Patent application number | Description | Published |
20100267136 | FABRICATION OF VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS - Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. | 10-21-2010 |
20110024346 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 02-03-2011 |
20110056882 | MICROMACHINED BILAYER UNIT OF ENGINEERED TISSUES - Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided. | 03-10-2011 |
20120118811 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 05-17-2012 |
20140234953 | FABRICATION OF VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS - Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. | 08-21-2014 |
Patent application number | Description | Published |
20100098742 | FABRICATION OF TISSUE LAMINA USING MICROFABRICATED TWO-DIMENSIONAL MOLDS - Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. | 04-22-2010 |
20110256619 | MICROFABRICATED COMPOSITIONS AND PROCESSES FOR ENGINEERING TISSUES CONTAINING MULTIPLE CELL TYPES - The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type. | 10-20-2011 |
Patent application number | Description | Published |
20080306884 | AUTOMATED MAILPIECE PROCESSING - System and method for the addressing of mail pieces by a variable printing system. Information allowing a mail piece to be associated with a mailing list of address information is printed on the mail piece prior to processing of the piece by a variable printing system. As the piece is processed by the variable printing system, the information printed on the piece is read and used to identify a mailing list from among a plurality of available mailing lists. Address information for that mail piece is obtained from the identified mailing list and printed on the mail piece by the variable printing system. | 12-11-2008 |
20090219575 | PREPARATION OF AGGREGATE JOBS FOR PRODUCTION - System and method for automated scheduling and creation of gang shells specifying gangs of individual jobs for production to be created and produced in the future. Individual jobs and related production parameters and order information are retained electronically in a database of pending jobs awaiting production. Based on production capacity at the production facility and the production parameters of the individual pending jobs in the database, a plurality of gang shells having defined production parameters, but not having specific individual jobs associated therewith, are defined and used for scheduling equipment and personnel at the production facility during a work shift or other desired period of time. The specific individual jobs for a gang are selected from the database relatively shortly prior to the gang's scheduled production time. | 09-03-2009 |
20100274610 | ORDER AGGREGATION SYSTEM AND METHOD - A computerized system, method, and computer-readable medium implementing a method for aggregating orders for items to be filled is presented. Given a plurality of received orders, a plurality of individual orders that are aggregatable based on one or more predetermined aggregation criteria are identified and aggregated into an aggregate order. Items combined in the aggregate order may be grouped into one or more fulfillment groups independently of the individual orders from which the items originated and comprising items from the aggregate order to be simultaneously filled. | 10-28-2010 |
20140316558 | AUTOMATED MAILPIECE PROCESSING - System and method for the addressing of mail pieces by a variable printing system. Information allowing a mail piece to be associated with a mailing list of address information is printed on the mail piece prior to processing of the piece by a variable printing system. As the piece is processed by the variable printing system, the information printed on the piece is read and used to identify a mailing list from among a plurality of available mailing lists. Address information for that mail piece is obtained from the identified mailing list and printed on the mail piece by the variable printing system. | 10-23-2014 |
Patent application number | Description | Published |
20090153482 | COMPUTER INPUT DEVICE WITH INERTIAL INSTRUMENTS - A computer input device includes, in one embodiment, at least two accelerometers, at least two gyroscopes, and a processor within a housing. Signals from the accelerometers and the gyroscopes are utilized to determine the relative motion of the computer input device. | 06-18-2009 |
20090317233 | ROTARY NANOTUBE BEARING STRUCTURE AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, a rotary device includes a multiwall nanotube that extends substantially perpendicularly from a substrate. A rotor may be coupled to an outer wall of the multiwall nanotube, be spaced apart from the substrate, and be free to rotate around an elongate axis of the multiwall nanotube. | 12-24-2009 |
20090320606 | ACCESSIBLE STRESS-BASED ELECTROSTATIC MONITORING OF CHEMICAL REACTIONS AND BINDING - A sensor may include a substrate that has a cavity formed in a surface thereof. A diaphragm, having a conductive portion, may be suspended over the cavity, a selective coating may be present on a face of the diaphragm outside of the cavity, and a counterelectrode may be spaced from and in opposition to the diaphragm. The diaphragm may deform upon interaction of the selective coating with an analyte and thereby alter a capacitance of the sensor in a manner indicative of a degree of interaction. | 12-31-2009 |
20100005884 | High Performance Sensors and Methods for Forming the Same - A sensor includes a proof mass suspended by a suspension beam, the suspension beam having a thickness less than a thickness of the proof mass. | 01-14-2010 |
20110260800 | DEVICES, SYSTEMS, AND METHODS FOR CONTROLLING THE TEMPERATURE OF RESONANT ELEMENTS - A thermoelectric device transfers heat away from or toward an object using the Peltier effect. In some embodiments, the length of at least one thermoelectric element is at least ten times greater than a combined average cross-sectional dimension, orthogonal to the length, of two thermoelectric elements. | 10-27-2011 |
20120150294 | Multi-axis Tilt Estimation and Fall Remediation - Among other things, a vestibular prosthesis includes a wearable motion sensing system, the motion sensing system generating a motion signal indicative of a motion thereof, wherein the motion includes rotation about two distinct axes; a signal processor in communication with the motion sensing system, the signal processor being configured to generate an estimate of a tilt of the motion sensing system; and an actuator responsive to the estimate of the tilt made by the signal processor. | 06-14-2012 |
