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| 20100266284 | Method and Apparatus Using Distributed Raman Amplification and Remote Pumping In Bidirectional Optical Communication Networks - A bidirectional optical communications network comprises an optical transmission fiber for carrying a downstream signal at a first wavelength and a multiplicity of upstream signals at a second, different wavelength. The fiber is characterized by distributed Raman gain over at least an extended portion of its length. A first terminal, optically coupled to one end of the fiber, includes a first transmitter for generating the downstream signal, a first receiver for detecting the upstream signals, and at least one pump source for generating pump light that provides Raman amplification to either the downstream signal or the upstream signal or both. A multiplicity of second terminals, optically coupled to another end of the fiber, each includes a second transmitter for generating one of the upstream signals, and a second receiver for detecting a downstream sub-signal. A passive optical node is configured to (i) split the downstream signal into a multiplicity of downstream sub-signals each propagating at the first wavelength to a separate one of the second terminals and (ii) to combine each of the upstream signals from each of the second terminals onto the fiber for transmission to the first terminal. In another embodiment, the network is a GPON compatible with current ITU standards. | 10-21-2010 |
| 20110129190 | Techniques for Manipulating Crosstalk in Multicore Fibers - A multicore optical fiber includes a plurality of core regions disposed within a common cladding region. Each of the plurality of core regions is configured, in combination with the common cladding region, to propagate light along a longitudinal axis of the fiber. At least two core regions are configured to inhibit resonant coupling of propagated light therebetween within a selected region of operation. At least one segment of the fiber includes a twist that is configured such that when the twisted segment is subjected to a bend having a selected radius, the twist creates a controlled change in the amount of crosstalk between the at least two core regions, compared with the amount of crosstalk between the at least two core regions when a bend having the selected radius is introduced into a non-twisted segment of the fiber. | 06-02-2011 |
| 20110274398 | MULTICORE FIBERS AND ASSOCIATED STRUCTURES AND TECHNIQUES - A multicore fiber comprises a plurality of cores extending along the length of a fiber body. Each of the cores is surrounded by a cladding. The plurality of cores and surrounding cladding provide respective index variations, so as to form a respective plurality of waveguides for conducting parallel data transmissions from a first end of the fiber to a second end. The plurality of cores has a cross-sectional geometry in which the plurality of cores is configured in a polygonal array, in which at least some of the cores are positioned at the vertices of the array. The polygonal array is configured such that neighboring cores in the array are separated from each other by a distance that is sufficient to prevent crosstalk therebetween. | 11-10-2011 |
| 20110274435 | MULTICORE FIBER TRANSMISSION SYSTEMS AND METHODS - An optical data link includes first and second pluralities of transmission devices, at least one of which is configured as an array. A multichannel transmission link has a first end connected to the first plurality of transmission devices and a second end connected to the second plurality of transmission devices so as to form a plurality of parallel transmission channels therebetween. The multichannel transmission link includes a multicore fiber with a plurality of individual cores having a configuration matching the array configuration of the at least one plurality of transmission devices. The multicore fiber has an endface connected directly to the at least one plurality of transmission devices, with the individual cores of the multicore fiber aligned with respective devices in the at least one plurality of transmission devices. Further described are access networks and core networks incorporating a transmission link comprising at least one span of a multicore fiber. | 11-10-2011 |
| 20110279888 | MULTICORE TRANSMISSION AND AMPLIFIER FIBERS AND SCHEMES FOR LAUNCHING PUMP LIGHT TO AMPLIFIER CORES - An optical transmission and amplification system includes a multichannel transmission span with a length of a multicore transmission fiber having a plurality of individual transmission cores. A first tapered multicore coupler provides connectivity between the plurality of transmission cores of the multicore fiber and a respective plurality of individual transmission leads. A fiber amplifier is provided having a plurality of individual cores including at least one pump core and a plurality of amplifier core. A second tapered multicore coupler provides connectivity between the amplifier cores of the fiber amplifier and a respective plurality of amplifier leads, and between the at least one pump core and a respective pump lead. | 11-17-2011 |
