Patent application number | Description | Published |
20120214766 | CANNABINOID RECEPTOR MODULATORS - The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease. | 08-23-2012 |
20130023494 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single agent or in combination with one or more additional pharmaceutical agents, such as, an inhibitor of DPP-IV, a biguanide, an SGLT2 inhibitor, or an alpha-glucosidase inhibitor, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing a blood incretin level; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto. | 01-24-2013 |
20130165412 | CANNABINOID RECEPTOR MODULATORS - The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease. | 06-27-2013 |
20140066369 | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto - The present invention relates to compounds of Formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto. | 03-06-2014 |
20140206649 | CANNABINOID RECEPTOR MODULATORS - Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB | 07-24-2014 |
20150126477 | CANNABINOID RECEPTOR MODULATORS - Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB | 05-07-2015 |
Patent application number | Description | Published |
20100082830 | SYSTEM AND METHOD FOR PROCESSING MESSAGES USING PLUGGABLE PROTOCOL PROCESSORS IN A SERVICE-ORIENTED PIPELINE ARCHITECTURE - A computer-implemented system and method for processing messages using pluggable protocol processors in a service-oriented pipeline architecture is disclosed. The method in an example embodiment includes receiving a message having a protocol-specific portion and a protocol-agnostic portion; determining a protocol compatible with the received message; activating one of a plurality of pluggable protocol processors compatible with the received message; processing the protocol-specific portion of the received message using the activated pluggable protocol processor; and processing the protocol-agnostic portion of the received message using a message processing pipeline, the message processing pipeline including a plurality of stages for processing the protocol-agnostic portion of the received message. | 04-01-2010 |
20100223633 | API AND BUSINESS LANGUAGE SCHEMA DESIGN FRAMEWORK FOR MESSAGE EXCHANGES - A server system facilitates an exchange of messages with a remote client application. The server system includes a plurality of application servers hosting a plurality of applications. A plurality of Application Program Interfaces (APIs) provides programmatic access to the plurality of applications, each of the APIs being configured to receive request messages compiled by the remote client application. First and second request messages, respectively addressed to first and second APIs of the plurality of APIs by a remote client application, each comprise at least one common data component. Further, the first request message includes a first payload specific to the first API, and the second request message includes a payload specific to the second API. | 09-02-2010 |
20110167430 | API AND BUSINESS LANGUAGE SCHEMA DESIGN FRAMEWORK FOR MESSAGE EXCHANGES - A server system facilitates an exchange of messages with a remote client application. The server system includes a plurality of application servers hosting a plurality of applications. A plurality of Application Program Interfaces (APIs) provides programmatic access to the plurality of applications, each of the APIs being configured to receive request messages compiled by the remote client application. First and second request messages, respectively addressed to first and second APIs of the plurality of APIs by a remote client application, each comprise at least one common data component. Further, the first request message includes a first payload specific to the first API, and the second request message includes a payload specific to the second API. | 07-07-2011 |
20130125147 | API AND BUSINESS LANGUAGE SCHEMA DESIGN FRAMEWORK FOR MESSAGE EXCHANGES - A plurality of application servers hosts a plurality of business applications. A plurality of Application Program Interface (API) servers host a plurality of APIs to provide programmatic access to the plurality of business applications, each of the APIs configured to receive request messages compiled by a remote client application. First and second request messages targeted to first and second APIs have at least one common data component. The first request message includes a first payload specific to the first targeted API and the second request message includes a second payload specific to the second targeted API, the first payload and the second payload each comprise a reusable identified schema definition specific to the targeted API. | 05-16-2013 |
Patent application number | Description | Published |
20090274680 | Human Phospholipases - The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME. | 11-05-2009 |
20100099617 | Secreted proteins - The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. | 04-22-2010 |
20110053217 | Polynucleotides encoding signal peptide-containing molecules - The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. | 03-03-2011 |
