Wittekind
David Wittekind, Lafayette, CO US
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20150276105 | Sealing System Having Interlocking Inner Diameter Seal Element to Resist Pressure Changes - Gasket seals for high pressure applications include retaining elements with inner diameter seal elements that interlock with the retaining element to provide resistance to movement in both axial and radial directions between the retaining element and seal element. High pressure sealing may be accomplished using a metallic core retaining element to which an electrically isolating material is bonded on either or both sides. Sealing is achieved through an inner diameter dielectric sealing element, such as a polytetrafluoroethylene (PTFE) inner diameter sealing ring. Flanges of a joint in a fluid flow ling may be bolted together with the gasket seal interposed therebetween. In the event of pressure changes, the inner diameter seal resists being drawn into the flow line, and resists axial movement relative to the retaining element, through dual locking members that secure the seal to the retaining element. | 10-01-2015 |
Frederick Leland Wittekind, Anderson, IN US
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20080217407 | Host Apparatus and Method Providing Calibration and Reagent Information to a Measurement Apparatus with Makes Use of a Consumable Reagent in a Measuring Process - Apparatuses and methods providing data such as, for example, calibration and reagent information ( | 09-11-2008 |
Lothar Wittekind, Osnabrueck DE
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20090295160 | METHOD FOR INCREASING ENERGY CAPTURE IN A WIND TURBINE - A method for operating a wind turbine. The method includes providing a wind turbine having a variable speed control system, the control system having an initial rotational speed set point. At least two operational parameters are obtained from one or more sensors. An adjusted rotational speed set point greater than the initial rotational speed set point is determined in response to the operational parameter. The control system is configured with the adjusted rotational speed set point. A wind turbine and wind turbine plant are also disclosed. | 12-03-2009 |
Lothar Wittekind, Keil DE
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20120091714 | WIND PLANT AND METHOD FOR INCREASING ENERGY CAPTURE IN A WIND PLANT - Method for increasing energy capture in wind plants includes providing a plurality of wind turbines having a variable speed control system including an initial rotational speed set point value which is a maximum rotational speed set point for wind turbines. Method includes obtaining at least two measured operational parameters from one or more sensors and comparing measured operational parameters to mechanical load of turbine. If mechanical load of turbine is decreased as a result of measured operational parameters, a speed control adjustment method is activated. Speed control adjustment method includes determining an adjusted rotational speed set point greater than initial rotational speed set point value in response to at least two measured and compared operational parameters and configuring control system with adjusted rotational speed set point where adjusted rotational speed set point increases maximum rotational speed set point of wind turbines. | 04-19-2012 |
Lothar Wittekind, Kiel DE
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20110064573 | SYSTEM AND METHODS FOR DETERMINING A MONITOR SET POINT LIMIT FOR A WIND TURBINE - A method for controlling operation of a wind turbine is described. The wind turbine includes a rotor having a plurality of rotor blades. The method includes measuring an atmospheric condition associated with the environment surrounding the wind turbine, providing the measured atmospheric condition to a processor, and determining at least one monitor set point limit based at least partially on the measured atmospheric condition. The method also includes applying the at least one monitor set point limit to wind turbine operation. | 03-17-2011 |
20160003220 | METHOD AND SYSTEM FOR MONITORING AN INDIVIDUAL BLADE ADJUSTMENT OF A WIND TURBINE - The invention relates to a method and a system for monitoring an individual blade adjustment of a wind turbine which includes a tower, a rotor which is arranged on the tower and has at least two rotor blades whose blade angle can be adjusted individually, and a blade adjustment system, wherein the blade adjustment system includes a blade controller and sensors for sensing individual actual blade angles of the at least two rotor blades, wherein an individual blade controller is included which receives a collective set point blade angle from the blade controller and which actuates at least two rotor blades with respectively individual set point blade angles, as well as a corresponding wind turbine. | 01-07-2016 |
Lothar Wittekind, Osnabruck DE
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20100284787 | INDIVIDUAL BLADE NOISE MEASUREMENT SYSTEM AND METHOD FOR WIND TURBINES - A method for configuring blades of a wind turbine for low noise generation. The method includes providing at least one noise measuring device. The noise measuring device is arranged and disposed in a position to measure noise of the blades during rotation. The wind turbine is configured to include a rotational trigger, the rotational trigger being arranged to provide a signal at a predetermined rotational position of the wind turbine blades. One or more of the blades is configured with an aerodynamic modifying device. Noise level is measured with the noise measuring device during wind turbine operation. The noise produced by each of the blades is determined. The blades are configured in response to the noise determined for each of the blades. A method for measuring the noise level generated by an individual blade and a wind turbine configured for desired noise level are also disclosed. | 11-11-2010 |
Michael Wittekind, New Canaan, CT US
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20130302306 | BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA - The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s). | 11-14-2013 |
20140024111 | HOST CELL FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS - The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides. | 01-23-2014 |
20150111813 | BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN - The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant | 04-23-2015 |
20150284471 | Human LCAT Antigen Binding Proteins and Their Use in Therapy - Antigen binding proteins that activate LCAT are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to modulate HDL particle size, increase plasma levels of HDL-C, and increase reverse cholesterol transport. Accordingly, the antigen binding proteins have utility in the treatment and prevention of atherosclerosis, various cardiovascular diseases and cholesterol-related disorders, inflammatory conditions, thrombosis-related conditions, metabolic syndrome, diabetes and insulin-resistance. The LCAT antigen binding proteins are also useful in treating the consequences, symptoms, and/or pathology associated with either genetic or acquired LCAT deficiency, including chronic kidney disease (CKD). | 10-08-2015 |
20150290299 | BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA - The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly | 10-15-2015 |
Michael Wittekind, Bainbridge Island, WA US
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20080220049 | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins - The present disclosure relates to novel sustained-release intraocular drug delivery systems and improvements in the treatment of retinopathies. In particular, fibronectin scaffold domain proteins that selectively inhibit VEGFR-2 are contemplated. | 09-11-2008 |
20100286374 | METHOD FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS - The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer. Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides. | 11-11-2010 |
20100310549 | INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS - The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. | 12-09-2010 |
20120009190 | IDENTIFICATION AND METHOD FOR USING THE PRE-LIGAND ASSEMBLY DOMAIN OF THE IL-17 RECEPTOR - The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided. | 01-12-2012 |
20120283184 | INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS - The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. | 11-08-2012 |
20130302886 | Pre-Ligand assembly domain of the IL-17 receptor - The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides which inhibit multimerization of a receptor complex comprising an IL-17R family member. Related PLAD-binding polypeptides, chimeric proteins, conjugates, nucleic acids, vectors, host cells, and methods are provided herein. | 11-14-2013 |
20140179896 | INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS - The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. | 06-26-2014 |
Michael Wittekind, Yonkers, NY US
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20160083456 | COMPOSITION AND METHODS BASED ON NEUTRALIZING ANTIBODIES DELIVERED INTRANASALLY FOR ENHANCED THERAPEUTIC EFFICACY - The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration. The invention provides compositions suitable for intranasal or inhalation treatment and administration. The invention includes methods for treatment or prophylaxis combining intranasal or inhalation administration with intraperitoneal or intravenous administration of antibodies. | 03-24-2016 |