Yoshikane
Yoshikane Akiyama, Komaki-Shi JP
Patent application number | Description | Published |
---|---|---|
20100327486 | Manufacturing Method of Cylindrical Member and Manufacturing Method of Vibration Damping Rubber Bushing Having the Cylindrical Member - A method of manufacturing a cylindrical member having anti-slip projections formed on axial end faces, the method comprising the steps of: employing a roller die, which is provided with a circumferential die groove of annular form extending through a medial section in a generatrix direction of a die face defined by an integral tapered outside peripheral face, and with a plurality of sloping die grooves extending in a tapered slope direction of the die face situated to both large-diameter and small-diameter sides of the circumferential die groove; providing plastic working to the axial end face with the small-diameter side of the roller die facing towards an inner peripheral side of the cylindrical member and with the large-diameter side facing towards an outer peripheral side, by pushing the die face against the axial end face while rotating circumferentially; and forming simultaneously an annular water barrier projection and the anti-slip projections. | 12-30-2010 |
20100327499 | VIBRATION DAMPING RUBBER BUSHING - A vibration damping rubber bushing including: an inner cylindrical member; a main rubber elastic body bonded to an outer circumferential face of the inner cylindrical member; a plurality of anti-slip projections provided on at least one of axial end faces of the inner cylindrical member that project axially outward from the axial end face and extend with ribbed shape in a diametrical direction on the axial end face to produce a spokewise pattern overall; and an annular water barrier projection provided on a diametrical medial section of the at least one of the axial end faces of the inner cylindrical member, projecting axially outwardly and extending circumferentially, with the anti-slip projections being disposed to both radially inner side and radially outer side of the annular water barrier projection. | 12-30-2010 |
Yoshikane Kikushige, Fukuoka JP
Patent application number | Description | Published |
---|---|---|
20120100131 | METHOD FOR TREATMENT OF BLOOD TUMOR USING ANTI-TIM-3 ANTIBODY - Disclosed is a therapeutic method comprising administering a TIM-3 antibody to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(−)CD34(+)CD38(−) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Also disclosed is a composition for preventing or treating blood tumor, which comprises a TIM-3 antibody as an active ingredient. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages), etc)), all of which are capable of expressing TIM-3. The diseases for which the therapeutic use is to be examined include blood diseases in which the expression of TIM-3 is observed in bone marrow or peripheral blood, particularly blood tumor. | 04-26-2012 |
20140134639 | METHOD FOR TREATMENT OF BLOOD TUMOR USING ANTI-TIM-3 ANTIBODY - Disclosed is a therapeutic method including administering a TIM-3 antibody or its TIM-3 binding fragment to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(−)CD34(+)CD38(−) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody or its TIM-3 binding fragment to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages), etc)). | 05-15-2014 |
Yoshikane Kikushige, Fukuoka-Shi JP
Patent application number | Description | Published |
---|---|---|
20120189617 | ANTI-TIM-3 ANTIBODY - The present invention provides an anti-human TIM-3 antibody which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure thereof and exhibits higher effector activity such as an antibody-dependent cellular cytotoxicity (ADCC activity) for diseases relating to a human TIM-3 expressing cell. The present invention provides a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient. In addition, the present invention provides an anti-human TIM-3 antibody having high ADCC activity by screening an anti-human TIM-3 antibody which competes with the monoclonal antibody or the antibody fragment thereof. | 07-26-2012 |
20140044728 | ANTI-TIM-3 ANTIBODY - Disclosed are an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; and a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient. | 02-13-2014 |
Yoshikane Yamanaka, Minato-Ku JP
Patent application number | Description | Published |
---|---|---|
20130332383 | PLANT SAFETY DESIGN ASSISTANCE DEVICE AND PLANT MONITORING AND MAINTENANCE ASSISTANCE DEVICE - A Plant safety design assistance device ( | 12-12-2013 |
Yoshikane Yamanaka, Tokyo JP
Patent application number | Description | Published |
---|---|---|
20130245792 | CONTROL PROGRAM ADMINISTRATION SYSTEM AND METHOD FOR CHANGING CONTROL PROGRAM - A control arithmetic device controls so that an approval-receiving device displays a content of a new control program that the control arithmetic device received from the editing device. The approval-receiving device receives input of approval information that indicates whether a change of a control program is approved or not from an manager. The control arithmetic device changes the control program to the new control program in the case where the approval information received from the approval-receiving device indicates approval of the control program. | 09-19-2013 |