Patent application number | Description | Published |
20090324538 | Fusion molecules and IL-15 variants - The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. | 12-31-2009 |
20100278774 | FUSION MOLECULES AND IL-15 VARIANTS - The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. | 11-04-2010 |
20110070191 | T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THERE OF - Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes. | 03-24-2011 |
20120177595 | MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME - The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention. | 07-12-2012 |
20120230946 | FUSION MOLECULES AND IL-15 VARIANTS - The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. | 09-13-2012 |
20140134128 | MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME - The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus). | 05-15-2014 |
20140205560 | MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME - The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention. | 07-24-2014 |
20140219955 | FUSION MOLECULES AND IL-15 VARIANTS - The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. | 08-07-2014 |
20140242025 | MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME - The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus). | 08-28-2014 |
20140378656 | SOLUBLE TCR MOLECULES AND METHODS OF USE - Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells. | 12-25-2014 |
20150079025 | T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF - Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes. | 03-19-2015 |
Patent application number | Description | Published |
20090158275 | Dynamically Resizing A Virtual Machine Container - Embodiments of the present invention pertain to dynamically resizing a virtual machine container. According to one embodiment, an optimal utilization is determined based on a desired performance for a multi-tiered application and transaction mix information that describes a mix of transactions that result from executing the multi-tiered application. Automatic modification of an amount of a physical resource a virtual machine container is entitled to for executing a particular application component associated with the multi-tiered application is enabled where the amount is automatically modified based on the optimal utilization. | 06-18-2009 |
20100091786 | Control of a Computing System Having Adjustable Inputs - A technique for controlling an output of a computing system having multiple adjustable inputs includes providing a set of adjustable inputs to the computing system, observing an output of the computing system while the system is in operation, and selecting a subset of adjustable inputs from the set of adjustable inputs based on the observation of the output. The inputs in the selected subset are then adjusted to achieve a desired output of the computing system. | 04-15-2010 |
20100115095 | AUTOMATICALLY MANAGING RESOURCES AMONG NODES - A system for managing resources automatically among nodes includes a node controller configured to dynamically manage allocation of node resources to individual workloads, where each of the nodes is contained in one of a plurality of pods. The system also includes a pod controller configured to manage live migration of workloads between nodes within one of the plurality of pods, where the plurality of pods are contained in a pod set. The system further includes a pod set controller configured to manage capacity planning for the pods contained in the pod set. The node controller, the pod controller and the pod set controller are interfaced with each other to enable the controllers to meet common service policies in an automated manner. The node controller, the pod controller and the pod set controller are also interfaced with a common user interface to receive service policy information. | 05-06-2010 |
20100205469 | POWER BUDGETING FOR A GROUP OF COMPUTER SYSTEMS - Power consumption of a group of computer systems is managed based on a maximum power consumption for the group. A power budget is determined from the power consumption of each computer system and the maximum power consumption for the group. The power budget identifies a power cap for each computer system in the group. The power caps in the power budget are distributed to the computer systems in the group. | 08-12-2010 |
20100235011 | DETERMINING OPTIMAL SETTINGS FOR RESOURCE ACTUATORS - A power model that relates the settings of resource actuators to power consumption levels of the resource actuators and a condition model that relates the settings of the resource actuators to an environmental condition at the location of the at least one entity and a power consumption level of the at least one entity are developed. A constraint optimization problem having an objective function and at least one constraint is formulated, where the objective function computes at least a proportional quantity of a total power consumption level of the resource actuators and the at least one constraint comprises a setpoint environmental condition at a location of the at least entity. A solution to the constraint optimization problem is determined, where the solution provides optimal values for the resource actuator settings. | 09-16-2010 |
20110055611 | SYSTEM FOR CONTROLLING POWER CONSUMPTION OF A NETWORK - A system for controlling power consumption of a network includes at least one terminal to receive a plurality of requests to route data from a plurality of data sources to a plurality of data sinks, where the data sources and the data sinks are connected to each other through a plurality of network nodes forming the network, and a network configuration unit. The network configuration unit includes a selection module configured to select a configuration of the network nodes that allows the network to have a lowest overall power consumption of the network among a plurality of configurations of the network, and an output module configured to output a plurality of instruction signals to the network nodes to perform the network configuration. A network path for transmitting a network flow is selected that does not allow the network flow to be split and flow through another network path. | 03-03-2011 |
20120005505 | Determining Status Assignments That Optimize Entity Utilization And Resource Power Consumption - In a method of determining status assignments for a plurality of entities that substantially optimizes a total power consumption of the plurality of entities and a plurality of resource actuators, at least one entity power model for the entities and at least one resource power model for the resource actuators are developed. In addition, a constraint optimization problem having an objective function and at least one constraint is formulated and the problem is solved by employing a search tool, the at least one entity power model, and the at least one resource power module on the objective function to identify status assignments for the entities that results in the optimized total power consumption. | 01-05-2012 |
20140380307 | PERFORMANCE-DRIVEN RESOURCE MANAGEMENT IN A DISTRIBUTED COMPUTER SYSTEM - A system and method for managing resources in a distributed computer system that includes at least one resource pool for a set of virtual machines (VMs) utilizes a set of desired individual VM-level resource settings that corresponds to target resource allocations for observed performance of an application running in the distributed computer system. The set of desired individual VM-level resource settings are determined by constructing a model for the observed application performance as a function of current VM-level resource allocations and then inverting the function to compute the target resource allocations in order to meet at least one user-defined service level objective (SLO). The set of desired individual VM-level resource settings are used to determine final RP-level resource settings for a resource pool to which the application belongs and final VM-level resource settings for the VMs running under the resource pool, which are then selectively applied. | 12-25-2014 |