Zheng, MD
Changyu Zheng, Rockville, MD US
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20090258935 | HYBRID ADENO-RETROVIRAL VECTOR FOR THE TRANSFECTION OF CELLS - An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid sequence, a nucleic acid sequence encoding a portion of a retroviral envelope protein adjacent to either the 5′ LTR or the 3′ LTR nucleic acid sequence, a retroviral packaging sequence and a nucleic acid sequence encoding a transgene located between the 5′ LTR and the 3′ LTR is provided. Host cells infected with this adenovirus are also provided. An adenoviral vector is provided that includes an adenoviral polynucleotide sequence comprising a nucleic acid encoding a transgene, a retroviral packaging signal, a 5′ and a 3′ retroviral LTR, and a portion of a retroviral envelope polypeptide, wherein the adenoviral polynucleotide sequence does not encode one or more of E1, E3 or E4. A method for transforming a cell is also provided using a virus or a vector of the invention, as is a method for introducing a transgene into a cell that is not able to produce viral particles with a single viral vector. A method is also provided for preventing or treating disorder in a subject using the adenoviral vectors of the invention. A pharmaceutical composition is also provided that includes an adenoviral vector of the invention and a pharmaceutically acceptable carrier. | 10-15-2009 |
Chen Zheng, Clarksville, MD US
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20130011798 | METHOD OF APPLYING PATTERNED METALLIZATION TO BLOCK FILTER RESONATORS - An embodiment of the present invention provides a method of applying patterned metallization to a ceramic block comprising applying a photodefinable ink to said ceramic block; drying said ink; exposing said photodefinable ink to UV radiation through a predefined mask according to the thickness of the film to form a pattern; developing said pattern in a developer solution thereby forming a patterned ceramic block; and rinsing, drying and firing said patterned ceramic block. | 01-10-2013 |
Feng Zheng, Rockville, MD US
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20090029908 | UTEROGLOBIN IN THE TREATMENT OF IgA MEDIATED AUTOIMMUNE DISORDERS - Uteroglobin has been discovered to prevent IgA mediated diseases, such as IgA nephropathy, by preventing the deposition of IgA-Fibronectin immunocomplexes in tissues such as the renal glomeruli. The invention therefore includes methods of treating such diseases by administering therapeutically effective amounts of uteroglobin (and variants or mimetics) to prevent or improve the IgA mediated condition. Transgenic uteroglobin knockout animals, and animals in which uteroglobin-protein expression is reduced by antisense technology, also provide systems for studying IgA mediated diseases, and screening for appropriate treatments. | 01-29-2009 |
Jie Zheng, Columbia, MD US
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20140322168 | PAENIBACILLUS ALVEI STRAIN TS-15 AND ITS USE IN CONTROLLING PATHOGENIC ORGANISMS ON CROPS - The present invention provides a newly isolated bacterial strain of | 10-30-2014 |
Jingmin Zheng, Frederick, MD US
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20090243163 | CO-FIRING OF MAGNETIC AND DIELECTRIC MATERIALS FOR FABRICATING COMPOSITE ASSEMBLIES FOR CIRCULATORS AND ISOLATORS - A method for making a composite magnetic-dielectric disc assembly includes forming a dielectric ceramic cylinder, forming a magnetic ceramic rod, assembling the magnetic ceramic rod coaxially inside the dielectric ceramic cylinder to form a rod-and-cylinder assembly, kilning (firing) the rod-and-cylinder assembly, slicing the rod-and-cylinder assembly to form a plurality of composite magnetic-dielectric disc-shaped assemblies. The magnetic-dielectric disc assemblies can be used in manufacturing, for example, circulators, isolators or similar electronic components. Accordingly, the method for making the disc assemblies can be included as part of a method for making such electronic components. | 10-01-2009 |
20110227678 | MAGNETIC-DIELECTRIC ASSEMBLIES AND METHODS OF FABRICATION - A method for making a composite magnetic-dielectric disc assembly includes forming a dielectric ceramic annular cylinder, forming a magnetic ceramic rod, assembling the magnetic ceramic rod coaxially inside the dielectric ceramic cylinder, joining the magnetic ceramic rod to the dielectric ceramic cylinder using an adhesive comprising a ceramic material to form a rod-and-cylinder assembly, and slicing the rod-and-cylinder assembly to form a plurality of composite magnetic-dielectric disc-shaped assemblies. The magnetic-dielectric disc assemblies can be used as components of, for example, circulators, isolators, or similar electrical assemblies. | 09-22-2011 |
