Patent application number | Description | Published |
20090048115 | Identification of sequences particularly useful for the diagnosis and identification of therapeutic targets for osteoarthritis - The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens. | 02-19-2009 |
20090208942 | Method and Apparatus for Correlating Levels of Biomarker Products with Disease - In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies. | 08-20-2009 |
20100143916 | OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). As would be understood, in order to measure the products of biomarkers of the invention, polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease progression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of compounds that bind and/or modulate the activity of the genes of the invention. The compounds identified via such methods are useful for the development of assays to study osteoarthritis and osteoarthritis progression. Further, the compounds identified via such methods are useful as lead compounds in the development of prophylactic and therapeutic compositions for the prevention, treatment, management and/or amelioration of osteoarthritis or a symptom thereof. | 06-10-2010 |
20100330574 | CHIMERIC PRIMERS WITH HAIRPIN CONFORMATIONS AND METHODS OF USING SAME - Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed. | 12-30-2010 |
20110020809 | MILD OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. | 01-27-2011 |
20130013214 | METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE - In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies. | 01-10-2013 |
20130017965 | OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing said polynucleotides and proteins and the use of said polynucleotides and proteins. The biomarker products can be used to identify therapeutic targets for osteoarthritis, and compounds that bind and/or modulate the gene activity. | 01-17-2013 |
20140057258 | METHOD OF DIAGNOSING MILD OSTEOARTHRITIS - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. | 02-27-2014 |
20140242586 | CHIMERIC PRIMERS WITH HAIRPIN CONFORMATIONS AND METHODS OF USING SAME - Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed. | 08-28-2014 |
20150191796 | Method and Apparatus for Correlating Levels of Biomarker Products with Disease - In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies. | 07-09-2015 |
Patent application number | Description | Published |
20130124241 | Method And System For Providing Business Intelligence Data - A computer implemented method for data mining and providing business intelligence data including generating by an analytics server one or more dimensions from source data imported from a computer readable medium, wherein the one or more dimensions define categories into which portions of the normalized data can be grouped; generating by the analytics server one or more measures from the source data linked to the one or more dimensions; storing by the analytics server the one or more dimensions and the one or more measures in a plurality of tables arranged in one of a snowflake and a star schema; determining by the analytics server relationship information between one or more measures and one or more dimensions in each of the plurality of tables; storing by the analytics server the relationship information on the computer readable medium; calculating by the analytics server a total cost of at least one product based on the relationship information; and, querying by a computer system in communication with the analytics server for the change in total cost of the at least one product based on a change in any one of the measures. | 05-16-2013 |
20130132139 | Method And System For Providing Business Intelligence Data - A machine implemented method for collecting business intelligence data including providing a master database table on a computer readable medium and accessible by an analytics server, accessing rows in the master database table by the analytics server, with each row in the master database table containing at least a partial set of measures for a plurality of dimensions, identifying by the analytics server a set of one or more dimensions from the plurality of dimensions subject to a query by one or more computing devices in communication with the analytics server, extracting the set of one or more dimensions and associated measures for each of the one or more dimensions from the master database table, and forming a baby fact table such that each row in the baby fact table contains the set of one or more dimensions subject to the query and the associated measures derived from the extracting step. | 05-23-2013 |
20130132435 | Method And System For Providing Business Intelligence Data - A system for data mining and providing business intelligence data including a source system having a computer readable database storing data aggregated from one or more data sources, and an analytics server in communication with the source system and including a computer readable medium having an intermediate data file stored thereon. The intermediate data file consisting of the data aggregated from the one or more data sources. The analytics server includes computer readable instructions for: importing the data aggregated from the one or more data sources for storing on the intermediate data file in the form of source data; normalizing the source data using predetermined scripts into normalized data stored in normalized data tables on the computer readable medium; generating one or more dimensions from the source data, wherein the one or more dimensions define categories into which portions of the normalized data can be grouped; generating one or more measures from the source data linked to the one or more dimensions; and, generating one or more formulae for calculating information from one or both of the dimensions and the measures. | 05-23-2013 |
20140195552 | METHOD AND SYSTEM FOR COLLATING AND PRESENTING INFORMATION - A system and method for collating and presenting information including at least one structured data source on a non-transitory computer readable medium; at least one unstructured data source on a non-transitory computer readable medium; an analytical engine in data communication with the at least one structured data source and the at least one unstructured data source; wherein the analytical engine combines and transforms data from the at least one structured data source and from the at least one unstructured data source into newly structured data; the newly structured data being stored on a computer readable medium; an engine data handler adapted to correspond with the analytical engine and to access the newly structured data; a schema definition stored on a computer readable medium accessible by the analytical engine and executed by a computer processor to define a domain of the newly structured data and one or more state views within the domain; a processor for configuring the at least one or more state views into at least one visual element capable of being displayed on a screen; and, a grid module executed by the processor and adapted to display the at least one visual element on the screen. | 07-10-2014 |
Patent application number | Description | Published |
20120315010 | SYSTEM AND METHOD FOR VIDEO SUMMARIZATION AND NAVIGATION BASED ON STATISTICAL MODELS - The disclosed method calculates video time density functions based on inter-frame mutual information or other similarity measures. The method includes acquiring a video sequence from memory, computing mutual information or other similarity measures between two consecutive frames of the video sequence, and constructing a video temporal density function based on the mutual information or similarity measures. The method enables fast navigation of the video sequence by performing a temporal quantization of the video time density function to determine a set of quanta. The video sequence can be navigated using the nearest neighbor video frames to the set of quanta. The method enables thumbnail extraction of a video sequence using statistical modeling by performing a temporal quantization of the video time density function to segment video sequence in time domain and using mixture (such as Gaussian mixture and ICA mixture) vector quantization to find the sample frames for each temporal segment. | 12-13-2012 |
20140308023 | SYSTEM AND METHOD FOR VIDEO SUMMARIZATION AND NAVIGATION BASED ON STATISTICAL MODELS - The disclosed method calculates video time density functions based on inter-frame mutual information or other similarity measures. The method includes acquiring a video sequence from memory, computing mutual information or other similarity measures between two consecutive frames of the video sequence, and constructing a video temporal density function based on the mutual information or similarity measures. The method enables fast navigation of the video sequence by performing a temporal quantization of the video time density function to determine a set of quanta. The video sequence can be navigated using the nearest neighbor video frames to the set of quanta. The method enables thumbnail extraction of a video sequence using statistical modeling by performing a temporal quantization of the video time density function to segment video sequence in time domain and using mixture (such as Gaussian mixture and ICA mixture) vector quantization to find the sample frames for each temporal segment. | 10-16-2014 |
20160019218 | SYSTEM AND METHOD FOR USING DATA INCIDENT BASED MODELING AND PREDICTION - A system and method for enabling information extraction from large data sets (so-called “big data”) according to a new paradigm is disclosed. This system does not generate functions describing why certain inputs result in certain outputs. Instead, it creates incident mappings of inputs to outputs without regard to why inputs result in outputs. These mappings can be distributions or other data sets representative of different outcomes occurring. This enables several useful operations. For example, by providing a data set indicative of outputs that have historically occurred following a particular input, the disclosed system can be used to predict future outcomes with probabilities. For example, if a particular stock price pattern is provided as an input, the system generates an output data set indicating the probabilities of certain price behaviors following that input pattern. This data set can thus be used to predict future behavior. Other useful operations are disclosed herein. | 01-21-2016 |