Patent application number | Description | Published |
20090048280 | Process for the preparation of substituted phenylalanines - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: | 02-19-2009 |
20090062540 | METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS - Methods useful for preparing compounds of formula I: | 03-05-2009 |
20090093496 | PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS - The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer. | 04-09-2009 |
20090099206 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-- YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE - Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3′-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and salts thereof are disclosed. | 04-16-2009 |
20090118505 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: | 05-07-2009 |
20090203925 | SYNTHESIS OF HIMBACINE ANALOGS - The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. | 08-13-2009 |
20090298901 | (E)-1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE OXIME DIHYDRATE AND METHODS OF ITS USE - (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-ethanone oxime dihydrate, compositions comprising it, and methods of its use are disclosed. | 12-03-2009 |
20090318705 | METHODS OF PREPARING IMIDAZOLE-BASED BICYCLIC COMPOUNDS - Methods of preparing compounds of formula I are disclosed: | 12-24-2009 |
20100036125 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS - The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl- | 02-11-2010 |
20100240906 | 1-PHENYL-1H-PYRAZOLE-BASED COMPOUNDS - Methods useful for preparing compounds of formula I: | 09-23-2010 |
20100249411 | Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines - In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: | 09-30-2010 |
20100280054 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE - Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: | 11-04-2010 |
20110098482 | METHODS OF PREPARING 1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE - Methods of preparing 1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone and derivatives thereof are disclosed. | 04-28-2011 |
20110124865 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds are disclosed. | 05-26-2011 |
20110130564 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: | 06-02-2011 |
20110301349 | METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS - Methods useful for preparing compounds of formula I: | 12-08-2011 |
20120157484 | TRYPTOPHAN HYDROXYLASE INHIBITORS - Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: | 06-21-2012 |
20130109865 | METHODS OF PREPARING 1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE | 05-02-2013 |