20120249273 | MAGNETIC-DIELECTRIC ASSEMBLY - A magnetic-dielectric disc assembly includes a magnetic ceramic disc coaxially secured within a dielectric ceramic ring by an adhesive that includes a powdered ceramic in an epoxy matrix. The powdered ceramic is selected from the group consisting of alumina, titania, silica, and zirconia. The magnetic-dielectric disc assembly can be used as a component of, for example, a circulator, isolator, or similar electrical assembly. | 10-04-2012 |
Lixen Zheng, Rockville, MD US
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20100041596 | Amelioration of Inflammatory Arthritis By Targeting the Pre-ligand Assembly Domain (Plad) of Tumor Necrosis Factor Receptors - The present invention provides a polypeptide comprising the isolated amino acid sequence of a pre-ligand assembly domain (PLAD) of a TNF receptor-like receptor. Also provided by this invention is a polypeptide comprising the isolated amino acid sequence of a pre-ligand assembly domain (PLAD), wherein the PLAD is selected from the group consisting of: the PLAD of a TNF-R, the PLAD of p60, the PLAD of p80, the PLAD of Fas (CD95/APO-1), the PLAD of TRAIL receptors, the PLAD of LTyR, the PLAD of CD40, the PLAD of CD30, the PLAD of CD27, the PLAD of HVEM, the PLAD of OX40 and the PLAD of DR4. TNF-R, p60, p80, Fas, TRAIL receptor, LTyR, CD40, CD30, CD27, HVEM, OX40, DR4, TROY, EDAR, XEDAR, DCR3, AITR, 4-1BB, DR3, RANK, TACI, BCMA, DR6, DPG, DR5, DCR1 AND DCR2 are all members of the TNF receptor superfamily or the TNF-like receptor family. The invention also provides the PLAD for other members of the TNF receptor superfamily. The polypeptides of the present invention can be utilized to inhibit oligomerization of members of the TNF receptor superfamily. These polypeptides can also be utilized to inhibit ligand binding to members of the TNF receptor superfamily. The present invention also provides a composition comprising an inhibitor of TNF receptor oligomerization. Further provided by this invention are members of the TNF receptor superfamily that are lacking a PLAD. | 02-18-2010 |
Mike Q. Zheng, Columbia, MD US
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20080230074 | Method and device for immobilization of the human breast in a prone position for radiotherapy - A system and method for immobilization of the human breast in a prone position during imaging and radiotherapy. The system includes a vacuum-assisted breast immobilization cup comprising two layers joined together with an air space between. The inner layer has densely perforated holes while the outer layer is airtight. When a negative vacuum is applied to the intermediate airspace the breast tissue is sucked against the mesh wall of the inner layer to preventing sliding. In addition, the cup assembly is locked into a fixed position against the patient torso via a body fixture, as well as against the patient support structure. The established geometric relationship among the cup, chest wall, imaging/treatment table or couch may be accurately repeated. The system further includes a three-dimensional localization system to uniquely place the breast in a coordinate system having fixed geometric relationship with the breast immobilization cup. | 09-25-2008 |
20120198624 | METHOD AND DEVICE FOR PATIENT LOADING AND POSITIONING - A method and device for accurately positioning patients for imaging and radiotherapy is disclosed. The device includes a support platform (such as a bed, a table, a couch, a chair, etc.) connected to a fixed base by at least two and preferably four offset supporting arms. The support arms are journaled into the support platform at passive-rotatable pivot joints and are journaled into the base at active-rotatable pivot points. The base contains actuators (manual or powered by motors, pneumatics or hydraulics) for articulating the support arms. The relative lengths of the support arms may be varied to create a pre-defined trajectory of the support platform, between a starting spatial position and orientation to an ending spatial position and orientation, and through a continuous range there between. This makes it possible to position a patient within a range from a low, standing up position to a high, forwarding, prone or supine position, or vice versa. | 08-09-2012 |
Ming Zheng, Rockville, MD US
