Patent application number | Description | Published |
20090047265 | COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF TREATING CANCER USING COMPOSITIONS THEREOF - The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer. | 02-19-2009 |
20090263369 | Compositions of Prokaryotic Phenylalanine Ammonia-Lyase and Methods of Treating Cancer Using Compositions Thereof - The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer. | 10-22-2009 |
20100278802 | COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF TREATING CANCER USING COMPOSITIONS THEREOF - The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer. | 11-04-2010 |
20100297021 | Variants of C-Type Natriuretic Peptide - The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis). | 11-25-2010 |
20120316114 | Variants of C-type Natriuretic Peptide - The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis). | 12-13-2012 |
20130039898 | COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF - Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer. | 02-14-2013 |
20140161788 | Targeted Therapeutic Lysosomal Enzyme Fusion Proteins and Uses Thereof - The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. | 06-12-2014 |
Patent application number | Description | Published |
20160031963 | Targeted Therapeutic Lysosomal Enzyme Fusion Proteins and Uses Thereof - The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. | 02-04-2016 |
20160031964 | Targeted Therapeutic Lysosomal Enzyme Fusion Proteins and Uses Thereof - The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. | 02-04-2016 |
20160031965 | Targeted Therapeutic Lysosomal Enzyme Fusion Proteins and Uses Thereof - The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. | 02-04-2016 |
Patent application number | Description | Published |
20100283453 | Methods for Calibrating an Electric Meter - An energy measurement by an electric meter is determined by a method, comprising the steps of: determining a normalization constant (K) representative of a unit of measured energy for each pulse generated by said electric meter; receiving a pulse by said electric meter; and generating an energy measurement by applying said normalization constant to said received pulse. | 11-11-2010 |
20100286935 | Methods for Extrapolating an Energy Measurement - A method for generating an energy pulse representative of a unit of consumed energy is disclosed, comprising the steps of: receiving a first energy measurement; receiving a second energy measurement; and if the second energy is greater than or equal to an energy threshold, generating an energy measurement pulse as a function of said first energy measurement, said second energy measurement, and said energy threshold. | 11-11-2010 |
20140327369 | THREE-LEVEL LED BULB MICROPROCESSOR-BASED DRIVER - An LED bulb is described, comprising LEDs within a shell and a driver circuit to operate the LEDs at a plurality of brightness levels. The driver circuit comprises first and second inputs to receive AC, a neutral input, a converter circuit, first and second rectifier circuits, a detector circuit, and a processing circuit. The first rectifier circuit is connected to the first and neutral inputs and rectifies the AC received. The second rectifier circuit is connected to the second and neutral inputs and rectifies the AC received. The detector circuit is connected to the first and second rectifier circuits. The processing circuit has a first and a second processor input, and is connected to the detector circuit. The processing circuit produces a chop signal with a duty cycle based on whether the first or second input is hot. The converter circuit powers the LEDs based on the chop signal. | 11-06-2014 |
20150077005 | THREE-LEVEL LED BULB MICROPROCESSOR-BASED DRIVER - An LED bulb is described, comprising LEDs within a shell and a driver circuit to operate the LEDs at a plurality of brightness levels. The driver circuit comprises first and second inputs to receive AC, a neutral input, a converter circuit, first and second rectifier circuits, a detector circuit, and a processing circuit. The first rectifier circuit is connected to the first and neutral inputs and rectifies the AC received. The second rectifier circuit is connected to the second and neutral inputs and rectifies the AC received. The detector circuit is connected to the first and second rectifier circuits. The processing circuit has a first and a second processor input, and is connected to the detector circuit. The processing circuit produces a chop signal with a duty cycle based on whether the first or second input is hot. The converter circuit powers the LEDs based on the chop signal. | 03-19-2015 |