Patent application number | Description | Published |
20090286248 | Methods for Determining Drug Responsiveness - The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the mRNA levels of a gene that responds to the drug, such as a steroid, to the MRNA levels of a gene that does not respond to the drug. Methods according to the invention are useful for predicting the ability of a patient (or a tissue, body fluid or cell sample in vitro) to respond to a drug or steroid at any stage of their treatment (i.e., before, during or after), and to monitor the patient (or a tissue, body fluid or cell) over time to assess continued responsiveness to the drug or steroid. | 11-19-2009 |
20090286267 | Methods for Determining Drug Responsiveness - The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the protein levels of a gene that responds to the drug, such as a steroid, to the protein levels of a gene that does not respond to the drug. Methods according to the invention are useful for predicting the ability of a patient (or a tissue, body fluid or cell sample in vitro) to respond to a drug or steroid at any stage of their treatment (i.e., before, during or after), and to monitor the patient (or a tissue, body fluid or cell) over time to assess continued responsiveness to the drug or steroid. | 11-19-2009 |
20110207164 | Method for Assessment of Folate Phenotypes, Disease Risk and Response to Therapy - The invention provides a method for measuring the levels of 5-methyltetrahydrofolate (5-MTHF), tetrahydrofolate (THF), and 5,10-MTHF in a biological sample. The method includes employing an isotope dilution liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS) methodology. | 08-25-2011 |
Patent application number | Description | Published |
20100125077 | Polymorphs of Brimonidine Pamoate - A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system. | 05-20-2010 |
20120015951 | Polymorphs of Brimonidine Pamoate - A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system. | 01-19-2012 |
20120232039 | PRIMARY AMINE DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES - A compound having the structure | 09-13-2012 |
20130203760 | Polymorphs of Brimonidine Pamoate - A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system. | 08-08-2013 |
20130203761 | Polymorphs of Brimonidine Pamoate - A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system. | 08-08-2013 |
Patent application number | Description | Published |
20120221478 | TARGETED INFORMATION DISSEMINATION BASED ON AIRPORT GATE-SPECIFIC UTILIZATION - Implementing targeted information dissemination based on gate-specific utilization includes collecting gate-specific utilization characteristics for an airport gate, the airport gate associated with a display device. Traveler data is collected for the airport gate and is aggregated. The implementation of targeted information dissemination includes identifying a pattern from aggregated traveler data, and disseminating information to the display device. The pattern is designated with an association with the information for dissemination. | 08-30-2012 |
20130036100 | DEDUPLICATION IN NETWORK STORAGE WITH DATA RESIDENCE COMPLIANCE - Deduplication in a network storage environment includes, for files stored in a network, determining a location constraint status specified by a compliance agreement for each of the files. Location constraint statuses include a location of persistent residency and no residency restriction. Deduplication also includes selecting a file from the files in the network and identifying corresponding redundant files, the selected file and the corresponding redundant files representing a set. Deduplication further includes determining the location constraint status for each of the files in the set. For the files in the set having a location constraint status specifying a location of persistent residency, the deduplication includes retaining a master copy at the respective location of persistent residency, and removing the corresponding redundant files from the network. | 02-07-2013 |
20130211862 | AGGREGATED ADVERTISING - A server may receive a first check-in corresponding to at least one person, wherein a check-in is a indication of presence. The server may receive a second check-in to form an aggregation of people. The server may characterize the aggregation based on the cumulative characteristics selected from at least one of the group consisting of age, marital status, and parental status associated with at least one of the first check-in and second check-in to form an aggregated population characteristic. The server may select at least one advertisement based on the aggregated population characteristic. The server may dispatch the at least one advertisement. | 08-15-2013 |
Patent application number | Description | Published |
20100230359 | POROUS AND DURABLE CERAMIC FILTER MONOLITH COATED WITH A RARE EARTH FOR REMOVING CONTAMINANTS FROM WATER - The invention is directed generally to a porous and durable ceramic filter monolith coated with one or more rare earth-containing compositions for removing contaminants from a fluid, particularly for removing one or more contaminants from water. | 09-16-2010 |
20100258448 | USE OF A RARE EARTH FOR THE REMOVAL OF ANTIMONY AND BISMUTH - The invention relates generally to a process for removing one or more contaminants from an electrolytic solution and more particularly to a process for removing the one or more contaminants contained in an electrorefining solution using rare earth metals. | 10-14-2010 |
