Patent application number | Description | Published |
20080310791 | All-fiber current sensor - Embodiments of the present invention provide a current sensing device. The current sensing device includes, inter alia, a three-by-three (3×3) optical coupler made of polarization-maintaining (PM) fibers and thus being a PM fiber coupler; a light source and at least one photon-detector connected to a first side of the 3×3 PM fiber coupler; and a fiber coil connected to a second side of the 3×3 PM fiber coupler. The 3×3 PM fiber coupler is adapted to split an input light from the light source into first and second optical signals while maintaining their respective polarization directions; and is adapted to cause coherent interference of third and fourth optical signals, related respectively to the first and second optical signals and received from the fiber coil. | 12-18-2008 |
20090214152 | Polarization-maintaining optical coupler and method of making the same - Embodiments of the present invention provide an optical coupler. The optical coupler includes a fused optical coupling region made of part of a first and a second single-mode (SM) fiber, with a portion of the second SM fiber being a pigtail fiber on a first side of the fused optical coupling region; and a first and a second polarization-maintaining (PM) fiber on the first side and a second side of the fused optical coupling region respectively. Methods of making the optical coupler and system that utilizes the optical coupler are also provided. | 08-27-2009 |
20100141955 | Sensor probe for fiber-based current sensor - Embodiments of the present invention provide a sensor probe for fiber-based electric current sensors. The sensor probe includes a conductor of spiral shape and a relatively straight optical fiber being placed at a through-hole formed by the spiral shape conductor. An electric current conveyed by the spiral shape conductor causes polarization direction of a light traveling along the optical fiber to rotate. By detecting the amount of rotation that the light experiences at the ends of the optical fiber, the amount of current carried by the spiral shape conductor is determined. Method of making the sensor probe is also disclosed. | 06-10-2010 |
20100279320 | High-throughput cell transfection device and methods of using thereof - Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in functional genomic study and drug discovery. Development of high-throughput cell transfection technology will permit functional analysis of massive number of genes and how their activities could be modulated by chemical or biological entities inside cells. This invention describes design, construction of device and apparatus for high throughput effective cell transfection. Procedures and protocols for using the device and apparatus are also described in the application. Novel methods of using the device in cell-based assays are also disclosed. | 11-04-2010 |
20100305005 | High-throughput cell transfection device and methods of using thereof - Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in functional genomic study and drug discovery. Development of high-throughput cell transfection technology will permit functional analysis of massive number of genes and how their activities could be modulated by chemical or biological entities inside cells. This invention describes design, construction of device and apparatus for high throughput effective cell transfection. Procedures and protocols for using the device and apparatus are also described in the application. Novel methods of using the device in cell-based assays are also disclosed. | 12-02-2010 |
20100317548 | High-throughput cell transfection device and methods of using thereof - Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in functional genomic study and drug discovery. Development of high-throughput cell transfection technology will permit functional analysis of massive number of genes and how their activities could be modulated by chemical or biological entities inside cells. This invention describes design, construction of device and apparatus for high throughput effective cell transfection. Procedures and protocols for using the device and apparatus are also described in the application. Novel methods of using the device in cell-based assays are also disclosed. | 12-16-2010 |
20120057823 | Plastic fiber coupler and method of manufacturing thereof - Embodiments of the present invention provide a plastic fiber coupler. The plastic fiber coupler includes a bundle of plastic optical fibers (POFs) arranged in a ring-shape; and an optical mixing tube attached to a cross-section of the bundle of POFs. In one embodiment, a cross-section of the optical mixing tube may be coated with a reflective film forming a reflective type plastic fiber coupler; in another embodiment, the optical mixing tube is attached to a second bundle of plastic optical fibers forming a transmissive type plastic fiber coupler. | 03-08-2012 |
20120244593 | METHOD, DEVICE AND APPARATUS FOR INDUCING SELF-ADJUSTING CELL ELECTROPORATION - The invention provides methods, devices and apparatuses for providing cell electroporation. In accordance with an aspect of the invention, self-adjusting cell electroporation may be provided. A cell transfection apparatus may be provided. The cell transfection apparatus may include a plate comprising a plurality of chambers configured to receive and confine a population of host cells. The cell transfection apparatus may also include a plurality of electrodes configured to be in electrical communication with a corresponding chamber of said plate. A predetermined electrical current may be directed through a chamber to effect transfection of said host cells. | 09-27-2012 |
20130195395 | Sensing fiber, coil of sensing fiber, and all-fiber current sensor - Embodiments of the present invention provide a sensing fiber, which includes a polarization-maintaining (PM) fiber being spun around a core thereof to have a first, a second, and a third sections, wherein the first section has an increasing rate of spin from a predetermined slow rate to a predetermined fast rate; the second section is spun at the predetermined fast rate; and the third section has a decreasing rate of spin from the predetermined fast rate to the predetermined slow rate. The first and third sections have a substantially same length and changes in rate of spin are substantially symmetric to each other. Embodiments of the present invention also provide a fiber coil made by the sensing fiber, with the first section and the third section being substantially overlapped along the coil, and provide an all-fiber current sensor employing the fiber coil. | 08-01-2013 |
20130225444 | HIGH-THROUGHPUT CELL TRANSFECTION DEVICE AND METHODS OF USING THEREOF - Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in functional genomic study and drug discovery. Development of high-throughput cell transfection technology will permit functional analysis of massive number of genes and how their activities could be modulated by chemical or biological entities inside cells. This invention describes design, construction of device and apparatus for high throughput effective cell transfection. Procedures and protocols for using the device and apparatus are also described in the application. Novel methods of using the device in cell-based assays are also disclosed. | 08-29-2013 |