Verrips
Cornelis T. Verrips, Vlaardingen NL
Patent application number | Description | Published |
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20120309054 | Products Comprising Inactivated Yeasts or Moulds and Active VHH-Type Antibodies - The use of VHHs in the preparation of products to provide stability of antibody specificity under destabilising conditions whereby normally lower eukaryotes or traditional antibodies are killed or inactivated. | 12-06-2012 |
Cornelis Theodorus Verrips, Houten NL
Patent application number | Description | Published |
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20100093030 | PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI - The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype. | 04-15-2010 |
20100323905 | Vhh for the Diagnosis, Prevention and Treatment of Diseases Associated with Protein Aggregates - The present invention provides heavy chain variable domain antibodies (VHH) for preventing and/or dissolving aggregates. VHH of the invention are preferably used in the treatment of human diseases that are associated with the formation of aggregates in the body. The invention further provides, among others, means and methods for selecting and using VHH. | 12-23-2010 |
20120276103 | VHH FOR APPLICATION IN TISSUE REPAIR, ORGAN REGENERATION, ORGAN REPLACEMENT AND TISSUE ENGINEERING - The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant. | 11-01-2012 |
20130189733 | PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI - The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype. | 07-25-2013 |
Cornelis Theodorus Verrips, Besse Sur Issole (var) FR
Patent application number | Description | Published |
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20110182897 | AMINO ACID SEQUENCES DIRECTED AGAINST ENVELOPE PROTEINS OF A VIRUS AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. | 07-28-2011 |
Cornelis Theodorus Verrips, Utrecht NL
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20150158934 | BROADLY NEUTRALIZING VHH AGAINST HIV-1 - The invention relates to a novel class of broadly neutralizing anti-HIV antibodies, more specifically to broadly neutralizing heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies for diagnostic and therapeutic and/or prophylactic treatment of individuals that are infected with HIV, or are at risk of becoming infected. | 06-11-2015 |
Theo Verrips, Utrecht NL
Patent application number | Description | Published |
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20110294982 | AMINO ACID SEQUENCES DIRECTED AGAINST INTEGRINS AND USES THEREOF - The present invention relates to amino acid sequences that are directed against (as defined herein) Integrins, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as | 12-01-2011 |
20130316365 | Method of Preparing a Biological Sample for Inspection with Electron Microscopy and Fluorescent Light Microscopy - The invention relates to a method of forming sections for inspection in an electron microscope and a fluorescent light microscope. Conventionally these sections are made by for example the Tokuyama method, which involves freeze substitution and fixing at cryogenic temperatures. A problem is the time that it takes to come from a sample to sections, as the diffusion speed of the chemicals (organic solvents and fixatives) is extremely low. The invention comprises the sectioning of the sample at cryogenic temperature and fixing afterwards. As the sections are much thinner (e.g. 100 nm or less) than the sample (often >1 μm), the total time it takes to come from a sample to a section ready for inspection is less than 8 hours. This makes it possible to achieve results relevant for health care within one workday. | 11-28-2013 |
Theodorus Cornelis Verrips, Naarden NL
Patent application number | Description | Published |
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20140256579 | Protein Arrays - Protein arrays are provided comprising single domain antibodies obtainable from | 09-11-2014 |