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Xu, MA
Aihua Xu, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120232959 | OPTIMIZED PRICING SOLVER WITH PRIORITIZED CONSTRAINTS - A pricing optimization system can solve a constrained optimization problem by generating one or more prices for one or more items that satisfy a maximum number of prioritized constraints. The one or more generated prices can be one or more prices that represent a minimal deviation between the generated one or more prices and one or more original prices for the one or more items. By satisfying a maximum number of prioritized constraints, and by minimizing a deviation from the one or more original prices for the one or more items, the generated one or more prices are one or more optimal prices. | 09-13-2012 |
Chanxing Wilson Xu, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090130676 | Interaction trap systems for detecting protein interactions - Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed. Finally, populations of eukaryotic cells are disclosed, each cell having a recombinant DNA molecule encoding a conformationally-constrained intracellular peptide. | 05-21-2009 |
Cheng-Bae Xu, Southborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120077120 | PHOTORESISTS COMPRISING MULTI-AMIDE COMPONENT - New photoresist compositions are provided that comprise a component that comprises two or more amide groups. Preferred photoresists of the invention may comprise a resin with photoacid-labile groups; a photoacid generator compound; and a multi-amide component that can function to decrease undesired photogenrated-acid diffusion out of unexposed regions of a photoresist coating layer | 03-29-2012 |
Clarke Xu, Maynard, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100133101 | CROSS-LINKED ENZYME MATRIX AND USES THEREOF - An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors. | 06-03-2010 |
Danny Xu, Milton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090320231 | STEAM MOP - A steam mop including a mop housing is provided. The mop housing includes a water tank with a water inlet and a water outlet, a water pump with a pump inlet and a pump outlet and a boiler. A mop handle is connected to the mop housing at one end and a steam frame is connected to the housing at the opposite end. The water tank has a water inlet opening to a surface of the housing with a removable inlet cap where the surface of the housing about the cap has a funnel shape. The water pump is coupled to the outlet of the water tank and inlet of the boiler so that movement of the steam mop activates the pump to pump water from the water container to the boiler for the generation of steam. In addition, a steam frame assembly provided with a fabric steam pocket is selectively removable from the housing. The frame has an opening about the middle of rear wall for mounting a connector including a top end having a steam inlet for connecting to a steam housing and a bottom end having a pair of steam nozzles for connecting to the steam frame and a plurality of baffles are disposed perpendicular to the pair of steam nozzles between the front and rear walls. | 12-31-2009 |
David Beijia Xu, Medfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105546 | Nickel-Based Reforming Catalysts - The present invention relates unique pore structures in nickel supported on alumina with the negligible formation of macropores. Incorporation of additional elements stabilizes the pore structure of the nickel supported on alumina. Additional element(s) were then further added into the nickel-supported materials. These additional element(s) further stabilize the pore structures under heating conditions. The improvements of pore structure stability under heating conditions and negligible presence of macropores limit the sintering of nickel metal to a mechanism of impeded diffusion. The negligible presence of macropores also limits the deposition of alkali metal hydroxide(s)/carbonate(s) on the outer shell of the catalyst pellet in the molten carbonate fuel cells. Both the negligible presence of macropores and improvement in pore structure stability allow for prolonging the catalyst life of these nickel supported on alumina catalysts of the present invention for reforming hydrocarbons. | 04-29-2010 |
| 20100298452 | Proton-Conducting Polymer with a Two-Dimensional Backbone of Metal-Oxygen Bonding - The present invention relates a new proton-conducting polymer with a two dimensional backbone with metal-oxygen bonding. The metal ion in the backbone of the proton-conducting polymer of the present invention comprises elements from Group IIIA, IVA, VA, IIIB, IVB, VB, VIB, lanthanides, etc in the Chemical Periodic Table. It is more preferred for the metal ion of the proton-conducting polymer of the present invention to be silicon, aluminum, boron, gallium, indium, tin, antimony, bismuth, titanium, or zirconium. It is further preferred that the backbone of the proton-conducting polymer of the present invention comprises silicon, aluminum, boron, zirconium, or titanium. It is further preferred that the proton-conduction polymer of the present invention comprises silicon in its two dimensional backbone. The backbone of the proton-conducting polymer of the present invention is chemically stable to attacks from the hydroxyl free radicals in the fuel cells. The invented polymer with a two dimensional backbone of metal-oxygen bonding is thermally stable for high temperature usage as a proton-exchange membrane for proton-exchange membrane fuel cells. The polymer with a two dimensional backbone of metal-oxygen bonding is also flexible and ductile enough to allow successful fabrication of the invented material into membrane-electrode-assembly for fuel cells. The flexibility and conductivity of the proton-conducting polymer of the present invention also allow the proton-exchange membrane fuel cell to have a long lifespan with minimal issues in membrane delamination and denaturing during fuel cell operation at a high temperature. | 11-25-2010 |