| 20110280517 | TECHNIQUES AND DEVICES FOR LOW-LOSS, MODEFIELD MATCHED COUPLING TO A MULTICORE FIBER - Devices and techniques are described for connecting each of plurality of terminals to respective individual cores of a multicore fiber. Each of the plurality of terminals is provided with a respective length of a single-core fiber. The single-core fibers are configured to maintain modal properties that arc substantially the same, within a tolerance range, at the front and rear ends, as the single-core fiber is tapered. The single-core fibers are assembled together. The front end of the assembly is tapered to form a front cross-section in which the single-core fiber cores are arranged in a configuration matching that of the cores of the multicore fiber. | 11-17-2011 |
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| 20080295761 | STIMULUS INDICATING DEVICE EMPLOYING POLYMER GELS - The present invention relates to a stimulus-indicating device. More particularly, the present invention relates to an apparatus for evidencing when a stimulus sensitive product has been exposed to a designated or predetermined stimulus for a certain period of time, and the invention relates to a method for manufacturing aspects of that apparatus. | 12-04-2008 |
| 20090010803 | Stimulus Indicating Device Employing Polymer Gels - The present invention relates, for example, to a stimulus-indicating device. More particularly, the present invention includes an apparatus for evidencing when a stimulus sensitive product has been exposed to a designated or predetermined stimulus for a certain period of time, and the invention further may include a method for manufacturing aspects of that apparatus. | 01-08-2009 |
| 20120027647 | Stimulus indicator employing stimulus sensitive metals and gels - The present invention relates, for example, to a stimulus-indicating device. More particularly, the present invention includes an apparatus for evidencing when a stimulus sensitive product has been exposed to a designated or predetermined stimulus for a certain period of time, and the invention further may include a method for manufacturing aspects of that apparatus. | 02-02-2012 |
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| 20090218714 | APPARATUS - The invention relates to apparatus for filling a cavity during production of a pharmaceutical dosage form. The apparatus comprises a cavity open at an upper surface and closed at a lower surface. The lower surface is defined by an initial layer of powder. A powder source and a fluid pump are also provided. The fluid pump is arranged to draw gas away from the cavity such that the gas pressure within the cavity is reduced below the ambient gas pressure before the cavity is filled to a predetermined fill level with powder from the powder source. | 09-03-2009 |
| 20100003321 | SOLID DOSAGE FORMS OF VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE AND METHOD OF MAKING THE SAME - Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made. | 01-07-2010 |
| 20100331387 | LYOPHILIZED PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, an chelator/antioxidant, a buffer or buffer component, and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus or iv infusion, or administered orally, e.g. as a drink solution. | 12-30-2010 |
| 20120164218 | SOLID DOSAGE FORMS OF VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE AND METHOD OF MAKING THE SAME - Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made. | 06-28-2012 |
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| 20090129296 | METHOD OF CALL CONFERENCING TO SUPPORT SESSION CONTINUITY FOR MULTI-MODE CLIENTS - The present invention provides methods of inter-technology handoff of a multi-mode mobile unit in a packet-switched communication system. One embodiment of the method includes establishing a call from a first application layer client in the first mobile unit using a first wireless communication link that operates according to a first wireless access technology. The method also includes sending, in response to detecting changing conditions of the first wireless communication link, a request to form a conference call including the first application layer client and inviting a second application layer client in the first mobile unit to join the conference call. The second application layer client uses a second wireless communication link that operates according to a second wireless access technology. The method further includes handing off the call from the first application layer client to the second application layer client. | 05-21-2009 |
| 20090141683 | METHOD OF BEST EFFORT HANDOFF TO MAINTAIN RADIO BEARER AND MIP SESSION CONTINUITY FOR MULTI-MODE MOBILE UNITS - The present invention provides a method of best effort hand off that is implemented in a mobile unit capable of communicating with a network according to multiple wireless access technologies. The method includes performing a handoff of the mobile unit from a first wireless communication link established according to a first wireless access technology to a second wireless communication link established according to a second wireless access technology. The method also includes transmitting, over the second wireless communication link, a de-registration message requesting de-registration of the first wireless communication link in response to performing the handoff. | 06-04-2009 |