20120138528 | METHOD AND APPARATUS FOR REMOVING ARSENIC FROM AN ARSENIC BEARING MATERIAL - A method and apparatus for removing arsenic from an arsenic-bearing material. The method includes the steps of contracting an arsenic-bearing material with an arsenic leaching agent to form an arsenic-containing solution and arsenic-depleted solids. The leaching agent can be an inorganic salt, an inorganic acid, an organic acid, and/or an alkaline agent. The arsenic-depleted solids are separated from the arsenic-containing solution, which is contacted with a fixing agent to produce an arsenic-depleted solution and an arsenic-laden fixing agent. The fixing agent comprises a rare earth-containing compound that can include cerium, lanthanum, or praseodymium. The fixing agent is then separated from the arsenic-depleted solution. A recoverable metal in the arsenic-depleted solids, arsenic-containing solution or arsenic-depleted solution can be separated and recovered. Recoverable metals can include metal from Group IA, Group IIA, Group VIII and the transition metals. | 06-07-2012 |
20120138529 | METHOD AND APPARATUS FOR RECOVERING A METAL AND SEPARATING ARSENIC FROM AN ARSENIC CONTAINING SOLUTION - A method and apparatus for recovering a metal and separating arsenic from an arsenic-containing solution. The method includes contacting the arsenic-containing solution with a fixing agent that comprises a rare earth compound to produce an arsenic-depleted solution and an arsenic-laden fixing agent. The fixing agent comprises a rare earth-containing compound that can include cerium, lanthanum, or praseodymium. The fixing agent is separated from the arsenic-depleted solution and a recoverable metal is separated from one or more of the arsenic-containing solution and the arsenic-depleted solution. Recoverable metals can include metal from Group IA, Group IIA, Group VIII and the transition metals. The arsenic-containing solution can be formed by contacting an arsenic-containing material with a leaching agent. Arsenic-depleted solids formed during the leach can also be separated and recovered. An apparatus of the invention can include two or more arsenic fixing units configured to conduct the method on a continuous basis. | 06-07-2012 |
20120138530 | METHOD AND APPARATUS FOR REMOVING ARSENIC FROM A SOLUTION - A method and apparatus for separating arsenic from an aqueous solution containing arsenic. The method includes the steps of contacting an arsenic-containing solution with a first portion of fixing agent to remove at least a portion of the arsenic. An arsenic-laden fixing agent is separated from the solution and the partially depleted solution is contacted with a second portion of fixing agent. The fixing agent can include a high surface area insoluble compound containing one or more of cerium, lanthanum, or praseodymium. Following removal of the arsenic, the arsenic-depleted solution can be further processed to separate a recoverable metal through metal refining. The arsenic-laden fixing agent can be filtered to recover and recycle a filtrate to the solution for additional treatment, as well as using a partially saturated fixing agent to remove arsenic from fresh solution. An arsenic-containing solution can be formed from arsenic-containing solids such as contaminated soils, industrial byproducts and waste materials. | 06-07-2012 |
Patent application number | Description | Published |
20110035823 | Inbred Corn Line BB46 - An inbred corn line, designated BB46, is disclosed. The invention relates to the seeds of inbred corn line BB46, to the plants and plant parts of inbred corn line BB46 and to methods for producing a corn plant, either inbred or hybrid, by crossing inbred corn line BB46 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from inbred corn line BB46. | 02-10-2011 |
20110035834 | Inbred Corn Line BB59 - An inbred corn line, designated BB59, is disclosed. The invention relates to the seeds of inbred corn line BB59, to the plants and plant parts of inbred corn line BB59 and to methods for producing a corn plant, either inbred or hybrid, by crossing inbred corn line BB59 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from inbred corn line BB59. | 02-10-2011 |
20130239245 | INBRED CORN LINE CB15 - An inbred corn line, designated CB15, is disclosed. The invention relates to the seeds of inbred corn line CB15, to the plants and plant parts of inbred corn line CB15 and to methods for producing a corn plant, either inbred or hybrid, by crossing inbred corn line CB15 with itself or another corn line. The invention also relates to products produced from the seeds, plants, or parts thereof, of inbred corn line CB15 and/or of the hybrids produced using the inbred as a parent. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from inbred corn line CB15. | 09-12-2013 |
20130239249 | INBRED CORN LINE BB86 - An inbred corn line, designated BB86, is disclosed. The invention relates to the seeds of inbred corn line BB86, to the plants and plant parts of inbred corn line BB86 and to methods for producing a corn plant, either inbred or hybrid, by crossing inbred corn line BB86 with itself or another corn line. The invention also relates to products produced from the seeds, plants, or parts thereof, of inbred corn line BB86 and/or of the hybrids produced using the inbred as a parent. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from inbred corn line BB86. | 09-12-2013 |
