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| 20080234213 | Oncogenic regulatory RNAs for diagnostics and therapeutics - A method of identifying regulatory RNAs, including miRNAs, using insertional mutagenesis to generate tumors in mice and determining the human orthologs is disclosed. Further, specific miRNA sequences are identified. The causal nature and expression patterns of these regulatory RNAs and miRNAs in human tumors demonstrate their utility in diagnosis and therapy of cancer. Furthermore, a set of co-mutations that act in conjunction with miRNAs in tumor formation is disclosed. | 09-25-2008 |
| 20090123484 | Methods for Diagnosing and Treating Kidney Cancer - Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue. | 05-14-2009 |
| 20090220501 | Anti-CD19 Antibody, Immunotoxin and Treatment Method - Provided is an immunotoxin including (a) an anti-CD19 antibody lacking an Fc fragment, (b) a modified exotoxin A protein having both Domains II and III, but lacking Domain I, and (c) a peptide linker joining the C-terminal end of the antibody to the N-terminal end of the modified exotoxin A protein. The linker is substantially resistant to extracellular cleavage. The modified exotoxin A protein may be further modified to include a C-terminal KDEL sequence (SEQ ID NO: 6) that promotes transport of the protein to the endoplasmic reticulum of cells that have taken up the immunotoxin. Also provided is an anti-CD19 antibody having enhanced binding activity, antibody-dependent cellular cytotoxicity (ADCC) and methods for using the antibody to treat a disease state associated with B-lineage cells that express CD19. The antibody variable light and variable heavy chains have unique sequences in their J region relative to known anti-CD19 antibody sequences. | 09-03-2009 |
| 20090258358 | Methods for Diagnosing and Treating Kidney and Colorectal Cancer - Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or colorectal cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue. | 10-15-2009 |
| 20100041126 | METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER - Devices and methods for diagnosing and treating prostate cancer are disclosed. In practicing the method, a subject's body-fluid sample is assayed for GPC3 protein, and the GPC3 level observed is used in determining whether the subject has an elevated GPC3 level associated with prostate cancer. Patients with such elevated levels may be treated, in accordance with the present disclosure, with a variety of GPC3-related immunotherapy agents. | 02-18-2010 |
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| 20090037442 | Reconfiguring Propagation Streams in Distributed Information Sharing - Splitting and merging database object information sharing streams. Streams are also referred to herein as “propagations”. Splitting and merging information sharing streams can be used to improve performance in a information sharing environment when a failed or slow DBS impacts the performance. In one embodiment, an auto split process monitors the progress of applying changes at each node and detects the presence of a failed or a slow node. Once the failed or slow node is identified, the auto split process splits the propagation such that the offending node is sent through a separate propagation. Furthermore, an auto merge process can be started to monitor the newly created separate propagation. At a later point, the new propagation can be merged back into the original stream. For example, if the offending node catches up with other nodes, the auto merge process merges the newly created propagation back to the original propagation. | 02-05-2009 |
| 20090037553 | Configuring or Reconfiguring a Multi-Master Information Sharing Environment - Configuring an n-way multi-master information sharing topology. Adding a new node (e.g., database server) to the information sharing topology can be implemented as follows. Initially, the new node is added as a slave of a particular co-master in the information sharing topology. The objects to replicate are instantiated on the new node by propagating data from the particular co-master to the new node. Furthermore, a capture process is created on the particular co-master to send changes to the objects to the slave. Meanwhile, the co-masters continue to propagate changes to each other. To promote the slave to a master, changes to objects stored at the slave are propagated to each of the co-masters. Furthermore, changes at each of the masters are propagated to the promoted node. | 02-05-2009 |
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| 20120100867 | Determining Points of Interest of a Mobile User - Methods, systems and apparatus for tracking points of interest of a user of a mobile device are disclosed. One method includes determining points of interest of a user of a mobile device. The method includes obtaining user-related information, wherein the user-related information includes spatial information about the user, and determining at least one point of interest of the user based on the user-related information. Another embodiment includes an apparatus for determining points of interest of a user. For one embodiment, the apparatus is a mobile device. The mobile device is operative to obtain user-related information, wherein the user-related information comprising spatial information about the user, and the mobile device is operative to determine at least one point of interest of the user based on the user-related information. | 04-26-2012 |