| 20130053237 | NICKEL-BASED REFORMING CATALYST - The present invention relates unique pore structures in nickel supported on alumina with the negligible formation of macropores. Incorporation of additional elements stabilizes the pore structure of the nickel supported on alumina. Additional element(s) were then further added into the nickel-supported materials. These additional element(s) further stabilize the pore structures under heating conditions. The improvements of pore structure stability under heating conditions and negligible presence of macropores limit the sintering of nickel metal to a mechanism of impeded diffusion. The negligible presence of macropores also limits the deposition of alkali metal hydroxide(s)/carbonate(s) to the outer shell of the catalyst pellet. Both of the negligible presence of macropores and improvement in pore structure stability allow for prolonging the catalyst life of these nickel supported on alumina catalysts of the present invention for reforming hydrocarbons. | 02-28-2013 |
Fang Xu, Auburndale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080205172 | DESIGN-FOR-TEST MICRO PROBE - Systems and techniques for testing a device having first and second interconnected chips that are internal to the device include selecting a site on a communication pathway along which an internal signal travels inside the device between the first and second chips, and connecting a test probe to the site. | 08-28-2008 |
| 20080208495 | ELECTRICALLY STIMULATED FINGERPRINT SENSOR TEST METHOD - Systems and techniques for testing a fingerprint sensor are described. A conductive material is placed on a surface of the fingerprint sensor, and an electrical signal is applied to the conductive material. The electrical signal affects a first electrical property associated with first and second electrodes of the fingerprint sensor. First and second measurements of a second electrical property associated with the first and second electrodes are acquired, the second electrical property being correlated to the first electrical property. The first and second measurements are analyzed to determine whether the fingerprint sensor has one or more defects. | 08-28-2008 |
Fang Xu, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080243983 | Residual Fourier-Padding Interpolation for Instrumentation and Measurement - A technique for interpolating a series of samples includes constructing a mathematical model of the series that describes its large signal behavior. The model is subtracted from the original series to yield a residue. A discrete Fourier transform (DFT) is taken of the residue, and the DFT is zero-padded. An inverse DFT of the padded result yields an interpolated residue, which is then added back to the mathematical model to construct an interpolated version of the series of samples. Using this technique, accurate interpolation can generally be attained even when the series of samples is not coherently sampled. | 10-02-2008 |
Fangmin Xu, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120003888 | BIOADHESIVE CONSTRUCTS WITH POLYMER BLENDS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive polymer blend. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive blend constructs can be used to treat and repair, for example, hernias and damaged tendons. | 01-05-2012 |
| 20120116424 | ADHESIVE COMPOUNDS AND METHODS USE FOR HERNIA REPAIR - The invention describes new synthetic medical adhesives and films which exploit the key components of natural marine mussel adhesive proteins. | 05-10-2012 |
| 20120149849 | MULTI-ARMED CATECHOL COMPOUND BLENDS - The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling. | 06-14-2012 |
| 20120179083 | THIN FILM COMPOSITIONS AND METHODS OF SYNTHESIS AND USE THEREFOR - The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types. | 07-12-2012 |
Gouyou Xu, Tthaca, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120035352 | 6-11 Bicyclic Ketolide Derivatives - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 02-09-2012 |
Guoyou Xu, Auburndale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090324577 | 6-11 Bicyclic Ketolide Derivatives - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 12-31-2009 |
Hailong Xu, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120169287 | BATTERY CONDITIONER WITH POWER DISSIPATER - The present application is directed to a power dissipation apparatus including a conductive trace formed on a substrate and to methods of using the power dissipation apparatus. The power dissipation apparatus may be used to dissipate heat generated from electrical current passed through the conductive trace of the power dissipation apparatus. The current may be provided from, for example, a battery conditioner. | 07-05-2012 |
He Xu, Needham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110212969 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 09-01-2011 |
| 20110213003 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 09-01-2011 |
| 20110251184 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 10-13-2011 |
| 20120015943 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 01-19-2012 |