Patent application number | Description | Published |
20090141839 | Apparatus and method for downstream power management in a cable system - An apparatus and method is disclosed to calculate the actual received desired channel power from the downstream transmit power of a Cable Modem Termination System (CMTS) when operating at the nominal line voltage and/or at the normal room temperature as per the DOCSIS specification. A Set-top Device produces a Downstream Power Management (DPM) gain measurement signal having a known power level. The Set-top Device embeds the DPM gain measurement signal onto a received downstream multi-channel communication signal. After embedding the DPM gain measurement signal onto the downstream multi-channel communication signal, the Set-top Device downconverts the combined DPM gain measurement signal and downstream multi-channel communication signal to recover one or more communication channels containing information of a broadcast. The Set-top Device measures a power level of a representation of the DPM gain measurement signal embedded within the one or more communication channels containing the information of the broadcast to determine a Set-top Device gain. The Set-top Device measures a power level of the one or more communication channels containing the information of the broadcast. The Set-top Device calculates the actual received desired channel power from the downstream transmit power of the CMTS based on the Set-top Device gain and the power level of the one or more communication channels containing the information of the broadcast. | 06-04-2009 |
20100244926 | Apparatus and Method for Downstream Power Management in a Cable System - An apparatus and method is disclosed to calculate the actual received desired channel power from the downstream transmit power of a Cable Modem Termination System (CMTS) when operating at the nominal line voltage and/or at the normal room temperature as per the DOCSIS specification. A Set-top Device produces a Downstream Power Management (DPM) gain measurement signal having a known power level. The Set-top Device embeds the DPM gain measurement signal onto a received downstream multi-channel communication signal. After embedding the DPM gain measurement signal onto the downstream multi-channel communication signal, the Set-top Device downconverts the combined DPM gain measurement signal and downstream multi-channel communication signal to recover one or more communication channels containing information of a broadcast. The Set-top Device measures a power level of a representation of the DPM gain measurement signal embedded within the one or more communication channels containing the information of the broadcast to determine a Set-top Device gain. The Set-top Device measures a power level of the one or more communication channels containing the information of the broadcast. The Set-top Device calculates the actual received desired channel power from the downstream transmit power of the CMTS based on the Set-top Device gain and the power level of the one or more communication channels containing the information of the broadcast. | 09-30-2010 |
20130125183 | Spectrum Analysis and Plant Diagnostic Tool for Communications Systems - A system, method, and apparatus to allow an operator of a broadcast communication system, such as a cable television or satellite television service to provide some examples, to diagnose performance of this communication system remotely. The operator of a first communication device, such as a cable modem termination system (CMTS) to provide an example, may remotely diagnosis performance problems, or potential performance problems, occurring at a second communication device, such as a cable modem (CM) to provide an example, or a group of second communication devices. For example, the operator of the first communication device may view a spectrum analysis of communication signals being routed to, processed by, and/or provided by the second communication device, or group of second communication devices, to diagnose the performance problems, or the potential performance problems, in real time. | 05-16-2013 |
20150082363 | Spectrum Analysis and Plant Diagnostic Tool for Communication Systems - A system, method, and apparatus to allow an operator of a broadcast communication system, such as a cable television or satellite television service to provide some examples, to diagnose performance of this communication system remotely. The operator of a first communication device, such as a cable modem termination system (CMTS) to provide an example, may remotely diagnosis performance problems, or potential performance problems, occurring at a second communication device, such as a cable modem (CM) to provide an example, or a group of second communication devices. For example, the operator of the first communication device may view a spectrum analysis of communication signals being routed to, processed by, and/or provided by the second communication device, or group of second communication devices, to diagnose the performance problems, or the potential performance problems, in real time. | 03-19-2015 |
Patent application number | Description | Published |
