Patent application number | Description | Published |
20080221511 | BONE VOID FILLER - A novel composition and kit for a bone void filler are provided. The improved bone void filler includes a porous, collagen scaffolding admixed with calcium phosphate and at least one stabilizer agent. Optionally, the bone void filler further includes at least one bioactive agent. | 09-11-2008 |
20080260598 | Devices, methods and systems for hydrating a medical implant material - Devices for hydrating materials, such as, for example, medical implant materials include a container body defining therein a hydration chamber. A barrier separates the chamber into a material holding area and a hydrating fluid bay and defines at least one aperture and is configured to allow passage of hydrating fluid from the hydrating fluid bay to the material holding area. In some embodiments, devices provided by the present application are operable for use in hydrating and delivering a material. | 10-23-2008 |
20080262616 | OSTEOCHONDRAL GRAFT AND METHOD OF USE FOR REPAIRING AN ARTICULAR CARTILAGE DEFECT SITE - An osteochondral graft for use in repairing an articular cartilage defect site includes a cartilage cap and a wall extension. The cartilage cap has a top surface and a bottom surface with the wall extension projecting from the bottom surface. The wall extension includes an external surface and an internal surface with the internal surface defining an internal space. At least one of the internal surface or external surface may be tapered at an angle to facilitate implantation of the graft. The graft may be fabricated from collagen and configured as a composite construct, the cartilage cap being made from a porous collagen material to facilitate cartilage regeneration and the wall extension being made from a substantially cross-linked collagen to provide structural strength to facilitate insertion of the graft into the articular cartilage defect site. A method of repairing an articular cartilage defect with the osteochondral graft is also disclosed. | 10-23-2008 |
20080317805 | LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS - This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot. | 12-25-2008 |
20090026123 | System for the production of autologus platelet gel useful for the delivery of medicinal and genetic agents - A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components. | 01-29-2009 |
20090043394 | Spinal fusion implants and tools for insertion and revision - An interbody fusion device in one embodiment includes a tapered body defining a hollow interior or chamber for receiving bone graft or bone substitute material. The body defines exterior threads which are interrupted over portions of the outer surface of the device. The fusion device includes truncated side walls so that on end view the body takes on a cylindrical form. In another embodiment, the tapered body is solid and formed of a porous biocompatible material having sufficient structural integrity to maintain the intradiscal space and normal curvature. The material is preferably a porous tantalum composite having fully interconnected pores to facilitate complete bone tissue ingrowth into the implant. In further embodiments, the fusion devices are provided with osteogenic material to facilitate bone ingrowth. A cap is also provided to block the opening of hollow fusion devices. The cap includes an occlusion body and an elongated anchor. In some embodiments the anchor includes a lip which is engageable to openings in the body wall. Tools are also provided for manipulating caps for interbody fusion devices. In one embodiment the tool includes a pair of prongs each having facing engagement surfaces for engaging the fusion device, and a shaft slidably disposed between the prongs. The shaft has a first end defining a cap-engaging tip for engaging a tool hole in the cap. In one embodiment the cap engaging tip defines threads. In another embodiment the prongs include a pair of releasing members on each of the facing engagement surfaces. The releasing members have a height and a width for being insertable into apertures in a body wall in the fusion device to disengage the elongate anchors from the apertures. | 02-12-2009 |
20090054313 | METHOD FOR INDUCING DEPOSITION AND MATURATION OF BONE COMPRISING A CO-THERAPEUTIC REGIMEN OF LMP-1 AND BMP-2 - The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics. | 02-26-2009 |
20090060971 | METHODS OF TREATING A TRAUMA OR DISORDER OF THE KNEE JOINT BY LOCAL ADMINISTRATION AND SUSTAINED-DELIVERY OF A BIOLOGICAL AGENT - Methods and apparatus of providing a subject with post-operative, sustained-release of a biological agent within a synovial joint is disclosed. These methods involve securing a depot containing the biological agent to a ligament, tendon, muscle within the joint to provide sustained-release of the agent while allowing for normal joint articulation. This methodology may be utilized to provide for sustained-release of a biological agent useful in treating various traumas and disorders of the joint. Such biological agents include antagonists of inflammation-related proteins, such as TNF-α, IL-1β, IL-6, IL-8, NF-κB, High Mobility Group Box 1 (HMG-B1), IL-2, IL-15 and steroidal and non-steroidal anti-inflammatories. Other biological agents include anti-inflammatory cytokines such as IL-10, IL-4, IL-13, and TGF-β. The biological agents also include osteogenic and cartilage producing growth factors such as, but not limited to, BMP-2, BMP-4, BMP-6, BMP-7, BMP-8, and MIA CD-RAP. Finally, the biological agents include siRNA and/or therapeutic antibodies. | 03-05-2009 |
20090062922 | METHOD AND APPARATUS FOR DELIVERING TREATMENT TO A JOINT - The present invention relates to an apparatus and method for treating inflammation and/or infection within a synovial joint. The invention is comprised of a depot, tether and cap. The depot is comprised of a biodegradable polymer which is impregnated with a biological agent targeted to treat the inflammation and/or infection. The depot is inserted into the synovial joint through an incision or hole in the synovial membrane. A tether that extends from the depot is then thread back through the incision or hole and coupled to a cap such that the depot is coupled to the synovial membrane on an interior side of the synovial joint capsule and the cap is secured to the membrane on an exterior side of the synovial joint capsule. Once secured, the depot degrades and gradually releases the biological agent over a sustained time period. The biological agent then treats the targeted inflammation and/or infection. | 03-05-2009 |
20090105117 | STEM CELLS AND LIM MINERALIZATION PROTEINS - Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo. | 04-23-2009 |
20090110637 | LMP and Regulation of Tissue Growth - Novel methods are provided for changing cell phenotype, comprising a method of changing a phenotype of a target cell comprising: increasing an amount of an amino acid sequence in a source cell, wherein the source cell is located within a volume of a media and wherein the amino acid sequence is selected from the group consisting of LMP-1 protein, an LMP-2 protein, an LMP-3 protein, an LMP-1s protein, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or combination thereof; collecting at least a portion of the volume of the media; and contacting the target cell with at least the portion of the media. | 04-30-2009 |
20090131908 | DEVICES AND METHODS FOR DELIVERING DRUG DEPOTS TO A SITE BENEATH THE SKIN - Devices and methods are provided for delivering a drug depot at or near the spinal column of a patient. In various embodiments, the drug depot comprises a drug cartridge containing drug pellets for delivery at or near the spinal column of a patient. | 05-21-2009 |
20090157193 | Tendon and Ligament Repair Sheet and Methods of Use - Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet, has a porous layer and a denser layer, and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing. | 06-18-2009 |
20090182432 | Artificial disc implant - An artificial disc implant includes an upper shell, a lower shell, and a spacer therebetween. The spacer preferably has properties similar to that of a natural spinal disc, while the upper and lower shells form a rigid interface between the implant and the adjacent vertebral bodies. The upper and lower shells can be configured to prevent expulsion of the spacer from the disc space. The implant upper and lower shells may further be configured into partially cylindrical shapes for ease of insertion through an insertion tube as presently known for interbody fusion devices. The devices may further be configured for insertion through a double-barreled insertion tube. Methods and instruments for inserting an artificial disc implant are also provided. | 07-16-2009 |
