Patent application number | Description | Published |
20080227845 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION - The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination. | 09-18-2008 |
20090192211 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION - The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination. | 07-30-2009 |
20110046190 | COMBINATIONS COMPRISING A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR - A combination therapy for treating patients suffering from pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, is disclosed. The patient is treated concurrently with a cycloocygenase-2 inhibitor and at least one compound selected from the group consisting of a microtubule interfering agent, an epithelial growth factor receptor tyrosine protein kinase inhibitor and a vascular endothelial growth factor receptor tyrosine kinase inhibitor. | 02-24-2011 |
Patent application number | Description | Published |
20090069385 | Antidiabetic Oxazolidinediones and Thiazolidinediones - Pyridinyloxyphenyl and pyridinyloxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes. | 03-12-2009 |
20100029688 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 02-04-2010 |
20100075987 | ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 03-25-2010 |
20110028501 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 02-03-2011 |
20120142706 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 06-07-2012 |
20120178681 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 07-12-2012 |
20130131042 | SPIROXAZOLIDINONE COMPOUNDS - Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety. | 05-23-2013 |
20140057893 | SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included | 02-27-2014 |
20140128368 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT - Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included. | 05-08-2014 |
20140296202 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS - Substituted piperidinyl compounds of the formula (I): are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. | 10-02-2014 |
20140329798 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS - Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included | 11-06-2014 |
Patent application number | Description | Published |
20090172162 | Method of throttling unwanted network traffic on a server - The invention provides a method and device for limiting unwanted network traffic, including unwanted emails. The method proceeds by assigning at least one network address to a category of network addresses based on a level of trust of the network address. Connection resources are allocated to the category. When a connection is received from a network address to which the category has been assigned, a portion of the allocated resources in the category are provided to the network address. | 07-02-2009 |
20100153394 | Method and Apparatus for Reclassifying E-Mail or Modifying a Spam Filter Based on Users' Input - A method is disclosed including passing a plurality of e-mails through a spam filter and classifying at least of the plurality of e-mails as not spam. Thereafter, the plurality of e-mails are received at each of a plurality of user computers. The method may further include receiving a plurality of reports, the plurality of reports including one report from each of the plurality of user computers that one or more of the plurality of e-mails are spam that was not classified as spam by the spam filter. Based on the plurality of reports, one or more of the plurality of e-mails is reclassified as spam and/or the spam filter is modified. | 06-17-2010 |
20120271954 | Method of Throttling Unwanted Network Traffic on a Server - The invention provides a method and device for limiting unwanted network traffic, including unwanted emails. The method proceeds by assigning at least one network address to a category of network addresses based on a level of trust of the network address. Connection resources are allocated to the category. When a connection is received from a network address to which the category has been assigned, a portion of the allocated resources in the category are provided to the network address. | 10-25-2012 |
20130227045 | Bot-Network Detection Based on Simple Mail Transfer Protocol (SMTP) Characteristics of E-Mail Senders Within IP Address Aggregates - A method and system for determining whether an IP address is part of a bot-network are provided. The IP-address-aggregate associated with the IP address of an e-mail sender is determined. The IP-address-aggregate is associated with an IP-address-aggregate-category based on the current SMTP traffic characteristics of the IP-address-aggregate and the known SMTP traffic characteristics of an IP-address-aggregate-category. A bot-likelihood score of the IP-address-aggregate-category is then associated with IP-address-aggregate. IP-address-aggregate-categories can be established based on historical SMTP traffic characteristics of the IP-address-aggregates. The IP-address-aggregates are grouped based on SMTP characteristics, and the IP-address-aggregate-categories are defined based on a selection of IP-address-aggregates with similar SMTP traffic characteristics that are diagnostic of spam bots vs. non-botnet-controllers spammers. Bot likelihood scores are determined for the resulting IP-address-aggregate-categories based on historically known bot IP addresses. | 08-29-2013 |
20150026804 | Method and Apparatus for Reclassifying E-mail or Modifying a Spam Filter Based on Users' Input - A method is disclosed including passing a plurality of e-mails through a spam filter and classifying at least of the plurality of e-mails as not spam. Thereafter, the plurality of e-mails are received at each of a plurality of user computers. The method may further include receiving a plurality of reports, the plurality of reports including one report from each of the plurality of user computers that one or more of the plurality of e-mails are spam that was not classified as spam by the spam filter. Based on the plurality of reports, one or more of the plurality of e-mails is reclassified as spam and/or the spam filter is modified. | 01-22-2015 |
Patent application number | Description | Published |
20110255153 | Cladding-Pumped Optical Amplifier Having Reduced Susceptibility to Spurious Lasing - An optical amplifier comprises at least two gain regions, an intermediate region situated between the gain regions, and a transition region situated between the intermediate region and each gain region. The aforesaid regions have claddings that collectively form a path for pump radiation propagating from at least one of the gain regions to the other gain region, and cores that collectively form a path for signal radiation propagating from at least one of the gain regions to the other gain region. The cores in the gain regions support multiple propagating optical modes, including at least one signal mode and at least one non-signal mode. The intermediate region, however, supports fewer propagating core modes than are supported by the gain regions. The transition regions are conformed such that when radiation in propagating non-signal core modes passes from the gain regions into the intermediate region, it is at least partly coupled into cladding modes of the intermediate region. | 10-20-2011 |
20120224852 | System, Method, and Apparatus for High-Sensitivity Optical Detection - An apparatus transmits data using a format where information bits intended for transmission are mapped into symbols each carrying a plurality of bits, some of which are encoded through pulse position modulation (PPM) format and the rest of which are encoded through an additional modulation format on each PPM pulse. The additional modulation format for the PPM pulse may be at least one of a polarization-division-multiplexed (PDM) modulation, phase-shift keying (PSK) modulation, polarization shift keying (PolSK) modulation, amplitude modulation (AM), quadrature-amplitude modulation (QAM) modulation, or a combination thereof. In one embodiment, the additional modulation of the PPM pulses is through polarization-division-multiplexed quadrature-phase-shift keying (PDM-QPSK). The unique combined use of PDM-QPSK and PPM produces much higher receiver sensitivity than either PPM or PDM-QPSK alone. | 09-06-2012 |
20120224862 | System, Method, and Apparatus for High-Sensitivity Optical Detection - An apparatus receives data encoded in a format where information bits for transmission are mapped into symbols each carrying a plurality of bits, some of which are encoded through a pulse position modulation (PPM) format and the rest of which are encoded through an additional modulation format on at least one PPM pulse. The receiver detects the signal through a dual-polarization coherent receiver front-end, and recovers polarization components of the signal by decoding a first non-zero portion of a plurality of bits carried by a symbol based on slot position of at least one PPM pulse in the polarization components and a second non-zero portion of the plurality of bits carried by the symbol based on the additional modulation carried by at least one PPM pulse in the polarization components. Pilot-assisted single-carrier frequency-division equalization (PA-SC-FDE) may be used for reliable signal reception in the presence of severe PPM errors. | 09-06-2012 |