20090324746 | SYSTEM FOR PRODUCING AND DISPENSING CHLORINE DIOXIDE - The invention relates to a multi-component chlorine dioxide producing system. The invention produces effective amounts of chlorine dioxide in five minutes or less without instantaneous production or loss of chlorine dioxide. The invention further includes a dispensing apparatus to allow for the dispensing of the multi component system to allow for insitu production of chlorine dioxide. | 12-31-2009 |
20130067648 | REPLACEMENT CLOSET FLANGE - The present invention provides a replacement closet flange for installing into an end of a drain pipe having an inner surface and a method of assembling a replacement closet flange. In general, the replacement closet flange includes a main body comprising a substantially cylindrical section and a flange section extending radially outward from and approximately perpendicular to an upper end of the cylindrical section, a flexible seal attached to at least a portion of the cylindrical section proximate a lower end thereof and configured, when the replacement closet flange is installed, to sealingly engage with the inner surface of the drain pipe, and at least one retaining clip attached to a location about an outer periphery of the cylindrical section. The retaining clip includes a retaining tab proximate an end thereof configured, when the replacement closet flange is installed, to fixedly engage with an inner surface of the drain pipe. | 03-21-2013 |
20140352798 | PLUMBING OUTLET BOX - Plumbing outlet boxes, such as for connecting washing machines, ice makers, and other plumbed appliances to plumbing systems, are provided that increase the energy efficiency of a building thermal envelope. In particular, plumbing outlet boxes are described that include a continuous flange and a compressible seal contacting the flange. The plumbing outlet boxes are designed to be mounted within a cutout in a drywall panel such that, when a faceplate is engaged with the housing, the seal creates a sealing effect between the plumbing outlet box and the wall, thereby maximizing the energy efficiency of the installation by reducing the air leakage between the interior side of the wall and the exterior side of the wall. | 12-04-2014 |
Patent application number | Description | Published |
20090117432 | Water Removal Features for PEMFC Stack Manifolds - A bipolar plate includes angled facets oriented to form V-shaped projections on the plate edge. Liquid leaving the reactant channels is drawn back into the V-shaped grooves of the projections, leaving no liquid to obstruct the channel exit openings. The bipolar plate includes one portion of the bipolar plate offset from another portion of the bipolar plate so as to expose the reactant channels. The liquid is drawn toward the end portions of the reactant channels by capillary forces, while the gas flows can exit near the beginning of the offset portion. A fuel cell stack includes angled facets that are rotated to lie in the plane of the bipolar plate edges. The edges are chamfered so the channel exit openings of the reactant channels are at the tip portions thereof, thus allowing the liquid to flow away from the channel exit openings and the gas to exit freely. | 05-07-2009 |
20090239106 | INTEGRATED CHARGE AIR HEAT EXCHANGER - An integrated charge air heat exchanger for use in a vehicle fuel cell system is provided. The integrated charge air heat exchanger includes a plurality of coolant conduits adapted for a coolant fluid to flow therethrough. The integrated charge air heat exchanger further includes a plurality of heating elements and a plurality of fin elements. One heating element is disposed on a first surface of each of the coolant conduits, and one of the fin elements is disposed on a second surface of each of the coolant conduits. A method for heating the coolant fluid in a first operational mode and cooling a charge air stream in a second operational mode is also provided. | 09-24-2009 |
20100098975 | LOW COST THERMAL INSULATION FOR A FUEL CELL STACK INTEGRATED END UNIT - An end unit for a fuel cell stack is provided. The end unit includes a main body having a cavity and a substantially impermeable barrier disposed thereon to militate against heat transfer within the end unit and minimize a cost of insulating the end unit. A fuel cell system and a method of fabricating the end unit for use in a fuel cell system are also provided. | 04-22-2010 |
20110207010 | Relative Humidity Control For A Fuel Cell - A model uses various operating characteristics of a fuel cell to predict the relative humidity profile that is occurring within the fuel cell as a function of the reaction progress. The model is used to predict the relative humidity profile that will occur in response to changes to one or more of the operating characteristics of the fuel cell. A high frequency resistance of the fuel cell can also be used as a measure that is indicative of the humidity within the fuel cell. The model and/or the high frequency resistance can be used in a closed-loop feedback system to control the operation of the fuel cell to maintain the humidification of the MEA and fuel cells within a desired range to achieve a desired fuel cell performance. | 08-25-2011 |
Patent application number | Description | Published |