20090196904 | HIGHLY-MINERALIZED OSTEOGENIC SPONGE COMPOSITIONS AND USES THEREOF - Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described. | 08-06-2009 |
20090240255 | Osteogenic packing device and method - An osteogenic material packing device is used to pack osteogenic material onto a spinal fusion device. The packing device has a cavity defined therein, which is adapted to receive the spinal fusion device. The packing device further includes an access port, which intersects the cavity to receive the osteogenic material. A cannula is coupled to the packing device and an inserter is coupled to the fusion device in order to insert the fusion device into the packing device. Osteogenic material is packed through the access port around the fusion device. The fusion device then is slid through the cannula and inserted in the intervertebral space between adjacent vertebrae. | 09-24-2009 |
20090246123 | PHARMACEUTICAL GELS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS TO A SITE BENEATH THE SKIN - Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site. | 10-01-2009 |
20090246244 | MALLEABLE MULTI-COMPONENT IMPLANTS AND MATERIALS THEREFOR - Described are implantable, malleable medical materials comprising mineral particles, insoluble collagen fibers, and a gel-forming polysaccharide component and/or another added gel-former. The malleable medical materials can be used treat bone or other tissue defects in patients, including in conjunction with biologically active factors such as osteogenic proteins. Also described are methods and materials that can be used to prepare the malleable medical materials. | 10-01-2009 |
20090263319 | METHODS AND COMPOSITIONS FOR TREATING POSTOPERATIVE PAIN COMPROSING KETOROLAC - Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of ketorolac or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of ketorolac or pharmaceutically acceptable salt thereof over a period of 3 to 10 days. | 10-22-2009 |
20090263444 | Fluocinolone Formulations in a Biodegradable Polymer Carrier - Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-22-2009 |
20090263450 | ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES - Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease. | 10-22-2009 |
20090263461 | ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE - Effective treatments of pain and/or inflammation from degenerative disc disease and/or facet joint are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a degenerative disc and/or facet joint, one can reduce, prevent or treat pain and/or inflammation caused by the degenerative disc disease and/or facet joint. | 10-22-2009 |
20090264472 | METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING A LOCAL ANESTHETIC - The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days. | 10-22-2009 |
20090264478 | SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER - Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-22-2009 |
20090264490 | CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-22-2009 |
20090264491 | METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE - The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days. | 10-22-2009 |
20090264531 | SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL - Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-22-2009 |
20090265017 | RIGID BONE GRAFT SUBSTITUTE - A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix. | 10-22-2009 |
20090298776 | SPINAL FUSION METHODS AND DEVICES - Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an interwertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenctic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided. | 12-03-2009 |
20090298777 | SPINAL FUSION METHODS AND DEVICES - Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an intervertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenctic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided. | 12-03-2009 |
20090304649 | Methods of inducing or increasing the expression of proteoglycans such as aggrecan in cells - Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus). | 12-10-2009 |
20100015196 | Drug Depot Implantable Within a Joint - Methods and compositions for treating a tissue within a synovial joint in a patient in need of such treatment are provided. The methods and compositions involve inserting a drug depot through the synovial joint and attaching the drug depot to the inside of the synovial joint capsule so that the drug depot does not substantially interfere with movement of the joint, wherein said depot comprises a polymer and at least one pharmaceutical agent. | 01-21-2010 |
20100021516 | DRUG DEPOTS HAVING ONE OR MORE ANCHORING MEMBERS - A drug depot implantable at or near a target tissue site beneath the skin of a patient is provided, the drug depot comprising a therapeutically effective amount of a drug and at least one surface adapted to receive one or more anchoring members so as to limit movement of the drug depot at or near the target tissue site, wherein at least one region of the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day. In some embodiments, the drug depot provided can include an effective amount of at least analgesic and at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, particularly postoperative pain. | 01-28-2010 |
20100047350 | OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT - An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair. | 02-25-2010 |
20100049322 | OSTEOCHONDRAL REPAIR IMPLANTS AND METHODS - An osteochondral repair implant is provided, comprising a tissue scaffold configured to allow growth of at least bone and/or cartilage and to fit within at least a portion of an osteochondral hole, the tissue scaffold comprising one or more recesses and/or projections; and a biodegradable carrier containing a growth factor, the biodegradable carrier being placed in and/or around the recesses and/or projections of the tissue scaffold and reduce compression of the biodegradable carrier by the tissue scaffold. In some embodiments, methods for repairing an osteochondral defect are provided that utilize an osteochondral plug and a biodegradable carrier containing a growth factor. | 02-25-2010 |
20100056989 | INSTRUMENTATION FOR INJECTION OF THERAPEUTIC FLUID INTO JOINTS - Described are novel medical delivery devices that can be used to effectively distribute a medical agent to multiple sites within a tissue volume without requiring the device to be repositioned, including for example to distribute the medical agent within the nucleus pulposus tissue of a spinal disc. Also described are medical delivery devices configured to simultaneously remove fluid from the tissue volume into which a medical agent is being delivered, thus avoiding or otherwise decreasing any pressure build-up and facilitating an effective, uniform delivery of the therapeutic agent. | 03-04-2010 |
20100106137 | Drug Delivery System - Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, a device for delivering a drug depot to a site beneath the skin of patient is provided, the device comprising: a cannula capable of insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot; a drug cartridge comprising at least two chambers, wherein each chamber is configured to store and release a drug depot into the cannula when the cannula is aligned with a first chamber and the plunger. In some embodiments, the drug depot delivery device and methods provide dial-a-dose technology for delivering the drug depot to the target tissue site. | 04-29-2010 |
20100111829 | FLOWABLE COMPOSITION THAT HARDENS ON DELIVERY TO A TARGET TISSUE SITE BENEATH THE SKIN - Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site. | 05-06-2010 |
20100112034 | DRUG DEPOT WITH ANCHOR - A drug depot implantable at or near a target tissue site beneath the skin of a patient is provided, the drug depot comprising a therapeutically effective amount of a drug; at least one line having a distal end and a proximal end, the proximal end of the line attached to the drug depot; an anchor attached to the distal end of the line and configured to limit movement of the drug depot at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day. In some embodiments, the drug depot provided can include an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain. | 05-06-2010 |
