Young, MD
Alice Young, Gaithersburg, MD US
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20110281767 | COMPOSITIONS AND METHODS FOR MOLECULAR BIOLOGY - The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications. | 11-17-2011 |
20140206577 | COMPOSITIONS AND METHODS FOR MOLECULAR BIOLOGY - The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications. | 07-24-2014 |
Charles C. Young, Mount Airy, MD US
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20100261612 | Purification and Concentration of Proteins and DNA from a Complex Sample Using Isotachophoresis and a Device to Perform the Purification - A method of simultaneously co-purifying and concentrating nucleic acid and protein targets into a single volume is described. The method includes automation of the entire sample preparation process, performed by having an analyst add a sample into a device that performs all of the steps necessary to prepare a sample for analysis. The method provides for samples are not split during the sample preparation process and where common purification methods can be used for purifying multiple analytes. | 10-14-2010 |
20100323913 | Purification and Concentration of Proteins and DNA from a Complex Sample Using Isotachophoresis and a Device to Perform the Purification - A method of simultaneously co-purifying and concentrating nucleic acid and protein targets is described. The method includes automation of the entire sample preparation process, performed by having an analyst add a sample into a device that performs all of the steps necessary to prepare a sample for analysis. The method provides for samples that are not split during the sample preparation process and where common purification methods can be used for purifying multiple analytes. | 12-23-2010 |
20140332389 | KIT FOR CO-PURIFICATION AND CONCENTRATION OF DNA AND PROTEINS USING ISOTACHOPHORESIS - A kit for separating and concentrating nucleic acid and protein targets includes labeled reagents which affect simultaneous co-purification and concentration of a nucleic acid and a protein, a gel isotachophoresis separation unit to which a sample comprising the nucleic acid and the protein is added, a detection unit for the detection of the presence of the nucleic acid and the protein, and instructions for use. The gel electrophoresis includes a gel box having a negative electrode side and a positive electrode side, the negative electrode side being filled with a first buffer comprising 2-Hydroxy-N-(tris(hydroxymethyl)methyl)-3-aminopropanesulfonic acid buffer and the positive electrode side being filled with a second buffer being different than the first buffer. The gel isotachophoresis separation is configured to subject the sample to isotachophoresis using a voltage. | 11-13-2014 |
David Young, Ellicott City, MD US
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20140322226 | ACTH FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME - Provided herein are methods of treatment of acute respiratory distress syndrome comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual in need thereof | 10-30-2014 |
David Young, Ellicot City, MD US
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20090214599 | PROTON PUMP INHIBITOR FORMULATIONS, AND METHODS OF PREPARING AND USING SUCH FORMULATIONS - Pharmaceutical formulation comprising at least one proton pump inhibitor structured and arranged to provide an initial pH-dependent delayed release, and a pH-dependent extended release of the at least one proton pump inhibitor. | 08-27-2009 |
David W. Young, Clarksville, MD US
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20110206386 | Apparatus and Method for Stabilizing Power to an Optical Multimode Receiver - To stabilize power to an optical multimode receiver a multimode variable optical attenuator is connected to the receiver with the attenuator's voltage being controlled using a feedback signal provided by an output detector, the signal being processed using a control algorithm based on proportional-integrate-differential theory. | 08-25-2011 |
20110229081 | Apparatus and Method for Increasing the Effective Capture Area in Optical Terminals - At least two single-mode optical fibers are fused together such that their cores are separated by only a few microns to serve as a capture element of an incoming beam of light in an optical terminal. | 09-22-2011 |
20120063773 | High Speed Error Detector for Fading Propagation Channels - A customized bit error rate tester that characterizes data transmission through a free space optical channel that overcomes the limitations of commercial based bit error rate testers by providing visibility into packet based channel capacity by measuring bit-level statistics not dominated by fades. In this manner, fade characteristics can be measured and a relationship between fade time and data packet lengths can be developed. Further, analog outputs provide visual real-time data link statistics. | 03-15-2012 |
