actuated by pressure, such as when a sealed container is exposed to changes in atmospheric pressure. One way and two way breather valves allow air flow in either one or two desired directions according to resilient, deformable member and pressure movable member of each respective direction. | 07-31-2014 |
Gregory A. Zuercher, South Whitley, IN US
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20090271001 | BACnet Protocol MS/TP Automatic MAC Addressing - A Building Automation System (BAS) includes at least one Direct Digital Control (DDC) controller operating as a BACnet MS/TP master considered to be an “Anchor”. The Anchor operates an algorithm or method which automatically assigns BACnet Protocol MS/TP Media Access Control (MAC) addresses to other BAS components (considered Nomads) being installed into the network. The Anchor gathers MAC addresses existing on the MS/TP network, and issues an available MAC Pool Announcement. Each Nomad randomly picks a temporary MAC address. When the Anchor verifies singular communication at the temporary MAC address, the Anchor assigns a permanent MAC address to the Nomad, which can later be locked into flash memory. Using the preferred algorithm and method, Nomad devices are automatically assigned unused MAC addresses to join the MS/TP network in a non-conflicting, orderly way, with all communications occurring within the confines of BACnet MS/TP Protocol. | 10-29-2009 |
Hannes Georges Zuercher, Sunnyvale, CA US
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20100027377 | Locating oil or gas actively by exciting a porous oil and gas saturated system to give off its characteristic resonance response, with optional differentiation of oil, gas and water - This patent deals with methods to selectively excite and analyze the resonance phenomena existing in an enclosed oil, gas and or water reservoir, thereby locating its presence, by doing qualitative and quantitative estimates of its extent via forward modeling. The oil, gas or water reservoir is represented as a fluid filled crack system or as a fluid saturated sponge located in solid rock. This patent covers the actively excited response and details methods to optimize the excitation. Due to interaction between either fluid filled fractures or fluid saturated rock lenses and the surrounding rock, the incident seismic energy is amplified in specific frequency ranges corresponding to the resonance frequencies of such systems. Measurements are made over the survey area, singly or in arrays. These are first used to determine qualitatively the resonance behavior, by relating them to resonance signal sources and possibly their direction. Overall statistical analysis assesses dominant frequencies in the spectrum. H/V analysis excludes resonance effects in rock structures. Time windows are used in the frequency domain to help isolate oscillations in a cursory manner in the noise, which can then be refined to extract oscillation parameters more precisely with the Sompi method. Such found oscillations can then be related to oscillator properties from theoretical and numerical model simulations. A direction analysis with array measurements can be used to locate sources in the earth. Dimensions of the source are estimated via mapping techniques of strong signal areas. The influence of gas bubbles on the fluid velocity, expected to often present, enhances the impedance difference significantly, leading to a stronger resonance effect; to take this into consideration is an important part of this patent. A qualitative method in form of a numerical simulation using one of several specific physical concepts is used for further analysis. For instance the oscillation behavior is known from existing fluid dynamic research for cracks. A single or an assemblage of cracks can be used. For fluid saturated rock pillows with significant over-pressure there is a simplified theoretical model presented. Numerical models using Biot's theory for higher precision results represent a further example. By using a successive forward modeling/investigation with feedback, more details about the fluid saturated area below the surface are gained. It is also possible to determine the type of fluid present with the techniques of this patent. The physical properties of oil, water and gas affect the oscillating characteristics (frequency and Q value) of fluid filled fractures and fluid filled pillows enclosed in rock. These differences in the oscillations allow determining the type of fluid present. Specifically a qualitative survey method and a quantitative method based on a numerical modeling in conjunction with the Monte Carlo method are used to relate the oscillation characteristics to fluid properties. In the Monte Carlo method only fluid parameters are varied, while all other parameters are kept constant. There are specific dependencies on crack length in the case of cracks which needs to be properly estimated to obtain good results. We expect similar constraints for liquid filled pillows. The uniqueness of this method is that it is directly sensitive to the oil or gas itself, because the resonance effect is only present when a fluid is there. Non fluid related oscillations due to impedance differences have shear waves involved and can be excluded using H/V technique. In summary the patent uses techniques to relate the actual measurement with a numerical model based on specific physical concepts, and so arriving at relevant conclusions about the reservoir. | 02-04-2010 |
20100036614 | Locating oil or gas passively by observing a porous oil and gas saturated system giving off its characteristic resonance response to ambient background noise, including optional differentiation of oil, locatinggas and water - This patent deals with methods to extract and analyze seismic signals due to resonance phenomena in an enclosed oil, gas, or water reservoir, which are passively excited by seismic background noise, locating thereby the presence of the reservoir by doing qualitative and quantitative estimates via forward modeling. Measurements are first used in a qualitative analysis in eight steps. The influence of gas bubbles is important. A quantitative method in form of a numerical simulation using one of several specific physical concepts is used for further analysis. By using successive forward modeling, together with investigation and feedback and in conjunction with the Monte Carlo method, more details are gained. It is also possible to determine the fluid type. The uniqueness of the methods is first that it is purely passive; second it is directly sensitive to the oil or gas, because the resonance effect is only present for a fluid. | 02-11-2010 |
Joseph C. Zuercher, Brookfield, WI US
