Patent application number | Description | Published |
20110280209 | COMPRESSION OF BASEBAND SIGNALS IN BASE TRANSCEIVER SYSTEMS - A signal compression method and apparatus for a base transceiver system (BTS) in a wireless communication network provides efficient transfer of compressed signal samples over serial data links in the system. For the uplink, an RF unit of the BTS compresses baseband signal samples resulting from analog to digital conversion of a received analog signal followed by digital downconversion. The compressed signal samples are transferred over the serial data link to the baseband processor then decompressed prior to normal signal processing. For the downlink, the baseband processor compresses baseband signal samples and transfers the compressed signal samples to the RF unit. The RF unit decompresses the compressed samples prior to digital upconversion and digital to analog conversion to form an analog signal for transmission over an antenna. Compression and decompression can be incorporated into operations of conventional base stations and distributed antenna systems, including OBSAI or CPRI compliant systems. | 11-17-2011 |
20120008696 | COMPRESSION OF BASEBAND SIGNALS IN BASE TRANSCEIVER SYSTEM PROCESSORS - A signal compression method and apparatus for a base transceiver system (BTS) in a wireless communication network provides efficient transfer of compressed signal samples over serial data links in the system. For the uplink, an RF unit of the BTS compresses baseband signal samples resulting from analog to digital conversion of a received analog signal followed by digital downconversion. The compressed signal samples are transferred over the serial data link to the baseband processor then decompressed prior to normal signal processing. For the downlink, the baseband processor compresses baseband signal samples and transfers the compressed signal samples to the RF unit. The RF unit decompresses the compressed samples prior to digital upconversion and digital to analog conversion to form an analog signal for transmission over an antenna. Compression and decompression can be incorporated into operations of conventional base stations and distributed antenna systems, including OBSAI or CPRI compliant systems. | 01-12-2012 |
20120014421 | COMPRESSION OF BASEBAND SIGNALS IN BASE TRANSCEIVER SYSTEM INTERFACES - A signal compression method and apparatus for a base transceiver system (BTS) in a wireless communication network provides efficient transfer of compressed signal samples over serial data links in the system. For the uplink, an RF unit of the BTS compresses baseband signal samples resulting from analog to digital conversion of a received analog signal followed by digital downconversion. The compressed signal samples are transferred over the serial data link to the baseband processor then decompressed prior to normal signal processing. For the downlink, the baseband processor compresses baseband signal samples and transfers the compressed signal samples to the RF unit. The RF unit decompresses the compressed samples prior to digital upconversion and digital to analog conversion to form an analog signal for transmission over an antenna. Compression and decompression can be incorporated into operations of conventional base stations and distributed antenna systems, including OBSAI or CPRI compliant systems. | 01-19-2012 |
20120014422 | COMPRESSION OF BASEBAND SIGNALS IN BASE TRANSCEIVER SYSTEM RADIO UNITS - A signal compression method and apparatus for a base transceiver system (BTS) in a wireless communication network provides efficient transfer of compressed signal samples over serial data links in the system. For the uplink, an RF unit of the BTS compresses baseband signal samples resulting from analog to digital conversion of a received analog signal followed by digital downconversion. The compressed signal samples are transferred over the serial data link to the baseband processor then decompressed prior to normal signal processing. For the downlink, the baseband processor compresses baseband signal samples and transfers the compressed signal samples to the RF unit. The RF unit decompresses the compressed samples prior to digital upconversion and digital to analog conversion to form an analog signal for transmission over an antenna. Compression and decompression can be incorporated into operations of conventional base stations and distributed antenna systems, including OBSAI or CPRI compliant systems. | 01-19-2012 |
20130007076 | COMPUTATIONALLY EFFICIENT COMPRESSION OF FLOATING-POINT DATA - Compression of floating-point numbers is realized by comparing the exponents of the floating-point numbers to one or more exponent thresholds to classify the floating-point numbers and to apply different compression types to the different classes. Each class and compression type is associated with an indicator. An indicator array contains M indicators for M floating-point numbers. The position of the indicator in the indicator array corresponds to one of the floating-point numbers and the indicator value specifies the class and compression type. The floating-point number is encoded in accordance with the compression type for its class. A compressed data packet contains the indicator array and up to M encoded floating-point numbers. Decompression extracts the indicator array and the encoded floating-point numbers from the compressed data packet and decodes the encoded floating-point numbers in accordance with the compression type associated with the indicator value to form a reconstructed floating-point number. | 01-03-2013 |