20130004181 | Fiber-Optic Automatic Gain Control Systems and Methods - Methods and systems to control a gain applied to a free-space optical (FSO) signal to reduce time-varying intensity fluctuations. An optical pre-amplifier may provide a first, relatively moderate gain with low noise factor (NF). A second optical amplifier may provide a second gain. Amplification may include doped fiber amplification (DFA), such as erbium-doped fiber amplification (EDFA) and/or Raman amplification. A variable optical attenuator (VOA) may be controllable with a relatively fast response time to reduce the time-varying intensity fluctuations. The VOA may effectively control an overall system gain. The gain of the first and/or second optical amplifier may also be controllable to reduce the time-varying intensity fluctuations. Optical intensities may be detected at one or more locations to support one or more feed-forward and/or feedback control loops. A clamp may be applied when an optical power reaches a threshold. | 01-03-2013 |
Emory L. Young, Reisterstownown, MD US
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20110063700 | SYSTEM, METHOD, AND DEVICE FOR PRODUCING, TRANSMITTING AND DISPLAYING IMAGES IN HOLOGRAPHIC FORM OF UP TO THREE DIMENSIONS - A system, method, and device for producing, transmitting and displaying images in holographic form of up to three dimensions. Information representative of a three dimensional image can be converted into three-dimensional positional data. The three-dimensional position data can be converted into an electromagnetic field which can be received by nanomachines configured to adjust position in accordance with the electromagnetic field and including mirrored endpoints for reflecting light. The nanomachines can adjust position in three dimensions so that the mirrored endpoints reflect light in a manner that reproduces the three dimensional image in holographic form. | 03-17-2011 |
Emory L. Young, Reisterstown, MD US
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20100029117 | COMPUTER-CONTROLLED CONNECTOR-PANEL SYSTEM - A system and method for ensuring that a large number of connectors, such as fiber-optic cable-connectors, which are plugged-into connector-receptacles arrayed across a connector-panel, are not intentionally disconnected by an un-authorized user with malicious intent, or accidentally unplugged by an authorized technician who may be trying to manually pull-out a specific connector for testing or other purposes but, inadvertently, could otherwise unplug a neighboring connector because of not being able to clearly see which plug is actually being removed due to the large number of cables that are connected to the panel. The connectors are locked in place by restraining arms which are controlled by solenoids or motors. Each restraining arm can be commanded to release its respective connector, but only when the correct command from a computer is received. The same system and method can be applied to connector-receptacles arrayed on one or both sides of the panel. The same system and method can be applied to other cables, such as coax cables or Cat 5 cables. | 02-04-2010 |
20100074124 | METHOD AND SYSTEM FOR SIMPLIFYING PROTOCOL ANALYSIS - A system and method in accordance with exemplary embodiments may include receiving, from a user system, one or more protocol analysis request messages via a network, transmitting, to one or more multipurpose interface devices, one or more control signals based on the one or more protocol analysis request messages, receiving, from the one or more multipurpose interface devices, protocol analysis data associated with data traffic transmitted on one or more test networks in response to the transmitted control signals, and outputting, to the user system, the protocol analysis data via the network. | 03-25-2010 |
20110003544 | SYSTEM FOR AND METHOD OF RECEIVING INTERNET RADIO BROADCAST VIA SATELLITE RADIO - A system for and method of receiving internet radio broadcast via satellite radio is presented. The system and method allow internet radio to be delivered to consumers on a mobile electronic device. Internet radio can be individually customized to deliver certain types of content and can also deliver on-demand content. The system and method therefore provides for the delivery of customizable on-demand content to a consumer's mobile device with the stable and wide-ranging connectivity of satellite radio. | 01-06-2011 |
20110066956 | SYSTEM FOR AND METHOD OF PROVIDING GRAPHICAL CONTENTS DURING A COMMUNICATION SESSION - A system for and method for providing graphical contents during a communication session is presented. The system and method include receiving, via an input/output module, one or more call invite request messages to establish a communication session in a communication network, processing, via a processing module, the one or more call invite request messages to identify a graphical content account associated with one or more users of the communication session, and transmitting, via a presentation module, one or more graphical contents from the graphical content account associated with at least one of the one or more users before an establishment of the communication session. | 03-17-2011 |
