Weir, GB
Alexander Weir, Edinburgh GB
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20100085964 | COMMUNICATIONS SYSTEM AND METHOD - A method for transmitting data using data packets includes dividing a data portion of the data packet into two or more data segments, each having a corresponding check portion. The data packet may also be communicated over two or more logical communication channels. The order of data portions in one communication channel may differ from the order of data portions in a second communication channel. Identical or different check portions may be assigned to respective data portions. | 04-08-2010 |
20100226412 | WIRELESS DEVICE AND METHOD - A wireless device performs background scanning of one or more radio channels in a wireless network by sending a signal to one or more other devices connected to the wireless network that the device is entering a pre-defined hibernation mode. The background scanning is then performed whilst the other devices on the network consider the device to be in hibernation mode. | 09-09-2010 |
Andrew Neil Charles Weir, Reading GB
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20080269465 | BIOLOGICAL PRODUCTS - There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα. | 10-30-2008 |
Charles Weir, Carlisle GB
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20110161363 | ORGANIZING POINTERS TO OBJECTS - The invention may be a method and apparatus of organizing pointers. The pointers may identify addresses where objects are stored. The pointers may be stored in arrays so that at least two key entries are required from an input device for determining a byte and comparing the byte with bytes representing elements of objects in a database. The invention may be embodied as a machine designed to carry out the method, or as a memory device that is capable of causing a computer to carry out the method. | 06-30-2011 |
Christopher John William Weir, Solihull GB
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20120210716 | Pumping Arrangement - An aircraft fuel pumping arrangement comprises a first fuel pump, an electrically powered motor operable to drive the first fuel pump to deliver fuel to an outlet, a second fuel pump, a gas driven turbine operable to drive the second fuel pump to deliver fuel to the outlet, and a controller operable to control the operation of the gas driven turbine to determine the rate at which the second fuel pump is driven. | 08-23-2012 |
Iain S. Weir, Axebridge GB
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20110004454 | STATISTICAL METHOD FOR ANALYZING THE PERFORMANCE OF OILFIELD EQUIPMENT - A statistical methodology is disclosed to provide time-to-event estimates for oilfield equipment. A method according to the present invention extracts unbiased information from equipment performance data and considers parameters interactions without recourse to data thinning. The analysis explicitly accounts for items of equipment that are still operational at the time of analysis. A method according to the present invention may also be utilized to apply survival analysis to any oilfield equipment components where time-to-event information has been recorded. The method of the present invention allows comparative reckoning between different components present in the system comprising several or many individual components and allows analysis of these components either individually or simultaneously, i.e., in the presence of other components. | 01-06-2011 |
Malcolm Peter Weir, Welwyn Garden City GB
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20110027910 | SCREENING - A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular conformation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed. | 02-03-2011 |
20110046351 | MUTANT PROTEINS AND METHODS FOR SELECTING THEM - A method for selecting a membrane protein with increased stability, the method comprising: a) providing one or more mutants of a parent membrane protein in a membrane-containing composition, wherein the one or more mutants are exposed to an amount of a membrane destabilising agent which is effective to destabilise the parent membrane protein in-situ, b) determining whether the or each mutant membrane protein has increased stability with respect to its structure and/or a biological activity compared to the stability of the parent membrane protein with respect to its structure and/or the same biological activity, and c) selecting the one or more mutants which have increased stability compared to the stability of the parent membrane protein. | 02-24-2011 |
20140316116 | METHODS FOR SCREENING FOR BINDING PARTNERS OF G-PROTEIN COUPLED RECEPTORS - A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed. | 10-23-2014 |
Malcolm Peter Weir, London GB
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20100190188 | MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM - A method for selecting a G-protein coupled receptor (GPCR) with increased stability, the method comprising (a) providing one or more mutants of a parent GPCR, (b) selecting a ligand, the ligand being one which hinds to the parent GPCR when the GPCR is residing in a particular conformation, (c) determining whether the or each mutant GPCR has increased stability with respect to binding the selected ligand compared to the stability of the parent GPCR with respect to binding that ligand, and (d) selecting those mutants that have an increased stability compared to the parent GPCR with respect to binding the selected ligand. Mutants of β-adrenergic receptor, adenosine receptor and neurotensin receptor are also disclosed. | 07-29-2010 |
20120270230 | MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM - The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same. | 10-25-2012 |
Malcolm Peter Weir, Hertfordshire GB
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20130224238 | GPCR AS VACCINES OR FOR REMOVING/INHIBITING AUTOANTIBODIES, TOXINS OR LIGANDS BINDING TO THE GPCR - There is provided a G protein coupled receptor (GPCR) or a polynucleotide encoding said GPCR for use as a vaccine. There is also provided methods of antagonising or agonising A GPCR in vivo comprising the administration of a GPCR or a polynucleotide encoding a GPCR to a subject. The invention further provides a GPCR for use in inhibiting an activity of a GPCR binding partner in a subject. | 08-29-2013 |
Rebecca Weir, Oxford GB
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20140031663 | Health Monitoring - An electrode assembly for making electrocardiogram measurements includes a substrate and at least two electrodes. The substrate includes at least one electronic item sealed therewithin and is laminated or otherwise constructed so as to facilitate removal of the electronic item from the substrate prior to disposal. The electronic item may therefore be re-used in the manufacture of new electrode assemblies. | 01-30-2014 |
20140058280 | Health Monitoring - Health monitoring devices allow for monitoring of the vital signs of a subject. Wireless devices can enable a subject's cardiac and/or respiratory functions to be monitored remotely, e.g. without the subject being attached to bedside equipment. A cardiac monitoring device may include a substrate, electrodes for measuring ECG signals, and an electronics module including a data processor and a wireless transmitter. The electronics module is sealed within the substrate and arranged to receive the measured ECG signals. Each ECG signal associated with a heartbeat is processed in the data processor to provide key data relating to that heartbeat. The key data may include the temporal position of a characteristic feature in the ECG signal. The key data is provided to the wireless transmitter for transmission. | 02-27-2014 |
Ross John Weir, Leicestershire GB
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20090280968 | Abdominal muscle training device - A training device ( | 11-12-2009 |
20100269240 | TRAINING GARMENT - A training garment ( | 10-28-2010 |
Ross William Weir, Cambridge GB
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20130304081 | OBSTETRIC VACUUM EXTRACTOR - An obstetric vacuum extractor ( | 11-14-2013 |