| 20090245200 | Method and apparatus for communication between wireless telecommunications networks of different technology types - For handover between wireless telecommunications networks of different technology types, an air interface is set up between a first node | 10-01-2009 |
| 20110026424 | Triggering Migration of a Network Access Agent Associated with an Access Terminal - A method is provided for triggering migration of call session state information. The method includes determining whether to migrate a network access agent associated with an access terminal in a wireless communication system based on at least one of mobility information associated with the access terminal and status information associated with the wireless communication system. | 02-03-2011 |
| 20110188469 | METHOD AND APPARATUS FOR COMMUNICATION BETWEEN WIRELESS TELECOMMUNICATIONS NETWORKS OF DIFFERENT TECHNOLOGY TYPES - For handover between wireless telecommunications networks of different technology types, an air interface is set up between a first node | 08-04-2011 |
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| 20080233916 | Signaling method to support geo-location emergency services - In a method to support geo-location emergency services in a wireless network, a request message is transmitted from a source base station of one vendor to a target base station of another vendor. For example, the request message might be sent subsequent to a wireless unit initiating an emergency services communication, where it is desired to determine the location of the wireless unit by radiolocation, or otherwise at the network level. Upon receiving the request message, the target base station transmits a report message to the source base station, which includes a one-way transmission delay (or other propagation delay information) of the wireless unit as measured at the target base station. Communication protocols in the network are configured so that there are no automatic transmissions of propagation delay information. Instead, base stations transmit propagation delay information only upon the receipt of request messages requesting the information. | 09-25-2008 |
| 20090003215 | Method and system for unified overload and overflow control to support VoIP and multiple QOS flow traffic in communication network - In a method and system for controlling base station processing unit overload and buffer overflow in a unified manner, one or more processing units of the base station are monitored to determine if the processing unit(s) has entered an overload condition. If so, on a per flow basis, the system generates an advertise window for controlling the amount of data in the data flow, as transmitted to the processing unit from an upstream entity. The advertise window is generated taking into consideration both processor overload and buffer overflow factors. By incorporating these factors, the advertise windows collectively serve to limit both processor overload and buffer overflow, on a system wide basis. | 01-01-2009 |
| 20100091694 | Method and system of traffic processor selection for broadcast/multicast service in a wireless network - A method and system for selecting traffic processors for processing and transmitting broadcast/multicast service flow in a cellular network includes evaluating processor occupancy of a plurality of traffic processors and selecting the traffic processors with the highest available processor occupancy. The cellular network has one or more base stations that are connected to a radio network controller, the radio network controller having a plurality of traffic processors to process the radio signals and data traffic to be transmitted to the base stations. A required processor occupancy for transmitting the broadcast/multicast service flow to the base stations is estimated and the traffic processors are selected such that their combined available processor occupancy is greater than the required processor occupancy for the broadcast/multicast service flow. The method and system optimizes resource utilization and distribution among the plurality of traffic processors. | 04-15-2010 |
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| 20090046603 | PATH DISCOVERY AND MESSAGE TRANSFER IN PARTIALLY CONNECTED MOBILE AD HOC NETWORKS - A method and system is presented for path discovery and asynchronous message transfer in a partially connected middleware communication space comprising mobile ad hoc networks. Embodiments of the present invention use mobile devices to bridge separated islands of networks and store and propagate messages. The system and software architecture supports methods for routing, messaging caching, and transferring. More specifically, embodiments provide methods and systems that extend a communication space concept into a distributed environment and combine it with the standard Web Services technologies, i.e., SOAP, and WS series protocols. The communication space provides an extension of Web Services to mobile ad hoc networks and provides asynchronous message caching, transferring and routing. | 02-19-2009 |