| 20120094997 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 04-19-2012 |
He Xu, Natick, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110039827 | Substituted hydroxamic acids and uses thereof - This invention provides compounds of formula (I): | 02-17-2011 |
| 20110046157 | Substituted hydroxamic acids and uses thereof - This invention provides compounds of formula (I): | 02-24-2011 |
Huansheng Xu, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120009158 | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF - The present invention generally relates to methods and compositions to generate a secondary iPS (2iPS) cell to produce somatic cells of a rare differentiation cell type fate. In some embodiments, the method relates to an increase in efficiency of differentiation and production of high yields of somatic cells of a rare differentiation cell type fate produced from secondary iPS (2iPS) cells as compared to their differentiation from other pluripotent stem cell sources such as ES cells or primary iPS cells. In some embodiments, the present invention relates to compositions, methods and systems for reprogramming a first somatic cell into a primary iPS cell, where the primary iPS cell is then differentiated along a selected linage to produce a second somatic cell, which is then reprogrammed to a secondary iPS cell (2iPS) cell. The 2iPS cell has a high efficiency of differentiating into a cell of the same cell type as the second somatic cell, e.g., a somatic cells of a rare differentiation cell type fate such as but not limited to a ventricular cardiomyocyte, a pancreatic β-cell or a hepatic cell. In some embodiments, the first somatic cell is a fibroblast, or a cardiac cell, but is not limited to cardiac fibroblast cells. In some embodiments, the present invention relates to compositions, methods and systems to produce ventricular cardiomyocytes from secondary induced pluripotent stem cells (iPSC), where the iPSC are themselves generated from ventricular cardiomyocytes. The secondary iPS (2iPS) cell generated from ventricular cardiomyocytes have a higher cardiomyogenic potential and high cardiomyogenic yield as compared to primary iPSC, and are useful in drug discovery, disease modeling and cell-based therapy. | 01-12-2012 |
Jianguo Xu, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120002717 | METHOD AND SYSTEM FOR LIVE STREAMING VIDEO WITH DYNAMIC RATE ADAPTATION - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
| 20120004960 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
| 20120005364 | SYSTEM AND METHOD FOR NETWORK AWARE ADAPTIVE STREAMING FOR NOMADIC ENDPOINTS - In a system for streaming data over a network, the type and rate of streaming are automatically varied based on available network bandwidth. Video media is transcoded into different bit rate encodings that are divided into segment files. Segments are sent from a network-aware adaptive streaming (NAAS) server and reassembled and presented to a media player at a client device. The system may download additional segment files ahead of time from multiple NAAS servers to increase throughput. A playback status (“bookmark”) may be maintained to keep track of what the user has viewed and to allow the user to continue playing from where the user left off. The user may continue watching from the bookmark point on the same device or on a different device. | 01-05-2012 |
| 20120005365 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
| 20120005366 | METHOD AND APPARATUS FOR RETRIEVING AND RENDERING LIVE STREAMING DATA - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
| 20120011267 | LIVE STREAMING MEDIA DELIVERY FOR MOBILE AUDIENCES - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. The live streaming system includes a live streaming recorder operative to (1) capture a live media stream generated by a live media source and save the captured live media stream as a recorded stream in a recorded media file, and (2) transcode the recorded stream into a plurality of transcoded media files of respective different media encoding formats. The system further includes a stream distribution subsystem operative to generate a plurality of distributed media streams each generated from one or more of the transcoded media files, each distributed media stream being delivered to a corresponding set of the mobile endpoint devices. | 01-12-2012 |
| 20120265892 | METHOD AND SYSTEM FOR SECURE AND RELIABLE VIDEO STREAMING WITH RATE ADAPTATION - A system for media delivery includes a server-side proxy for aggregating and encrypting stream data for efficient HTTP-based distribution over an unsecured network. A client-side proxy decrypts and distributes the encapsulated stream data to client devices. A multicast-based infrastructure may be used for increased scalability. The encoded rate of the media delivered over the persistent HTTP proxy connections may be dynamically adapted. The client-side proxy may be integrated within a mobile device for maximum network security and reliability. | 10-18-2012 |
Jianwen Xu, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100068168 | THERMAL RESPONSIVE POLYMER SILOXANES, COMPOSITIONS, AND METHOD AND APPLICATIONS RELATED THERETO - The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. | 03-18-2010 |
| 20100098761 | Polymer Compositions For Biomedical And Material Applications - The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules. | 04-22-2010 |