20130007077 | COMPRESSION OF FLOATING-POINT DATA - Compression of exponents, mantissas and signs of floating-point numbers is described. Differences between exponents are encoded by exponent tokens selected from a code table. The mantissa is encoded to a mantissa token having a length based on the exponent. The signs are encoded directly or are compressed to produce fewer sign tokens. The exponent tokens, mantissa tokens and sign tokens are packed in a compressed data packet. Decompression decodes the exponent tokens using the code table. The decoded exponent difference is added to a previous reconstructed exponent to produce the reconstructed exponent. The reconstructed exponent is used to determine the length of the mantissa token. The mantissa token is decoded to form the reconstructed mantissa. The sign tokens provide the reconstructed signs or are decompressed to provide the reconstructed signs. The reconstructed sign, reconstructed exponent and reconstructed mantissa are combined to form a reconstructed floating-point number. | 01-03-2013 |
20130007078 | COMPRESSION OF FLOATING-POINT DATA IN ENCODING GROUPS - Exponents, mantissas and signs of floating-point numbers are compressed in encoding groups. Differences between maximum exponents of encoding groups are encoded by exponent tokens selected from a code table. Each mantissa of an encoding group is encoded to a mantissa token having a length based on the maximum exponent. Signs are encoded directly or are compressed to produce sign tokens. Exponent tokens, mantissa tokens and sign tokens are packed in a compressed data packet. For decompression, the exponent tokens are decoded using the code table. The decoded exponent difference is added to a previous reconstructed maximum exponent to produce the reconstructed maximum exponent for the encoding group. The reconstructed maximum exponent is used to determine the length of the mantissa tokens that are decoded to produce the reconstructed mantissas for the encoding group. The reconstructed sign, reconstructed exponent and reconstructed mantissa are combined to form a reconstructed floating-point number. | 01-03-2013 |
20130054661 | BLOCK FLOATING POINT COMPRESSION WITH EXPONENT DIFFERENCE AND MANTISSA CODING - A method and apparatus for compressing signal samples uses block floating point representations where the number of bits per mantissa is determined by the maximum magnitude sample in the group. The compressor defines groups of signal samples having a fixed number of samples per group. The maximum magnitude sample in the group determines an exponent value corresponding to the number of bits for representing the maximum sample value. The exponent values are encoded to form exponent tokens. Exponent differences between consecutive exponent values may be encoded individually or jointly. The samples in the group are mapped to corresponding mantissas, each mantissa having a number of bits based on the exponent value. Removing LSBs depending on the exponent value produces mantissas having fewer bits. Feedback control monitors the compressed bit rate and/or a quality metric. This abstract does not limit the scope of the invention as described in the claims. | 02-28-2013 |
20130060827 | BLOCK FLOATING POINT COMPRESSION WITH EXPONENT TOKEN CODES - A method and apparatus for compressing signal samples uses block floating point representations where the number of bits per mantissa is determined by the maximum magnitude sample in the group. The compressor defines groups of signal samples having a fixed number of samples per group. The maximum magnitude sample in the group determines an exponent value corresponding to the number of bits for representing the maximum sample value. The exponent values are encoded to form exponent tokens. Exponent differences between consecutive exponent values may be encoded individually or jointly. The samples in the group are mapped to corresponding mantissas, each mantissa having a number of bits based on the exponent value. Removing LSBs depending on the exponent value produces mantissas having fewer bits. Feedback control monitors the compressed bit rate and/or a quality metric. This abstract does not limit the scope of the invention as described in the claims. | 03-07-2013 |
20130188065 | RAW FORMAT IMAGE DATA PROCESSING - A raw format image representing an image received from an image capture device at an image data rate, can be compressed at least as fast as the image data rate (i.e. in real time) using compact and low cost components. The compressed image data can then be transferred across a chip-to-chip data channel to a memory system or to a host processor where it can be stored as compressed data. The host processor or other processor can read and decompress the compressed raw data and apply digital signal processing including industry-standard data compression or other image processing algorithms to the recovered raw format image without being constrained to real-time processing. | 07-25-2013 |
