Patent application number | Description | Published |
20100106728 | System and Method for Indexing, Searching and Presenting Technical Concepts - A data processing system and method are provided to index, search and present information about defined, “fuzzy” concepts across language, chemical and product identity, composition, biological classification and legal reference. The database system and method permits the use of combinations of concepts, such as labeling, health claims and/or nutritional claims, across linguistic, scientific and legal usages. The user is able to search for concepts in a defined way across any language or means of reference. The definition of the concepts used in the database is accepted as a standard by the database system (user(s). Such standardization then permits one user to pass the results of a search to another user with common meaning, and permits value-added services, such as the capability to provide news services about changes in worldwide regulation of goods and services, i.e., changes in information applicable to the concepts of interest to specific users. | 04-29-2010 |
20100153360 | Apparatus and Method for the Automatic Discovery of Control Events from the Publication of Documents - A method and system for discovering a control event from electronically published documents is provided, in which a control program on a computer identifies electronically published documents stored in a plurality of network servers which potentially contain control events relevant to the control of goods and/or services, the control events being identified by reference to a user interest database containing user interest identifiers. Identified documents are analyzed by a classification program to determine whether control events are present, referring to a control event database. A control event classification is assigned to documents determined to contain at least one discovered control event, the assigned control event classification and information identifying the associated document is stored in a classification database, and a report of discovery of documents containing control events is be provided to a user. The report may includes a link to the control event classification and/or its associated document. | 06-17-2010 |
20110093403 | Document Validation System and Method - The present invention relates generally to the field of self-validating documents in supply chain management, documentation services and method for creating the same. | 04-21-2011 |
20110302171 | Apparatus and Method for the Automatic Discovery of Control Events from the Publication of Documents - A method and system for discovering a control event from electronically published documents and received data streams is provided, in which a computer control program identifies electronically published documents and data stored in a plurality of network servers which potentially contain control events relevant to the control of goods and/or services, the control events identified by reference to user interest identifiers. Identified material is analyzed by a classification program to determine whether control events are present. A control event classification is assigned to documents and received data determined to contain at least one discovered control event, the assigned control event classification and information identifying the associated document and data is stored in a classification database, and a report of discovery of documents and data containing control events is be provided to a user. The report may includes a link to the control event classification and/or its associated document or data. | 12-08-2011 |
20110307292 | System and Method for Analysis and Visualization of Emerging Issues in Manufacturing and Supply Chain Management - An apparatus and method is provided for compliance management system for use in, for example, a food-related supply chain, manufacturing, processing and distribution of a product that might also be a consumer product, as well as an industrial chemical or article. The user may be one engaged in the production of the commodity or a governmental agency, association, or service provider. The apparatus includes a database system and hardware for collection of regulatory and/or industry-related event information from a News Aggregator, analysis of trends discernable from the event information, and presentation of the trend information in a manner which permits user visualization of the trends to permit timely response to the developing trend in product manufacturing and supply chain management. The trend analyses may be distributed as an electronic network service to participants of a network and supply chain affected by the discovered trends. | 12-15-2011 |
20120016707 | System and Method for Supplier and Customer Management of Technical and Regulatory Requirements in Procurement Standards - A system and method is provided for automated supplier and customer management of technical information and regulatory requirements in a supply chain where materials must meet high standards of health, safety, and performance, including in procurement of food product, food ingredient and food packaging as well as in the manufacture of products that may have hazardous properties may be subjected to rigorous material acceptance policy in procurement of such materials between supplier and customer. The system and method provide for management of procurement projects having project tasks in a manner which permits automated analysis of supplier responses to regulatory and customer requirement inquiries and automated presentation of compliance task status, including highlighting of incomplete tasks for further review and/or analysis to the project manager. The system and method may also provide a clearinghouse to provide supplier information to customers supplied by companies that are themselves customers of an upstream supplier. | 01-19-2012 |