20120299662 | DEVICES, SYSTEMS, AND METHODS FOR CONTROLLING THE TEMPERATURE OF RESONANT ELEMENTS - A thermoelectric device transfers heat away from or toward an object using the Peltier effect. In some embodiments, the length of at least one thermoelectric element is at least ten times greater than a combined average cross-sectional dimension, orthogonal to the length, of two thermoelectric elements. | 11-29-2012 |
20130098866 | ROTARY NANOTUBE BEARING STRUCTURE AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, a rotary device includes a multiwall nanotube that extends substantially perpendicularly from a substrate. A rotor may be coupled to an outer wall of the multiwall nanotube, be spaced apart from the substrate, and be free to rotate around an elongate axis of the multiwall nanotube. | 04-25-2013 |
20150054589 | RADIATION-HARD PRECISION VOLTAGE REFERENCE - According to one aspect, embodiments herein provide a PVR comprising a resonator having an oscillation frequency, the resonator comprising at least one proof-mass, a mechanical reference, at least one drive plate located adjacent a first side of the at least one proof-mass, and at least one sense plate located adjacent a second side of the at least one proof-mass, a voltage source coupled to the drive and sense plates, a reference oscillator configured to provide a reference signal having a reference frequency to the voltage source; and an output, wherein the voltage source is configured to provide a bias voltage signal to the at least one drive and at least one sense plates of the resonator to drive the oscillation frequency of the resonator to match the reference frequency, and wherein the bias voltage signal is also provided to the output of the PVR as a voltage reference signal. | 02-26-2015 |
Patent application number | Description | Published |
20080299540 | Hormone responsive tissue culture system and uses thereof - The invention provides tissue culture system for primary cells (e.g. normal mammalian primary epithelial progenitors). This system includes: a) a serum-free, chemically defined cell culture media; and, b) methods for isolation and in vitro long-term propagation of primary cells (e.g. primary epithelial cells). Primary cells so isolated and cultured can be kept undifferentiated and proliferate for many weeks (>15 weeks) or population doubling (>35 PD) without senescence, or any detectable genetic alterations. Upon changing media/culture conditions, these cells can be induced to differentiate. | 12-04-2008 |
20110206614 | SYSTEMIC INSTIGATION SYSTEMS TO STUDY TUMOR GROWTH OR METASTASIS - The present invention provides tumor instigation systems that can be used to characterize tumor growth and/or metastasis. In some embodiments, the present invention provides a method for studying tumor outgrowth or metastasis including the steps of: (a) providing an animal host; (b) introducing into the animal host one or more cells that instigate the growth of an otherwise indolent tumor; (c) introducing into the animal host a tumor; wherein the presence of the one or more cells or a progeny thereof in the animal host enhances the growth and/or metastasis of the tumor. Among other things, the inventive methods and systems in accordance with the present invention can be used to identify modulators and/or contributors of tumor growth or metastasis, as well as diagnostic and/or therapeutic agents for use in monitoring and/or modulating tumor growth and/or metastasis. | 08-25-2011 |
20120164074 | METHODS OF DIAGNOSING, PREVENTING AND TREATING CANCER METASTASIS - The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis. | 06-28-2012 |
Patent application number | Description | Published |
20080234216 | TGF-beta type receptor cDNAs encoded products and uses therefor - DNA encoding TGF-β type III receptor of mammalian origin, DNA encoding TGF-β type II receptor of mammalian origin, TGF-β type III receptor, TGF-β type II receptor and uses therefor. | 09-25-2008 |
20090214483 | Progenitor Cells and Uses Thereof - Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities. | 08-27-2009 |
20100260827 | Methods of diagnosing, preventing and treating cancer metastasis - The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis. | 10-14-2010 |
20110244502 | HORMONE RESPONSIVE TISSUE CULTURE SYSTEM AND USES THEREOF - The invention provides tissue culture system for primary cells (e.g. normal mammalian primary epithelial progenitors). This system includes: a) a serum-free, chemically defined cell culture media; and, b) methods for isolation and in vitro long-term propagation of primary cells (e.g. primary epithelial cells). Primary cells so isolated and cultured can be kept undifferentiated and proliferate for many weeks (>15 weeks) or population doubling (>35 PD) without senescence, or any detectable genetic alterations. Upon changing media/culture conditions, these cells can be induced to differentiate. | 10-06-2011 |
20120041048 | COMPOSITIONS AND METHODS RELATING TO miR-31 - MicroRNA-31 (miR-31), targets of miR-31, the role of miR-31 in inhibiting tumor metastasis, and the role of miR-31 target genes in promoting tumor metastasis are disclosed. | 02-16-2012 |
20120258084 | PROGENITOR CELLS AND USES THEREOF - Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities. | 10-11-2012 |
20130055417 | HORMONE RESPONSIVE TISSUE CULTURE SYSTEM AND USES THEREOF - The invention provides tissue culture system for primary cells (e.g. normal mammalian primary epithelial progenitors). This system includes: a) a serum-free, chemically defined cell culture media; and, b) methods for isolation and in vitro long-term propagation of primary cells (e.g. primary epithelial cells). Primary cells so isolated and cultured can be kept undifferentiated and proliferate for many weeks (>15 weeks) or population doubling (>35 PD) without senescence, or any detectable genetic alterations. Upon changing media/culture conditions, these cells can be induced to differentiate. | 02-28-2013 |
20140294729 | METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS - The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. | 10-02-2014 |
20140343121 | COMPOSITIONS AND METHODS RELATING TO miR-31 - MicroRNA-31 (miR-31), targets of miR-31, the role of miR-31 in inhibiting tumor metastasis, and the role of miR-31 target genes in promoting tumor metastasis are disclosed. | 11-20-2014 |
20150017134 | EMT-INDUCING TRANSCRIPTION FACTORS COOPERATE WITH SOX9 - In some aspects, compositions and methods useful for generating stem cells from epithelial cells are disclosed. | 01-15-2015 |