Patent application number | Description | Published |
20090170853 | NOVEL INHIBITORS OF KINASES - The present invention provides compounds of formula I, | 07-02-2009 |
20110034416 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed are compounds of Formula (I): | 02-10-2011 |
20110052583 | PYRIDINONE COMPOUNDS - The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: | 03-03-2011 |
20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS - The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds. | 12-01-2011 |
20110295015 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 12-01-2011 |
20120114643 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed are compounds of Formula (I): | 05-10-2012 |
20130158031 | ALKYNE-BRIDGED HETERO-AROMATICS AND USES THEREOF - This invention relates to novel alkyne-bridged hetero-aromatics as described in the specification which are PDE10A inhibitors and useful for the treatment of neurological, psychiatric disorder, metabolic disorders, such as Schizophrenia, Parkinson's disease, Huntington's disease, Alzheimer's disease, learning memory disorder, drug addiction (abuse), sleeping disorder, depression, obesity, non-insulin dependent diabetes, bipolar disorder, obsessive compulsive disorder, or pain; to process for their preparation; to pharmaceutical compositions comprising them; and to methods of using them. | 06-20-2013 |
20140012007 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 01-09-2014 |
20140135318 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS - Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds. | 05-15-2014 |