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20140174991 | Fractionating nanomaterials by a liquid multiphase composition - A process for fractionating a nanoparticle composition, the process includes combining a first polymer, a second polymer, and a solvent to form a fluid and contacting the nanoparticle composition with the fluid. The nanoparticle composition includes a plurality of first nanoparticles, a plurality of second nanoparticles, and a dispersant disposed on an exterior surface of the first nanoparticles and the second nanoparticles. Fractionating the nanoparticle composition also includes forming a multiphase composition that includes a first phase and a second phase by partitioning the first polymer and the second polymer such that a concentration of the first polymer is greater than a concentration of the second polymer in the first phase, and the concentration of the second polymer is greater than the first polymer in the second phase, wherein the solvent is present in the first phase and the second phase. Additionally, the process includes apportioning the first nanoparticles and the second nanoparticles among the first phase and the second phase to fractionate the nanoparticle composition, based on a relative affinity of the first nanoparticles and the second nanoparticles for the first polymer and the second polymer, wherein the first nanoparticles are present in the first phase and substantially absent in the second phase, and the second nanoparticles are present in the second phase and substantially absent in the first phase. | 06-26-2014 |
Nengan Zheng, Baltimore, MD US
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20080294354 | System and method for detecting structural damage - A system and method for detecting structural damage is provided that utilizes a general order perturbation methodology involving multiple perturbation parameters. The perturbation methodology is used iteratively in conjunction with an optimization method to identify the stiffness parameters of structures using natural frequencies and/or mode shape information. The stiffness parameters are then used to determine the location and extent of damage in a structure. A novel stochastic model is developed to model the random impact series produced manually or to generate a random impact series in a random impact device. The random impact series method or the random impact device can be used to excite a structure and generate vibration information used to obtain the stiffness parameters of the structure. The method or the device can also just be used for modal testing purposes. The random impact device is a high energy, random, and high signal-to-noise ratio system. | 11-27-2008 |
Qiao-Xi Zheng, Hanover, MD US
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20110250202 | REAGENTS, METHODS, AND SYSTEMS FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS - The present invention provides PBP2a peptide antigens for generating antibodies against MRSA, and provides high-affinity binding agents that detect MRSA by selective immunoreactivity with PBP2a. The antibodies are useful in methods and systems for detecting MRSA, including biosensor systems, or as components of diagnostic or detection kits. The antibodies, in some embodiments, have therapeutic value against MRSA infection. | 10-13-2011 |
Qinfen Zheng, Ellicott City, MD US
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20100033574 | Method and System for Object Surveillance and Real Time Activity Recognition - Method and system for objects surveillance and real-time activity recognition is based on analysis of spatio-temporal images of individuals under surveillance where a spatio-temporal volume occupied by each individual is decomposed by crossing the same at specific heights to form 2-dimensional slices, each containing representation of trajectory of the motion of corresponding portions of the individual body. The symmetry of the trajectories (Gait DNA) is analyzed and classified to generate data indicative of a type of activity of the individual based on the symmetry or asymmetry of the Gait DNA in each 2-dimensional slice. An effective occlusion handling ability is implemented which permits to restore the occluded silhouette of an individual. | 02-11-2010 |
20100046797 | METHODS AND SYSTEMS FOR AUDIENCE MONITORING - Systems and methods for audience monitoring are provided that include receiving an input including a recording or live feed of an audience composed of several persons, detecting foreground of the input, performing blob segmentation of the input, and analyzing human presence on each segmented blob by identifying at least one person, identifying a spatial distribution of at least one identified person, determining a dwell time of at least one identified person, determining a temporal distribution of at least one identified person, and determining a gaze direction of at least one identified person. Such detecting provides the ability to track individual persons present in the audience, and how long they remain in the audience. The method also provides the ability to determine gaze direction of persons in the audience, and how long one or more persons are gazing in a particular direction. | 02-25-2010 |