20110317562 | METHOD AND SYSTEM FOR SIMPLIFYING PROTOCOL ANALYSIS - A system and method in accordance with exemplary embodiments may include receiving, from a user system, one or more protocol analysis request messages via a network, transmitting, to one or more multipurpose interface devices, one or more control signals based on the one or more protocol analysis request messages, receiving, from the one or more multipurpose interface devices, protocol analysis data associated with data traffic transmitted on one or more test networks in response to the transmitted control signals, and outputting, to the user system, the protocol analysis data via the network. | 12-29-2011 |
20120274999 | SYSTEM, METHOD, AND DEVICE FOR PRODUCING, TRANSMITTING AND DISPLAYING IMAGES IN HOLOGRAPHIC FORM OF UP TO THREE DIMENSIONS - A system, method, and device for producing, transmitting and displaying images in holographic form of up to three dimensions. Information representative of a three dimensional image can be converted into three-dimensional positional data. The three-dimensional position data can be converted into an electromagnetic field which can be received by nanomachines configured to adjust position in accordance with the electromagnetic field and including mirrored endpoints for reflecting light. The nanomachines can adjust position in three dimensions so that the mirrored endpoints reflect light in a manner that reproduces the three dimensional image in holographic form. | 11-01-2012 |
Erik B. Young, Annapolis, MD US
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20110125109 | WOUND STICK - A device for introducing a haemostatic agent into a penetrating wound. The device includes an elongate introducing member and a haemostatic agent applied to the elongate introducing member. The haemostatic agent may be applied to the introducing member using a flexible membrane, configured to be rolled around the elongate introducing member, a biocompatible foam, or a gel. | 05-26-2011 |
Erik Brian Young, Annapolis, MD US
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20130264224 | METHOD AND DEVICE FOR SECURE DISPOSAL OF AN ARTICLE - A method and structure for a secure storage container having a front and back shell and a locking mechanism built in such that the secure storage container cannot be opened after being closed and a disposal method utilizing the secure storage container. | 10-10-2013 |
Howard A. Young, North Potomac, MD US
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20130109619 | PEPTIDE-BASED INHIBITOR OF INTERLEUKIN-10 OR INTERFERON-GAMMA SIGNALING | 05-02-2013 |
James Young, Potomac, MD US
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20100203641 | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS - The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses. | 08-12-2010 |
20110045586 | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS - The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses. | 02-24-2011 |
20120329150 | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS - The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses. | 12-27-2012 |
James F. Young, Gaithersburg, MD US
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20160000902 | COMBINATION VACCINE FOR RESPIRATORY SYNCYTIAL VIRUS AND INFLUENZA - The present disclosure is directed to compositions and methods for raising immune responses against influenza and respiratory syncytial virus by administering combination immunogenic composition against both viruses at the same time. The combination compositions contain an RSV component and one, two, three, four, or more influenza components. The combination compositions provide a greater immune response than that obtained by separately administering the RSV and influenza components. | 01-07-2016 |
James F. Young, Potomac, MD US
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20090130111 | Method of Identifying Membrane Ig Specific Antibodies and Use Thereof for Targeting Immunoglobulin-Producing Precursor Cells - The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. | 05-21-2009 |
20100028948 | METHODS OF ADMINISTERING/DOSING ANTI-RSV ANTIBODIES FOR PROPHYLAXIS AND TREATMENT - The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection. | 02-04-2010 |
20100098708 | METHODS OF PREVENTING AND TREATING RSV INFECTIONS AND RELATED CONDITIONS - The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (k | 04-22-2010 |
20100239574 | HIGH POTENCY RECOMBINANT ANTIBODIES AND METHOD FOR PRODUCING THEM - High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are of either the neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses, as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for producing high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed. | 09-23-2010 |