| 20090103461 | HIERARCHICAL APPLICATION PROGRAMMING INTERFACE FOR COMMUNICATION MIDDLEWARE IN PARTIALLY CONNECTED MOBILE AD HOC NETWORKS - An application programming interface and related system is presented for a middleware communication space that provides asynchronous message delivery service for partially connected mobile ad hoc networks. Embodiments of the present invention use mobile devices to bridge separated islands of networks and store and propagate messages. The system and software architecture supports methods for messaging caching, transferring and routing. More specifically, embodiments provide methods and systems that extend a communication space concept into a distributed environment and combine it with the standard Web Services technologies, i.e, SOAP, and WS series protocols. The communication space provides an extension of Web Services to mobile ad hoc networks and provides asynchronous message caching, transferring and routing. | 04-23-2009 |
| 20100241684 | OARCHITECTURES FOR SUPPORTING DIVERSE CLIENT TYPES IN TRANSACTIONAL SYSTEMS - Architectures for supporting diverse client types in transactional systems are provided. These architectures provide computer-based systems that include any number of processors. These systems may also include computer-readable storage media that provide a transaction assistant module. In turn, the transaction assistant module may include an adaptive presentation layer and a shared logic layer. The adaptive presentation layer includes presentation components that correspond respectively to various types of client devices. The shared logic layer includes back-end components that are shared between the client devices to perform common functions on behalf of the client devices. | 09-23-2010 |
| 20120131178 | Multimedia Aware Cloud for Mobile Device Computing - Techniques for configuring and operating a multimedia aware cloud, particularly configured for mobile device computing, are described herein. In some instances, clusters of servers are organized for general computing, graphic computing and data storage. A load balancing server may be configured to: identify multimedia types currently being processed within the multimedia edge cloud; determine desired quality of service levels for each identified multimedia type; evaluate individual abilities of devices communicating with the multimedia edge cloud; and assess bandwidth of each network over which the multimedia edge cloud communicates with a mobile device. With that information, multimedia data may be adapted accordingly, to result in an acceptable quality of service level when delivered to a specific mobile device. In one example of the techniques, graphic computing server clusters may be configured to process workload using a configuration that includes elements of both parallel and serial computing. | 05-24-2012 |
| 20120294510 | DEPTH RECONSTRUCTION USING PLURAL DEPTH CAPTURE UNITS - A depth construction module is described that receives depth images provided by two or more depth capture units. Each depth capture unit generates its depth image using a structured light technique, that is, by projecting a pattern onto an object and receiving a captured image in response thereto. The depth construction module then identifies at least one deficient portion in at least one depth image that has been received, which may be attributed to overlapping projected patterns that impinge the object. The depth construction module then uses a multi-view reconstruction technique, such as a plane sweeping technique, to supply depth information for the deficient portion. In another mode, a multi-view reconstruction technique can be used to produce an entire depth scene based on captured images received from the depth capture units, that is, without first identifying deficient portions in the depth images. | 11-22-2012 |
| 20120320032 | Computing Three-Dimensional Image Models in Parallel - This document describes techniques for creating three-dimensional models of image collections using a network-accessible (e.g., cloud-based) computation service, rather than a client computing device. In some instances described below, the computation service performs at least a portion of the operations for creating these models in parallel. | 12-20-2012 |
| 20130014064 | Predictive, Multi-Layer Caching Architectures - Predictive, multi-layer caching architectures may be used to predict which elements a user is most likely to navigate to within a collection of elements associated with a predefined layout and, in response, to increase the accessibility of these elements to a client device of the user. For instance, the techniques may utilize a predictive, multi-layer caching architecture for storing these predicted elements to decrease the latency to render these images if the user navigates within the collection of elements in the predicted manner. The collection of elements may comprise images (e.g., a 3D model, a map, etc.), video files, audio files, text files, or any other type of file that is consumable on a client device. | 01-10-2013 |
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| 20090286830 | HETEROATOM-LINKED SUBSTITUTED PIPERIDINES AND DERIVATIVES THEREOF USEFUL AS HISTAMINE H3 ANTAGONISTS - Disclosed are novel compounds of the formula | 11-19-2009 |
