Patent application number | Description | Published |
20100037682 | BIOSENSOR BASED ON POLYMER CANTILEVERS - A microcantilever sensor includes a supporting substrate, a cantilever spring element at least partially disposed over the support substrate, a probe layer disposed over the first side of the cantilever spring element, and a piezoresistive transducer attached to the second side of the cantilever spring element. The cantilever spring element is characterized by having a first side and a second side and comprising a polymer having a Young's modulus less than about 100 Gpa. Sensing systems that incorporate the cantilever sensor of the invention include a detector in communication with the piezoresistive transducer to provide measurements of surface strain changes in the piezoresistive transducer. | 02-18-2010 |
20100270889 | PIEZO DEVICES WITH AIR-SPACED CANTILEVER - An arrangement that converts mechanical energy into electrical energy employs a base member and a cantilever member coupled thereto. The cantilever member has two piezoelectric layers with an air space therebetween. A proof mass is coupled to the cantilever member distal from the base member. The first and second piezoelectric layers are formed of lead zirconate titanate (PZT), and the output voltage of the cantilever member is proportional to the height of the air gap. A piezoresistive accelerometer that is useful for measuring mechanical vibration has a suspension beam and a piezoresistive layer be separated from the suspension beam. A method of monitoring an acoustic vibration utilizes a piezoresistive element having an air-spaced cantilever formed of a piezoelectric material in the vicinity of the system to be monitored and obtains an alternating voltage form the air-spaced cantilever of the piezoresistive element. | 10-28-2010 |
20110184503 | METHOD OF MAKING 3-DIMENSIONAL NEURAL PROBES HAVING ELECTRICAL AND CHEMICAL INTERFACES - A method of fabricating a three-dimensional neural probe includes the steps of: growing thermal oxide layer; depositing a layer of Au/Cr on the thermal oxide layer; patterning the layer of Au/Cr; depositing a layer of parylene C; etching the thermal oxide layer to release a plurality of islands; and folding the islands onto one another in stacked relation. The layer of Au/Cr is formed by an evaporation process, and the layer of parylene C is deposited to a thickness of approximately 8 μm. DRIE is used to perform the etching, and HF is used to remove the thermal oxide. A spacer is disposed intermediate of two of the islands. | 07-28-2011 |
20140183669 | RESONANT SENSOR WITH ASYMMETRIC GAPPED CANTILEVERS - A resonant sensor is provided. The resonant sensor may have a structure including a base portion, a mass portion, and a mechanical beam connecting the base portion to the mass portion. In addition, the structure may include a first sensing beam formed from a sensing material responsive to mechanical strain where a gap is formed between the sensing beam and the mechanical beam. | 07-03-2014 |
Patent application number | Description | Published |
20080261988 | IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS - The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): | 10-23-2008 |
20080293733 | AXL KINASE INHIBITORS - Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase. | 11-27-2008 |
20090285772 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 11-19-2009 |
20090298900 | Oxo-Imidazolyl Compounds - Compounds represented by Formula I and II, or pharmaceutically acceptable salts thereof: | 12-03-2009 |
20100204221 | Pyrrolopyrimidinyl axl kinase inhibitors - Compounds represented by Formula (I): | 08-12-2010 |
20100227861 | IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS - The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): | 09-09-2010 |
20110256092 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 10-20-2011 |
20110269772 | AXL KINASE INHIBITORS - Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase. | 11-03-2011 |
20110281863 | IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS - The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): | 11-17-2011 |
20120058997 | IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS - The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): | 03-08-2012 |
20130303539 | COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF - Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed. | 11-14-2013 |
20140329807 | HETEROCYCLIC PROTEIN KINASE INHIBITORS - The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R | 11-06-2014 |
Patent application number | Description | Published |
20110282181 | EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING - The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses. | 11-17-2011 |
20110313298 | FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS - The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. | 12-22-2011 |
Patent application number | Description | Published |
20120033555 | ROUTING METHOD, APPARATUS AND SYSTEM - A routing method and apparatus are provided. The routing method includes the following steps: sending a probe frame that carries an address of a destination node to a neighboring node(s); receiving a response message returned; selecting one neighboring node from the neighboring node(s) that returns the response message as a next-hop node to which data is sent. A neighboring node with a cost parameter which is lower than a cost parameter in a routing table of the destination node is selected as the next-hop node. In the routing method, when a routing node forwards data, the route is found in real time by broadcasting a probe frame, and data may be sent as long as any one of the neighboring nodes that may arrive at the destination node is in an active state, and thus a data transmission delay is shortened. | 02-09-2012 |
20130297671 | METHOD, APPARATUS AND SYSTEM FOR PROCESSING PACKETS - A system for processing packets in a distributed architecture system includes a main control board, at least one service board, and at least one interface board. The system determines a specified CPU corresponding to a received packet; and, by the service board corresponding to the CPU, processes the received packet. The received packets are processed in the service board corresponding to the specified CPU. Therefore, the packets are evenly distributed to all service boards for being processed, the workload of the main control board is relieved, the service throughput is increased significantly, and the packet processing efficiency of the whole architecture is improved. | 11-07-2013 |
20140003584 | CROSS ARM OF X-RAY EQUIPMENT AND A CORRESPONDING X-RAY EQUIPMENT | 01-02-2014 |
Patent application number | Description | Published |
20130047883 | LOWER SIDE BEARING FOR RAILROAD CAR WHEEL TRUCK - A lower side bearing for a wheel truck, including: a first friction board, a second friction board, an inner pedestal, a bearing sleeve sleeving the inner pedestal, a pressure block, a pressure plate, and an elastic component. The pressure block is disposed on an upper part of the inner pedestal, and the second friction board is disposed on a top of the pressure block. The pressure plate is disposed on an upper part of the bearing sleeve, and the first friction board is disposed on a top of the pressure plate. A friction coefficient μ | 02-28-2013 |
20130055922 | RAILROAD CAR WHEEL TRUCK - A wheel truck for a railroad car, including: a front wheel pair assembly and a rear wheel pair assembly; two side frame assemblies, each side frame assembly including a square box and journal-box guides; two spring suspension devices; and a bolster assembly including two ends disposed on the two spring suspension devices, respectively. The bolster assembly includes a pilot hole in the center and two mounting holes on the two ends, the pilot hole is rotationally matched with a cylindrical upper center plate of a car body for transmitting vertical and horizontal forces from the car body, and the two mounting holes are disposed above the two spring suspension devices, respectively. Each mounting hole receives a lower side bearing, and the lower side bearing is matched with a corresponding upper side bearing disposed on each side of the car body for transmitting the vertical load from the car body. | 03-07-2013 |
20130056919 | DAMPING DEVICE - A damping device, including: a wedge assembly having a wedge including a vertical surface and an inclined surface; a primary friction board disposed on the vertical surface; and a secondary friction board disposed on the inclined surface; and a damping spring assembly disposed underneath the wedge assembly. The wedge assembly has the following structure parameters: α=16-30°, and μ03-07-2013 | |