Patent application number | Description | Published |
20090130117 | Substituted Tetrazole Compounds and Uses Thereof - The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention. | 05-21-2009 |
20100183603 | Compositions and Methods for the Treatment of Cancer - The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II) | 07-22-2010 |
20100239525 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS - The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 09-23-2010 |
20100239526 | SUBSTITUTED IMIDAZOLYL-5,6-DIHYDROBENZO[N]ISOQUINOLINE COMPOUNDS - The present invention relates to substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 09-23-2010 |
20100249120 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS - The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof. | 09-30-2010 |
20100249127 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS - The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof. | 09-30-2010 |
20110160215 | Substituted Triazolo-Pyrazine Compounds - The present invention relates to substituted triazolo-pyrazine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted triazolo-pyrazine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 06-30-2011 |
20110245236 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds - The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof. | 10-06-2011 |
Patent application number | Description | Published |
20080228194 | METHOD AND APPARATUS FOR ENDOSCOPIC ACCESS TO THE VAGUS NERVE - An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described. | 09-18-2008 |
20080228252 | LEAD AND APPARATUS FOR STIMULATION OF THE CARDIAC PLEXUS - A medical electrical lead adapted to stimulate a patient's cardiac plexus includes a flexible distal portion having a surface adapted to conform to an outer surface of an aortic region generally associated with the cardiac plexus. The distal portion can have one or more elongate members. Alternatively, the distal portion can have a generally planar portion. The distal portion is flexible such that it can be furled or otherwise compacted such that it can be delivered to a target stimulation site using a guide catheter or other delivery tool, such as a cannula. | 09-18-2008 |
20080249596 | MYOCARDIAL LEAD WITH FIXATION MECHANISM - The present invention is a myocardial lead attachment system for securing a distal end of a cardiac lead within a myocardium of a patient's heart and anchoring against an epicardium of the patient's heart. The system includes an anchor configured to advance in a first orientation and anchor against an epicardial surface in a second orientation and a tether having a proximal end and a distal end. The anchor is coupled to the distal end of the tether. The system includes a cardiac lead having a lead body, a lumen extending through the lead body, a conductive member, a proximal end, a distal end, and an electrode configured for stimulating the myocardium located at the distal end. The lead body and the lumen are configured such that the lead body can be threaded over the proximal end of the tether and slideably advanced over the tether toward the anchor during implantation. The system includes a fixation mechanism at the distal end of the cardiac lead. The fixation mechanism is adapted to collapse to a first configuration during implantation and deploy to a second configuration after implantation. | 10-09-2008 |
20090036947 | Transvenous Phrenic Nerve Stimulation System - A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve. | 02-05-2009 |
20110060380 | RESPIRATORY RECTIFICATION - A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied. | 03-10-2011 |
20110077726 | MEDICAL LEAD WITH PREFORMED BIAS - A medical electrical lead and methods of implanting medical electrical leads in lumens. Leads in accordance with the invention employ preformed biases to stabilize the lead within a lumen and to orient electrodes in a preferred orientation. | 03-31-2011 |
20110224682 | METHODS OF IMPLANTING ELECTRODE LEADS FOR USE WITH IMPLANTABLE NEUROMUSCULAR ELECTRICAL STIMULATOR - Electrode leads for providing neuromuscular stimulation of the spinal muscles, and methods of implantation of electrode leads, are provided that reduce injury to target muscles, and avoid extended recuperation period, by enabling a clinician to visualize and confirm the implantation site of the electrode leads during an implantation procedure | 09-15-2011 |
20120209284 | Medical Lead and Implantation - A lead for navigating small vessels and a catheter system for implantation of leads into small vessels. Veins that return blood to the heart against the force of gravity often have valves in them to prevent backflow of deoxygenated blood. Leads and catheter systems in accordance with embodiments of the invention allow cannulation and lead implantation in small, tortuous, obstructed, and difficult to access veins enabling a range of stimulation and sensing applications. | 08-16-2012 |
20130158625 | Respiratory Rectification - A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied. | 06-20-2013 |
20140114371 | Muscle and Nerve Stimulation - A lead system for an implantable medical device and applications for the lead system. Also includes therapeutic systems, devices, and processes for detecting and treating disordered breathing and treating cardiac and breathing issues together with an implantable device. | 04-24-2014 |