20100266614 | ULTRA HIGH AFFINITY NEUTRALIZING ANTIBODIES - Ultra high affinity antibodies with binding affinities in the range of 10 | 10-21-2010 |
20100278813 | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies - The present invention relates to methods for broad spectrum prevention and treatment of viral respiratory infection. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with respiratory syncytial virus (RSV), parainfluenza virus (PIV), and/or human metapneumovirus (hMPV) infection, the methods comprising administering to a subject an effective amount of one or more anti-RSV-antigen antibodies or antigen-binding fragments thereof, one or more anti-hMPV-antigen antibodies or antigen-binding fragments thereof, and/or one or more anti-PIV-antigen antibodies or antigen-binding fragments thereof. In certain embodiments, a certain serum titer of the anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof is achieved in said subject. In certain specific embodiments, the subject is human and, preferably, the anti-RSV-antigen antibody, anti-PIV-antigen antibody, and/or anti-hMPV-antigen antibodies are human or humanized. The present invention relates further to compositions comprising the anti-RSV-antigen is antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof. The present invention also relates to detectable or diagnostic compositions comprising the one or more anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof and methods for detecting or diagnosing RSV, PIV and/or hMPV infection utilizing the compositions. | 11-04-2010 |
20110158985 | METHODS OF PREVENTING AND TREATING RSV INFECTIONS AND RELATED CONDITIONS - The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (k | 06-30-2011 |
20120070447 | METHODS OF ADMINISTERING / DOSING ANTI-RSV ANTIBODIES FOR PROPHYLAXIS AND TREATMENT - The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection | 03-22-2012 |
20120135006 | ULTRA HIGH AFFINITY NEUTRALIZING ANTIBODIES - Ultra high affinity antibodies with binding affinities in the range of 10 | 05-31-2012 |
20120141463 | Method Of Identifying Membrane Ig Specific Antibodies And Use Thereof For Targeting Immunoglobulin-Producing Precursor Cells - The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. | 06-07-2012 |
Janel E. Young, Baltimore, MD US
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20090274764 | Hollow Foam Beads for Treatment of Glioblastoma - Compositions and methods for the treatment of tumors are disclosed. Specifically, the present invention provides hollow foam beads having a chemotherapeutic agent incorporated therein. A method of making such beads is disclosed. In addition, a method for treating a glioblastoma tumor and other types of tumors with the compressible hollow foam beads is disclosed. | 11-05-2009 |
Jason V. Young, Baltimore, MD US
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20140072946 | Identity Management for Computer Based Testing System - A method and system for identity management and authentication of examination candidates by, for example, capturing biometric data and identification information from an examination candidate and storing the data and information in a database. The method and system includes, for example, capturing biometric data from an individual at a later time for comparison with data stored in the database, and which allows authentication of the individual after determining that the biometric data matches the previously stored data and the individual matches the previously stored information. | 03-13-2014 |
Jason Valentine Young, Baltimore, MD US
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20080293033 | IDENTITY MANAGEMENT SYSTEM, INCLUDING MULTI-STAGE, MULTI-PHASE, MULTI-PERIOD AND/OR MULTI-EPISODE PROCEDURE FOR IDENTIFYING AND/OR AUTHENTICATING TEST EXAMINATION CANDIDATES AND/OR INDIVIDUALS - A method and/or system for identity management and authentication of examination candidates by, for example, capturing biometric data and identification information from an examination candidate and storing the data and information in a database. The method and/or system includes, for example, capturing biometric data from an individual at a later time for comparison with data stored in the database, and which allows authentication of the individual after determining that the biometric data matches the previously stored data and the individual matches the previously stored information. | 11-27-2008 |
Jeffery Hunter Young, Baltimore, MD US
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20150254402 | Consumer Health Score Bureau System and Method to Facilitate a Multi-Sponsor Model of Health Improvement - Certain exemplary embodiments of the invention can provide computer-based systems and methods for an online health service bureau that allows participant consumers to accurately quantify their health by calculating, on behalf of each consumer, a personal health score that is based on each consumer's own measured biomarkers and other related information. The health service bureau may also provide secure mechanisms by which interested third parties, such as employers and insurance companies, can incentivize participant consumers to undertake health-improving activities and thereby improve the consumers' overall health scores, without compromising the privacy of individual consumer identity and health information | 09-10-2015 |