20120014937 | Human Beta-Adrenergic receptor kinase polypeptide and methods - Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP. | 01-19-2012 |
20120270809 | HUMAN TRANSMEMBRANE PROTEINS - The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN. | 10-25-2012 |
20130058942 | HUMAN BETA-ADRENERGIC RECEPTOR KINASE POLYPEPTIDE AND METHODS - Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP. | 03-07-2013 |
20130244927 | POLYNUCLEOTIDES ENCODING SIGNAL PEPTIDE-CONTAINING MOLECULES - The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. | 09-19-2013 |
20140056906 | SECRETED PROTEINS - The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP. | 02-27-2014 |
20140242086 | POLYNUCLEOTIDES ENCODING SIGNAL PEPTIDE-CONTAINING MOLECULES - The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. | 08-28-2014 |
20140356342 | HUMAN BETA-ADRENERGIC RECEPTOR KINASE POLYPEPTIDE AND METHODS - Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP. | 12-04-2014 |
20150017173 | ANTIBODIES TO HUMAN TRANSMEMBRANE PROTEINS - The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN. | 01-15-2015 |
20150291701 | METHODS FOR TREATING DISORDERS ASSOCIATED WITH HUMAN SIGNAL PEPTIDE-CONTAINING MOLECULES - The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. | 10-15-2015 |
Patent application number | Description | Published |
20110020179 | Systems and Methods for Multiple Analyte Detection - Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials. | 01-27-2011 |
20110052446 | FLOW CELLS AND METHODS OF FILLING AND USING SAME - Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods. | 03-03-2011 |
20140162264 | Systems and Methods for Multiple Analyte Detection - Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials. | 06-12-2014 |
20160025630 | ANALYTICAL INSTRUMENT SYSTEMS - The invention provides optical instrument systems and methods for analyzing signals from biological arrays, and performing analytical amplification reactions for identifying the presence or absence of a target nucleic acid sequence in a sample to be analyzed. | 01-28-2016 |
Patent application number | Description | Published |
20100270824 | CLAMP STRUCTURE FOR TONNEAU COVER - A clamp structure for a tonneau cover is disclosed and mounted to one frame section of a tonneau cover for releasably securing the frame section on a cargo bed of a pick-up truck. The clamp comprises: a foundation rail having two side grooves and a recess formed between the two side grooves; and a sliding block having two side hangers extended into and slidably moving along the two side grooves and a pivotal portion received in the recess; a clamp bolt; a grip element; and a handle. The side hangers of the sliding block is used to slidably move along the side grooves of the foundation rail, so that the sliding movement of the clamp structure pivotally connected to the sliding block in relation to the foundation rail is more stable and smooth based on two strong support points of the two side hangers in the two side grooves. | 10-28-2010 |
20120274091 | COMPOSITE TONNEAU COVER OF PICK-UP TRUCK - A composite tonneau cover of a pick-up truck is disclosed. The composite tonneau cover has at least one frame section and is releasably secured on a side wall of a cargo bed of the pick-up truck. Each of the frame section comprises: a flexible cover material; a rigid metal panel covered by the flexible cover material and having at least two end edges; and a plurality of outer rails covered by the flexible cover material. Each of the outer rails has an inner side formed with an installation groove, and each of the end edges of the rigid metal panel is inserted into the installation groove of one of the outer rails. Thus, the composite tonneau cover can provide dual advantages of hard-top type tonneau cover and soft-top type tonneau cover. | 11-01-2012 |
20120274092 | CLAMP STRUCTURE FOR TONNEAU COVER OF PICK-UP TRUCK - A clamp structure for a tonneau cover of a pick-up truck is disclosed and mounted to one frame section of a tonneau cover for releasably securing the frame section on a side wall of a cargo bed of the pick-up truck. The clamp structure has a composite grip element which has a metal grip body and a plastic sleeve. The metal grip body has an engaging portion to stably engage with the side wall of the pick-up truck. The plastic sleeve has a first abutment flange to smoothly abut against a turning handle, and a second abutment end facing a sliding block. Thus, the composite grip element can provide advantages of both of metal and plastic material, so that the operational stability and reliability of the clamp structure can be enhanced, and the lifetime thereof can be elongated. | 11-01-2012 |
20120274093 | SIDE FASTENING ASSEMBLY FOR FLEXIBLE TONNEAU COVER SYSTEM OF PICK-UP TRUCK - A side fastening assembly for a flexible tonneau cover system of a pick-up truck is provided and has a first fastener sewn on an elongated slat by two sewing threads. The first fastener sewn on the elongated slat can ensure the attachment strength of the first fastener, so as to elongate the lifetime of the first fastener and lower the maintenance cost thereof. The side fastening assembly further has a second fastener attached to a flexible cover material of a flexible cover assembly. The first fastener and the second fastener are engaged with each other in a case that the flexible cover material is unrolled rearward on the side rail to cover the cargo bed. | 11-01-2012 |