20120099765 | METHOD AND SYSTEM OF VIDEO OBJECT TRACKING - Methods and systems are provided to determine a target tracking box that surrounds a moving target. The pixels that define an image within the target tracking box can be classified as background pixels, foreground pixels, and changing pixels which may include pixels of an articulation, such as a portion of the target that moves relatively to the target tracking box. Identification of background image pixels improves the signal-to-noise ratio of the image, which is defined as the ratio between the number of pixels belonging to the foreground to the number of changing pixels, and which is used to track the moving target. Accordingly, tracking of small and multiple moving targets becomes possible because of the increased signal-to-noise ratio. | 04-26-2012 |
Qingdong Zheng, Baltimore, MD US
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20110163301 | PYROMELLITIC DIIMIDE ORGANIC SEMICONDUCTORS AND DEVICES - n-type organic semiconductors have a pyromellitic diimide structure and electronic or electro-optic devices include pyromellitic diimide compounds as organic semiconductors. Specific semiconductors include pyromellitic diimide compounds have sidechains comprising fluorine substituted aliphatic or aromatic moieties linked to the pyromellitic diimide structure by an alkylene or heteroalkylene linking group. An electronic or electro-optic device includes a first electrode, a second electrode space apart from the first electrode, and an organic semiconductor layer arranged between the first and second electrodes. The organic semiconductor layer comprises a pyromellitic diimide compound. | 07-07-2011 |
Wenxin Zheng, Ellicott City, MD US
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20080226227 | Privacy in an Optical Fiber Link - Methods and apparatuses are described for providing privacy features on an optical fiber link. By providing such features, the effects on the optical fiber link by certain outside influences, such as acoustical waves, may be prevented from being remotely monitored from a position outside the link. | 09-18-2008 |
20100065535 | METHOD AND APPARATUS FOR GENERATING A PLASMA FIELD - A method and associated apparatus for generating a plasma field, including: arranging the points of discharge of a plurality of electrodes into a plane, applying voltage to each electrode, providing at least one grounded electrode, and controlling the path between the electrodes and corresponding temperature of the plasma formed between the electrodes by controlling the signal and phase to the high voltage generators. | 03-18-2010 |
20110052121 | FIBER BALL LENS APPARATUS AND METHOD - A method for producing a ball lens including determining a feed length of optical fiber based on a target ball lens diameter; providing heat energy to a heating zone; moving, at a predetermined speed, one of the optical fiber and the heating zone so that the end of the optical enters the heating zone to heat the end of the optical fiber; and stopping the heating of the end of the optical fiber when the amount of moving the one of the optical fiber and the heating zone equals the determined feed length. | 03-03-2011 |
20110138598 | METHOD FOR SPLICING A BEND-OPTIMIZED OPTICAL FIBER - A method of splicing a bend-optimized optical fiber in which a mesh of nanometer-scale pockets is formed in the cladding of the fiber is provided. The method may include cleaving the fiber; heating a section of the fiber at a distance from an end of the fiber; allowing the fiber to cool; transmitting light through the fiber; and splicing the fiber by analyzing an image of the fiber. Alternatively, the method may include heating a section of the fiber; allowing the fiber to cool; cleaving the fiber through the section of the fiber that was heated; transmitting light through the fiber; and splicing the fiber by analyzing an image of the fiber. | 06-16-2011 |