20130262538 | DATA COMPRESSION FOR DIRECT MEMORY ACCESS TRANSFERS - Memory system operations are extended for a data processor by DMA, cache, or memory controller to include a DMA descriptor, including a set of operations and parameters for the operations, which provides for data compression and decompression during or in conjunction with processes for moving data between memory elements of the memory system. The set of operations can be configured to use the parameters and perform the operations of the DMA, cache, or memory controller. The DMA, cache, or memory controller can support moves between memory having a first access latency, such as memory integrated on the same chip as a processor core, and memory having a second access latency that is longer than the first access latency, such as memory on a different integrated circuit than the processor core. | 10-03-2013 |
20130262539 | CONVERSION AND COMPRESSION OF FLOATING-POINT AND INTEGER DATA - Compression and decompression of numerical data can apply to floating-point or integer samples. Floating-point samples are converted to integer samples and the integer samples are compressed and encoded to produce compressed data for compressed data packets. For decompression, the compressed data retrieved from compressed data packets are decompressed to produce decompressed integer samples. The decompressed integer samples may be converted to reconstruct floating-point samples. Adaptive architectures can be applied for integer compression and decompression using one or two FIFO buffers and one or two configurable adder/subtractors. Various parameters can adapt the operations of adaptive architectures as appropriate for different data characteristics. The parameters can be encoded for the compressed data packet. This abstract does not limit the scope of the invention as described in the claims. | 10-03-2013 |
20130262809 | PROCESSING SYSTEM AND METHOD INCLUDING DATA COMPRESSION API - Memory system operations are extended for a data processor by an application programming interface API, including a set of operations and parameters for the operations, which provides for data compression and decompression during or in conjunction with processes for moving data between memory elements of the memory system. The set of operations can be configured to use the parameters and perform the operations of the API. The API can support moves between memory having a first access latency, such as memory integrated on the same chip as a processor core, and memory having a second access latency that is longer than the first access latency, such as memory on a different integrated circuit than the processor core. | 10-03-2013 |
20140095561 | ENHANCED MULTI-PROCESSOR WAVEFORM DATA EXCHANGE USING COMPRESSION AND DECOMPRESSION - Configurable compression and decompression of waveform data in a multi-core processing environment improves the efficiency of data transfer between cores and conserves data storage resources. In waveform data processing systems, input, intermediate, and output waveform data are often exchanged between cores and between cores and off-chip memory. At each core, a single configurable compressor and a single configurable decompressor can be configured to compress and to decompress integer or floating-point waveform data. At the memory controller, a configurable compressor compresses integer or floating-point waveform data for transfer to off-chip memory in compressed packets and a configurable decompressor decompresses compressed packets received from the off-chip memory. Compression reduces the memory or storage required to retain waveform data in a semiconductor or magnetic memory. Compression reduces both the latency and the bandwidth required to exchange waveform data. This abstract does not limit the scope of the invention as described in the claims. | 04-03-2014 |
20140101485 | DATA COMPRESSION PROFILER FOR CONFIGURATION OF COMPRESSION - A method and apparatus for determining one or more compression parameters suitable to compress a class of signals, may include inputting a test data set, being representative of a data set to be compressed, characterizing the test data, selecting a compression algorithm, calculating a distortion level to be used in determining the compression ratio (or a compression ratio to be used in determining the distortion level), generating a computer implemented model for the test data, selecting a recommended operating point based on a computer implemented model, and determining compression parameters corresponding to the operating point. The compression parameters may subsequently be applied for configuration of compression applied to one or more production data sets that are similar to the test data. This abstract does not limit the scope of the invention as described in the claims. | 04-10-2014 |