20090275418 | FUNCTIONAL CONTROL/GRIP-ENHANCED SPORTS GLOVE FOR BOWLING - The present invention is a modified glove with control/grip-enhancing and perspiration retention properties, offering the bowler a range of functions and options specific to the individual bowler's abilities, equipment selection (i.e. bowling ball), and the lane conditions faced. An elastomeric, control/grip-enhancing material circumferences the fingertips of at least one finger, providing a similar shape and feel to the commonly used, cylindrical inserts/grips; the glove designed to be used in lieu of finger inserts. The present glove invention can be interchangeable between right and left-handed bowlers of approximately the same hand size. The perspiration retentive fabric combined with the elastomeric, control/grip-enhancing material eliminates or significantly reduces perspiration from an otherwise naked inserted finger, which normally has contact with the hole(s) of a bowling ball. Consequently, the present glove invention results in more consistent control and release of the ball off the hand, increased ball energy, increased ball motion and revolution potential, a higher impact between ball and pins, leading to more lively pin scattering, all of which ultimately results in higher scoring potential. Functionality and performance characteristics of various embodiments of the glove invention provide the bowler a range of control/grip-enhanced, textured and non-textured surface materials at the fingertip area of the glove. Likewise, the control/grip enhanced material of the palm area of the glove works to grip the surface of the bowling ball. The ball position in the cupped and gloved hand is maintained even though the bowler moves his/her hand slightly either away from towards or laterally with respect to the bowling ball. Embodiments of the glove invention offer the bowlers a variety of options for the fingers, as well as for support around the wrist area. | 11-05-2009 |
Patent application number | Description | Published |
20090275418 | FUNCTIONAL CONTROL/GRIP-ENHANCED SPORTS GLOVE FOR BOWLING - The present invention is a modified glove with control/grip-enhancing and perspiration retention properties, offering the bowler a range of functions and options specific to the individual bowler's abilities, equipment selection (i.e. bowling ball), and the lane conditions faced. An elastomeric, control/grip-enhancing material circumferences the fingertips of at least one finger, providing a similar shape and feel to the commonly used, cylindrical inserts/grips; the glove designed to be used in lieu of finger inserts. The present glove invention can be interchangeable between right and left-handed bowlers of approximately the same hand size. The perspiration retentive fabric combined with the elastomeric, control/grip-enhancing material eliminates or significantly reduces perspiration from an otherwise naked inserted finger, which normally has contact with the hole(s) of a bowling ball. Consequently, the present glove invention results in more consistent control and release of the ball off the hand, increased ball energy, increased ball motion and revolution potential, a higher impact between ball and pins, leading to more lively pin scattering, all of which ultimately results in higher scoring potential. Functionality and performance characteristics of various embodiments of the glove invention provide the bowler a range of control/grip-enhanced, textured and non-textured surface materials at the fingertip area of the glove. Likewise, the control/grip enhanced material of the palm area of the glove works to grip the surface of the bowling ball. The ball position in the cupped and gloved hand is maintained even though the bowler moves his/her hand slightly either away from towards or laterally with respect to the bowling ball. Embodiments of the glove invention offer the bowlers a variety of options for the fingers, as well as for support around the wrist area. | 11-05-2009 |
Patent application number | Description | Published |
20080289460 | OXYGEN SENSOR SOCKET REMOVAL AND INSTALLATION TOOL - An oxygen sensor removal tool includes an axial throughbore with an oxygen sensor socket bore at one end and a socket drive bore at the opposite end, and further including a radially extending drive socket arm with a drive socket opening so that the tool may be placed over an oxygen sensor and a socket drive or other drive may be attached to the tool to provide for effective force to permit adequate torque to disengage the oxygen sensor from a vehicle exhaust system. | 11-27-2008 |
20090255384 | TOOL KIT FOR REMOVAL OF BROKEN SPARK PLUGS - A kit for removal of a broken spark plug from a cylinder head includes first and second tools. The first tool is designed to position a broken porcelain element into the spark plug tip so that the second tool may be utilized to engage the tip by threading into the tip and thereafter axially withdraw the plug tip from the cylinder head by rotation of the tool. | 10-15-2009 |
20110179911 | Wrench for Removal of Motor Vehicle Radiator Cap and/or Oil Filter Cap - An automotive repair tool for removal of an engine fluid cap includes a scalloped interior opening through a circular base having a circumferential edge surface transverse to the axis of the rotation of the cap. The base receives a U-shape metal bracket welded thereto and aligned axially with the rotational axis of the base member. The opening through the base member is compatible with and generally congruent with a fluid cap for an internal combustion automobile engine. | 07-28-2011 |