| 20100280561 | Thermal-Responsive Polymer Networks, Compositions, And Methods And Applications Related Thereto - The invention relates to materials comprising polymer network containing siloxanes or organic-based core structures, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to an organic core functionalized with polymers. In another embodiment, organic core-polymer conjugates comprise polylactone segments. The organic core-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments | 11-04-2010 |
Jian-Wu Xu, Lawrence, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110255789 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA FROM ELECTRONIC DOCUMENTS CONTAINING MULTIPLE LAYOUT FEATURES - A method of automatically extracting data from an electronic document containing a plurality of layout features through progressive refinement is provided. The method includes: analyzing each document to automatically extract images and text features wherein each document includes at least two features that are related to each other, and wherein said analyzing compares extracted features with a first search space of candidate features to try and recognize the extracted features; if one of the at least two related features is not recognized and at least one feature is recognized, selecting a second search space of candidate features in response thereto and in response to predefined rules about the relationship between the two features; and comparing the unrecognized feature with said selected second search space. | 10-20-2011 |
| 20110258150 | SYSTEMS AND METHODS FOR TRAINING DOCUMENT ANALYSIS SYSTEM FOR AUTOMATICALLY EXTRACTING DATA FROM DOCUMENTS - A method of training a document analysis system to extract data from documents is provided. The method includes: automatically analyzing images and text features extracted from a document to associate the document with a corresponding document category; comparing the extracted text features with a set of text features associated with corresponding category of the document, in which the set of text features includes a set of characters, words, and phrases; if the extracted features are found to consist of the characters, words, and phrases belonging to the set of text features associated with the corresponding document category, storing the extracted text features as the data contained in the corresponding document; and, if the extracted text features are found to include at least one text feature that does not belong to the set of text features associated with the corresponding document category, submitting the unrecognized text features to a training phase. | 10-20-2011 |
Jingjing Xu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120296033 | Hard, Impermeable, Flexible and Conformal Organic Coatings - Disclosed is a substantially alternating copolymer that is conformal, hard, flexible, and has low oxygen permeability. Also disclosed is an iCVD-based method of coating a substrate with the substantially alternating copolymer. | 11-22-2012 |
Jingwang Xu, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100063021 | Modulators of muscarinic receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 03-11-2010 |
| 20120004226 | Modulators of Muscarinic Receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 01-05-2012 |
| 20120196857 | Modulators of Muscarinic Receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 08-02-2012 |
Jinwang Xu, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090099222 | Modulators of muscarinic receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 04-16-2009 |
| 20110059936 | C-MET PROTEIN KINASE INHIBITORS - The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. | 03-10-2011 |
| 20120039849 | TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 02-16-2012 |
Jinxi Xu, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080215309 | Extraction-Empowered machine translation - The invention relates to systems and methods for automatically translating documents from a first language to a second language. To carry out the translation of a document, elements of information are extracted from the document and are translated using one or more specialized translation processes. The remainder of the document is separately translated by a statistical translation process. The translated elements of information and the translated remainder are then merged into a final translated document. | 09-04-2008 |
| 20090240487 | MACHINE TRANSLATION - A method for computer-assisted translation from a source language to a target language makes use of number of rules. Each rule forms an association between a representation of a sequence of source language tokens with a corresponding tree-based structure in the target language. The tree-based structure for each of at least some of the rules represents one or more asymmetrical relations within a number of target tokens associated with the tree-based structure and provides an association of the target tokens with the sequence of source language tokens of the rule. An input sequence of source tokens is decoded according to the rules to generate a representation of one or more output sequences of target language tokens. Decoding includes, for each of at least some sub-sequences of the input sequence of source tokens, determining a tree-based structure associated with the sub-sequence according a match to one of the plurality of rules. | 09-24-2009 |
Lihui Xu, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120244163 | BISPECIFIC BINDING AGENTS TARGETING IGF-1R AND ERBB3 SIGNALLING AND USES THEREOF - Disclosed are bispecific binding agents that specifically target both of the IGF-1 and the ErbB intracellular signaling pathways. For example, bispecific binding agents that comprise an anti-IGF-1R antibody and an anti-ErbB3 antibody connected by a linker are described herein. These bispecific agents are capable of antagonizing signal transduction by both of the IGF-1 and the ErbB signaling pathways and are useful in inhibiting the proliferation of tumor cells whose growth involves the signaling activity of both pathways. | 09-27-2012 |