| 20120100869 | Location Based User Behavior Analysis and Applications - Methods, systems and apparatuses for generating a user profile of a mobile device user are disclosed. One method includes tracking user stays of the user over time, wherein the user stays include at least one location, and generating the user profile based at least in part on at least one of an arrival time, a time duration or a frequency of visits of the user at each of the user stays. Another method includes determining a current state of a mobile device user. The method includes tracking locations of user stays of the mobile device user over time, and determining a current state of a mobile device user based on user stays within a predetermined time of a present time, wherein the predetermined time is dependent upon an application of the user device or an observed behavior of a user of the user device. | 04-26-2012 |
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| 20090268500 | WORDLINE RESISTANCE REDUCTION METHOD AND STRUCTURE IN AN INTEGRATED CIRCUIT MEMORY DEVICE - Methods and structures for reducing resistance in wordlines of an integrated circuit memory device are disclosed. In one embodiment, the method includes forming multiple columns of polycrystalline silicon for respective number of wordlines, forming core transistor junctions and periphery transistor junctions associated with the wordlines, performing a salicidation process for the periphery transistor junction and performing a salicidation process for the columns of polycrystalline silicon to from the wordlines with low resistance. | 10-29-2009 |
| 20090278173 | MEMORY DEVICE INTERCONNECTS AND METHOD OF MANUFACTURING - An integrated circuit memory device, in one embodiment, includes a substrate having a plurality of bit lines. A first and second inter-level dielectric layer are successively disposed on the substrate. Each of a plurality of source lines and staggered bit line contacts extend through the first inter-level dielectric layer. Each of a plurality of source line vias and a plurality of staggered bit line vias extend through the second inter-level dielectric layer to each respective one of the plurality of source lines and the plurality of staggered bit line contacts. The source lines and staggered bit line contacts that extend through the first inter-level dielectric layer are formed together by a first set of fabrication processes. The source line vias and staggered bit line contacts that extend through the second inter-level dielectric layer are also formed together by a second set of fabrication processes. | 11-12-2009 |
| 20100078815 | Ruthenium interconnect with high aspect ratio and method of fabrication thereof - An electrically conductive interconnect is provided through an opening in a dielectric layer, electrically connecting two conductive layers. In one embodiment, the interconnect is formed by ruthenium entirely filling the opening in the dielectric layer. In another embodiment, an adhesion layer of titanium is provided in the opening prior to providing the ruthenium. In using this approach, an aspect ratio (i.e., the ratio of the length of the interconnect to the width thereof) of 20:1 or greater is achievable. | 04-01-2010 |
| 20110095370 | WORDLINE RESISTANCE REDUCTION METHOD AND STRUCTURE IN AN INTEGRATED CIRCUIT MEMORY DEVICE - Methods and structures for reducing resistance in wordlines of an integrated circuit memory device are disclosed. In one embodiment, the method includes forming multiple columns of polycrystalline silicon for respective number of wordlines, forming core transistor junctions and periphery transistor junctions associated with the wordlines, performing a salicidation process for the periphery transistor junction and performing a salicidation process for the columns of polycrystalline silicon to from the wordlines with low resistance. | 04-28-2011 |
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| 20110097628 | NUCLEATION AND GROWTH OF TIN PARTICLES INTO THREE DIMENSIONAL COMPOSITE ACTIVE ANODE FOR LITHIUM HIGH CAPACITY ENERGY STORAGE DEVICE - Embodiments of the present invention generally relate to lithium-ion batteries, and more specifically, to a system and method for fabricating such batteries using thin-film processes that form three-dimensional structures. In one embodiment, an anodic structure used to form an energy storage device is provided. The anodic structure comprises a flexible conductive substrate, a plurality of conductive microstructures formed on the conductive substrate, comprising a plurality of columnar projections and dendritic structures formed over the plurality of columnar projections and a plurality of tin particles formed on the plurality of conductive microstructures. In another embodiment, the anodic structure further comprises a tin nucleation layer comprising tin particles formed on the flexible conductive substrate between the flexible conductive substrate and the plurality of conductive microstructures. | 04-28-2011 |