20110185842 | FLYWHEEL LOCKING TOOL KIT - A flywheel locking tool kit comprises unitary body blocks designed to fit through and respectively compatible with the opening of a bell housing of a transmission so that teeth provided on one sector of the tool may be engaged with the flywheel teeth and projections and elements of the opposite end of the tool may be engaged with the sides or edges of the opening through the bell housing to retain the tool in a fixed, desired position. | 08-04-2011 |
20110252925 | Extractor Tool and Extractor Tool Kit - An extractor tool for Torx brand and other fluted fasteners comprising an end section for engaging a fastener opening comprising six equally spaced, uniformly sized, pitched flutes separated by uniform depth grooves located at the end of a shank with a cylindrical connecting section joined thereto, in turn, joined to an impact drive end of the shank. The fluted end section has a frusto-conical configuration with the narrow dimension of the fluted end section at the distal end of the tool and wherein the distal end has a flat surface transverse to the longitudinal axis of the shank. | 10-20-2011 |
Patent application number | Description | Published |
20080286132 | REDUCING CYLINDER WEAR IN A DRUG PUMP - The present invention relates to a method and related apparatus for rotating a piston of a drug pump during the pumping stroke to reduce drug pump wear. The actuator may move a piston that pumps fluid through a pumping channel. In the present invention, the armature includes one or more openings or shapes that cause the actuator, including the armature and the piston, to rotate about a longitudinal axis of the piston during the pumping stroke. Rotation of the actuator member may help to reduce wear to the actuator member and the pump itself caused by repetitive pumping motions. | 11-20-2008 |
20080312595 | ARTICULATED ACTUATOR FOR IMPLANTABLE PUMP - The present invention is an actuator for a piston pump that includes a separately formed piston and armature. The piston and the armature are later assembled together or are inserted into the piston pump in such a manner as to cooperate during pumping. Assembling the piston and the armature as separate components may provide for improved form of the piston component when manufactured separately from the armature, due to, for example, increased simplification of the manufacturing process. In addition, effects of manufacturing the piston and the armature together, such as stress on the piston, may be reduced. | 12-18-2008 |
20100152714 | AIR TOLERANT IMPLANTABLE PISTON PUMP - An implantable infusion device includes a reservoir for housing an infusion medium and a drive mechanism having an inlet chamber, a piston and a piston channel. The inlet chamber is in fluid communication with the reservoir. The piston channel is in fluid communication with the inlet chamber, and has a distal end and a proximal end, the proximal end being closer to the inlet channel than the distal end. The piston is axially moveable within the piston channel to drive infusion medium out of the distal end of the piston channel. The clearance between the piston and the channel is sufficiently small to prevent undissolved gas in the inlet chamber from passing through the clearance. The inlet chamber may be sufficiently large to allow undissolved gas to accumulate without adversely affecting the performance of the infusion device. | 06-17-2010 |
20100280447 | MEDICAL PUMP WITH FIXED STROKE LENGTH - A method comprises measuring a volume of fluid delivered per pump stroke for each of a plurality of substantially identical medical pumps. The substantially identical medical pumps each have a fixed stroke length. The method further comprises: storing indications of the measured volumes on one or more data storage mediums; and for each of the plurality of substantially identical medical pumps, generating a separate therapy control program based on the indication of the measured volume associated with that one of the plurality of substantially identical medical pumps. | 11-04-2010 |
20100280501 | MODULAR MEDICAL PUMP ASSEMBLY - A medical pump subassembly comprises a magnetic cup forming a recess. The magnetic cup includes a protrusion within the recess. The cup forms a central aperture through the protrusion. The medical pump subassembly further comprises an electromagnetic coil within the recess and circumscribing the protrusion, a weld ring surrounding the recess, a barrier plate covering the recess, and a seal between the weld ring and the barrier plate to fluidically separate an interior of the cup from an external surface of the barrier plate. | 11-04-2010 |
20100280502 | MODULAR MEDICAL PUMP - An implantable medical device comprises a fluid reservoir configured to store a therapeutic agent; a port configured to deliver the therapeutic agent to a patient; a medical pump subassembly configured to actively transfer the therapeutic fluid from the fluid reservoir to the port; and a housing that contains the fluid reservoir, the port and the medical pump subassembly. The medical pump subassembly is configured to facilitate mechanical and electrical testing of the medical pump subassembly as a standalone component. | 11-04-2010 |
