Zsuzsa
Zsuzsa Bebok, Hoover, AL US
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20140073632 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS - Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell. | 03-13-2014 |
Zsuzsa Izsvák, Gyongyos HU
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20100255505 | GENETICALLY MODIFIED STEM CELLS AND METHODS FOR IDENTIFYING TISSUES DIFFERENTIATED THEREFROM - Genetically modified stem cells and the selection of cells differentiated therefrom are disclosed. Particularly, the herein disclosed invention relates to stem cells or cells differentiated therefrom containing a copy of a stably inheritable expression construct that is suitable for the expression of transgenes in stem cells, wherein said construct comprises at least a double-feature constitutive promoter being operable both in stem cells and in differentiated tissues, the expression level thereof being subject to a tissue or cell type specific regulation in differentiated cells, and, optionally, under the control of said promoter, a transgene, wherein said transgene is expressed in the stem cell. Furthermore methods are disclosed to produce such stem cells, as well as specific uses of said stem cells in assay methods and in human therapy and in veterinary practice. | 10-07-2010 |
Zsuzsa Izsvák, Gyongyos HU
Patent application number | Description | Published |
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20100255505 | GENETICALLY MODIFIED STEM CELLS AND METHODS FOR IDENTIFYING TISSUES DIFFERENTIATED THEREFROM - Genetically modified stem cells and the selection of cells differentiated therefrom are disclosed. Particularly, the herein disclosed invention relates to stem cells or cells differentiated therefrom containing a copy of a stably inheritable expression construct that is suitable for the expression of transgenes in stem cells, wherein said construct comprises at least a double-feature constitutive promoter being operable both in stem cells and in differentiated tissues, the expression level thereof being subject to a tissue or cell type specific regulation in differentiated cells, and, optionally, under the control of said promoter, a transgene, wherein said transgene is expressed in the stem cell. Furthermore methods are disclosed to produce such stem cells, as well as specific uses of said stem cells in assay methods and in human therapy and in veterinary practice. | 10-07-2010 |
Zsuzsa Preitl, Erlangen DE
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20120255300 | SOLAR THERMAL POWER PLANT AND METHOD FOR OPERATING A SOLAR THERMAL POWER PLANT - A solar thermal power plant including a solar collector steam generator unit for generating steam, a solar collector steam superheater unit for superheating the steam, and a steam turbine is provided. The solar thermal power plant includes an intermediate storage which is connected to the steam conduit system in a first high-temperature storage connecting point interposed between the solar thermal steam superheater unit and the steam turbine to remove steam superheated in a storage mode from the steam conduit and which includes a heat reservoir in which thermal energy is drained from the steam fed into during the storage mode and is accumulated and the stored thermal energy is given off to the steam in an extraction mode, steam being fed to the steam conduit system from the intermediate storage. The intermediate storage is connected to a condenser and/or a relaxation device of the plant in a low-temperature storage connecting point. | 10-11-2012 |