20120030221 | Document Validation System and Method - The present invention relates generally to the field of self-validating documents in supply chain management, documentation services and method for creating the same. | 02-02-2012 |
20120036420 | Document Validation System and Method - The present invention relates generally to the field of self-validating documents in supply chain management, documentation services and method for creating the same. | 02-09-2012 |
20120254160 | System and Method for Indexing, Searching and Presenting Technical Concepts - A data processing system and method are provided to index, search and present information about defined, “fuzzy” concepts across language, chemical and product identity, composition, biological classification and legal reference. The database system and method permits the use of combinations of concepts, such as labeling, health claims and/or nutritional claims, across linguistic, scientific and legal usages. The user is able to search for concepts in a defined way across any language or means of reference. The definition of the concepts used in the database is accepted as a standard by the database system (user(s). Such standardization then permits one user to pass the results of a search to another user with common meaning, and permits value-added services, such as the capability to provide news services about changes in worldwide regulation of goods and services, i.e., changes in information applicable to the concepts of interest to specific users. | 10-04-2012 |
Patent application number | Description | Published |
20120036947 | MULTI-CHANNEL FREQUENCY DOMAIN TEST AND MEASUREMENT INSTRUMENT - A test and measurement instrument including a plurality of input ports; an acquisition system coupled to the input ports and configured to acquire frequency domain data from the input ports; a user interface configured to present frequency domain controls for at least two of the input ports; and a controller configured to adjust frequency domain acquisition parameters of the acquisition system in response to the frequency domain controls such that frequency domain acquisition parameters associated with a first input port can be different from frequency domain acquisition parameters associated with a second input port. | 02-16-2012 |
20120038369 | TIME-DOMAIN MEASUREMENTS IN A TEST AND MEASUREMENT INSTRUMENT - A test and measurement instrument and method for receiving a radio frequency (RF) signal, digitizing the RF signal using an analog-to-digital converter, downconverting the digitized signal to produce I (in-phase) and Q (quadrature) baseband component information, generating one or more IQ-based time-domain traces using the I and Q baseband component information, and measuring and displaying a variety of measurement values of the IQ-based time-domain traces. The IQ-based time-domain measurement values can be automatically generated and displayed, and/or transmitted to an external device. | 02-16-2012 |
20120197598 | TEST AND MEASUREMENT INSTRUMENT WITH COMMON PRESENTATION OF TIME DOMAIN DATA - A test and measurement instrument and method for generating IQ-based time domain waveform information and presenting the IQ-based time domain waveform information together with other time domain waveform on a common axis through a user interface. The test and measurement instrument can include, for example, one or more input terminals to receive an electrical signal under test, an analog-to-digital converter (ADC) to digitize the signal under test, a digital downconverter to produce I (in-phase) and Q (quadrature) baseband component information from the digitized signal, a memory configured to store the IQ baseband component information, a user interface, and a controller. The controller can be configured to generate an IQ-based time domain waveform using the IQ baseband component information, and present the IQ-based time domain waveform and a second time domain waveform on a common axis through the user interface. | 08-02-2012 |
20120278763 | METHOD OF GROUPING WAVEFORMS FOR A SINGLE CHANNEL ON A SINGLE DISPLAY - A method of grouping multiple waveforms for a single channel of acquired data on a display area uses a graphic icon with the display area. The graphic icon has a first portion with a symbol indicating the single channel and with an indicator defining a baseline for the display area. The graphic icon also has a second portion with symbols indicating which of the multiple waveforms currently are being displayed. The symbol for the single channel and the symbol for a selected one of the multiple waveforms currently being displayed are highlighted. The highlighting may be via color, where the highlight color corresponds to the color of the waveforms currently being displayed. | 11-01-2012 |
20130044112 | APPARATUS AND METHOD FOR PROVIDING FREQUENCY DOMAIN DISPLAY WITH VISUAL INDICATION OF FFT WINDOW SHAPE - A test and measurement instrument includes a display having a time domain graticule and a frequency domain graticule. A processor is configured to process an input signal to generate a time domain waveform for display in the time domain graticule, the input signal being correlated to a time base. The processor is also configured to process a second input signal and generate a frequency domain waveform for display in the frequency domain graticule, the second input signal being correlated to the same time base. The frequency domain waveform is correlated to a selected time period of the time base. The processor is also configured to generate a spectrum time indicator configured to graphically illustrate a transform parameter, a location and the selected time period in the time domain graticule with respect to the frequency domain waveform. | 02-21-2013 |