20110309056 | APPARATUS AND METHOD FOR ARC CALIBRATION OF FUSION SPLICERS - A method of calibrating a fusion splicer, including: heating ends of a first and second fiber with an arc; measuring fiber end melt-back at a corner of the first fiber and a corner of the second fiber; increasing the heat of the arc and heating the ends of the first and second fibers with the arc; measuring fiber end melt-back at the corner of the first fiber and the corner of the second fiber; determining a slope of the fiber end melt-back; and based on said slope, setting a value to adjust the heat produced by the splicer. | 12-22-2011 |
20140361452 | METHOD AND APPARATUS FOR MAKING A TAPER IN AN OPTICAL FIBER - A method of making a taper in an optical fiber including: securing the optical fiber in a first holder and a second holder, heating the optical fiber, and moving the first holder in a first direction with a pulling speed and at the same time moving the second holder in the first direction with a feeding speed, wherein a ratio of the pulling speed to the feeding speed is greater than one. | 12-11-2014 |
Xiaoyu Alan Zheng, Germantown, MD US
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20160136395 | SYSTEMS AND METHODS FOR PROVIDING SECUREMENT AND POSITION VERIFICATION FOR MEDICAL CATHETERS - An antimicrobial, securement, and position verification device for medical catheters is disclosed. A film, medical grade adhesive, and antimicrobial substance disposed on the medical grade adhesive operate in conjunction to secure the device to the patient's skin and to prevent infections. The catheter is secured by guide channels in the foundation and securement cover through the use of one or more adhesives impregnated with antimicrobial substances. The device further comprises catheter position alert media and indicators configured to indicate any unintentional positional changes. | 05-19-2016 |
Yixian Zheng, Baltimore, MD US
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20090280111 | Isolation of the Mitotic Spindle Matrix and its Methods of Use - The invention encompasses a purified preparation of the mitotic spindle matrix essential for mitotic spindle assembly, which allows for identifying an agent that modulates a cell division and/or differentiation signaling pathway comprising determining the effect of the agent on spindle formation, MT nucleation, or lamin matrix assembly wherein the change in spindle formation, MT nucleation or lamin matrix assembly. | 11-12-2009 |
Yun Zheng, Rockville, MD US
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20120217389 | ELECTROSPRAY IONIZATION FOR CHEMICAL ANALYSIS OF ORGANIC MOLECULES FOR MASS SPECTROMETRY - An electrospray ionization laboratory on a chip for in situ detection of organic molecules includes a substrate, an input for accepting organic molecule samples, an enrichment column for concentrating organic molecule samples and delivering a concentrated sample to a micro fluidic channel, an analytical column connected in serial to the enrichment column for accepting the concentrated sample, a detector for accepting a pressurized fluid output from the analytical column, and an output nozzle assembly for generating an electrospray output for mass spectrometry analysis. The nozzle assembly may include 1, 2 or 4 (arranged in a rectangular fashion) nozzles. | 08-30-2012 |
20140065034 | MICROFLUIDIC DEVICE AND METHOD OF FABRICATING MICROFLUIDIC DEVICES - Lab-on-a-chip microfluidic devices having micro-channels able to withstand an internal channel pressure of more than 4,000 psi are described. The micro-channels have rounded cross-sections that prevent turbulent flow within a fluid conveyed within the channel. The channel may have serpentine-shaped length extending between a channel inlet and a channel outlet, the channel thereby being of sufficient length to observe both the stationary and moving phases of the fluid in a chip having a sufficiently small footprint that it is suitable for incorporation into a miniaturized spectrometer. Methods of fabricating lab-on-a-chip microfluidic devices are described by etching recesses in chip substrates such that a first substrate recess mirrors a second substrate recess in an opposed orientation, aligning the substrates such the recesses cooperatively define a micro-channel having a rounded cross-section, and bonding the substrates to define a smooth-walled micro-channel. | 03-06-2014 |
Yunhui Zheng, Crofton, MD US
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20110051121 | TELESCOPE WITH A WIDE FIELD OF VIEW INTERNAL OPTICAL SCANNER - A telescope with internal scanner utilizing either a single optical wedge scanner or a dual optical wedge scanner and a controller arranged to control a synchronous rotation of the first and/or second optical wedges, the wedges constructed and arranged to scan light redirected by topological surfaces and/or volumetric scatterers. The telescope with internal scanner further incorporates a first converging optical element that receives the redirected light and transmits the redirected light to the scanner, and a second converging optical element within the light path between the first optical element and the scanner arranged to reduce an area of impact on the scanner of the beam collected by the first optical element. | 03-03-2011 |
