Patent application number | Description | Published |
20130004432 | MONOCLONAL ANTIBODIES THAT BIND B7H6 AND USES THEREOF - Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells. | 01-03-2013 |
20140234342 | NKP46-MEDIATED NK CELL TUNING - The present invention relates to compounds (e.g. antibodies) that specifically bind and inhibit NKp46. Such compounds are capable, when administered to a mammal, capable of increasing the frequency of reactive and/or active NK cells. The invention also relates to pharmaceutical composition and methods of using the antibodies and compositions to treat or prevent diseases, e.g. cancer, infection, autoimmune diseases, inflammatory diseases and the like. | 08-21-2014 |
20150056214 | MONOCLONAL ANTIBODIES THAT BIND B7H6 AND USES THEREOF - Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells. | 02-26-2015 |
20150233928 | METHODS AND KITS FOR PREDICTING THE SENSITIVITY OF A SUBJECT TO CHEMOTHERAPY - The present invention relates to a method of predicting or monitoring the sensitivity of a subject having a tumor to a chemotherapy, to a method of selecting an appropriate chemotherapeutic treatment of cancer, to a method of screening or identifying a compound suitable for improving the treatment of a cancer, and to corresponding kits. The method of predicting or monitoring the sensitivity of a subject having a tumor to a chemotherapy typically comprises a step a) of determining, in a biological sample from said subject, the presence, absence or expression level of at least one of a soluble B7H6 (sB7H6 or sB7-H6) and a soluble MIC (sMIC) and when the expression level is determined a step b) of comparing said expression level to a reference expression level, thereby assessing or monitoring whether the subject having a tumor is responsive or resistant to the chemotherapy. | 08-20-2015 |
Patent application number | Description | Published |
20140329060 | Construction Panel and Manufacture Thereof - A panel for use in building construction comprises a substrate board having two opposed faces. A lamina is secured to a first one of the faces of the substrate board by means of one or more regions of bonding between the lamina and the board. The one or more regions of bonding cover a total area that is less than 20% of the total interfacial area between the lamina and the board. | 11-06-2014 |
20150192163 | ANCHOR FOR FIXING IN A WALL - A self-drilling anchor including a screw and an anchor body configured to receive a shank of the screw, the anchor body including: a flange at an end oriented toward a head of the screw, a threaded portion, a deformable expansion portion between the flange and the threaded portion, and a rotation locking mechanism preventing rotation of the anchor body relative to the wall. The threaded portion is configured to engage with the screw thread and advance in a direction of the flange, by deforming the expansion portion, when the screw is screwed into the threaded portion. The anchor body further includes a piercing element at the opposite end from the flange, the anchor including a fastening mechanism between the screw and the anchor body, the fastening mechanism being detachable by a torque, applied between the screw and the anchor body, equal to or greater than a predetermined torque. | 07-09-2015 |
20150233409 | EXPANSION ANCHOR - An expansion anchor includes a screw and an anchor body configured to receive a shank of the screw, the anchor body including: a flange configured to be directed towards the screw head; a nut-forming portion configured to cooperate with the screw thread; and a deformable expansion portion between the flange and the nut-forming portion. The nut-forming portion is configured to advance in the direction of the flange, by deforming the expansion portion to a deployed state, by screwing the screw in the nut-forming portion. When the anchor is mounted inside a hole in a wall, with the flange bearing against a first face of the wall, the expansion portion in the deployed state forms a continuous contact surface facing a second face of the wall and has a load-bearing section, transversely with respect to the screw axis, which is generally decreasing from the contact surface towards the nut-forming portion. | 08-20-2015 |