| 20110129732 | COMPRESSED POWDER 3D BATTERY ELECTRODE MANUFACTURING - Embodiments of the invention contemplate forming an electrochemical device and device components, such as a battery cell or supercapacitor, using thin-film or layer deposition processes and other related methods for forming the same. In one embodiment, a battery bi-layer cell is provided. The battery bi-layer cell comprises an anode structure comprising a conductive collector substrate, a plurality of pockets formed on the conductive collector substrate by conductive microstructures comprising a plurality of columnar projections, and an anodically active powder deposited in and over the plurality of pockets, an insulative separator layer formed over the plurality of pockets, and a cathode structure joined over the insulative separator. | 06-02-2011 |
| 20110168550 | GRADED ELECTRODE TECHNOLOGIES FOR HIGH ENERGY LITHIUM-ION BATTERIES - Embodiments described herein provide methods and systems for manufacturing faster charging, higher capacity energy storage devices that are smaller, lighter, and can be more cost effectively manufactured at a higher production rate. In one embodiment, a graded cathode structure is provided. The graded cathode structure comprises a conductive substrate, a first porous layer comprising a first cathodically active material having a first porosity formed on the conductive substrate, and a second porous layer comprising a second cathodically active material having a second porosity formed on the first porous layer. In certain embodiments, the first porosity is greater than the second porosity. In certain embodiments, the first porosity is less than the second porosity. | 07-14-2011 |
| 20110200881 | ELECTRODE FOR HIGH PEFORMANCE Li-ION BATTERIES - A method for forming an electrode for a battery is disclosed. The method includes providing a substrate. A plurality of clusters of lithium containing compound is formed over the substrate, with each cluster having a plurality of sub-structures of lithium containing compound that exhibit nanocrystalline structure. The plurality of sub-structures of lithium containing compound are transformed to exhibit cation ordering structure. In some embodiments, a protective layer is disposed over the cluster of Li containing compound. An electrode for a battery and a system for processing the substrate are also disclosed. | 08-18-2011 |
| 20110217585 | INTEGRATED COMPOSITE SEPARATOR FOR LITHIUM-ION BATTERIES - Embodiments of the present invention relate generally to lithium-ion batteries, and more specifically, to batteries having integrated separators and methods of fabricating such batteries. In one embodiment, a lithium-ion battery having an electrode structure is provided. The lithium-ion battery comprises an anode stack, a cathode stack, and an integrated separator formed between the anode stack and the cathode stack. The anode stack comprises an anodic current collector and an anode structure formed over a first surface of the anodic current collector. The cathode stack comprises a cathodic current collector and a cathode structure formed over a first surface of the cathodic current collector. The integrated separator comprises a first ceramic layer, a second ceramic layer, and a polymer material layer deposited between the first ceramic layer and the second ceramic layer. | 09-08-2011 |
| 20120064225 | SPRAY DEPOSITION MODULE FOR AN IN-LINE PROCESSING SYSTEM - In one embodiment, an apparatus for simultaneously depositing an anodically or cathodically active material on opposing sides of a flexible conductive substrate is provided. The apparatus comprises a chamber body defining one or more processing regions in which a flexible conductive substrate is exposed to a dual sided spray deposition process, wherein each of the one or more processing regions are further divided into a first spray deposition region and a second spray deposition region for simultaneously spraying an anodically active or cathodically active material onto opposing sides of a portion of the flexible conductive substrate, wherein each of the first and second spray deposition regions comprise a spray dispenser cartridge for delivering the activated material toward the flexible conductive substrate and a movable collection shutter. | 03-15-2012 |
| 20120082884 | ELECTROSPINNING FOR INTEGRATED SEPARATOR FOR LITHIUM-ION BATTERIES - Embodiments of the present invention relate generally to lithium-ion batteries, and more specifically, to batteries having integrated separators and methods of fabricating such batteries. In one embodiment, a lithium-ion battery having an electrode structure is provided. The lithium-ion battery comprises an anode stack, a cathode stack, and a porous electrospun polymer separator comprising a nano-fiber backbone structure. The anode stack comprises an anodic current collector and an anode structure formed over a first surface of the anodic current collector. The cathode stack comprises a cathodic current collector and a cathode structure formed over a first surface of the cathodic current collector. The porous electrospun polymer separator is positioned between the anode structure and the cathode structure. | 04-05-2012 |
| 20120219841 | LITHIUM ION CELL DESIGN APPARATUS AND METHOD - A spray module for depositing an electro-active material over a flexible conductive substrate is provided. The spray module comprises a first heated roller for heating and transferring the flexible conductive substrate, a second heated roller for heating and transferring the flexible conductive substrate, a first spray dispenser positioned adjacent to the first heated roller for depositing electro-active material onto the flexible conductive substrate as the flexible conductive substrate is heated by the first heated roller, and a second spray dispenser positioned adjacent to the second heated roller for depositing electro-active material over the flexible conductive substrate as the flexible conductive substrate is heated by the second heated roller. | 08-30-2012 |
