Patent application number | Description | Published |
20150272468 | System And Method For Functional Brain Organization Mapping - Systems and method for producing functional brain organization maps are provided. The method includes providing functional connectivity magnetic resonance image (fcMRI) data, a population atlas, a variation map indicative of inter-subject variability in the atlas. The method also includes initializing a subject map using the atlas, determining a reference signal for each functional connectivity network in the subject map using signals derived from the fcMRI data, computing correlations between the signals and reference signal of each functional connectivity network, and iteratively updating the subject map by reassigning locations in the subject brain when correlating with a functional connectivity network, updating at each iteration the reference signal using the subject map, the population atlas, the variation map, and the set of fcMRI data. The method further includes generating a report indicative of a functional brain organization for the brain of the subject using the subject map. | 10-01-2015 |
20150272493 | System and Method For Measuring Functional Brain Specialization - A system and method for measuring a functional lateralization of a subject brain is provided. The method includes providing a set of functional magnetic resonance imaging (fMRI) data acquired during a resting state of a subject, and selecting a plurality of seed voxels associated with locations in hemispheres of a brain of the subject. The method also includes determining a degree of within-hemisphere connectivity for each seed voxel using the fMRI data, determining a degree of cross-hemisphere connectivity for each seed voxel using the fMRI data, and computing an autonomy index for each seed voxel using the degree of within-hemisphere connectivity and the degree of cross-hemisphere connectivity, wherein the autonomy index is indicative of a connectivity asymmetry between the hemispheres. The method further includes generating a report indicative of a specialization profile determined for a region of interest in the brain of the subject. | 10-01-2015 |
Patent application number | Description | Published |
20120305174 | LAYER PROCESSING FOR PHARMACEUTICALS - Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet. | 12-06-2012 |
Patent application number | Description | Published |
20090017043 | Connective tissues growth factor antibodies - The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney. | 01-15-2009 |
20100291098 | Diabetic nephropathy therapies - The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided. | 11-18-2010 |
20110039878 | METHODS FOR REDUCING BLOOD PRESSURE - The present invention provides methods and medicaments for reducing blood pressure. Methods and medicaments for treating or preventing hypertension are also provided. | 02-17-2011 |
20110091468 | Connective tissue growth factor antibodies - The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney. | 04-21-2011 |
20110166145 | Stabilization of hypoxia inducible factor (HIF) alpha - The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided. | 07-07-2011 |
20110166178 | Methods for treating anemia using inhibitors of hypoxia-inducible factor (HIF) hydroxylase - The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds. | 07-07-2011 |
20120149712 | Methods for improving kidney function - The invention relates to methods for improving renal (kidney) function. Methods for decreasing blood urea nitrogen (BUN), for increasing glomerular filtration rate (GFR), and for decreasing serum creatinine are also provided. | 06-14-2012 |
20130203805 | Methods for treating anemia using inhibitors of hypoxia-inducible factor (HIF) hydroxylase - The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds. | 08-08-2013 |
20130245037 | Stabilization of Hypoxia Inducible Factor (HIF) Alpha - The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided. | 09-19-2013 |
20140073047 | Connective Tissue Growth Factor Antibodies - The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney. | 03-13-2014 |
20140163061 | Methods For Reducing Blood Pressure - The present invention provides methods and medicaments for reducing blood pressure. Methods and medicaments for treating or preventing hypertension are also provided. | 06-12-2014 |
20150080425 | METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE - The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase. | 03-19-2015 |
20160024198 | CONNECTIVE TISSUE GROWTH FACTOR ANTIBODIES - The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney. | 01-28-2016 |
Patent application number | Description | Published |
20140173457 | BROWSING ELECTRONIC MESSAGES DISPLAYED AS TILES - Electronic messages are displayed as tiles. A tile may include a background related to the electronic message. For example, the background of a tile may be a preview of an attachment to the message. When the message includes an attachment (e.g. document, picture, link . . . ), an overlay is displayed over the background. The overlay includes information relating to the electronic message (i.e. subject, sender, time, message preview . . . ). When the message does not include an attachment then the tile may include all/portion of the content of the electronic message. For example, the tile may include the subject, sender, time stamp, and message content. A user may switch between different browsing experiences (e.g. conversation view, list view, strip view, . . . ). When a tile represents a conversation each sender within the conversation may be displayed on a tile along with a preview of the messages of the conversation (i.e. the most recent message). | 06-19-2014 |
20140181219 | SUGGESTING RELATED ITEMS - Recommendations, such as recipients and attachments, are determined from content that is associated with a message item. A user may enter one or more: recipients; attachments; and message content for the message that may be used in determining recommendations. Keywords may also be identified by analyzing the content of the message to determine recommended content/recipients. Behavior patterns may also be used to determine recommendations. The recommended users/content of a message may be obtained from a messaging program, a local data store, a network data store, a cloud service, and the like. The recommended items (e.g. users/content) determined from analyzing the content are displayed such that they may be used by the user when editing the message item. The recommended items may be ranked by relevancy using metrics such as keywords, people, time last viewed and use patterns. | 06-26-2014 |
20150261411 | DISPLAYING COLLABORATION ICONS FOR COLLABORATION STATES - A collaboration icon system displays collaboration icons representing a current collaboration state of a resource. The collaboration icon system determines the collaboration state of the resource. When the collaboration state indicates that the resource does not have multiple editors, the collaboration icon system displays a share icon that is selectable to support sharing the resource. When the collaboration state indicates that the resource has multiple editors, the collaboration icon system displays an editors icon to support sharing the resource and accessing information relating to the editors. The share icon and the editors icon provide an indication of the collaboration state while the resource is being accessed. | 09-17-2015 |
20160034433 | DIGITAL DOCUMENT CHANGE CONFLICT RESOLUTION - A first set of changes to a first version of a digital document, as compared to a baseline version of the document, can be detected. The first set of changes can include a first change to a page of the document in the first version of the document, as compared to the baseline version of the document. Also, a second set of changes to a second version of a document, as compared to the baseline version of the document, can be detected. The second set of changes can include a second change to the page of the document in the second version of the document, as compared to the baseline version of the document. A conflict between the first change and the second change can be detected, and the conflict can be resolved by receiving user input or applying conflict resolution rule(s) to choose between the first and second changes. | 02-04-2016 |