20130044134 | APPARATUS AND METHOD FOR TIME CORRELATED SIGNAL ACQUISITION AND VIEWING - A test and measurement instrument includes a display having a time domain graticule and a frequency domain graticule. A processor is configured to sample an input signal to generate a time domain waveform for display in the time domain graticule. The processor is also configured to generate a frequency domain waveform for display in the frequency domain graticule, the frequency domain waveform being correlated to a selected time period of the time domain graticule. The processor is also configured to generate a spectrum time indicator configured to graphically illustrate a location and the selected time period of the time domain graticule with respect to the frequency domain waveform. | 02-21-2013 |
20140002508 | SELECTIVE DISPLAY OF WAVEFORMS GOVERNED BY MEASURED PARAMETERS | 01-02-2014 |
20140032149 | CROSS DOMAIN TRIGGERING IN A TEST AND MEASUREMENT INSTRUMENT - An apparatus and method for triggering an oscilloscope is disclosed. The oscilloscope is configured to process a first signal in a first domain and a second signal in a second domain. The method includes choosing a different domain for processing each of the first and second signals, respectively. A desired trigger type is selected for one of the chosen domains. The first and second signals are acquired in response to an occurrence of a trigger of the selected trigger type. The first and second signals are processed according to the selected different chosen domains. The method may also include displaying a result of said processing on a display screen. | 01-30-2014 |
20140142880 | COMBINATORIAL MASK TRIGGERING IN TIME OR FREQUENCY DOMAIN - Embodiments of the invention include methods and instruments for performing combinatorial mask triggering. One or more mask triggers can be configured. Combinatorial mask triggering logic can make various determinations about the relationship between a digitized signal and the one or more mask triggers. The various determinations about the relationship can include considerations of both space and time. When the combinatorial trigger criteria have been satisfied, a trigger signal is generated, and the digital data associated with an incoming signal is stored to memory. The combinatorial mask triggering logic can operate on signals in the frequency domain, the time domain, or both. | 05-22-2014 |
Patent application number | Description | Published |
20090068732 | Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby - The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have enhanced folding properties. | 03-12-2009 |
20090142820 | Directed evolution methods for improving polypeptide folding, solubility and stability - The invention provides directed evolution methods for improving the folding, solubility and stability (including thermostability) characteristics of polypeptides. In one aspect, the invention provides a method for generating folding and stability-enhanced variants of proteins, including but not limited to fluorescent proteins, chromophoric proteins and enzymes. In another aspect, the invention provides methods for generating thermostable variants of a target protein or polypeptide via an internal destabilization baiting strategy. Internally destabilization a protein of interest is achieved by inserting a heterologous, folding-destabilizing sequence (folding interference domain) within DNA encoding the protein of interest, evolving the protein sequences adjacent to the heterologous insertion to overcome the destabilization (using any number of mutagenesis methods), thereby creating a library of variants. The variants in the library are expressed, and those with enhanced folding characteristics selected. | 06-04-2009 |
20090170721 | Circular permutant GFP insertion folding reporters - Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited. | 07-02-2009 |
20100222551 | Highly thermostable fluorescent proteins - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 09-02-2010 |
20100261267 | Circular permutant GFP insertion folding reporters - Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited. | 10-14-2010 |
20110245464 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 10-06-2011 |
20110256620 | NUCLEIC ACID ENCODING A SELF-ASSEMBLING SPLIT-FLUORESCENT PROTEIN SYSTEM - The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from | 10-20-2011 |
20120077266 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 03-29-2012 |
20120282643 | CYAN AND YELLOW FLUORESCENT COLOR VARIANTS OF SPLIT GFP - Disclosed herein are Split-Fluorescent proteins (SFPs) including Split-Yellow Fluorescent Proteins and Split-Cyan Fluorescent proteins. Further disclosed are methods of using SFPs. For example, methods of identifying the subcellular localization of a protein and methods of identifying the membrane topology of a membrane protein are disclosed herein. | 11-08-2012 |
