Patent application number | Description | Published |
20110245167 | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 10-06-2011 |
20110306570 | Na/K-Atpase Expression as an Indicator for the Treatment of Cancer - Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed. | 12-15-2011 |
20120289479 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and Cholesterol - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 11-15-2012 |
20120302630 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - Na/K-ATPase/Src ligands, assays and uses thereof are disclosed. | 11-29-2012 |
20130011335 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and SRC - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 01-10-2013 |
20130150294 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 06-13-2013 |
20140031419 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 01-30-2014 |
20140128356 | Na/K-ATPase Ligand - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 05-08-2014 |
20140179608 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphatase and SRC - Described herein are methods to bind a compound to the SH2 domain of Src in a Src-expressing cell which includes contacting a compound comprising an amino acid compound to a Src-expressing cell; and binding a compound to the SH2 domain of Src. | 06-26-2014 |
20140187484 | NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 07-03-2014 |