20100114075 | DEVICE AND METHOD FOR DIRECTIONAL DELIVERY OF A DRUG DEPOT - Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve. | 05-06-2010 |
20100114175 | Facet Fusion Implants and Methods of Use - An implant is insertable onto a vertebral facet joint includes a body with an inner surface that mates with one or both articular processes of the facet joint. The inner surface may define an interior cavity that accepts at least a portion of an inferior articular process and a superior articular process forming the facet joint. The body may be constructed of a bone growth material that fuses with the articular processes. The implant may help retain bone growth promoting substance that is inserted between or on articulating surfaces of the facet joint. A receiving portion of an exterior surface of one or both articular process may be prepared to stimulate bone growth. The implant may be placed onto the receiving portion to cover an exterior junction between or on the articulating surfaces of the facet joint. The implant may be secured to one or both of the articular processes. | 05-06-2010 |
20100158800 | DRUG DEPOT IMPLANT DESIGNS AND METHODS OF IMPLANTATION - The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement. | 06-24-2010 |
20100161074 | BIODEGRADABLE OSTEOGENIC POROUS BIOMEDICAL IMPLANT WITH IMPERMEABLE MEMBRANE - A biomedical implant is disclosed with osteogenic factors and a solid impermeable membrane occluding a portion of its surface for the generation of new bone growth at the target site of the implant. The implant is porous, bioresorbable, and forms a three dimensional architectural scaffold for the formation of new bone tissue. The implant is formed with a polymer or collagen, bone morphogenetic protein and ceramic particles. | 06-24-2010 |
20100174243 | Apparatus for Delivery of Therapeutic Material to an Intervertebral Disc and Method of Use - An apparatus, for introducing fluent therapeutic material through an annulus fibrosus of an intervertebral disc, includes a needle having a distal end for insertion through an entry site of the annulus fibrosus. The needle defines a first conduit through which the pressurized fluent therapeutic material is introduced. An expandable seal is disposed about an exterior surface of the needle. The expandable seal has a non-expanded, non-sealing configuration to facilitate penetration of the needle through the annulus fibrosus and withdrawal of the needle therefrom. The expandable seal also has an expanded, sealing configuration during introduction of the fluent therapeutic material. The expandable seal then engages the annulus fibrosus in its expanded, sealing configuration to prevent or minimize leakage of fluent therapeutic material through the entry site. The expandable seal assumes its expanded, sealing configuration during introduction of fluent therapeutic material under pressure into the annulus fibrosus. | 07-08-2010 |
20100189757 | DRUG DEPOT IMPLANT DESIGNS AND METHODS OF IMPLANTATION - The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement. | 07-29-2010 |
20100209474 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions. | 08-19-2010 |
20100226959 | MATRIX THAT PROLONGS GROWTH FACTOR RELEASE - An implantable matrix is provided, the matrix having a porous interior configured to release a growth factor and to allow influx of at least progenitor, bone and/or cartilage cells therein; and a biodegradable membrane disposed on the porous interior, the biodegradable membrane being less porous than the porous interior and configured to retain the growth factor and release the growth factor from the porous interior as the biodegradable membrane degrades at or near the target tissue site. In some embodiments, a method for making the implantable collagen matrix is provided, the method comprising: providing a porous collagen layer configured to release a growth factor and to allow influx of at least progenitor, bone and/or cartilage cells therein, and disposing a collagen membrane on the porous collagen layer, the collagen membrane being less porous than the porous collagen layer and configured to retain the growth factor. | 09-09-2010 |
20100228097 | METHODS AND COMPOSITIONS TO DIAGNOSE PAIN - Effective treatments of pain are provided. Through the administration of a drug depot containing an effective amount of a pain reliever near a target site, one can diagnose the location of the pain generator. In some embodiments, through the administration of a drug depot containing an effective amount of a pain reliever near a target site, one can prevent surgery at an incorrect anatomical location. | 09-09-2010 |
20100234953 | Osteogenic fusion device - An interbody osteogenic fusion device is provided that includes opposite end pieces with an integral central element. The end pieces are sized to maintain the height of an intervertebral disc space. The central element has a much smaller diameter so that the osteogenic fusion device forms an annular pocket around the central element. An osteogenic material is disposed within the annular pocket between the opposite end pieces. In one embodiment, the osteogenic material constitutes a collagen sheet soaked in a solution containing a bone morphogenetic protein. The osteogenic fusion device is configured so that the osteogenic material is in direct contact with the adjacent vertebral bone. In addition to the enhanced area of contact between the vertebral bone and the fusion material, the inventive osteogenic fusion device reduces stress-shielding and minimizes the radiopacity of the implant so that growth of the fusion mass can be continuously assessed. In yet another embodiment, the osteogenic fusion device includes at least one end piece with a truncated surface. The osteogenic fusion devices of the present invention may be combined with other fusion devices to form an implant system. The implant system includes at least one load bearing member having a truncated surface configured to nest within another load bearing member, preferably the load bearing, osteogenic fusion device of the present invention. The invention also provides implant systems comprising adjacent load bearing members connected to one another to resist lateral separation. Methods of promoting fusion bone growth in the space between adjacent vertebrae utilizing devices and systems of the invention are also described. | 09-16-2010 |
20100234957 | ARTIFICAL DISC IMPLANT - An artificial disc implant includes an upper shell, a lower shell, and a spacer therebetween. The spacer preferably has properties similar to that of a natural spinal disc, while the upper and lower shells form a rigid interface between the implant and the adjacent vertebral bodies. The upper and lower shells can be configured to prevent expulsion of the spacer from the disc space. The implant upper and lower shells may further be configured into partially cylindrical shapes for ease of insertion through an insertion tube as presently known for interbody fusion devices. The devices may further be configured for insertion through a double-barreled insertion tube. Methods and instruments for inserting an artificial disc implant are also provided. | 09-16-2010 |
20100239545 | Methods of expressing LIM mineralization protein in non-osseous cells - Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Expression of the LIM mineralization protein can stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen. Methods for treating disc disease associated with trauma or disc degeneration are also described. | 09-23-2010 |
20100247600 | THERAPEUTIC DRUG ELUTING IMPLANT COVER AND METHOD OF MAKING THE SAME - A drug-eluting implant cover fabricated from a drug-eluting biocompatible matrix containing at least one elutable drug, a drug-eluting implant cover kit containing at least one drug-eluting implant cover, and a method of manufacturing the same. | 09-30-2010 |
20100262175 | MINIMALLY INVASIVE INSTRUMENT AND METHODS TO TREAT PERIODONTAL DISEASE - The invention provides an instrument and methods for minimally invasive surgical scaling and/or planning procedures, thus reducing patient recovery time. Furthermore, the present invention overcomes the shortcoming in the prior art of inadequately preparing the diseased site or creating an aerosol by providing a device that is more mechanically abrasive by way of utilizing a rotational mechanical action of a plurality of bristles. | 10-14-2010 |
20100266657 | PREFORMED DRUG-ELUTING DEVICE TO BE AFFIXED TO AN ANTERIOR SPINAL PLATE - A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same. | 10-21-2010 |