Lei Young, Gaithersburg, MD US
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20090275086 | ASSEMBLY OF LARGE NUCLEIC ACIDS - A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described. | 11-05-2009 |
20100035768 | METHODS FOR IN VITRO JOINING AND COMBINATORIAL ASSEMBLY OF NUCLEIC ACID MOLECULES - The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g., to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization. | 02-11-2010 |
20100184187 | IN VITRO RECOMBINATION METHOD - The present invention relates, e.g., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising contacting the two DNA molecules in a reaction mixture with (a) a non-processive 5′ exonuclease; (b) a single stranded DNA binding protein (SSB) which accelerates nucleic acid annealing; (c) a non strand-displacing DNA polymerase; and (d) a ligase, under conditions effective to join the two DNA molecules to form an intact double stranded DNA molecule, in which a single copy of the region of sequence identity is retained. The method allows the joining of a number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. | 07-22-2010 |
20150240280 | METHODS FOR IN VITRO JOINING AND COMBINATORIAL ASSEMBLY OF NUCLEIC ACID MOLECULES - The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g., to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization. | 08-27-2015 |
Marian F. Young, Silver Spring, MD US
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20100330182 | Tendon Stem Cells - The invention relates to tendon stem cell useful for treating a variety of diseases and conditions, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin. | 12-30-2010 |
20140065108 | Tendon Stem Cells - The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin. | 03-06-2014 |
Matthew R. Young, Ijamsville, MD US
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20110190240 | NUCLEAR FACTOR KAPPA B PATHWAY INHIBITOR COMPOSITION AND USE OF SAME - An embodiment of the invention provides a pharmaceutical composition comprising a compound of formula (I)a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Another embodiment of the invention provides a method of treating or preventing a condition associated with increased expression and/or activity of an NFκB pathway using same compounds. A further embodiment of the invention provides a method of diagnosing a condition in an individual using same compounds. | 08-04-2011 |
Mike Young, Sparks, MD US
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20130217013 | EXTERNAL FILES FOR DISTRIBUTION OF MOLECULAR DIAGNOSTIC TESTS AND DETERMINATION OF COMPATIBILITY BETWEEN TESTS - Embodiments disclosed herein relate to methods and systems for performing an automated assay, and particularly to performing an assay on a plurality of samples on an automated instrument. | 08-22-2013 |
Randell Young, Ellicott City, MD US
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20100310531 | PEPTIDE-COATED CELL LOCALIZATION TO DISEASED OR DAMAGED TISSUES AND METHODS RELATED THERETO - Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature. | 12-09-2010 |
Randell G. Young, Ellicott City, MD US
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20100068191 | PURIFIED MESENCHYMAL STEM CELL COMPOSITIONS AND METHODS OF PURIFYING MESENCHYMAL STEM CELL COMPOSITIONS - One or more purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold limits for intravenous administration of mesenchymal stem cell pharmaceutical compositions comprising residual animal products are also disclosed. | 03-18-2010 |
20140105872 | PURIFIED MESENCHYMAL STEM CELL COMPOSITIONS AND METHODS OF PURIFYING MESENCHYMAL STEM CELL COMPOSITIONS - One or more purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold limits for intravenous administration of mesenchymal stem cell pharmaceutical compositions comprising residual animal products are also disclosed. | 04-17-2014 |
Robert M. Young, Ellicott City, MD US
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20090194870 | Method and Apparatus for Solid State Cooling System - The disclosure relates to a Point Cooler based on a combination of principles, including large area, low current density PN junction cooling, and electron emission from heavily doped shallowly-depleted P tips. Using Junction Cooling rather than thermoelectric cooling enables an all silicon device to be made that favorably competes with the commercial thermoelectric cooling systems. Theoretical values of T | 08-06-2009 |
Robert Miles Young, Ellicott City, MD US
