Wolchok
Jedd D. Wolchok, New York, NY US
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20120128714 | Alphavirus Replicon Particles Expressing TRP2 - The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and/or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogenic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered. | 05-24-2012 |
20140271677 | Newcastle Disease Viruses and Uses Thereof - Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell. | 09-18-2014 |
20150037346 | Prediction of Responsiveness to Treatment with Immunomodulatory Therapeutics and Method of Monitoring Abscopal Effects During Such Treatment - Efficacy of a therapeutic to enhance antitumor immunity in a patient is predicted, where the therapeutic is one that targets an immunomodulatory leukocyte membrane protein (ILMP) to enhance immune activity. Peripheral blood sample from the patient is tested for levels of monocytes having specific cell surface markers (CD14 | 02-05-2015 |
Jedd David Wolchok, New York, NY US
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20150368349 | Anti-GITR Antibodies and Methods of Use Thereof - The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity. | 12-24-2015 |
Jeffrey Collins Wolchok, Salt Lake City, UT US
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20120121719 | METHODS OF MAKING AND USING THREE-DIMENSIONAL EXTRACELLULAR MATRICES - Three-dimensional extracellular matrices lacking synthetic scaffolds are provided. Methods of making the three-dimensional extracellular matrices and methods of using the three-dimensional extracellular matrices are also provided. | 05-17-2012 |
Scott W. Wolchok, Menlo Park, CA US
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20140067781 | Graph Query Language API Querying and Parsing - In one embodiment, a method includes accessing one or more graphs stored in one or more data stores, each graph comprising one or more nodes arranged in a hierarchical format, each node representing one or more data items, each data item having a particular one of a plurality of data types; generating a first query requesting a data structures of a specific data type; retrieving the data structure of the specific data type from the graphs; generating a second query requesting one or more specific data items having the specific data type, the second query being expressed in a format corresponding to the retrieved data structure of the specific data type; and retrieving the specific data items from the graphs. | 03-06-2014 |