20100266658 | Osteogenic Implants with Combined Implant Materials and Methods for Same - Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention. | 10-21-2010 |
20100266660 | Osteogenic Implants with Combined Implant Materials and Methods for Same - Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention. | 10-21-2010 |
20100266661 | OSTEOGENIC IMPLANTS WITH COMBINED IMPLANT MATERIALS AND METHODS FOR SAME - Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention. | 10-21-2010 |
20100297255 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions. | 11-25-2010 |
20100298815 | MEDICAL IMPLANTS WITH RESERVOIR(S), AND MATERIALS PREPARABLE FROM SAME - Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients. | 11-25-2010 |
20100312173 | Devices and Methods for Delivering Medical Agents - Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue. | 12-09-2010 |
20100320647 | SYNTHETIC LOADBEARING COLLAGEN-MINERAL COMPOSITES USEFUL FOR SPINAL IMPLANTS, AND METHODS OF MANUFACTURE - Described are intervertebral spinal implants that include a biocompatible load bearing composite comprised of a particulate mineral material and collagen and having a wet compressive strength of at least about 200 N/cm | 12-23-2010 |
20100330260 | Implant Depots to Deliver Growth Factors to Treat Osteoporotic Bone - The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle. | 12-30-2010 |
20110022028 | DEVICE AND METHOD FOR DELIVERY OF A DRUG DEPOT NEAR THE NERVE - Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve. | 01-27-2011 |
20110028981 | BONE GRAFT MEASURING APPARATUS AND METHOD OF USE - A bone void measuring apparatus includes a compliant inflatable member adapted for disposal with bone adjacent soft tissue. The bone has a bone defect surface that defines a bone defect cavity. A lumen is connected to the inflatable member and a fluid source for communication therebetween. The inflatable member receives a fluid of the fluid source for compliant inflation in a configuration such that outer surface of the inflatable member engagingly conforms to the bone defect surface and avoids displacement of the adjacent soft tissue to measure a volume of the bone defect cavity. The measured volume of the bone defect cavity is equivalent to a volume of bone void filler configured for introduction to the bone defect cavity. Methods of use are also disclosed. | 02-03-2011 |
20110033817 | MINIMALLY INVASIVE INSTRUMENT AND METHOD TO TREAT PERIODONTAL DISEASE - The invention provides an instrument and methods for minimally invasive surgical scaling and/or planning procedures, thus reducing patient recovery time. Furthermore, the present invention overcomes the shortcoming in the prior art of inadequately preparing the diseased site or creating an aerosol by providing a device that is more mechanically abrasive by way of utilizing a rotational mechanical action of a plurality of bristles. | 02-10-2011 |
20110105905 | ULTRASONIC DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS - Ultrasonic devices and methods are provided that diagnose one or more pain generators. In some embodiments, the ultrasonic devices and methods are utilized to map one or more pain generators at or near the spine so that appropriate diagnostic and treatment methods can be performed. | 05-05-2011 |
20110106110 | DEVICES AND METHODS FOR IMPLANTING A PLURALITY OF DRUG DEPOTS HAVING ONE OR MORE ANCHORING MEMBERS - The present invention is directed to a device for implanting a plurality of drug depots at or near a target tissue site beneath the skin of a patient. The device comprises at least three or more drug depots, wherein each of the at least three or more drug depots has a first surface adapted to receive one or more anchoring members so as to limit movement of the at least three or more drug depots at or near the target tissue site, and wherein at least two of the at least three or more drug depots comprise a second surface adapted to receive the anchoring member after the anchoring member contacts the target tissue site. Each drug depot is capable of releasing a therapeutically effective amount of a drug over a period of at least one day. | 05-05-2011 |
20110123705 | COHESIVE OSTEOGENIC PUTTY AND MATERIALS THEREFOR - Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients. | 05-26-2011 |
20110165215 | COHESIVE OSTEOGENIC PUTTY AND MATERIALS THEREFOR - Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients. | 07-07-2011 |
20110182961 | OSTEOGENIC CELL DELIVERY MATRIX - Compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) within a matrix provided. By adding calcium and/or phosphate ions to the matrix, one may foster greater bone regeneration. | 07-28-2011 |
20110182962 | RESORBABLE MATRIX HAVING ELONGATED PARTICLES - Compression resistant matrices and methods are provided that have elongated particles embedded therein. The compression resistant matrices provide improved stability and mechanical strength and resists shifting, extrusion and rotation after implantation. In some embodiments, the matrices provided reduce or prevent surface compression of the implantable matrix which will cause unwanted increased amounts of growth factor (e.g., bone morphogenic protein) to leak from the matrix. | 07-28-2011 |
20110182963 | OSTEOIMPLANT AND METHODS FOR MAKING - An osteoimplant is disclosed and includes a plurality of partially demineralized fibers. Each fiber has an elongated, thin body having a length of about 1 centimeter to about 3 centimeters. Further, the plurality of fibers engages to establish a matrix of material. The disclosure is further directed to a method of making the above-mentioned osteoimplant. | 07-28-2011 |
20110182965 | HIGHLY COMPRESSION RESISTANT MATRIX WITH POROUS SKELETON - A highly compression resistant matrix is provided for implantation at or near a target tissue site beneath the skin. The matrix comprises a polymer and a ceramic skeleton. The compression resistance provides retention of a volume that facilitates bone regeneration. | 07-28-2011 |
20110184284 | NON-INVASIVE DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS - Devices and methods are provided that diagnose one or more pain generators at or near the spine in a patient suffering from pain. In one embodiment, a device is provided that includes: an external transducer probe having a proximal end, a distal end and a body therebetween wherein the probe is configured to be placed in contact with the skin of a patient near a pain generator or suspected pain generator; an energy source that supplies the probe with energy; and a conduit for engaging the energy source and the proximal end of the probe. The energy is transferred from the energy source to the distal end of the probe through the skin of the patient and has an intensity to deliver and produce a pain signal when at least the distal end of the probe is near the pain generator or suspected pain generator. | 07-28-2011 |
20110184338 | CATHETER DEVICES AND DRAINAGE SYSTEMS FOR DELIVERING THERAPEUTIC AGENTS - A catheter for drainage of a wound and delivery of a therapeutic agent at or near the wound of a patient is provided. The catheter comprises: a proximal end configured to receive the therapeutic agent and permit passage of bodily fluid, the proximal end configured to be coupled to a drainage tube and/or a therapeutic agent delivery device; a distal end for insertion at or near the wound; and a body disposed between the proximal end and distal end of the catheter and configured to receive the therapeutic agent from the proximal end of the catheter, the body having a first set of holes configured to allow passage of the therapeutic agent from the proximal end to a site at or near the wound and the body having a second set of holes configured to allow drainage of bodily fluid from the wound into the catheter. | 07-28-2011 |
20110184349 | DRUG DISPENSING BALLOON FOR TREATING DISC DISEASE OR PAIN - Methods for administering medication at or near an intervertebral spinal disc are provided. In various embodiments, a microporous uninflated balloon is inserted into a spinal disk and after insertion of the balloon into the disc space, a medication is inserted into the interior of the balloon. Due to both the pressure on the balloon from the spine and drug diffusion, the medication moves through the pores over time. | 07-28-2011 |