| 20120269812 | MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES - Provided herein are novel monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided. | 10-25-2012 |
Ming Laura Xu, Wayland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110283550 | CUTTING MEMBERS FOR SHAVING RAZORS - Cutting members for razors are provided that have been subjected to a localized heat-treating process, e.g., application of laser energy. In some cases, the cutting members include a bent portion, and the localized heat-treating process is used to enhance ductility and thereby facilitate formation of the bent portion. | 11-24-2011 |
Ming-Qun Xu, Hamilton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090035814 | Method for producing circular or multimeric protein species in vivo or in vitro and related methods - A method is disclosed for forming multimeric proteins. The method relies on intermolecular trans-splicing of a split intein either in vivo or in vitro. | 02-05-2009 |
Minzhen Xu, Northborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080305122 | Ii-Key/antigenic epitope hybrid peptide vaccines - Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope. In addition, the nucleic acid molecule comprises a second expressible nucleic acid sequence encoding an antigen presentation enhancing hybrid polypeptide. The antigen presentation enhancing hybrid polypeptide includes the following elements: i) an N-terminal element consisting essentially of 4-16 residues of the mammalian Ii-Key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and non-N-terminal deletion modifications thereof that retain antigen presentation enhancing activity; ii) a C-terminal element comprising an MHC Class II-presented epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, the MHC Class II-presented epitope being contained in the protein of interest of step a); and iii) an intervening peptidyl structure linking the N-terminal and C-terminal elements of the hybrid, the peptidyl structure having a length of about 20 amino acids or less. | 12-11-2008 |
| 20090060889 | Ii-RNAi involved Ii suppression in cancer immunotherapy - Provided are compositions and methods involving the inhibition of Ii expression in cells for the purpose of altering antigen presentation pathways. Human Ii-RNAi constructs that effectively inhibit Ii expression in human cancer cells have been generated. The combination of different Ii-RNAi constructs that target different positions of Ii mRNA has a synergistic effect on Ii inhibition. Furthermore, specific promoters for driving Ii-RNAi expression are critical for the activity of Ii-RNAi in different types of cells. Active Ii-RNAi sequences were cloned into plasmids in which Ii-RNAi sequences are driven by either a CMV or an EF-1α promoter. Compositions and methods are disclosed for inhibiting Ii and treating cancer. Provided are siRNAs and expression constructs comprising DNA sequences which encode siRNAs effective to inhibit Ii expression, cells containing such DNA constructs or siRNAs, and methods for use of the same. | 03-05-2009 |
| 20090060936 | Ii-Key/Her-2/neu hybrid cancer vaccine - Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK (SEQ ID NO: 2) residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide. | 03-05-2009 |
| 20100080817 | HUMAN PAPILLOMAVIRUS / Ii-KEY HYBRIDS AND METHODS OF USE - The present invention is directed towards compositions comprising Ii-Key/HPV hybrid peptides. The hybrid peptides of the present invention are effective in the generation of CD4+ helper T cell immune responses directed towards the specific HPV epitopes encoded in the hybrid peptide. The inclusion of the Ii-key peptide in the hybrid causes the peptide to have greater immunogenicity as compared to control peptide. The inclusion of Ii-Key/HPV hybrid in a peptide vaccine formulation composing both HPV hybrid and HPV CTL epitope peptide (administered concurrently or sequentially) leads to a greater CTL activity against HPV CTL epitopes. The hybrid peptides of the present invention may be useful, for example, for the immunization of subjects against HPV. | 04-01-2010 |
| 20100150953 | Ii-KEY/HER-2/NEU HYBRID CANCER VACCINE - Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide. | 06-17-2010 |
| 20100255019 | Ii-KEY/HER-2/NEU HYBRID CANCER VACCINE - Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK [SEQ ID NO.: 2] residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide. | 10-07-2010 |
| 20100291145 | Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES - Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope, or said encoded protein or peptide. In addition, the nucleic acid molecule comprises a second expressible nucleic acid sequence encoding an antigen presentation enhancing hybrid polypeptide, or said encoded protein or peptide. The antigen presentation enhancing hybrid polypeptide includes the following elements: i) an N-terminal element consisting essentially of 4-16 residues of the mammalian Ii-Key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and non-N-terminal deletion modifications thereof that retain antigen presentation enhancing activity; ii) a C-terminal element comprising an MHC Class II-presented epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, the MHC Class II-presented epitope being contained in the protein of interest of step a); and iii) an intervening peptidyl structure linking the N-terminal and C-terminal elements of the hybrid, the peptidyl structure having a length of about 20 amino acids or less. | 11-18-2010 |
