Patent application number | Description | Published |
20100285111 | SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY - Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor. | 11-11-2010 |
20110008395 | MIXED MICELLES INCLUDING AMPHIPATHIC CONJUGATES OF RNA AGENTS, AND USES THEREOF - Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic conjugates of the iRNA agents and amphipathic micelle-forming molecules with extended hydrophilic chains. Also disclosed are methods of using the pharmaceutical formulations to increase delivery of an iRNA agent to an intracellular target, and to decrease extracellular nuclease degradation of an iRNA agent in the formulations. | 01-13-2011 |
20110038939 | THERAPEUTIC STABLE NANOPARTICLES - Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics. | 02-17-2011 |
20110117582 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 05-19-2011 |
20120177723 | SiRNA PHOSPHOLIPID CONJUGATE - siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides in such cells, are described. | 07-12-2012 |
20130330747 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 12-12-2013 |
20140120167 | MULTIFUNCTIONAL CHEMO- AND MECHANICAL THERAPEUTICS - Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation-therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (GNPs), near-infrared short laser pulses, and X-rays. | 05-01-2014 |
20150216991 | COMPOSITIONS FOR THE DELIVERY OF RNA AND DRUGS INTO CELLS - Provided is a co-polymer of formula A-L-D, or a pharmaceutically acceptable salt thereof, wherein A is a linear, branched or dendritic polyamine; D is a lipid; and L is a linker comprising a water soluble polymer; wherein L is connected to A at a first end through a first covalent bond and connected to D at a second end through a second covalent bond. | 08-06-2015 |