20130033061 | TENSION CONTROL ASSEMBLY FOR FLEXIBLE TONNEAU COVER SYSTEM OF PICK-UP TRUCK - A tension control assembly for a flexible tonneau cover system of a pick-up truck has an adjustable engagement plate and a screw assembly. The adjustable engagement plate has an engagement hook to selectively engage in one of engagement holes formed on a side rail, and further has a positioning hole to position the screw assembly according to the engagement relationship between the engagement hook and the engagement holes, so that the adjustable engagement plate and the screw assembly can be used to adjust and stably keep a longitudinal position of a front header in relation to a length direction of the side rail, so as to prevent from causing vibration noise. Meanwhile, a transverse position of the front header in relation to a width direction of the side rail can be simultaneously adjusted during adjusting the longitudinal position of the front header. | 02-07-2013 |
20130114997 | CORNER ASSEMBLY FOR TONNEAU COVER SYSTEM OF PICK-UP TRUCK - A corner assembly for a tonneau cover system of a pick-up truck is provided and has a corner member, a lid member and a lengthened cushion member. A connection surface of the corner member is formed with a stepped recess, and the lid member is embedded in the stepped recess to cover ribs and cavities in the stepped recess. The lengthened cushion member is L-shaped and attached to the connection surface of the corner member, the lid member and two surfaces of two adjacent frame members. Thus, the present invention can efficiently maintain the effective buffering thickness of the lengthened cushion member, absorb vibration, and prevent from impact between frame members and a cargo box to thus reduce or eliminate noise. | 05-09-2013 |
20150224862 | FOLDABLE TONNEAU COVER FOR PICK-UP TRUCK AND WATERPROOF FLEXIBLE STRIP THEREOF - A foldable tonneau cover is disclosed and has two frame sections and at least one hidden-type hinge. Two frame members of two adjacent frame sections are correspondingly formed with two embedded holes. The hidden-type hinge is pivotally connected between the adjacent frame members. When the frame sections are horizontally extended relative to each other, the hidden-type hinge is substantially received in the embedded holes. When the frame sections are rotated or folded relative to each other, the hidden-type hinge is partially exposed out of the embedded holes. Thus, the occupied space of the hidden-type hinge and the gap between the adjacent frame sections can be minimized. The waterproof flexible strip can be continuously extended along the entire length of the two adjacent frame members without being interfered with by the hidden-type hinge substantially hidden within frame members, so as to enhance the waterproof reliability thereof. | 08-13-2015 |
Patent application number | Description | Published |
20140365113 | Navigation Application with Several Navigation Modes - A method for providing navigation instructions on a device is described. As the device traverses a navigated route according to a first mode of transportation, the method displays a first turn-by-turn navigation presentation defined for the first mode. Based on data gathered by the device, the method determines that the device is navigating the route according to a second mode of transportation. The method automatically displays a second, different turn-by-turn navigation presentation defined for the second mode. | 12-11-2014 |
20150247736 | Map Application with Improved Navigation Tools - Some embodiments provide a mapping application with novel navigation and/or search tools. In some embodiments, the mapping application formulates predictions about future destinations of a device that executes the mapping application, and provides dynamic notifications regarding these predicted destinations. For instance, when a particular destination is a likely destination (e.g., most likely destination) of the device, the mapping application in some embodiments presents a notification regarding the particular destination (e.g., plays an animation that presents the notification). This notification in some embodiments provides some information about (1) the predicted destination (e.g., a name and/or address for the predicted destination) and (2) a route to this predicted destination (e.g., an estimated time of arrival, distance, and/or amount of ETD for the predicted destination). In some embodiments, the notification is a dynamic not only because it is presented dynamically as the device travels, but also because the information that the notification displays about the destination and/or route to the destination is dynamically updated by the mapping application as the device travels. | 09-03-2015 |