20110184350 | NEEDLE GUIDE SYSTEM - A needle guide system comprising a needle guide including at least one wall defining an internal cavity and an outside of the needle guide. A lock is connected to the needle guide. The lock is movable between a first and a second position. A needle is disposed in the internal cavity of the needle guide, the needle having a long axis and a tip. The needle is movable along the long axis with respect to the needle guide when the lock is in the first position and the needle is locked to the needle guide and the tip extends beyond the wall of the needle guide when the lock is in the second position. Visual indicia on the lock may indicate whether the lock is in the first or the second position. | 07-28-2011 |
20110190588 | SURGICAL RETRACTOR INSTRUMENT SYSTEMS AND METHODS OF USING THE SAME - A retractor system for percutaneous surgery in a patient includes first and second retractor portions positionable opposite one another in an incision of the patient. The system also includes at least one actuating member operable to provide an oscillating motion to at least one of the first and second retractor portions. The actuating member is in communication with a controller and is responsive to the controller to move and adjust at least one of the first and second retractor portions between a first position and a second position. The system also includes at least one pressure sensor and display and at least one timing circuit with display. In another form, a method is directed to retracting tissue for percutaneous access to a surgical site in a patient using the pressure sensors and display as will as the timing circuit and display to assure that the amount of pressure applied and the duration does not exceed pre-determined values. | 08-04-2011 |
20110270401 | SYNTHETIC REINFORCED INTERBODY FUSION IMPLANTS - Interbody fusion implants that include a load bearing body composed of a calcium phosphate material hardened around one or more structural reinforcing members are provided. The reinforcing members aid the load bearing body in resisting bending forces and, in certain forms, aid in preventing expulsion of the implant after implantation. Methods for promoting fusion bone growth in the space between adjacent vertebrae and methods for making the inventive implants are also provided. | 11-03-2011 |
20110286939 | OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT - An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein- | 11-24-2011 |
20110308665 | BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE - Bone cement mixing and delivery devices and methods of using the devices are provided. The bone cement mixing and delivery devices and methods comprise a container having a bottom opening that can be sealed by a spacer in a syringe where movement of the plunger of the syringe moves the spacer away from the bottom opening in the container to dispense bone cement into the syringe. In some embodiments, the devices and methods increases efficiency and reduce the mess associated with transferring the bone cement to the syringe for delivery to a patient. | 12-22-2011 |
20120009230 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions. | 01-12-2012 |
20120021369 | PERIODONTAL DISEASE SPACE MAINTENANCE DEVICES AND METHODS - Devices and methods are provided for maintaining space to treat a periodontal defect adjacent to a tooth, the devices and methods comprise a supporting structure comprising a pin, or suture or mesh having a body configured to extend over the periodontal defect and hold gingival tissue above the defect, the supporting structure having a first end configured to retain the supporting structure against at least a portion of the tooth and a second end configured to be attached or implanted in or on at least a portion of bone adjacent to the periodontal defect. The devices and methods provided maintain space between at least gingival tissue and the periodontal ligament and avoid compression of any bone replacement material in the defect. In some embodiments, the devices and methods provided can be removed from the healed periodontal defect without the need to cut into healed soft tissue. | 01-26-2012 |
20120022541 | BONE REPLACEMENT MATERIAL DELIVERY DEVICES AND METHODS OF MONITORING BONE REPLACEMENT MATERIAL - Bone material delivery devices and methods of using the devices are provided. The bone material delivery devices and methods comprise thermochromic material disposed on the exterior of the syringe, the thermochromic material configured to provide an indication of temperature, viscosity, and/or age of bone replacement material in the interior of the syringe. In some embodiments, a time indicating label is disposed on the exterior of the syringe, the time indicating label comprising a label substrate having a first surface comprising an acid-base indicator and a second surface comprising an activator, wherein when the first surface is brought into contact with the second surface or when the second surface is brought into contact with the first surface, at least a portion of the label changes color indicating elapsed time. In some embodiments, the devices and methods allow the practitioner to know the dough time, working time, and setting time of the bone replacement material when it is in the syringe. | 01-26-2012 |
20120100225 | OSTEOINDUCTIVE BONE GRAFT INJECTABLE CEMENT - Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption. | 04-26-2012 |
20120107383 | OSTEOCONDUCTIVE MATRICES COMPRISING CALCIUM PHOSPHATE PARTICLES AND STATINS AND METHODS OF USING THE SAME - Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site. | 05-03-2012 |
20120107401 | OSTEOCONDUCTIVE MATRICES COMPRISING STATINS AND METHODS OF USING THE SAME - Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site. | 05-03-2012 |
20120130386 | BONE GRAFT INJECTION SYRINGE - A syringe that has a barrel with curvature is provided. The curvature enables a greater volume of bone graft materials to be housed than in a straight syringe without increasing the absolute distance from the handle of the plunger to dispensing end of the syringe. Additionally by maintaining a constant diameter, the barrel permits bone graft material to be dispersed with reduced likelihood of clogging. | 05-24-2012 |
20120141557 | HIGHLY-MINERALIZED OSTEOGENIC SPONGE COMPOSITIONS AND USES THEREOF - Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described. | 06-07-2012 |
20120142643 | CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 06-07-2012 |
20120142648 | METHODS FOR DELIVERING CLONIDINE COMPOSITIONS IN BIODEGRADABLE POLYMER CARRIER AND LOCAL STERIODS TO A TARGET TISSUE SITE - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a steroid at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 06-07-2012 |
20120142649 | COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer. | 06-07-2012 |
20120142747 | COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer. | 06-07-2012 |
20120156644 | BONE AUGMENTATION DEVICE AND METHOD - A bone augmentation device includes at least one axial member defining a longitudinal axis and a plurality of transverse members. Each transverse member extends from a first end, removably connected to the at least one axial member to a second end configured for fixation with bone. The transverse members are spaced apart and disposed along the longitudinal axis. The at least one axial member and the transverse members are disposed in a configuration to define a bone graft cavity. Methods of use are also disclosed. | 06-21-2012 |
20120185046 | INTERBODY CONTAINMENT IMPLANT - An interbody containment implant includes a body configured for delivery along a surgical pathway and disposed adjacent vertebrae. The body defines a cavity. At least one biologically compatible agent is configured for disposal within at least the cavity. A barrier is connected to the body and configured to be deployed to prevent the agent from migrating into the surgical pathway. Methods of use are disclosed. | 07-19-2012 |
20120203096 | METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE USING PAIN STIMULI - Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck, back or leg pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise causing painful stimuli at or near the pain generator or suspected pain generator in the patient suffering from back pain; labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator. | 08-09-2012 |