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20100149700 | POWER DISTRIBUTION SYSTEM AND ELECTRICAL SWITCHING APPARATUS EMPLOYING A FILTER TRAP CIRCUIT TO PROVIDE ARC FAULT TRIP COORDINATION - An electrical switching apparatus comprises: a first terminal; a second terminal; separable contacts electrically connected between the first terminal and the second terminal; an operating mechanism structured to open and close the separable contacts; and an arc fault trip circuit cooperating with the operating mechanism and structured to trip open the separable contacts responsive to an arc fault condition. An inductor is electrically connected in series between the first terminal and the second terminal. A capacitor includes a first lead electrically connected between the inductor and the second terminal, and a second lead electrically connected to a ground or neutral conductor. The inductor and the capacitor are structured to cooperate with a power circuit impedance downstream of the second terminal to form a filter trap circuit. | 06-17-2010 |
20110090607 | STRING AND SYSTEM EMPLOYING DIRECT CURRENT ELECTRICAL GENERATING MODULES AND A NUMBER OF STRING PROTECTORS - A string includes direct current electrical generating modules electrically connected in series to form a first end and a remote second end. A power line is electrically connected to one DC EGM at the first end. A return line is electrically connected to another DC EGM at the remote second end. A first string protector is in the power line of the string, and a second SP is in the return line of the string at the remote second end. One of the first and second SPs includes a number of an over current protector, an arc fault protector, a reverse current protector and a ground fault protector. The other one of the first and second SPs includes a number of an over current protector, an arc fault protector, a reverse current protector, a ground fault protector, and a remotely controlled switch in series with the power or return lines. | 04-21-2011 |
20110141644 | DIRECT CURRENT ARC FAULT CIRCUIT INTERRUPTER, DIRECT CURRENT ARC FAULT DETECTOR, NOISE BLANKING CIRCUIT FOR A DIRECT CURRENT ARC FAULT CIRCUIT INTERRUPTER, AND METHOD OF DETECTING ARC FAULTS - A direct current arc fault circuit interrupter includes separable contacts and a trip circuit to trip open the contacts. The trip circuit includes a number of alternating current sensors structured to sense a current flowing through the separable contacts, a number of filter circuits cooperating with the AC current sensors to output a number of AC signals, a number of peak detectors cooperating with the filter circuits to output a number of peak current signals, and a processor cooperating with at least the peak detectors. The processor inputs the number of peak current signals as a plurality of peak current signals or inputs the number of peak current signals and determines the plurality of peak current signals. The processor also determines if the peak current signals exceed corresponding predetermined thresholds for a predetermined time, and responsively causes the contacts to trip open. | 06-16-2011 |
20110301772 | PROTECTION, MONITORING OR INDICATION APPARATUS FOR A DIRECT CURRENT ELECTRICAL GENERATING APPARATUS OR A PLURALITY OF STRINGS - A protection apparatus is for a direct current electrical generating apparatus. The protection apparatus includes a first terminal; a second terminal; a third terminal; a fourth terminal; at least one current sensor structured to sense current flowing between the first and second terminals or between the third and fourth terminals; a voltage sensor structured to sense a voltage between the first terminal and the third terminal; at least one switch structured to interrupt the current flowing between the first and second terminals or between the third and fourth terminals; and a processor cooperating with the at least one current sensor, the voltage sensor and the at least one switch, and being structured to provide feed forward fault protection for the direct current electrical generating apparatus. | 12-08-2011 |
Joseph Charles Zuercher, Brookfield, WI US
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20090322289 | SYSTEM AND METHOD FOR PERFORMING ULTRACAPACITOR CELL BALANCING - A circuit for balancing a sub-stack voltage in a stack of ultracapacitors includes a pair of electrical leads that are connectable across a first sub-stack of one or more ultracapacitors, wherein a stack includes N sub-stacks of ultracapacitors coupled to an electrical bus, a discharge device switchably connectable with the pair of electrical leads, the discharge device configured to discharge the sub-stack of ultracapacitors, a voltage sensing circuit coupled to the electrical bus and configured to sense and output a voltage of the stack of ultracapacitors after the first sub-stack of one or more ultracapacitors has been discharged to a given threshold, and a voltage amplifier coupled to the output of the voltage sensing circuit and coupled to the pair of electrical leads, the voltage amplifier configured to provide a re-charge voltage to the first sub-stack of one or more ultracapacitors. | 12-31-2009 |
20100315033 | SYSTEM AND METHOD OF DYNAMIC REGULATION OF REAL POWER TO A LOAD - A system and method for controlling an AC motor drive includes a control system programmed with an energy algorithm configured to optimize operation of the motor drive. Specifically, the control system receives input of an initial voltage-frequency command to the AC motor drive, receives a real-time output of the AC motor drive generated according to the initial voltage-frequency command, and determines a real-time value of a motor parameter based on the real-time output of the AC motor drive. The control system also inputs a plurality of modified voltage-frequency commands to the AC motor drive, determines the real-time value of the motor parameter corresponding to each of the plurality of modified voltage-frequency commands, and identifies an optimal value of the motor parameter based on the real-time values of the motor parameter. The control system maintains an input of a current modified voltage-frequency command when the real-time value of the motor parameter corresponds to the optimal value of the motor parameter. | 12-16-2010 |
William Zuercher, Durham, NC US
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20080221176 | Chemical Compounds - This invention relates to compounds that are modulators of the liver X receptors (LXRs), and also to the methods for the making and use of such compounds. | 09-11-2008 |
William J. Zuercher, Durham, NC US
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20090253659 | Cycloalkylidene Compounds As Modulators of Estrogen Receptor - The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. | 10-08-2009 |