Patent application number | Description | Published |
20100290994 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 11-18-2010 |
20100305151 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 12-02-2010 |
20110086043 | STAT5a AND ITS FUNCTIONAL TUMOR SUPPRESSOR ANALOGS FOR TREATMENT OF MALIGNANCIES EXPRESSING NPM/ALK AND OTHER ONCOGENIC KINASES - The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein. | 04-14-2011 |
20110104304 | O-Methylated Rapamycin Derivatives For Alleviation And Inhibition Of Lymphoproliferative Disorders - The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal. | 05-05-2011 |
Patent application number | Description | Published |
20120303721 | HYBRID REQUEST/RESPONSE AND POLLING MESSAGING MODEL - A hybrid messaging model including a method that sends a first request message from a control process executing on a computer to a plurality of subordinate processes. The first request message directs the subordinate processes to enter a first state. An expected state is set equal to the first state in response to sending the first request message. A status message, including the expected state, is periodically broadcast from the control process to the plurality of subordinate processes. At least one confirmation message is received from each of the subordinate processes confirming that the subordinate process is in the expected state. Each of the confirmation messages is responsive to either the first request message or to the status message. A second request message is sent from the control process to the plurality of subordinate processes in response to receiving at least one confirmation message from each of the subordinate processes. | 11-29-2012 |
20120303913 | TRANSPARENT FILE SYSTEM MIGRATION TO A NEW PHYSICAL LOCATION - Transparent file system migration including a method that identifies a source physical storage location in a file system that supports simultaneous access by multiple independent processes. A target physical storage location in the file system is identified and its contents are migrated to the target physical storage location. The migrating includes disallowing new allocations to the source physical storage location and copying contents from the source physical storage location to the target physical storage location. A write request to write data to the source physical storage location is received prior to or during the migrating. The write request is serviced contemporaneously with the migrating. Read and write requests directed to the source physical storage location are redirected to the target physical storage location. The redirecting is responsive to the migrating completing. The requests are from the multiple independent processes and include both logical and physical input/outputs. | 11-29-2012 |
20140095508 | EFFICIENT SELECTION OF QUERIES MATCHING A RECORD USING A CACHE - A method is provided for constructing a cache for storing results of previously evaluated queries in a binary tree based on a cache key. The cache is searched, by a processing device, for a node representing a set of previously evaluated queries that match a given record using an instance of the cache key. In response to finding a representative node that matches the instance of the cache key, the method performs processing associated with the set of previously evaluated queries. In response to finding no representative nodes, the method creates a new node using the instance of the cache key. The method of the invention then updates the cache by classifying the compatibility of newly registered queries with the cache key and evaluating whether compatible newly registered queries match the record. | 04-03-2014 |
20140095531 | DYNAMIC OUTPUT SELECTION USING HIGHLY OPTIMIZED DATA STRUCTURES - A node container is constructed with multiple binary tree views. A processing device creates a primary view binary tree within the node container based on a primary key. A set of records that match fields of the primary key is chained to the primary view. The processing device also creates one or more alternate views within the node container to allow access to the same set of records via one or more alternate keys, which are subsets of the fields of the primary key. The chain of records is extracted from the node container when matched to a subsequent query search. | 04-03-2014 |
20140101164 | EFFICIENT SELECTION OF QUERIES MATCHING A RECORD USING A CACHE - A method is provided for constructing a cache for storing results of previously evaluated queries in a binary tree based on a cache key. The cache is searched, by a processing device, for a node representing a set of previously evaluated queries that match a given record using an instance of the cache key. In response to finding a representative node that matches the instance of the cache key, the method performs processing associated with the set of previously evaluated queries. In response to finding no representative nodes, the method creates a new node using the instance of the cache key. The method of the invention then updates the cache by classifying the compatibility of newly registered queries with the cache key and evaluating whether compatible newly registered queries match the record. | 04-10-2014 |
20140259021 | JOB SCHEDULING IN A SYSTEM OF MULTI-LEVEL COMPUTERS - Systems, methods, and computer program products for job scheduling are disclosed. An exemplary computer-implemented method includes receiving a job in a job scheduling system. At least part of the job is transmitted to a job reader. An indication of one or more functions required for performing the job is received from the job reader. A first computing device is selected from among a plurality of computing devices, where the selection is based, at least in part, on whether the first computing device supports the functions required for performing the job. | 09-11-2014 |