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20140264230 | PHASE CHANGE MATERIAL SWITCH AND METHOD OF MAKING THE SAME - A phase change material (PCM) switch is disclosed that includes a resistive heater element, and a PCM element proximate the resistive heater element. A thermally conductive electrical insulating barrier layer positioned between the PCM heating element and the resistive heating element, and conductive lines extend from ends of the PCM element and control lines extend from ends of the resistive heater element | 09-18-2014 |
20140266300 | PHASE-CHANGE MATERIAL RECONFIGURABLE CIRCUITS - One embodiment of the invention includes a reconfigurable circuit comprising a phase-change material switch. The phase-change material switch includes an actuation portion configured to receive a control signal having one of a first state and a second state and to emit a first heat profile in response to the first state of the control signal and a second heat profile in response to the second state of the control signal. The phase-change material switch also includes a switch portion comprising a phase-change material in proximity with the actuation portion. The switch portion can be selectable between a conducting state in response to the first heat profile to conduct an input signal from an input to an output of the phase-change material switch and a blocking state in response to the second heat profile to substantially block the input signal from the input to the output. | 09-18-2014 |
Robin M. Young, Abingdon, MD US
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20120310213 | Medical Catheter With Bump Tubing Proximal Segment - A medical catheter for inserting into a body includes a bump tubing section with proximal and distal ends, wherein the proximal end is configured to mate with a hub. The bump tubing section has an intermediate portion extending away from the proximal end with a substantially constant outer diameter and thickness, and a taper portion adjacent the distal end with generally decreasing inside and outside diameters to provide a gradually increasing flexibility toward the distal end of the bump tubing section. The bump tubing section is comprised of a polymer having a predetermined flexural modulus. A tip section is disposed distally of the distal end of the bump tubing section comprising a distal liner and a distal cover such that at least a majority of the tip section has a substantially constant stiffness and a flexural modulus substantially equal to or greater than the predetermined flexural modulus. | 12-06-2012 |
Sheena Young, Randallstown, MD US
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20120023652 | TOILET SEAT LINER - One example embodiment includes a system for preventing contaminants on a toilet seat coming in contact with a user. The system includes a substrate. The system also includes a sanitizing substance, where the sanitizing substance is embedded in at least a portion of the substrate. | 02-02-2012 |
20120227281 | SHOE-SLIPPER COMBINATION - One example embodiment includes a shoe-slipper combination. The shoe-slipper combination includes a shoe, wherein the shoe is configured to be worn by a wearer. The shoe-slipper combination also includes a slipper. The slipper is configured to fit on the foot of the wearer and fit at least partially within the shoe. | 09-13-2012 |
20150245688 | DOUBLE SHOE COMBINATION FOOTWEAR WITH A CONCEALED INNER SHOE - A double shoe combination footwear with a concealed inner shoe. The double shoe combination footwear may comprise: a first shoe; and a second shoe, both of which comprise at least an upper and an outsole being stiffer than the upper. The second shoe is adapted to fit within a shoe cavity of the first shoe and is preferably concealed within the first shoe. The upper of both shoes are preferably substantially similar in shape and size, such that the second shoe fits snugly within the shoe cavity of the first shoe. Preferably, the second upper of the second shoe is no larger in size than the first upper of the first shoe, such that, when the second shoe is inside the shoe cavity of the first shoe, the outer surface of the second upper of the second shoe is entirely concealed within the first shoe. | 09-03-2015 |
Shiqiong Susan Young, Bethesda, MD US
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20100067822 | SYSTEM AND METHOD OF SUPER-RESOLUTION IMAGING FROM A SEQUENCE OF TRANSLATED AND ROTATED LOW-RESOLUTION IMAGES - A method and system for super-resolving images from low-resolution sequences comprising an image processor having an input for inputting multiple images of a scene with sub-pixel translations and rotations; one of the images of the scene being a reference image; and at least one memory comprising a gross translation estimation algorithm for estimating overall translations of at least one image with respect to the reference image on the image processor and aligning the inputted images according to the gross translation estimates on the image processor; a sub-pixel estimation algorithm for obtaining the sub-pixel shift and rotation of each image with respect to the reference image; and an error reduction algorithm for applying at least one spatial frequency domain constraint and at least one spatial domain constraint to the images to produce a high-resolution image. | 03-18-2010 |