20120329673 | VECTORS AND METHODS FOR SELECTING OPEN READING FRAMES - The invention provides vectors and methods designed for screening large random DNA fragment libraries for the presence of open reading frames that are free of both internal ribosome binding sites (IRBS) and stop codons. The invention overcomes the principal limitation of known ORF-selector systems, namely the potential for ORF-induced folding interference of the downstream fused reporter, by not fusing the reporter to the ORF, but rather by providing a mechanism for coupled translation of an unfused downstream reporter. | 12-27-2012 |
20130040384 | CIRCULAR PERMUTANT GFP INSERTION FOLDING REPORTERS - Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited. | 02-14-2013 |
20140024555 | METHOD OF IDENTIFYING SOLUBLE PROTEINS AND SOLUBLE PROTEIN COMPLEXES - Provided herein are methods of identifying a protein as soluble, as well as methods of identifying a soluble protein complex of at least two proteins. The methods allow for the determination of in vitro solubility, or both in vitro and in vivo solubility, of a protein or protein complex. | 01-23-2014 |
20140141415 | NUCLEIC ACID ENCODING A SELF-ASSEMBLING SPLIT-FLUORESCENT PROTEIN SYSTEM - The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from | 05-22-2014 |
Patent application number | Description | Published |
20120277217 | Imidazole Derivatives as IDO Inhibitors - Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. | 11-01-2012 |
20140066625 | Fused Imidazole Derivatives Useful as IDO Inhibitors - Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleanine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. | 03-06-2014 |
20140323740 | IDO Inhibitors - Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R | 10-30-2014 |
20160002249 | Fused Imidazole Derivatives Useful as IDO Inhibitors - Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease. | 01-07-2016 |
20160060266 | Tricyclic Compounds as Inhibitors of Immunosuppression Mediated By Tryptophan Metabolization - Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease. | 03-03-2016 |
Patent application number | Description | Published |
20110053941 | IDO Inhibitors - Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein. | 03-03-2011 |
20110136796 | IDO Inhibitors - Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R | 06-09-2011 |
20130289083 | IDO Inhibitors - Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunsupression associated with an infectious disease, e.g., HIV-1 infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein. | 10-31-2013 |
Patent application number | Description | Published |
20130266538 | Solid Forms of a Thiophosphoramidate Nucleotide Prodrug - The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents. | 10-10-2013 |
20140154210 | Solid Forms of a Thiophosphoramidate Nucleotide Prodrug - The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents. | 06-05-2014 |
20140206888 | METHODS FOR PREPARATION OF THIOPHENE COMPOUNDS - A method of preparing Compound (1): | 07-24-2014 |
20150158872 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. | 06-11-2015 |
20150175647 | SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG - The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents. | 06-25-2015 |
Patent application number | Description | Published |
20100196674 | ACRYLATED NATURAL OIL COMPOSITIONS - The present invention relates to a radiation curable composition comprising (a) from 1 to 99% by weight of a (meth)acrylated natural oil which is the reaction product of an unsaturated natural oil with an unsaturated anhydride and a hydroxyl functional (meth)acrylate, and (b) from 1 to 99% by weight of a (meth)acrylated oligomer and/or monomer, and optionally an inert resin and/or filler, as well as their use for making inks and coatings. | 08-05-2010 |
20120108702 | PROCESS FOR THE PREPARATION OF RADIATION CURABLE COMPOSITIONS - The present invention relates to a process for the preparation of radiation curable compositions comprising at least one radiation curable (meth)acrylic copolymer A and at least one (meth)acrylated epoxy compound B, said process comprising:—the preparation of a copolymer P by copolymerization of monomers comprising: (i) from 0.1 to 50 mole % of at least one epoxy (meth)acrylate (a1), and (ii) from 50 to 99.9 mole % of at least one other copolymerizable monomer (m) different from (a1) in the presence of at least one non-copolymerizable epoxy compound (b1) and—further reacting copolymer P thereby obtained and the non-copolymerizable epoxy compound (b1) with at least one carboxylic (meth)acrylate (a3). | 05-03-2012 |
20120115987 | RADIATION CURABLE COMPOSITIONS - The invention relates to radiation curable compositions comprising at least one radiation curable (meth)acrylic copolymer A prepared by reacting a copolymer P obtained from copolymerizing monomers comprising (i) from 10 to 50 mole % of at least one (meth)acrylate (a1) comprising a first functional group, and (ii) from 50 to 90 mole % of at least one alkyl(meth)acrylate (a2) having at least 6 carbon atoms in the alkyl chain, with at least one (meth)acrylate (a3) comprising a second functional group which can react with the first functional group of (meth)acrylate (a1), said radiation curable (meth)acrylic copolymer A having a number average molecular weight Mn of 1000 to 23000, and their use for making inks, varnishes, adhesives and coatings. | 05-10-2012 |
20130309459 | ACRYLATED NATURAL OIL COMPOSITIONS - The present invention relates to a radiation curable composition comprising (a) from 1 to 99% by weight of a (meth)acrylated natural oil which is the reaction product of an unsaturated natural oil with an unsaturated anhydride and a hydroxyl functional (meth)acrylate, and (b) from 1 to 99% by weight of a (meth)acrylated oligomer and/or monomer, and optionally an inert resin and/or filler, as well as their use for making inks and coatings. | 11-21-2013 |