| 20100247514 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 09-30-2010 |
| 20100255005 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 10-07-2010 |
| 20110082153 | GAMMA SECRETASE MODULATORS - This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I). | 04-07-2011 |
| 20110243940 | BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complication, obesity, an obesity-related disorder or non-alcoholic fatty liver disease. Formula (I). Y is —C— when an optional and additional bond is present and Y is —CH— when an optional and additional bond is not present; Z is —O—, —NH— or —N(alkyl)- when the optional and additional bond between Y and Z Is absent, and Z Is —N— when the optional and additional bond between Y and Z is present; R | 10-06-2011 |
| 20110257156 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 10-20-2011 |
| 20110257163 | GAMMA SECRETASE MODULATORS - This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula Compounds of formula (I) include compounds of formulas (IA) and (IB). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I). | 10-20-2011 |
| 20110294756 | GAMMA SECRETASE MODULATORS - In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. | 12-01-2011 |
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| 20080319032 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS - This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells. | 12-25-2008 |
| 20100189708 | HYDROXY PIPERIDINE DERIVATIVES TO TREAT GAUCHER DISEASE - The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease. | 07-29-2010 |
| 20110245210 | THALIDOMIDE ANALOGS - Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs. | 10-06-2011 |
| 20130035363 | Thalidomide Analogs - Thalidomide analogs that modulate tumor necrosis factor alpha (TNFα) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs. | 02-07-2013 |
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| 20080242593 | HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS - The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The peptides of this invention show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes. | 10-02-2008 |
| 20100022457 | Sustained release glp-1 receptor modulators - The present invention provides novel pharmaceutical compositions comprising a human glucagon-like peptide-1 (GLP-1)-receptor modulator as an active ingredient in a sustained release formulation. | 01-28-2010 |
| 20100029656 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS - The present application describes CB-1 inverse agonists according to Formula (I) and (Ia), pharmaceutical compositions comprising at least one compound according to Formula (I) or (Ia), and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula (I) or (Ia), both alone and in combination with one or more additional therapeutic agents. The preferred compounds have the general Formula (Ia), including all prodrugs, pharmaceutically acceptable salts and stereoisomer, thereof, wherein R | 02-04-2010 |
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| 20080273752 | SYSTEM AND METHOD FOR VEHICLE DETECTION AND TRACKING - A method for vehicle detection and tracking includes acquiring video data including a plurality of frames, comparing a first frame of the acquired video data against a set of one or more vehicle detectors to form vehicle hypotheses, pruning and verifying the vehicle hypotheses using a set of course-to-fine constraints to detect a vehicle, and tracking the detected vehicle within one or more subsequent frames of the acquired video data by fusing shape template matching with one or more vehicle detectors. | 11-06-2008 |
| 20080275335 | Methods and apparatus for virtual coronary mapping - A virtual map of vessels of interest in medical procedures, such as coronary angioplasty is created so that doses of contrasting agent given to a patient may be reduced. A position of a coronary guidewire is determined and locations of vessel boundaries are found. When the contrast agent has dissipated, virtual maps of the vessels are created as new images. The locations of the determined vessel boundaries are imported to a mapping system and an image obtained without using a contrast agent is modified based on the imported locations of vessel boundaries. This creates a virtual map of the vessels. | 11-06-2008 |
| 20090010512 | System and method for coronary digital subtraction angiography - A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image. | 01-08-2009 |
| 20100034446 | System and Method for Coronary Digital Subtraction Angiography - A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image. | 02-11-2010 |
| 20100121181 | Method and System for Guidewire Tracking in Fluoroscopic Image Sequences - A method and system for tracking a guidewire in a fluoroscopic image sequence is disclosed. In order to track a guidewire in a fluoroscopic image sequence, guidewire segments are detected in each frame of the fluoroscopic image sequence. The guidewire in each frame of the fluoroscopic image sequence is then detected by rigidly tracking the guidewire from a previous frame of the fluoroscopic image sequence based on the detected guidewire segments in the current frame. The guidewire is then non-rigidly deformed in each frame based on the guidewire position in the previous frame. | 05-13-2010 |