Phyllis Xu, Cambridge, MA US
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|---|---|---|
| 20110027661 | ELECTRODE ELEMENT, METHOD OF MANUFACTURING ELECTRODE ELEMENT, AND LITHIUM ION SECONDARY BATTERY - An electrode element contains a positive electrode active material and a second solid electrolyte. The positive electrode active material has an active material and a first solid electrolyte. Seventy percent or more of a surface of the active material is coated with the first solid electrolyte. | 02-03-2011 |
Qiaobing Xu, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090295364 | Methods of Using a Nanotransfer Printing Stamp Having Conductively Coated Sidewalls - Methods and apparatuses for generating electrically-conductive and/or semi-conductive films, and more specifically, methods and apparatuses for generating conductive and/or semi-conductive films having nanoscale features are provided. In one embodiment, an electrically-conductive or semi-conductive film (e.g., a gold layer of less than 50 nanometer thickness) is provided on a substrate (e.g., a poly(dimethylsiloxane) (PDMS) stamp). The substrate may optionally include patterns or features having raised and recessed portions. A first portion of the film may be removed from the substrate, e.g., by methods such as physically contacting the first portion of the film with a surface to which the first portion preferentially adheres. This process can leave a second portion of the film remaining on the substrate. In some embodiments, the second portion includes at least one region having a dimension substantially parallel to a portion of the substrate i.e., of less than 50 nanometers. The second portion of the film may be used to establish electrical communication with an electrical contact. Advantageously, electrically-conductive and/or semi-conductive films having nanoscale features can be fabricated over large areas (e.g., areas greater than 1 cm | 12-03-2009 |
Shuai Xu, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120255355 | HAND MUSCLE MEASUREMENT DEVICE - The present disclosure relates to an integrated system for measuring hand strength and dexterity. Specifically, the integrated system allows for measuring of hand muscle strength through the pinch-grip test, of intrinsic hand muscle strength, and testing of performance in various dexterity tests. | 10-11-2012 |
Shuang-Yong Xu, Lexingston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080268507 | Recombinant Dna Nicking Endonuclease and Uses Thereof - Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where the mutation includes deletion of amino acid sequences at the C-terminal end of the protein. The nicking enzymes have been used for a number of purposes including: amplifying DNA from as few cells as can be found in a single bacterial colony in the presence of a strand displacing polymerase; and for removing genomic DNA in a biological preparation where it is deemed to be a contaminant. | 10-30-2008 |
Shuang-Yong Xu, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080213860 | Nicking Endonuclease Methods and Compositions - A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. | 09-04-2008 |
| 20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
| 20090029418 | METHOD FOR CLONING AND EXPRESSION OF STUI RESTRICTION ENDONUCLEASE AND STUI METHYLASE IN E. COLI - The present invention relates to compositions including: (1) isolated DNA encoding the Stul restriction endonuclease and isolated DNA encoding cognate and non-cognate methylase; (2) vectors and cells containing the isolated DNA; and (3) methods for producing the Stul restriction endonuclease. | 01-29-2009 |
| 20090280528 | Method for Cloning and Expression of NruI Restriction Endonuclease - Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes. | 11-12-2009 |
| 20110076720 | NICKING ENDONUCLEASE METHODS AND COMPOSITIONS - A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. | 03-31-2011 |
| 20110151450 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-23-2011 |
Tianlin Xu, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100075951 | Heteroaryls and uses thereof - This invention provides compounds of formula I: | 03-25-2010 |
| 20120172345 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: | 07-05-2012 |
| 20120178723 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-a or IB-a and subsets thereof: | 07-12-2012 |
| 20120202812 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula I: | 08-09-2012 |
| 20120214794 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula I-A or I-B: | 08-23-2012 |
Tong Xu, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100153957 | SYSTEM AND METHOD FOR MANAGING THREAD USE IN A THREAD POOL - A method and system for managing a thread pool of a plurality of first type threads and a plurality of second type threads in a computer system using a thread manager, specifically, a method for prioritizing, cancelling, balancing the work load between first type threads and second type threads, and avoiding deadlocks in the thread pool. A queue stores a first type task and a second type task, the second type task being executable by at least one of the plurality of second type threads. The availability of at least one of the plurality of first type threads is determined, and if none are available, the availability of at least one of the plurality of second type threads is determined. An available second type thread is selected to execute the first type task. | 06-17-2010 |