20120253315 | INJECTION NEEDLE FOR FRACTURES - A cannula having proximal and distal ends defines a hollow body. A tissue-piercing tip is formed at the distal end of the cannula and is fluidically sealed from the hollow body. At least one opening is formed in a sidewall of the cannula and fluidically coupled to the hollow body. A fracture may be treated by advancing the tip through soft tissue so that the at least one opening is at least partially disposed within or adjacent to the fracture. The needle is oriented so that the at least one opening faces an exposed end of fracture or within the plane of the fracture line. Then, a therapeutic composition, such as a bone growth factor, is pressured through the hollow body to exit from the at least one opening. | 10-04-2012 |
20120265308 | OSTEOGENIC FUSION DEVICE - An osteogenic fusion device is provided that includes opposite end pieces with an integral central element. The end pieces are sized to maintain the height of an intervertebral disc space. The central element has a smaller diameter so that the fusion device forms an annular pocket around the central element. An osteogenic material is disposed within the annular pocket between the opposite end pieces. The osteogenic material is in direct contact with the adjacent vertebral bone. The inventive osteogenic fusion device reduces stress-shielding and minimizes the radiopacity of the implant so that growth of the fusion mass can be continuously assessed. The osteogenic fusion devices of the present invention may be combined with other fusion devices to form an implant system. Methods of promoting fusion bone growth in the space between adjacent vertebrae utilizing devices and systems of the invention are also described. | 10-18-2012 |
20120270172 | BONE AUGMENTATION DEVICE AND METHOD - A bone augmentation device includes at least one axial member defining a longitudinal axis and a plurality of transverse members. Each transverse member extends from a first end, or removably connected to the at least one axial member to a second end configured for fixation with bone. The transverse members are spaced apart and disposed along the longitudinal axis. The at least one axial member and the transverse members are disposed in a configuration to define a bone graft cavity. Methods of use are also disclosed. | 10-25-2012 |
20120310348 | BONE GRAFTS - Spinal spacers | 12-06-2012 |
20120310366 | METHODS AND COMPOSITIONS TO ENHANCE BONE GROWTH COMPRISING A STATIN - Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site. | 12-06-2012 |
20130018320 | MEDICAL DEVICES AND METHODS COMPRISING AN ADHESIVE MATERIALAANM McKay; William F.AACI MemphisAAST TNAACO USAAGP McKay; William F. Memphis TN US - Improved medical devices and methods are provided that are implantable at or near a target tissue site beneath the skin of a patient, the medical device comprising an adhesive sheet having a region configured to receive a solid or semi-solid drug depot, the drug depot disposed within the region of the adhesive sheet, the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the adhesive sheet limits movement of the medical device at or near the target tissue site. In some embodiments, the medical device provided can include an effective amount of at least one analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, such as postoperative pain or orthopedic degenerative pathology pain. | 01-17-2013 |
20130018321 | MEDICAL DEVICES AND METHODS COMPRISING AN ADHESIVE SHEET CONTAINING A DRUG DEPOTAANM McKay; William F.AACI MemphisAAST TNAACO USAAGP McKay; William F. Memphis TN US - Improved medical devices and methods are provided that are implantable at or near a target tissue site beneath the skin of a patient, the medical device comprises an adhesive sheet having a region configured to receive a drug depot, the drug depot disposed within the region of the adhesive sheet and the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the adhesive sheet limits movement of the medical device at or near the target tissue site. In some embodiments, the medical device provided can include an effective amount of at least one analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, particularly postoperative pain or orthopedic degenerative pathology pain. | 01-17-2013 |
20130022661 | BIO-REMODABLE BONE AUGMENTATION DEVICE AND METHOD - A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having structural properties so as to aid in the generation of new bone tissue and eventually be reabsorbed in the newly formed bone tissue. This structural and bio-remodable implant reduces, if not eliminates, the need to remove the implantable member from the patient once new bone tissue is formed. A kit including the implantable devices and bone growth material is disclosed. Methods of use are also disclosed. | 01-24-2013 |
20130073041 | MEDICAL IMPLANTS WITH RESERVOIR (S), AND MATERIALS PREPARABLE FROM SAME - Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients. | 03-21-2013 |
20130197530 | DELIVERY SYSTEMS - A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering retains the first substance for mixing with a second substance prior to delivery at a surgical site. The covering may be a single or multi compartment structure capable of retaining at least partially the mixture of the at least first and second substances until the covering is placed at the surgical site. The elongated containment portion of the covering includes a first end and second end opposite each other, wherein at least one end defines an access port configured to receive a device capable of delivering a second substance into the elongated containment portion for mixing with the first substance prior to or during the surgical procedure. | 08-01-2013 |
20130216602 | CLONIDINE COMPOUNDS IN A BIODEGRADABLE POLYMER - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a drug depot at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate drug depot formulations are provided within biodegradable polymers, this pain relief can be continued for at least fourteen days. | 08-22-2013 |
20130243844 | Drug Depots Having Different Release Profiles for Reducing, Preventing or Treating Pain and Inflammation - Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain. | 09-19-2013 |
20130244985 | Drug Depots Having Different Release Profiles for Reducing, Preventing or Treating Pain and Inflammation - Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain. | 09-19-2013 |
20130261095 | Dexamethasone Formulations in a Biodegradable Material - Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-03-2013 |
20130261596 | DRUG DELIVERY SYSTEM - A drug delivery device for delivering a drug pellet to a site beneath the skin of a patient is provided, the drug delivery device including a housing having a chamber configured to hold at least one drug pellet, the chamber having a loading end and a delivery end, the loading end of the chamber having an opening for receiving a plunger and a drug pellet and the delivery end having an opening for receiving the plunger and passage of the drug pellet. The housing includes at least one hole substantially perpendicular to the chamber and formed to at least partially intersect the chamber. A capture pin is provided configured to be receivable within the at least one hole. | 10-03-2013 |
20130261634 | BONE DELIVERY SYSTEMS INCLUDING HOLDING AND FILLING DEVICES AND METHODS - A delivery system comprising a biodegradable single or multi compartment covering is provided. The covering can be a mesh bag including a pre-attached detachable holding member surrounding the opening of at least one compartment and a pre-attached removable filling member configured to fit within the opening of the at least one compartment. The opening of the bag can include a closing member. The pre-attached detachable holding member can be a collar including finger grips and is used to hold the bag in one position while filling it. In some embodiments, the pre-attached detachable filling member can be a funnel for loading the mesh bag with bone graft material. Once the covering is filled, the holding member and filling member can be removed and the covering is closed with a closing member such as a drawstring. A method of treatment utilizing the delivery system is also provided. | 10-03-2013 |
20130261660 | MEDICAL DEVICES AND METHODS FOR INSERTING AN ADHESIVE MEMBRANE - Improved medical devices and methods are provided that deliver an adhesive sheet or membrane at or near a target tissue site, the medical devices and methods comprise a cannula defining a longitudinal axis and having a proximal end and a distal end, the proximal end of the cannula having an opening configured to receive a flowable material, the distal end of the cannula connected to an expandable member, the expandable member having an interior configured to receive the flowable material and a surface aligned with and contacting at least a portion of the adhesive membrane, the adhesive membrane configured to attach to a select tissue surface of the target tissue site in an open position. | 10-03-2013 |