20110142366 | System and Method for Super-Resolution Imaging from a Sequence of Color Filter Array (CFA) Low-Resolution Images - A method and system for improving picture quality of color images by combing the content of a plurality of frames of the same subject; comprising: at least one processor; the at least one processor comprising a memory for storing a plurality of frames of a subject; the at least one processor operating to combine the content of plurality of frames of the subject into a combined color image by performing: a process in which at least two multicolored frames are converted to monochromatic predetermined color frames; a gross shift process in which the gross shift translation of one monochromatic predetermined color frame is determined relative to a reference monochromatic predetermined color frame; a subpixel shift process utilizing a correlation method to determine the translational and/or rotational differences of one monochromatic predetermined color frame to the reference monochromatic predetermined color frame to estimate sub-pixel shifts and/or rotations between the frames; and an error reduction process to determine whether the resolution of the resulting combined color image is of sufficient resolution; the error reduction process comprising applying at least one spatial frequency domain constraint and at least one spatial domain constraint to the combined color image to produce at least one high-resolution full color image. | 06-16-2011 |
20110150331 | System and Method for Super-Resolution Imaging from a Sequence of Color Filter Array (CFA) Low-Resolution Images - A method and system for improving picture quality of color images by combing the content of a plurality of frames of the same subject; comprising: at least one processor; the at least one processor comprising a memory for storing a plurality of frames of a subject; the at least one processor operating to combine the content of plurality of frames of the subject into a combined color image by performing: a process in which at least two multicolored frames are converted to monochromatic predetermined color frames; a gross shift process in which the gross shift translation of one monochromatic predetermined color frame is determined relative to a reference monochromatic predetermined color frame; a subpixel shift process utilizing a correlation method to determine the translational and/or rotational differences of one monochromatic predetermined color frame to the reference monochromatic predetermined color frame to estimate sub-pixel shifts and/or rotations between the frames; and an error reduction process to determine whether the resolution of the resulting combined color image is of sufficient resolution; the error reduction process comprising applying at least one spatial frequency domain constraint and at least one spatial domain constraint to the combined color image to produce at least one high-resolution full color image. | 06-23-2011 |
Shirley Clanton Young, Bowie, MD US
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20110031690 | Bible walk board game - A board game, Bible Walk provides fun while testing one's knowledge of the bible and teaches as you play. The game Bible Walk is designed to be and interactive multi-player game which includes a board, playing pieces and an electronic device which displays questions. The board is generally rectangle on which the players would move their pieces around the board. The board has colors and writings on the squares as well as on the center of the board. The electronic device contains questions from Genesis to Revelation from the Holy Bible. The players must answer short questions correctly in order to move to the next square. All questions are T-true or F-false. The game is meant to move at a fast pace. The first player or group of players to land on the well done square wins. Game may continue with other players for second or third and so on if players desire. | 02-10-2011 |
Stanley E. Young, Centreville, MD US
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20130006509 | Monitoring a Mobile Device - Devices, systems, and methods for monitoring traffic, such as vehicle traffic on a roadway, using identification information acquired using a Bluetooth protocol. A sensor is configured to scan for discoverable Bluetooth devices within a flow of vehicle traffic and to create a log of identified Bluetooth devices. A system includes multiple sensors at known locations along a route and is operable to identify a Bluetooth device identified at multiple sensors. | 01-03-2013 |