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| 20120072894 | In-Service Software Upgrade on Cards of Virtual Partition of Network Element that Includes Directing Traffic Away from Cards of Virtual Partition - A method within network element, for directing traffic away from cards of first virtual partition, before changing software on cards of first virtual partition, until after cards of first virtual partition have session data, while network element services sessions. Redistribute sessions, serviced by cards of first virtual partition, to cards of second virtual partition. Each of virtual partitions has control card and line card. Direct traffic away from cards of first virtual partition, prior to taking line card of first virtual partition offline. After redistributing sessions, change software on line card of first virtual partition, while cards of second virtual partition service sessions, including redistributed sessions. After changing software, synchronize session data, for sessions serviced by cards of second virtual partition to cards of first virtual partition. Traffic is directed away from cards before changing software on line card, and until after synchronizing session data to cards of first partition. | 03-22-2012 |
| 20120195189 | SYSTEM AND METHOD FOR PROVIDING COMMUNICATION CONNECTION RESILIENCE - A system and method for providing communication connection resilience between a mobile subscriber device and a network, such as the Internet. In one aspect, the invention provides improved communication connection resilience by using multiple nodes in multiple chassis to create redundant communication routes and to provide redundancy for control data relating to a mobile subscriber device. In one embodiment, a first node resides in a first chassis and a second node resides in a second chassis, and when an active communication link between the mobile subscriber device and the network via the first node becomes disrupted, the active communication link is rerouted such that data is communicated between the mobile subscriber device and the network via both of the first and second nodes. | 08-02-2012 |
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| 20100217668 | Optimizing Delivery of Online Advertisements - Disclosed are methods and apparatus for delivering online advertisements. For one of a plurality of users, a probability is obtained for each of a plurality of ads that the one of the plurality of users will click on the one of the plurality of ads. In addition, a lower bound is obtained for each of the plurality of ads. For each of the plurality of ads, a delta between the probability that the one of the plurality of users will click on the one of the plurality of ads and the lower bound for the one of the plurality of ads is determined. One of the plurality of ads to provide to the one of the plurality of users is selected based at least in part on the delta for each of the plurality of ads. | 08-26-2010 |
| 20110055003 | BUDGET-INFLUENCED RANKING AND PRICING IN SPONSORED SEARCH - Methods and systems are provided for ranking of sponsored search advertisements, and for auction pricing, based on revenue factors in addition to bid amounts and click through rates including budgets associated with advertising accounts, campaigns and portions thereof. Methods are provided in which linear programming or other techniques are used to optimize the search engine revenue, and the optimized solutions are used in ranking sponsored search advertisements based on factors including an advertiser bid amount associated with the advertisement, a historical, estimated or predicted click through rate associated with the advertisement, and a budget over a period of time, such as a daily budget, the budget including spend associated with the advertisement. Instead of one fixed position, the new ranking is a service distribution on multiple positions. | 03-03-2011 |
| 20110238486 | Optimizing Sponsored Search Ad Placement for Online Advertising - A method and a system are provided for optimizing sponsored search ad placement for online advertising. In one example, the system obtains advertiser bid amount information. The system obtains advertiser bid amount information. The bid amount information allows determination of amounts that advertisers will pay per user click on ads served in association with advertiser bids. The advertiser bid amounts are associated with advertising campaigns. The system obtains click-through-rate information associated with at least some of the ads. The system obtains budget information associated with the advertising campaign. The budget information specifies a maximum advertiser spending over a period of time in association with at least a portion of the advertising campaign. The system ranks a set of ads to be served based on the bid amount information, the click-through-rate information, and/or the budget information. The system optimizes ad placement of the set of ads by eliminating one or more keywords. The system then facilitates serving of the set of ads in accordance with at least one of the ranking of the set of ads and the optimizing of the ad placement. | 09-29-2011 |