20140208068 | DATA COMPRESSION AND DECOMPRESSION USING SIMD INSTRUCTIONS - Compression and decompression of numerical data utilizing single instruction, multiple data (SIMD) instructions is described. The numerical data includes integer and floating-point samples. Compression supports three encoding modes: lossless, fixed-rate, and fixed-quality. SIMD instructions for compression operations may include attenuation, derivative calculations, bit packing to form compressed packets, header generation for the packets, and packed array output operations. SIMD instructions for decompression may include packed array input operations, header recovery, decoder control, bit unpacking, integration, and amplification. Compression and decompression may be implemented in a microprocessor, digital signal processor, field-programmable gate array, application-specific integrated circuit, system-on-chip, or graphics processor, using SIMD instructions. Compression and decompression of numerical data can reduce memory, networking, and storage bottlenecks. This abstract does not limit the scope of the invention as described in the claims. | 07-24-2014 |
20140208069 | SIMD INSTRUCTIONS FOR DATA COMPRESSION AND DECOMPRESSION - An execution unit configured for compression and decompression of numerical data utilizing single instruction, multiple data (SIMD) instructions is described. The numerical data includes integer and floating-point samples. Compression supports three encoding modes: lossless, fixed-rate, and fixed-quality. SIMD instructions for compression operations may include attenuation, derivative calculations, bit packing to form compressed packets, header generation for the packets, and packed array output operations. SIMD instructions for decompression may include packed array input operations, header recovery, decoder control, bit unpacking, integration, and amplification. Compression and decompression may be implemented in a microprocessor, digital signal processor, field-programmable gate array, application-specific integrated circuit, system-on-chip, or graphics processor, using SIMD instructions. Compression and decompression of numerical data can reduce memory, networking, and storage bottlenecks. This abstract does not limit the scope of the invention as described in the claims. | 07-24-2014 |
20140219361 | IMAGE DATA ENCODING FOR ACCESS BY RASTER AND BY MACROBLOCK - Access encoding/decoding of image data has at least two preferred access modes, raster access and macroblock access. Arriving rasters containing pixels from an image sensor are converted to encoded macroblocks to support later random macroblock and raster access. Encoded macroblocks can be randomly accessed (read from or written to memory) by block-based video compression algorithms, such as H.264. Encoded macroblocks can also be decoded raster by raster for raster-oriented display devices. Access encoding/decoding may be implemented in a microprocessor, graphics processor, digital signal processor, FPGA, ASIC, or SoC. Access encoding/decoding of image data or reference frames can reduce memory and storage bottlenecks, processor access time, and processor and memory power consumption. A user interface can allow users to control the tradeoff between decoded video quality and battery life for a mobile device. This abstract does not limit the scope of the invention as described in the claims. | 08-07-2014 |
20140355665 | Adaptive Video Reference Frame Compression with Control Elements - An access encoder reduces power consumption during video playback and recording by reducing the bandwidth between a processor and a memory. A graphical user interface allows user selection, or software control, over the tradeoff between battery life and video quality. Battery life can be increased (decreased) by activating the access encoder. The access encoder may be implemented in a microprocessor, graphics processor, digital signal processor, FPGA, ASIC, or SoC. The access encoder's encoding/decoding can reduce memory and storage bottlenecks, processor access time, and processor and memory power consumption. A user interface allows users to adjust the tradeoff between decoded video quality and battery life for a mobile device. This abstract does not limit the scope of the invention as described in the claims. | 12-04-2014 |
20140355683 | Data Encoding for Attenuating Image Encoders - A hybrid access encoder includes one or more improvements to attenuation-based image and video encoders using images. The hybrid access encoder supports tradeoffs between encoded bit rate and decoded image and video quality. The hybrid access encoder monitors multiple redundancy removal filters and selects the best-performing filter for encoding. The hybrid access encoder operates in a mode that specifies a target decoded image quality and a target encoded bit rate, giving preference to one metric (image quality or bit rate) when both target values cannot be achieved. The hybrid access encoder performs a plurality of passes across each image and can optimize one or more parameters of the encoder settings between passes. A user interface allows users to control the tradeoff between decoded video quality and battery life for a mobile device. | 12-04-2014 |
Patent application number | Description | Published |
20090026720 | FRAME ASSEMBLY FOR IN-LINE SKATE - An in-line skate frame assembly has a rigid frame and an elongate grinding insert releasably engaged with the frame. The frame and insert are secured together to the sole of a shoe or boot by frame bolts extending through upper portions of the frame and insert. The frame has spaced side walls with downwardly facing recessed regions in which the insert is mounted. The insert extends along a major portion of the length of the frame and has a downwardly facing, centrally located grinding surface which terminates short of the opposite ends of the insert. Different inserts with grinding surfaces of different shapes and lengths are releasably secured to the frame for performing alternative grinding maneuvers. | 01-29-2009 |