20130006510 | Monitoring a Mobile Device - Devices, systems, and methods for monitoring traffic, such as vehicle traffic on a roadway, using identification information acquired using a Bluetooth protocol. A sensor is configured to scan for discoverable Bluetooth devices within a flow of vehicle traffic and to create a log of identified Bluetooth devices. A system includes multiple sensors at known locations along a route and is operable to identify a Bluetooth device identified at multiple sensors. | 01-03-2013 |
20140232565 | MONITORING A MOBILE DEVICE - Devices, systems, and methods for monitoring traffic, such as vehicle traffic on a roadway, using identification information acquired using a Bluetooth protocol. A sensor is configured to scan for discoverable Bluetooth devices within a flow of vehicle traffic and to create a log of identified Bluetooth devices. A system includes multiple sensors at known locations along a route and is operable to identify a Bluetooth device identified at multiple sensors. | 08-21-2014 |
Stanley E. Young, Centerville, MD US
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20090210141 | Monitoring a Mobile Device - Devices, systems, and methods for monitoring traffic, such as vehicle traffic on a roadway, using identification information acquired using a Bluetooth protocol. A sensor is configured to scan for discoverable Bluetooth devices within a flow of vehicle traffic and to create a log of identified Bluetooth devices. A system includes multiple sensors at known locations along a route and is operable to identify a Bluetooth device identified at multiple sensors. | 08-20-2009 |
Thomas James Young, Laurel, MD US
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20140217256 | CUP CARRYING DEVICE - A cup carrying device is provided. The cup carrying device may include a cup ring that is made of either a rigid or semi-rigid material. A basket may extend from the cup ring so that the cup ring forms an opening to the basket. The basket is sized to fit a beverage container within. The cup carrying device may further include an attachment component that is configured to attach to a support structure. Therefore, a user may secure the cup carrying device either to their person or a motorcycle for use with the beverage container. | 08-07-2014 |
Travis Young, Rockville, MD US
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20130311133 | METHOD FOR STEP DETECTION AND GAIT DIRECTION ESTIMATION - A method for detecting a human's steps and estimating the horizontal translation direction and scaling of the resulting motion relative to an inertial sensor is described. When a pedestrian takes a sequence of steps the displacement can be decomposed into a sequence of rotations and translations over each step. A translation is the change in the location of pedestrian's center of mass and a rotation is the change along z-axis of the pedestrian's orientation. A translation can be described by a vector and a rotation by an angle. | 11-21-2013 |
20130311134 | METHOD FOR STEP DETECTION AND GAIT DIRECTION ESTIMATION - A method for detecting a human's steps and estimating the horizontal translation direction and scaling of the resulting motion relative to an inertial sensor is described. When a pedestrian takes a sequence of steps the displacement can be decomposed into a sequence of rotations and translations over each step. A translation is the change in the location of pedestrian's center of mass and a rotation is the change along z-axis of the pedestrian's orientation. A translation can be described by a vector and a rotation by an angle. | 11-21-2013 |
20130332098 | METHODS FOR IMPROVED HEADING ESTIMATION - Methods for calibrating a body-worn magnetic sensor by spinning the magnetic sensor 360 degrees to capture magnetic data; if the spin failed to produce a circle contained in an x-y plane fit a sphere to the captured data; determining offsets based on the center of the sphere; and removing the offsets that are in the z-direction. Computing a magnetic heading reliability of a magnetic sensor by determining an orientation of the sensor at one location; transforming the orientation between two reference frames; measuring a first vector associated with the magnetic field of Earth at the location; processing the first vector to generate a virtual vector when a second location is detected; measuring a second vector associated with the magnetic field of Earth at the second location; and calculating the magnetic heading reliability at the second location based on a comparison of the virtual vector and the second vector. | 12-12-2013 |
Travis Michael Young, Rockville, MD US
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20120197461 | Vision Based Hover in Place - A method for providing vision based hover in place to an air vehicle is disclosed. Visual information is received using one or more image sensors on the air vehicle and based on the position of the air vehicle. A number of visual displacements is computed from the visual information. One or more motion values are computed based on the visual displacements. One or more control signals are generated based on the motion values. | 08-02-2012 |