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| 20080300389 | Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy - The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. | 12-04-2008 |
| 20090238756 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS - Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent. | 09-24-2009 |
| 20100278731 | Mechanism-Based Targeted Pancreatic Beta Cell Imaging and Therapy - Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals. | 11-04-2010 |
| 20110087003 | GLYCOPEPTIDE COMPOSITIONS - The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide. | 04-14-2011 |
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| 20080233218 | Methods for treating oral cancers with herbal compositions - The inventive subject matter relates to methods for treating oral cancers, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, | 09-25-2008 |
| 20110008457 | COMPOSITIONS AND METHODS FOR MODULATING LIPID COMPOSITION - The present subject matter relates to a novel herbal and oil composition and methods for modulating fatty acid composition and metabolism in an animal. In one aspect, the subject matter involves a composition comprising rosemary extract, oregano extract, and a polyunsaturated oil. In a particular embodiment, the polyunsaturated oil is fish oil or a derivative thereof. In some embodiments, the present subject matter relates to methods for modulating essential dietary fatty acid composition of lipoprotein particles or cell membranes, modulating essential fatty acid metabolism, regulating the activity of lipoxygenases and cyclooxygenases, improving cardiovascular health, and/or inhibiting cell proliferation diseases and disorders. | 01-13-2011 |
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| 20090078144 | LINER FOR SHAPED CHARGES - A liner for a shaped charge is disclosed which comprises a plurality of portions, where at least one portion is composed of powder materials. In one embodiment, the liner comprises two portions that are composed of different powder materials, while alternative embodiments of the liner comprise three portions or four portions. When the shaped charge is used in a perforating gun, reactive powder materials may be added to the plurality of portions of the liner to optimize the penetration or the enhancement of the perforating tunnel. | 03-26-2009 |
| 20090151949 | DEBRIS-FREE PERFORATING APPARATUS AND TECHNIQUE - An apparatus that is usable with a well includes a perforating system that is adapted to be fired downhole in the well. The perforating system includes a component, which includes an alloy that has a negative corrosion potential and is unable to passivate, or self-protect, while deployed in the well. The component is adapted to disintegrate to form substantially no debris in response to the firing of the perforating system. | 06-18-2009 |
| 20100044044 | CONTROLLING TRANSIENT UNDERBALANCE IN A WELLBORE - A method of perforating a well includes selecting a desired transient underbalanced condition, configuring a perforating gun string to achieve the transient underbalanced condition, deploying the perforating gun is a wellbore, and firing the perforating to achieve the transient underbalanced condition. | 02-25-2010 |
| 20100132578 | RADIAL-LINEAR SHAPED CHARGE PIPE CUTTER - A radial-linear shaped charge pipe cutter is constructed with the booster explosive packed intimately into a booster aperture that is bored axially through the charge upper end plate. The cutter explosive is initiated at the interface between the upper margin of the cutter explosive and the contiguous inside surface of the upper end plate. This interface is within a critical initiation distance from the half charge juncture plane. In one embodiment, a half charge liner is configured as the assembly of two, coaxial, frusto-cones with the smaller cone diverging from the half charge juncture plane at a smaller angle than the outer cone. In another embodiment, the liner thickness increases from the juncture plane out to the liner perimeter. | 06-03-2010 |
| 20100319562 | SHAPED CHARGE LINER WITH VARYING THICKNESS - A shaped charge has a case defining a volume therein. A liner is located in the volume. An explosive is located between the case and the liner. The liner defines an interior volume and an opening thereto. The liner also has an apex portion that is distal from the opening. The liner has a first thick portion and a second thick portion. A thin portion is located between the first thick portion and the second thick portion in a direction extending from the apex portion along the liner toward the opening. The thin portion is thinner than the first thick portion and thinner than the second thick portion. | 12-23-2010 |
| 20110056362 | ENERGETIC MATERIAL APPLICATIONS IN SHAPED CHARGES FOR PERFORATION OPERATIONS - A shaped charge includes a cup-shaped casing defining an interior volume; a liner located within the interior volume; an explosive disposed between the liner and the casing; and a reactive material disposed between the liner and the casing. A method for generating a dynamic overbalance inside a wellbore includes disposing a perforation gun in the wellbore; and detonating a shaped charge in the perforation gun, wherein the shaped charge includes a cup-shaped casing defining an interior volume, a liner located within the interior volume, an explosive disposed between the liner and the casing, and a reactive material disposed between the liner and the casing. | 03-10-2011 |
| 20110094406 | Dissolvable Material Application in Perforating - A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid. | 04-28-2011 |