Wei-Chu Xu, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120232077 | SELECTIVE ANTIBACTERIALS FOR CLOSTRIDIUM DIFFICILE INFECTIONS - The invention features compounds of formula (I): The compounds are useful as antibacterial agents, especially again | 09-13-2012 |
Weixin Xu, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090048286 | Inhibitors of Protein Tyrosine Phosphatase 1B - Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes. | 02-19-2009 |
Wen-Qing Xu, Medfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105546 | Nickel-Based Reforming Catalysts - The present invention relates unique pore structures in nickel supported on alumina with the negligible formation of macropores. Incorporation of additional elements stabilizes the pore structure of the nickel supported on alumina. Additional element(s) were then further added into the nickel-supported materials. These additional element(s) further stabilize the pore structures under heating conditions. The improvements of pore structure stability under heating conditions and negligible presence of macropores limit the sintering of nickel metal to a mechanism of impeded diffusion. The negligible presence of macropores also limits the deposition of alkali metal hydroxide(s)/carbonate(s) on the outer shell of the catalyst pellet in the molten carbonate fuel cells. Both the negligible presence of macropores and improvement in pore structure stability allow for prolonging the catalyst life of these nickel supported on alumina catalysts of the present invention for reforming hydrocarbons. | 04-29-2010 |
| 20100298452 | Proton-Conducting Polymer with a Two-Dimensional Backbone of Metal-Oxygen Bonding - The present invention relates a new proton-conducting polymer with a two dimensional backbone with metal-oxygen bonding. The metal ion in the backbone of the proton-conducting polymer of the present invention comprises elements from Group IIIA, IVA, VA, IIIB, IVB, VB, VIB, lanthanides, etc in the Chemical Periodic Table. It is more preferred for the metal ion of the proton-conducting polymer of the present invention to be silicon, aluminum, boron, gallium, indium, tin, antimony, bismuth, titanium, or zirconium. It is further preferred that the backbone of the proton-conducting polymer of the present invention comprises silicon, aluminum, boron, zirconium, or titanium. It is further preferred that the proton-conduction polymer of the present invention comprises silicon in its two dimensional backbone. The backbone of the proton-conducting polymer of the present invention is chemically stable to attacks from the hydroxyl free radicals in the fuel cells. The invented polymer with a two dimensional backbone of metal-oxygen bonding is thermally stable for high temperature usage as a proton-exchange membrane for proton-exchange membrane fuel cells. The polymer with a two dimensional backbone of metal-oxygen bonding is also flexible and ductile enough to allow successful fabrication of the invented material into membrane-electrode-assembly for fuel cells. The flexibility and conductivity of the proton-conducting polymer of the present invention also allow the proton-exchange membrane fuel cell to have a long lifespan with minimal issues in membrane delamination and denaturing during fuel cell operation at a high temperature. | 11-25-2010 |
| 20130053237 | NICKEL-BASED REFORMING CATALYST - The present invention relates unique pore structures in nickel supported on alumina with the negligible formation of macropores. Incorporation of additional elements stabilizes the pore structure of the nickel supported on alumina. Additional element(s) were then further added into the nickel-supported materials. These additional element(s) further stabilize the pore structures under heating conditions. The improvements of pore structure stability under heating conditions and negligible presence of macropores limit the sintering of nickel metal to a mechanism of impeded diffusion. The negligible presence of macropores also limits the deposition of alkali metal hydroxide(s)/carbonate(s) to the outer shell of the catalyst pellet. Both of the negligible presence of macropores and improvement in pore structure stability allow for prolonging the catalyst life of these nickel supported on alumina catalysts of the present invention for reforming hydrocarbons. | 02-28-2013 |
Xiao-Jin Xu, Jamaica Plain, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110136682 | ANTENNARY FUCOSYLATION IN GLYCOPROTEINS FROM CHO CELLS - The present invention provides methods of evaluating CHO cells and producing recombinant glycoproteins. | 06-09-2011 |
| 20110287465 | CHARACTERIZATION OF O-LINKED GLYCANS - The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein. | 11-24-2011 |
Xiao-Jin Xu, Southborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110045496 | GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS - The present invention provides methods of evaluating CHO cells. | 02-24-2011 |
Xiaoyang Xu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120269730 | Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles - The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle. | 10-25-2012 |
Xu Xu, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100092484 | CD44 ANTIBODIES - The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment. | 04-15-2010 |