20110181881 | POLARIZATION SWITCHING LIDAR DEVICE AND METHOD - A polarization switching lidar device is arranged for remote detection and characterization of airborne aggregations of particulates. It includes a pulsed laser, a mirror, a polarizing beam splitter, an actively controlled retarder arranged to be controllably alternated between a zero retardation state and a quarter-wave retardation state such that the transmitted portion of the exiting laser light beam is linearly polarized in a predetermined direction when the actively controlled retarder is in the zero retardation state, while being circularly polarized in a predetermined rotational sense when the actively controlled retarder is in the quarter-wave retardation state. A directable telescoping assembly is arranged to collect photons backscattered by the airborne aggregations of particulates and to redirect the collected portion of depolarized backscattered photons onto the polarizing beam splitter. A photodetector is arranged to generate at least one electronic signal proportional to the collected portion of depolarized backscattered photons. | 07-28-2011 |
20120026497 | POLARIZATION SWITCHING LIDAR DEVICE AND METHOD - A polarization switching lidar device, arranged for remote detection and characterization of airborne aggregations of particulates, includes a pulsed laser, a mirror, a polarizing beam splitter, an actively controlled retarder arranged to be controllably alternated between a zero retardation state and a quarter-wave retardation state such that the transmitted portion of the exiting laser light beam is linearly polarized in a predetermined direction when the actively controlled retarder is in the zero retardation state, while being circularly polarized in a predetermined rotational sense when the actively controlled retarder is in the quarter-wave retardation state. A directable telescoping assembly is arranged to collect photons backscattered by the airborne aggregations of particulates and to redirect the collected portion of depolarized backscattered photons onto the polarizing beam splitter. A photodetector is arranged to generate at least one electronic signal proportional to the collected portion of depolarized backscattered photons. | 02-02-2012 |
Yun-Ling Zheng, North Potomac, MD US
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20120270947 | Short Telomere Length on Chromosome 9P is Strongly Associated with Breast Cancer Risk - Disclosed are compositions and methods related to assessing the risk of cancer, such as breast cancer, through analyzing the length of telomeres, such as chromosome 9p telomere, such as the short arm of the 9p telomere. If the 9p arm is shorter than normal, the risk of cancer is increased. | 10-25-2012 |
20130217017 | Detection and Assessment of Cancer Risk Using Telomere Health - Disclosed are compositions and methods related to assessing the risk of cancer, such as breast cancer and lung cancer, through analyzing the length of telomeres, such as chromosome 9p, 15p, and/or Xp telomere, such as the short arm of the 9p, 15p, and/or Xp telomere. For example, if the 9p, 15p, and/or Xp arm is shorter than normal, the risk of cancer is increased. | 08-22-2013 |
20140287409 | Detection And Assessment Of Cancer Risk Using Telomere Health - Compositions and methods related to assessing the risk of cancer, such as breast cancer, lung cancer and bladder cancer, through analyzing the length of telomeres, such as chromosome 9p, 15p, and/or Xp telomere, such as the short arm of the 9p, 15p, and/or Xp telomere. | 09-25-2014 |
Zheng Zheng, Catonsville, MD US
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20150050476 | BURNTHROUGH RESISTANT LAMINATE FILM - A burnthrough resistant laminate film is described. Embodiments of the burnthrough resistant laminate film include a glass layer, a first film, a second film, and an adhesive. The glass layer can include a high purity silicon dioxide cloth. The first film and the second film can be adapted to be fire retardant. The adhesive can include at least one inorganic filler adapted to negate heat transfer. The glass layer, the first film, and the second film can be coupled together by the adhesive and thermally laminated. | 02-19-2015 |