20150323340 | NAVIGATION APPLICATION WITH SEVERAL NAVIGATION MODES - A method for providing navigation instructions on a device is described. As the device traverses a navigated route according to a first mode of transportation, the method displays a first turn-by-turn navigation presentation defined for the first mode. Based on data gathered by the device, the method determines that the device is navigating the route according to a second mode of transportation. The method automatically displays a second, different turn-by-turn navigation presentation defined for the second mode. | 11-12-2015 |
Patent application number | Description | Published |
20100214527 | LIQUID CRYSTAL OPTICAL SWITCH FOR OPTICAL SIGNAL HAVING ARBITRARY POLARIZATION - An optical device performs both switching and attenuation of an optical beam, where the beam has an arbitrary combination of s-polarized and p-polarized components. The optical device includes a birefringent displacer, a liquid crystal (LC) beam-polarizing structure having six subpixels organized in a first polarization group and a second polarization group, a half-wave plate positioned for polarization control of the second polarization group, and a polarization separating and rotating assembly. The structure of the LC beam-polarizing structure allows for 1×2 switching and attenuation control with a single control signal. The optical device may be configured for processing multiple input light beams, such as the multiple wavelength channels de-multiplexed from a wavelength division multiplexed (WDM) optical signal. | 08-26-2010 |
20100277658 | LIQUID CRYSTAL OPTICAL SWITCH CONFIGURED TO REDUCE POLARIZATION DEPENDENT LOSS - An optical device has the structure to perform switching and attenuation of an optical beam with reduced polarization dependent loss (PDL). The optical device includes a birefringent displacer and two liquid crystal (LC) structures. The first LC structure is used to condition s-polarized components of the optical beam and the second LC structure is used to condition p-polarized components of the optical beam. Each LC structure has a separate control electrode so that the s-polarized components of the optical beam and the p-polarized components of the optical beam can be conditioned differently and in such a manner that reduces PDL. The optical device may be configured for processing multiple input light beams, such as the multiple wavelength channels de-multiplexed from a wavelength division multiplexed (WDM) optical signal. | 11-04-2010 |
20100302469 | LIQUID CRYSTAL OPTICAL DEVICE CONFIGURED TO REDUCE POLARIZATION DEPENDENT LOSS AND POLARIZATION MODE DISPERSION - An LC-based optical device compensates for differences in optical path lengths of polarization components of input beam. As a result, PDL and PMD of the optical device are reduced. The compensation mechanism may be a glass plate that is disposed in an optical path of a polarization component so that the optical path length of that polarization component can be made substantially equal to the optical path length of the other polarization component that traverses through a half-wave plate. Another compensation mechanism is a birefringent displacer that has two sections sandwiching a half-wave plate, wherein the two sections are of different widths and the planar front surface of the birefringent displacer can be positioned to be non-orthogonal with respect to the incident input light beam. | 12-02-2010 |
20120020620 | Tunable optical filters with multiple ports - Described are tunable multiport optical filters that filter systems with many optical channels in a convenient and cost-effective manner. The tunable multiport optical filters of the invention are simple in design and have few optical components. The basic elements are a dispersion element and a rotating reflector. With properly arranged arrays of input and output optical fibers, individual wavelength components from a selected input beam are spatially separated and steered by the rotating reflector to selected output locations. The optical properties from the selected components may be measured by one or more photodetectors. The filters are also useful for selecting and routing optical signals. | 01-26-2012 |
20120212694 | Liquid Crystal Optical Device Configured to Reduce Polarization Dependent Loss and Polarization Mode Dispersion - An LC-based optical device compensates for differences in optical path lengths of polarization components of input beam. As a result, PDL and PMD of the optical device are reduced. The compensation mechanism may be a glass plate that is disposed in an optical path of a polarization component so that the optical path length of that polarization component can be made substantially equal to the optical path length of the other polarization component that traverses through a half-wave plate. Another compensation mechanism is a birefringent displacer that has two sections sandwiching a half-wave plate, wherein the two sections are of different widths and the planar front surface of the birefringent displacer can be positioned to be non-orthogonal with respect to the incident input light beam. | 08-23-2012 |