Xuejun Xu, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090012337 | METHOD FOR PRODUCING GRAPHITE NANOCATALYSTS HAVING IMPROVED CATALYTIC PROPERTIES - High temperature treatment of graphite nanofibers to increase their catalytic activity. The heat treated graphite nanofiber catalysts are suitable for catalyzing chemical reactions such as oxidation, hydrogenation, oxidative-dehydrogenation, and dehydrogenation. | 01-08-2009 |
Yixin Xu, Newton Lower Falls, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090068271 | EMBOLIZATION PARTICLES - Embolic particles, embolic particle chains, and methods for making embolic particles and embolic particle chains are described. | 03-12-2009 |
Yongkai Xu, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090248246 | LOADING AND UNLOADING STABILIZATION IN AN ACTIVE SUSPENSION SYSTEM - An active suspension system includes a relative slow-responding force bias eliminator (such as a pneumatic actuator) and a relatively fast-responding actuator (such as an electromagnetic actuator) that together support a plant (such as a truck seat or vehicle cabin). The system also includes a load-unload detector (which may be a physical or virtual detector) to detect a loading or unloading of the plant. When such a loading or unloading is detected, the system causes the force bias eliminator to respond quickly (e.g., as quick as possible) while controlling the fast-responding actuator so as to preserve the available energy for operating the actuator (e.g., so as to keep the fast-responding actuator from consuming all of its available energy) prior to when the force bias eliminator can respond. | 10-01-2009 |
| 20110148331 | MOTION CONTROL SYSTEM SELF-CALIBRATING - A motion control system including components such as an accelerometer for detecting zero force positions and for self-calibrating the motion control system. The motion control system may be implemented in an active seat suspension. | 06-23-2011 |
Yongyao Xu, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080311573 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer - The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 12-18-2008 |
Yong Yao Xu, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100075325 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER - The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 03-25-2010 |
| 20100105051 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 04-29-2010 |
| 20100291068 | NUCLEIC ACID MOLECULES AND PROTEINS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF OVARIAN CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided. | 11-18-2010 |
| 20110092388 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 04-21-2011 |
Zhang-Bao Xu, Tewksbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080227960 | Crystal structure of estrogen receptor-beta complex and uses thereof - This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents. | 09-18-2008 |
Zhen Xu, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080296086 | DIAPHRAGM SURROUND - A surround for supporting a diaphragm used to create acoustic waves includes a rib section extending away from the diaphragm and a membrane section that is supported by the rib section. The membrane section has a thickness in a direction substantially normal to opposing top and bottom surfaces of the membrane section which is substantially thinner than a thickness of the rib section in a direction substantially normal to opposing top and bottom surfaces of the rib section. A restoring force returning the diaphragm to a home position is contributed to more due to deformation of the rib section than to deformation of the membrane section. | 12-04-2008 |
Zhilei Xu, Cambridge, MA US
Zhilei Xu, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120131559 | Automatic Program Partition For Targeted Replay - Program partitioning of an application can include creating execution flow graphs and static flow graphs of targeted functions or operations of the application. Based on the execution flow graphs or static flow graphs, replay interfaces are created. The replay interfaces provide data flows that are usable in re-execution of the application during program development. | 05-24-2012 |
Zuoshang Xu, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090042828 | METHODS AND COMPOSITIONS FOR TREATING GAIN-OF-FUNCTION DISORDERS USING RNA INTERFERENCE - The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS), with RNAi agent. The invention further provides RNAi resistant replacement genes containing mismatches with their respective RNAi agents. The invention also provides for vectors that express RNAi agent and RNAi resistant replacement gene of the present invention. | 02-12-2009 |
| 20110160286 | ALLELE-SPECIFIC RNA INTERFERENCE - Human diseases caused by dominant, gain-of-function mutations develop in heterozygotes bearing one mutant and one wild-type copy of a gene. Because the wild-type gene often performs important functions, whereas the mutant gene is toxic, any therapeutic strategy must selectively inhibit the mutant while retaining wild-type gene expression. The present invention includes methods of specifically inhibiting the expression of a mutant allele, while preserving the expression of a co-expressed wild-type allele using RNAi, a therapeutic strategy for treating genetic disorders associated with dominant, gain-of-function gene mutations. The invention also includes small interfering RNAs (siRNAs) and small hairpin RNAs (shRNAs) that selectively suppress mutant, but not wild-type, expression of copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS). The present invention further provides asymmetric siRNAs and shRNAs with enhanced efficacy and specificity and mediating RNAi. | 06-30-2011 |