Whitty
Adrian Whitty, Hopkinton, MA US
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20090104150 | Polymer conjugates of interferon Beta-1a and uses - An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications. | 04-23-2009 |
20090215071 | METHODS OF TARGETING BAFF - The present disclosure provides compositions and methods relating to the structure of BAFF in solution. The disclosure includes BAFF 60-mers, BAFF trimers, methods of making BAFF 60-mers and BAFF trimers, antibodies that preferentially bind one form or the other, and methods of identifying or evaluating a compound on the basis of its relative binding to or activity towards a BAFF 60-mer and a BAFF trimer. The disclosure also provides computer-based systems and methods relating to BAFF structures. | 08-27-2009 |
20090286958 | INTERFERON-BETA FUSION PROTEINS AND USES - A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described. | 11-19-2009 |
20120214683 | METHODS OF TARGETING BAFF - The present disclosure provides compositions and methods relating to the structure of BAFF in solution. The disclosure includes BAFF 60-mers, BAFF trimers, methods of making BAFF 60-mers and BAFF trimers, antibodies that preferentially bind one form or the other, and methods of identifying or evaluating a compound on the basis of its relative binding to or activity towards a BAFF 60-mer and a BAFF trimer. The disclosure also provides computer-based systems and methods relating to BAFF structures. | 08-23-2012 |
20150011732 | POLYMER CONJUGATES OF INTERFERON BETA-1A AND USES - An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications. | 01-08-2015 |
James R. Whitty, Midland CA
Patent application number | Description | Published |
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20090304333 | Method and Apparatus for Accurately Aligning Optical Components - A first part has first, second and third inwardly-facing surface portions angularly spaced about an axis, and a second part has outwardly-facing fourth, fifth and sixth surface portions spaced angularly about the axis, a radial distance from the axis to each surface portion decreasing progressively in a given direction along the axis. Each of the fourth, fifth and sixth surface portions faces, is closely adjacent to, and is substantially congruent in shape with a respective one of the first, second and third surface portions. At least one of the first and second parts is an optical component. | 12-10-2009 |
20100321753 | Optical communications system with selective block/add capability of an optical channel - An optical communications system has a selective block/add capability of an optical channel. An optical beam separator receives and separates an input mixed optical beam into a separated optical channel and a remainder optical beam. A block/add unit receives as an input the separated optical channel and produces as an output a controllably modified separated optical channel. The block/add unit includes a source of an add input optical signal, and a controllable mirror. The controllable mirror is controllable between a first state in which the controllable mirror does not block the path of the separated optical channel, so that the separated optical channel is the output of the block/add unit, and a second state in which the controllable mirror blocks the path of the separated optical channel, and also reflects the add input optical signal as the output of the block/add unit. An optical beam combiner receives the output of the block/add unit and combines the output of the block/add unit with the remainder optical beam. | 12-23-2010 |
John Whitty, Richmond, VA US
Patent application number | Description | Published |
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20090107060 | PORTABLE SAFETY SKYLIGHT REPLACEMENT ASSEMBLY - A portable skylight replacement safety assembly that includes a first and second support frames releasably connected to each other and having a plurality of support handles and support members which extend substantially perpendicularly from the first support frame for supporting the first support frame on and/or over the skylight on a working surface at a predetermined distance. | 04-30-2009 |
20120137604 | PORTABLE SAFETY SKYLIGHT REPLACEMENT ASSEMBLY - A portable skylight replacement safety assembly that includes a first and second support frames releasably connected to each other and having a plurality of support handles and support members which extend substantially perpendicularly from the first support frame for supporting the first support frame on and/or over the skylight on a working surface at a predetermined distance. | 06-07-2012 |
Kevin Whitty, Salt Lake City, UT US
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20150030050 | ULTRASONIC TEMPERATURE MEASUREMENT DEVICE - An ultrasonic thermometer for measuring a temperature profile along a measurement axis of a structure, comprising a continuous measurement pathway of a structure ( | 01-29-2015 |
Kevin Whitty, Park City, UT US
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20130121373 | ULTRASONIC TEMPERATURE MEASUREMENT DEVICE - An ultrasonic thermometer for measuring a temperature profile along a measurement axis of a solid structure, comprising a continuous measurement pathway of a solid structure ( | 05-16-2013 |
Larry J. Whitty, Bettendorf, IA US
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20080224577 | Apparatus for storing and dispensing a plurality of boxes - The apparatus includes first and second side walls, and a bottom wall having a first, a second, a third and a fourth side edge. A lower edge of the first side wall is secured to the first side edge, and a lower edge of the second side wall is secured to the third side edge. A door is rotatably coupled to a front edge of the first side wall and latchable proximate to a front edge of the second side wall. When latched, a bottom edge of the door is located at a pre-determined distance from the second side edge of the bottom wall. The first and second side walls, the bottom wall and the door form a substantially rectangular enclosure when first and second cross-members, fixedly attached to respective top and bottom back edges of the first and second side walls, are affixed to a vertical structure. | 09-18-2008 |
Michael Whitty, West Hartford, CT US
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20160032781 | MOVEABLE SEALING ARRANGEMENT FOR A GAS TURBINE DIFFUSER GAP - A sealing arrangement for a gas turbine including exhaust and manifold diffusers separated by a circumferential diffuser gap. The sealing arrangement includes a forward clamp arrangement attached to the exhaust diffuser wherein the forward clamp arrangement includes a forward groove. The sealing arrangement also includes an aft clamp arrangement attached to manifold diffuser wherein the aft clamp arrangement includes an aft groove. Further, the sealing arrangement includes a flexible circumferential seal including forward and aft loop portions. The forward loop portion is located in the forward groove and the aft loop portion is located in the aft groove wherein the circumferential seal extends across the circumferential diffuser gap to seal the circumferential diffuser gap. The forward and aft loop portions are moveable in the forward and aft grooves to enable movement of the circumferential seal in a circumferential direction to accommodate thermal expansion of the exhaust and manifold diffusers. | 02-04-2016 |
Patrick Whitty, Stoney Creek CA
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20120279905 | Safe storage of hazardous materials - A method of safely storing containers containing chemical substances in accordance with a preconceived plan which comprises; examining each container to assure the integrity of each container containing such chemical substances and that said container is suitable for the storage of its contents for a predetermined period of time. If the container is deemed fit to store the contents, then, the exterior of the container is examined for exterior marks which will help to determine what the contents really are. Next a classification scheme for the said chemical substances is developed. This entails the establishment of a colour to be applied to the exterior surface of said container after a determination of the container's contents has been made. A corresponding number to be applied to the external surface of each container. The number of classes must next be determined for the plan (arbitrary). This is established in determining how and where the substances so classified may be safely stored, sorting the containers into like groups and storing the groups of containers marked with the same colours and numbers in accordance with the plan. | 11-08-2012 |