20120109099 | IMPLANTABLE MEDICAL PUMP DIAGNOSTICS - A method of detecting a fault condition within an implantable medical pump comprises delivering therapeutic fluid using a medical pump comprising an actuation mechanism configured to be energized to provide a pump stroke, detecting a property associated with energizing the actuation mechanism, and determining whether the property associated with energizing the actuation mechanism indicates that a fault condition exists with the medical pump. | 05-03-2012 |
20120197238 | MEDICAL PUMP WITH FIXED STROKE LENGTH - A method comprises measuring a volume of fluid delivered per pump stroke for each of a plurality of substantially identical medical pumps. The substantially identical medical pumps each have a fixed stroke length. The method further comprises: storing indications of the measured volumes on one or more data storage mediums; and for each of the plurality of substantially identical medical pumps, generating a separate therapy control program based on the indication of the measured volume associated with that one of the plurality of substantially identical medical pumps. | 08-02-2012 |
20130096503 | ACCUMULATOR FOR IMPLANTABLE INFUSION DEVICE - An accumulator is employed in an implantable infusion device to provide compliance in the flow path of the device. The accumulator may act to increase the pumping accuracy and repeatability while simultaneously reducing the energy requirements of the device. In one example, the accumulator is arranged at the outlet of a fluid delivery pump of the infusion device. The accumulator includes a cover and a diaphragm biased away from the cover and configured to deflect toward the cover under pressure generated by the therapeutic agent in a flow path of the infusion device. The cover of the accumulator is configured to withstand the pressure generated by the therapeutic agent in the flow path without deforming. | 04-18-2013 |
20130096537 | IMPLANTABLE INFUSION DEVICE INCLUDING ANTI-SEALING RESERVOIR - Techniques are disclosed for reducing the accumulation of gases in an implantable infusion device. In one example, an implantable infusion device (IID) includes a housing, an expandable and contractible reservoir, and a standoff member. The expandable and contractible reservoir is configured to store a therapeutic agent and is arranged within the housing. A first end of the reservoir is configured to collapse toward a second end of the reservoir as the reservoir contracts. The standoff member is interposed between the first end and the second end of the reservoir and is configured to hold at least a portion of the first end offset from the second end when the reservoir is in a contracted state. | 04-18-2013 |
Patent application number | Description | Published |
20090258036 | DENGUE TETRAVALENT VACCINE CONTAINING A COMMON 30 NUCLEOTIDE DELETION IN THE 3' -UTR OF DENGUE TYPES 1, 2, 3, AND 4 OR ANTIGENIC CHIMERIC DENGUE VIRUSES 1, 2, 3, AND 4 - The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4. | 10-15-2009 |
20090263424 | DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES - A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. | 10-22-2009 |
20100104598 | DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS - The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. | 04-29-2010 |
20100316670 | CHIMERIC SLE/DENGUE TYPE 4 ANTIGENIC VIRUSES - Embodiments described herein concern attenuated, St. Louis Encephalitis Virus/dengue virus type 4 antigenic chimeric viruses, which can be used to prepare immunogenic compositions, vaccines, and diagnostic reagents. Methods of making and using the foregoing are provided. | 12-16-2010 |
20130089567 | DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS - The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. | 04-11-2013 |
Patent application number | Description | Published |
20110200630 | LIVE ATTENUATED VIRUS VACCINES FOR LA CROSSE VIRUS AND OTHER BUNYAVIRIDAE - The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae. | 08-18-2011 |
20120114694 | DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES - A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. | 05-10-2012 |
20130011433 | DENGUE TETRAVALENT VACCINE CONTAINING A COMMON 30 NUCLEOTIDE DELETION IN THE 3'-UTR OF DENGUE TYPES 1, 2, 3, AND 4, OR ANTIGENIC CHIMERIC DENGUE VIRUSES 1, 2, 3, AND 4 - The invention relates to a dengue virus tetravalent vaccine containing a common | 01-10-2013 |
20140023679 | LIVE ATTENUATED VIRUS VACCINES FOR LA CROSSE VIRUS AND OTHER BUNYAVIRIDAE - The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae. | 01-23-2014 |
20140294892 | CONSTRUCTION OF WEST NILE VIRUS AND DENGUE VIRUS CHIMERAS FOR USE IN A LIVE VIRUS VACCINE TO PREVENT DISEASE CAUSED BY WEST NILE VIRUS - The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines. | 10-02-2014 |
20150064214 | DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES - A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. | 03-05-2015 |
Patent application number | Description | Published |
20130143794 | POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION - The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection. | 06-06-2013 |
20150038408 | Polypeptides for treating and/or limiting influenza infection - The present invention provides polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection. | 02-05-2015 |
Patent application number | Description | Published |