20130268075 | INTERBODY BONE IMPLANT DEVICE - An expandable implant device for implantation at a surgical site is provided. The implant device is made of cortical bone and includes a top and bottom piece, both pieces configured to couple with each other. The top piece has superior and inferior surfaces, and at least a tapered leading end configured to distract open an intervertebral disc space so that the top piece can be slidably inserted over the bottom piece until a desired overlap is achieved. A composite interbody bone implant device is also provided including a body skeleton having a non-bone composition, such as a polymer, formed into a shape and including one or more cavities which can be filled with other material, for example, allograft material. A method of placing an expandable device into a disc space is also provided. | 10-10-2013 |
20130274890 | INTERBODY BONE IMPLANT DEVICE - A composite interbody bone implant device is provided including a body having a non-bone composition, such as a polymer, formed into a shape and including one or more cavities. An osteoinductive material, such as bone allograft tissue, may be retained in the one or more cavities of the body. The body is formable via injection molding and/or machining into a shape and size adapted for implantation at a surgical site. The dimensions of the body include a length, a width and a thickness, and the thickness of the body may be less than at least one of the length and width. | 10-17-2013 |
20130282128 | FACET JOINT IMPLANT DEVICE - A bone graft implant device for treating a tissue site is provided, the device including an implant body including a demineralized allograft bone material portion, and at least one engagement member protruding from the implant body including a mineralized allograft bone material portion. The engagement member may be integrally formed with the implant body, or alternatively, the implant body may include an aperture and the engagement member may be insertable therein. At least one of the amount of demineralization or area of the demineralized allograft bone material portion is adjustable to impart a desired flexibility to the implant body. | 10-24-2013 |
20130282138 | INTERSPINOUS BONE IMPLANT DEVICE - A bone implant system is provided including a bone graft body having at least a demineralized surface for implantation at a bone site, the bone graft body including at least one attachment member. At least one bone delivery carrier including a covering is provided, the carrier configured to be attachable to the bone graft body and including at least one compartment. An affixing member may be provided for attaching the at least one bone delivery carrier to the at least one attachment member of the bone graft body. A demineralized bone matrix material is disposed within the at least one compartment, wherein the covering retains the demineralized bone matrix material for placement at the bone site and facilitates transfer of cells into and out of the covering. | 10-24-2013 |
20130297038 | BONE IMPLANTS AND METHODS COMPRISING DEMINERALIZED BONE MATERIAL - Bone implant compositions and methods are provide that have an outer surface, the outer surface comprising demineralized bone and having a cavity disposed in the outer surface, the cavity having a demineralized bone material coated therein; and an inner surface of the bone implant comprising cortical bone, the inner surface contacting the outer surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion. | 11-07-2013 |
20140031795 | DELIVERY SYSTEMS - A delivery system comprising a covering having at least two compartments is provided. A first compartment contains a first therapeutic agent and the second compartment can be unfilled and is configured to receive a second therapeutic agent. The first compartment and the second compartment are separated by at least one removable separation member, for example a drawstring, that can be pulled to allow the first and second therapeutic agents to mix prior to delivery at a selected surgical site. Either the first or second compartment of the covering define an opening further comprising a pre-attached sealing member, which can be a flap sealable by heat, sutures, pressing or interference fittings. The opening of the empty compartment can be configured to receive a filling member, such as a funnel fitted with a spring loaded clip for temporary attachment to the covering. A method of treating a bone defect in a patient utilizing the delivery system is also provided. | 01-30-2014 |
20140031937 | BONE IMPLANT DEVICE - An osteoimplant device is provided. The osteoimplant device includes a body of nondemineralized cortical bone and an outer surface having at least one region including demineralized bone. The osteoimplant device is formable into a shape and size configured for implantation at a surgical site. A disc shaped osteoimplant can be used for a facet joint fusion. A method of treating a patient having a bone defect in a host bone is also provided, the method including inserting the osteoimplant into the bone defect, for example, one associated with a facet joint. | 01-30-2014 |
20140072934 | PERIODONTAL DISEASE DEVICES AND METHODS - Devices and methods are provided for treating a periodontal defect adjacent to a tooth, the devices and methods use a barrier configured to reduce an amount of material from entering into the periodontal defect, the barrier having a first region configured to retain a portion of the barrier against at least a portion of the tooth and a second region configured to extend over at least a portion of the periodontal defect adjacent to the tooth so as to reduce the amount of material from entering into the periodontal defect. In some embodiments, the devices and methods provided can be removed from the healed periodontal defect without the need to cut into healed soft tissue. | 03-13-2014 |
20140094498 | METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE - The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days. | 04-03-2014 |
20140110356 | FILTRATION DEVICE - A device for separating particulate matter (e.g., cells) from a liquid including a housing defining an elongate chamber disposed between a receiving end and a dispenser end, a plunger slidably inserted within the chamber from the receiving end, an upper disc and a lower disc each independently slidably affixed to the plunger, the lower disc facing the dispenser end and including at least one filter arrangement, and a liquid including particulate matter disposed within the chamber when the upper disc and lower disc are in an aspiration mode. The upper disc is independently slidable with respect to the lower disc to achieve a filtration mode. | 04-24-2014 |
20140121656 | NERVE AND SOFT TISSUE CUTTING DEVICE - Cutting devices including a probe or needle useful for resecting nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The cutting devices include an internal passage and a distal end that can have a tip and a groove positioned near the tip or at the tip at the distal end of the probe. The probe or needle can have an electrically insulated layer or coating adjacent to and exposing the groove which is configured to receive pulsed plasma mediated radio frequency discharges adapted for cutting nerve and/or soft tissue. The internal passage of the probe or needle can be configured to engage a vacuum for suction of the cut nerve and/or tissue, or separate passage for injection of fluids, sealants or cements. Methods for cutting nerve and/or soft tissue utilizing the cutting devices are also provided. | 05-01-2014 |
20140134226 | COMPOSITIONS AND METHODS FOR INHIBITING BONE GROWTH - Compositions and methods are provided for a matrix that inhibits bone growth in a patient in need thereof. In one embodiment, a method of inhibiting bone growth is provided, the method comprising: implanting a matrix at a target tissue site, the matrix comprising a biodegradable polymer and dextran loaded in the matrix in an amount of from about 5% to about 95% by weight based on a total weight of the matrix. | 05-15-2014 |