20120228845 | SCOOTER ASSEMBLIES AND SCOOTER DECK ASSEMBLIES - A deck assembly for a scooter comprises a deck having a top surface, a bottom surface, and two side surfaces, and a grind plate having a front end, a rear end, a mating surface, and a grinding surface. The grind plate may be slidably attachable to the deck such that the mating surface of the grind plate mates with the bottom surface of the deck, and the bottom surface of the deck and at least a portion of each side surface of the deck are covered by the grind plate. A scooter assembly may further comprise a neck, a handlebar assembly, and steer tube extending through a down tube. The steer tube may be a butted tube member having a first wall thickness near a bottom portion of the butted tube member and a second wall thickness near a top portion of the butted tube member, the first wall thickness being greater than the second wall thickness. The steer tube may define a linear slot at or near the bottom portion of the steer tube and a key adapted to fit into the linear slot. | 09-13-2012 |
20120286006 | SCOOTER CARRYING CASE AND BACKPACK APPARATUS - A backpack apparatus comprises a backpack body, a holder panel assembly, and a closure device. The backpack body has a top portion, a bottom portion, a front portion, a back portion, a first side portion, and a second side portion and defines a main storage compartment. The holder panel assembly has a top edge, a bottom edge, a first side edge, and a second side edge. The holder panel assembly includes a first side wall and a second side wall. The bottom edge of the holder panel assembly is fixedly attached to the backpack body, and the top edge of the holder panel is unattached to the backpack body. The first side wall of the holder panel is fixedly attached to the backpack body, and the second side wall of the holder panel is fixedly attached to the backpack body. | 11-15-2012 |
20120286011 | SCOOTER CARRYING CASE AND BACKPACK APPARATUS - A backpack apparatus comprises a backpack body, a holder panel assembly, and a closure device. The backpack body has a top portion, a bottom portion, a front portion, a back portion, a first side portion, and a second side portion and defines a main storage compartment. The holder panel assembly has a top edge, a bottom edge, a first side edge, and a second side edge. The holder panel assembly includes at least one zipper assembly, a first side wall extending from a portion of the first side edge, and a second side wall extending from a portion of the second side edge. The bottom edge of the holder panel assembly is fixedly attached to the backpack body, and the top edge of the holder panel is unattached to the backpack body. The first side wall of the holder panel is fixedly attached to the backpack body, and the second side wall of the holder panel is fixedly attached to the backpack body. A closure device may be attached to the first side portion of the backpack body. | 11-15-2012 |
Patent application number | Description | Published |
20090018324 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR - Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others. | 01-15-2009 |
20090233302 | LABELED REACTANTS AND THEIR USES - Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated. | 09-17-2009 |
20100152424 | Modular Nucleotide Compositions and Uses Therefor - Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses. | 06-17-2010 |
20100323912 | REAL-TIME ANALYTICAL METHODS AND SYSTEMS - The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions. | 12-23-2010 |
20110059450 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR - Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others. | 03-10-2011 |
20110183320 | CLASSIFICATION OF NUCLEIC ACID TEMPLATES - Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. | 07-28-2011 |
20110311964 | LABELED REACTANTS AND THEIR USES - Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated. | 12-22-2011 |
20120058473 | Molecular Adaptors for Dye Conjugates - In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. | 03-08-2012 |
20120302459 | Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same - Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate. | 11-29-2012 |
20130022968 | MODULAR NUCLEOTIDE COMPOSITIONS AND USES THEREFOR - Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types, through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses. | 01-24-2013 |
20130183663 | LABELED REACTANTS AND THEIR USES - Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated. | 07-18-2013 |
20130240359 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 09-19-2013 |
20140186825 | LABELED NUCLEOTIDE ANALOGS - Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated. | 07-03-2014 |
20140309144 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 10-16-2014 |
20140315756 | Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same - Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate. | 10-23-2014 |
20140364324 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 12-11-2014 |
20150362503 | REAL-TIME ANALYTICAL METHODS AND SYSTEMS - The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions. | 12-17-2015 |