20080308435 | MEDIA STORAGE CONTAINER, APPARATUS AND METHOD - A media storage apparatus includes a frame, a shaft, and a plurality of retainers for retaining a plurality of portable planar storage media. The plurality of retainers is supported by the shaft and rotatable about the shaft from a selectable position to a selected position. The apparatus further includes a retainer selection mechanism, coupled to the frame, that traverses the frame to cause selected ones of the plurality of retainers traversed by the retainer selection mechanism to rotate in sequence from the selectable position to the selected position. | 12-18-2008 |
20090120898 | Water Bottle Cap With Integrated Indicator - A water bottle cap with an integrated indicator is disclosed. A combination bottle cap and indicator includes a threaded base adapted to engage the neck of a bottle and a fluid aperture within the threaded base. The combination bottle cap and indicator includes a top hingably mounted to the threaded base for sealing the fluid aperture while overlying the threaded base and for permitting access to the fluid aperture while rotated away from the threaded base. The combination bottle cap and indicator also includes multiple indicia and a rotatable bezel mounted to the top for positionally indicating one of the multiple indicia. | 05-14-2009 |
20090123901 | Magnetically Mounted Motivation Device With Integrated Indicator - A magnetically mounted motivation device with an integrated indicator is disclosed. A generally circular planar case includes a partially flexible upper surface and a lower surface that includes an acoustically transparent area. An audio storage element mounted within the generally circular planar case stores multiple spoken motivational messages. An audio output device coupled to the audio storage element is mounted within the generally circular planar case overlying the acoustically transparent area. If a switch mounted within the generally circular planar case and underlying the partially flexible upper surface is activated, the audio output device outputs one or more spoken motivational messages. A magnetic base mounted to an outer portion of the lower surface of the case surrounds the acoustically transparent area such that audio output is not impeded. A rotatable bezel mounted to the case includes multiple indicia that are indicated by a rotational position of the rotatable bezel. | 05-14-2009 |
20120129658 | Adjustable Exercise Bar - Adjustable-length exercise bars that can be non-destructively mounted between two upright members and resist forces oriented at any angle through the axis defined by the length of the bar. | 05-24-2012 |
20130233141 | APPARATUS AND METHOD FOR CUTTING FOOD ITEMS - An apparatus for cutting food items includes a base having an opening and being configured to support one or more blade inserts in the opening. At least one guide is coupled to the base and is configured to accommodate first and second telescoping members, the first telescoping member being nested within the guide, the second telescoping member being nested within the first telescoping member and the first and second telescoping member being slidably movable in a reciprocating manner along an axis relative to the base. A compression member is coupled to the first telescoping member and movable to a first maximum distance from the top portion of the base. A striking member has a weight sufficient to impart a concussive force on the compression member and is coupled to the second telescoping member and movable to a second maximum distance from the compression member. | 09-12-2013 |
20130233182 | ROTISSERIE OVEN - Rotisserie ovens comprise upper and lower enclosure members forming a cooking chamber therebetween and having a heating assembly therein. The upper member is movable and removably attached to the lower member. The cooking chamber is configured to accommodate a spit assembly that is rotated by an electric motor in the lower member. The lower member includes one or more support members operable to orient the oven in a cooking or a storage position, wherein the height profile of the oven in the storage position is about 50 percent or less then in a cooking position. The upper member is configured for storage placement within the lower member cooking chamber when removed therefrom and inverted, and the spit assembly when disassembled resides within a space between the inverted upper member and lower member to provide a compact low-profile self-contained package for placement and storage within a kitchen drawer or the like. | 09-12-2013 |
20130233185 | FOOD DEHYDRATOR DEVICE - The food dehydrator device is made of a top member, a bottom member, and a plurality of trays disposed there between. Each one of the trays comprise a support, upper and lower skirts disposed about a periphery of the support, and first and second opposing sides. The upper and lower skirts of adjacent support trays cooperate to form an enclosed side wall. First and second sets of posts are disposed along each one of the first and second opposing sides and in first and second arrangements, respectively. Adjacent trays may be actuated between first and second configurations by rotation of adjacent trays 90 degrees relative to one other. In the first configuration the first and second pairs of opposing sides of adjacent trays are aligned and in the second configuration, the first and second pairs of opposing sides of adjacent trays are offset by 90 degrees. | 09-12-2013 |