20140135285 | DEVICES AND METHODS FOR INHIBITING ADHESION FORMATION - Methods and compositions are provided for reducing, treating or preventing adhesions in a patient in need of such treatment. In one embodiment, an implantable device is provided for reducing or preventing adhesion formation at a post-operative tissue site in a patient, the implantable device including a biodegradable porous matrix comprising dextran, wherein the implantable device is capable of releasing the dextran over at least 2 days. | 05-15-2014 |
20140135286 | COMPOSITIONS AND METHODS FOR INHIBITING ADHESION FORMATION - Compositions and methods are provided for preparing an adhesion barrier that effectively reduce, prevent or treat adhesions in a patient in need thereof. In one embodiment, a matrix is provided comprising a biodegradable polymer and dextran loaded in the matrix in an amount of from about 5% to about 90% by weight based on a total weight of the matrix. The matrix is configured to release from about 30% to about 90% of the dextran loaded in the matrix within 24 to 48 hours. | 05-15-2014 |
20140195005 | OSTEOGRAFT IMPLANT - Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess. | 07-10-2014 |
20140271770 | Methods And Compositions For Treating Post-Operative Pain Comprising Clonidine - Effective implantable medical devices for reducing and treating post-operative pain are provided. The implantable medical device comprises clonidine in an amount from about 1 wt. % to about 30 wt. % of the implantable medical device. At least one biodegradable polymer and a pore forming agent in an amount from about 1 wt. % to about 30 wt. % of the implantable medical device is also provided. The implantable medical device is configured to release the clonidine over a period of at least 48 hours. Methods of use are also disclosed. | 09-18-2014 |
20140276699 | NERVE AND SOFT TISSUE ABLATION DEVICE - Ablation devices comprising a probe or needle useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The probe comprises at least two prongs spaced apart and parallel to each other. The at least two prongs each having an interior surface and an exterior surface and an internal passage disposed in the interior surface of the at least two prongs. A filament is disposed in the internal passage of the at least two prongs that has an opening configured to release a pressurized material into the interior surface of the at least two prongs so as to cool the exterior surface of the at least two prongs to a temperature configured for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276700 | NERVE AND SOFT TISSUE ABLATION DEVICE - Ablation devices useful for removing nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a plurality of probes each comprising an interior surface defining an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. A plurality of introducers are provided each comprising an interior surface configured for engagement with the probe where at least one air gap is produced by the introducer and probe engagement and an exterior surface comprising a heat conductive tip where the probe tip is snap fixed with the introducer tip in a configuration for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276701 | NERVE AND SOFT TISSUE ABLATION DEVICE - Ablation devices useful for destroying nerve and/or soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe having an interior surface that defines an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. An introducer is provided having an interior surface configured for engagement with the exterior surface of the probe. This engagement produces an air gap that surrounds the exterior surface of the probe to form a seal, and an exterior surface comprising an opening configured for engagement with the exterior surface of the probe is configured for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276702 | NERVE AND SOFT TISSUE ABLATION DEVICE AND METHOD - Ablation devices and methods are provided that allow for monitoring and control of temperature, pressure and position of ablating probes to achieve a more precise destruction of the nerve tissue and other soft tissue in a minimally invasive procedure. The ablation devices comprise at least a probe configured to generate pressure and temperature for ablating unwanted soft tissue and/or nerve tissue and at least one monitoring device coupled to the probe for recording and regulating temperature, pressure and position of the probe. The ablation devices can also include at least one imaging device coupled to the probe for identifying the area to be subjected to ablation. The ablation device includes a computer system coupled to the probe and programmed with software adapted to receive real or retrospective time data from the monitoring device and/or at least one imaging device configured to calculate optimal temperature, pressure, and position for the probe. | 09-18-2014 |
20140276703 | NERVE AND SOFT TISSUE ABLATION DEVICE FOR TREATING PAIN - Ablation kits useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe having an exterior and an interior. The exterior comprises a tip and the interior defines a passage having a filament and insulation disposed therein. The filament has an opening configured to release a pressurized material into the interior of the probe so as to cool the tip to a selected temperature to ablate nerve and/or soft tissue. A bone piercing instrument is provided that is configured to pierce bone so as to allow entry of the probe into the bone. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276704 | NERVE AND SOFT TISSUE ABLATION DEVICE - Ablation devices useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe comprising an outer tube having an exterior surface comprising a tip and an interior surface that defines an internal passage. An inner tube is disposed within the outer tube and comprises an interior surface that defines an internal passage having a filament disposed therein. The filament has an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the outer tube to a selected temperature. Disposal of the inner tube within the internal passage of the outer tube produces an air gap that surrounds the exterior surface of the inner tube, and the tip is configured for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276705 | NERVE AND SOFT TISSUE ABLATION DEVICE HAVING RELEASE INSTRUMENT - Ablation devices useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe comprising an interior surface that defines an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. A release instrument is provided comprising a sheath that comprises an exterior surface and an interior surface configured for engagement with the probe. The probe tip is configured for ablating nerve and/or soft tissue by forming an ice ball and the release instrument is configured to release the probe tip from the ice ball. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided. | 09-18-2014 |
20140276741 | PEAK PLASMA BLADE FOR SOFT TISSUE DECOMPRESSION - Cutting device for resecting nerve or soft tissue while reducing or preventing arcing or heating of surrounding tissues are provided. The cutting devices include a probe having a lumen, a distal end and a proximal end, the distal end having a tip and a cutting surface positioned near its tip. The cutting surface has cutting edges configured to receive and conduct pulsed plasma mediated RF discharges. The cutting devices also include a sleeve covering the probe, the sleeve containing at least one aperture configured to expose the cutting surface. Intermediate the probe and the sleeve, some cutting devices include a metal insert that can cover the probe exposing only the cutting edges of the cutting surface. Methods for cutting nerve and/or soft tissue utilizing the cutting devices are also provided. | 09-18-2014 |
20140314821 | MEDICAL IMPLANTS WITH RESERVOIR(S) AND MATERIALS PREPARABLE FROM SAME - Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients. | 10-23-2014 |
20140336162 | LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS - This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot. | 11-13-2014 |
20140341964 | COHESIVE OSTEOGENIC PUTTY AND MATERIALS THEREFOR - Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients. | 11-20-2014 |
20140377168 | PHARMACEUTICAL GELS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS TO A SITE BENEATH THE SKIN - Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site. | 12-25-2014 |
20150018390 | METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING A LOCAL ANESTHETIC - The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days. | 01-15-2015 |
20150065474 | DEXAMETHASONE FORMULATIONS IN A BIODEGRADABLE MATERIAL - Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 03-05-2015 |