| 20110033102 | System and Method for Coronary Digital Subtraction Angiography - A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image. | 02-10-2011 |
| 20110274334 | SYSTEM AND METHOD FOR IMAGE-BASED RESPIRATORY MOTION COMPENSATION FOR FLUOROSCOPIC CORONARY ROADMAPPING - A method for compensating respiratory motion in coronary fluoroscopic images includes finding a set of transformation parameters of a parametric motion model that maximize an objective function that is a weighted normalized cross correlation function of a reference image acquired at a first time that is warped by the parametric motion model and a first incoming image acquired at a second time subsequent to the first time. The weights are calculated as a ratio of a covariance of the gradients of the reference image and the gradients of the first incoming image with respect to a root of a product of a variance of the gradients of the reference image and the variance of the gradients of the first incoming image. The parametric motion model transforms the reference image to match the first incoming image. | 11-10-2011 |
| 20120140998 | Deformable Motion Correction for Stent Visibility Enhancement - A method for enhancing stent visibility includes acquiring a set of image frames including multiple test frames. A set of measurement points uniformly distributed within an image of a stent is defined in the test frames. A local image context is defined around each measurement point. A non-rigid deformation field relating the local image contexts of the test frames to local image contexts of a reference image is calculated. The non-rigid deformation field is optimized by maximizing a similarity function between the local image contexts of the test frames and the local image contexts of the reference image. The optimized non-rigid deformation field is used to deform images of a stent in the multiple test frames and combine the non-rigidly deformed images of the stent from the test frames. An image frame with the combined image of the stents superimposed thereon is displayed. | 06-07-2012 |
| 20120321169 | Shape Based Conditional Random Fields for Segmenting Intracranial Aneurysms - A method for segmenting intracranial aneurysms in digital medical images includes extracting a mesh representing a vessel surface from a volumetric digital image, the mesh comprising a set of points {p | 12-20-2012 |
| 20120323547 | METHOD FOR INTRACRANIAL ANEURYSM ANALYSIS AND ENDOVASCULAR INTERVENTION PLANNING | 12-20-2012 |
| 20130057686 | CROWD SOURCING PARKING MANAGEMENT USING VEHICLES AS MOBILE SENSORS - Systems and methods for monitoring parking spots are disclosed. A system includes at least one vehicle and a remote computer that are in communication with each other. A vehicle includes a camera that generates image data, a location device that generates geographic coordinates of the vehicle, a computing device that receives the image data from the camera and the geographic coordinates of the vehicle and optionally data from a laser scanner that is calibrated with the camera and is connected to a smartphone that transmits data to the remote computer. Image data generated by the camera is processed with a reference image and data from the laser scanner to determine an occupation status of the parking spot. The occupation status is transmitted by the remote computer to a second vehicle. | 03-07-2013 |
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| 20090028859 | Bispecific antibodies that bind to vegf receptors - The present invention is directed to production of antigen-binding proteins that bind specifically to an extracellular domains of two different VEGF receptors. The bispecific antigen-binding proteins block activation of the VEGF receptors and are used to reduce or inhibit VEGF-induced cellular functions such as mitogenesis of vascular endothelial cells and migration of leukemia cells. The antigen-binding proteins of the present invention can be monovalent or multivalent, have antigen-binding sites consisting of immunoglobulin heavy chain and light chain variable domains and may further include immunoglobulin constant domains. | 01-29-2009 |
| 20090053241 | PDGFRbeta-specific inhibitors - The invention is directed to novel PDGFRβ-specific antagonists. The antagonists include antibodies, which can be bispecific. The antibodies are used to reduce or inhibit tumor growth and or to treat an angiogenic disease. The invention also includes combinations of PDGFRβ-specific antagonists with VEGFR antagonists for such treatments. The antagonists can further be administered in combination with other anti-angiogenic or anti-neoplastic drugs. | 02-26-2009 |
| 20090142358 | HUMAN ANTIBODIES SPECIFIC TO KDR AND USES THEREOF - The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal. | 06-04-2009 |
| 20100143371 | INTRABODIES - A single domain intrabody that binds to an intracellular protein or to an intracellular domain of an intracellular protein, such as Etk. Also provided is a method of inhibiting an intracellular enzyme, and treating a tumor in a patient by administering the intrabody or a nucleic acid expressing the inventive intrabody. | 06-10-2010 |
