Patent application number | Description | Published |
20090111119 | Rapid in vivo identification of biologically active nucleases - Disclosed herein are methods and compositions for rapidly identifying and ranking nucleases for specific cleavage of a target sequence. | 04-30-2009 |
20090203140 | Genomic editing in zebrafish using zinc finger nucleases - Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. | 08-13-2009 |
20100199389 | Targeted integration into the Zp15 locus - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a plant Zp15 locus, for example, for expression of a polypeptide of interest. | 08-05-2010 |
20110041195 | Organisms homozygous for targeted modification - Disclosed herein are homozygously modified organisms and methods of making and using these organisms. | 02-17-2011 |
20110129898 | Methods and compositions for increasing nuclease activity - Disclosed herein are methods and compositions for increasing nuclease activity to increase nuclease-mediated genomic modifications. | 06-02-2011 |
20110201055 | Engineered cleavage half-domains - Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence. | 08-18-2011 |
20110247089 | Organisms homozygous for targeted modification - Disclosed herein are homozygously modified organisms and methods of making and using these organisms. | 10-06-2011 |
20110269234 | Methods and compositions for increasing nuclease activity - Disclosed herein are methods and compositions for increasing nuclease activity to increase nuclease-mediated genomic modifications. | 11-03-2011 |
20120142062 | ENGINEERED CLEAVAGE HALF-DOMAINS - Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence. | 06-07-2012 |
20120237926 | RAPID SCREENING OF BIOLOGICALLY ACTIVE NUCLEASES AND ISOLATION OF NUCLEASE-MODIFIED CELLS - Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications. | 09-20-2012 |