Patent application number | Description | Published |
20080213404 | Hif Modulating Compounds and Methods of Use Thereof - A method is provided for treating subjects, including humans, with infection or virulence by pathogens. The method involves administering an agent in amounts effective to eradicate or reduce infections and/or an inflammatory response caused by pathogens. Methods for identifying compounds useful as anti-infectives that decrease the immune resistance, virulence, or growth of microbes are also provided. More particularly, there are provided methods for identifying compounds which increase accumulation or stability or activity, or alternatively decrease the degradation of HIF-1a protein. | 09-04-2008 |
20090042976 | Antimicrobial therapy for bacterial infections - The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the | 02-12-2009 |
20090162401 | Streptococcus Iniae Phosphoglucomutase is a Virulence Factor and Target for Vaccine Development - The present invention relates generally to the identification of virulence factors from | 06-25-2009 |
20090306021 | ANTIMICROBIAL THERAPY FOR BACTERIAL INFECTIONS - The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the | 12-10-2009 |
20100166708 | ANTIMICROBIAL AND ANTI-INFLAMMATORY THERAPIES AND COMPOSITIONS - The disclosure provides methods and compositions useful for treating microbial and viral infections. In certain aspects, the compositions and methods relate to the use of an effective amount of a delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof. In other aspects, the compositions and methods relate to the use of an effective amount of | 07-01-2010 |
20130303437 | ANTIMICROBIAL THERAPY FOR BACTERIAL INFECTIONS - The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the | 11-14-2013 |
20140154302 | ANTIMICROBIAL COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS - The disclosure provides compounds and methods to treat a microbial or a bacterial pathogenesis, and demonstrates that the | 06-05-2014 |
20140294930 | STREPTOCOCCAL GlcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A | 10-02-2014 |