Vergani
Alessandro Vergani, Milano IT
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20100186872 | METHOD FOR LAYING DOWN AT LEAST AN ELASTIC ELEMENT IN A PROCESS FOR PRODUCING TYRES FOR VEHICLES, PROCESS FOR PRODUCING TYRES FOR VEHICLES AND APPARATUS FOR CARRYING OUT SAID LAYING DOWN METHOD - A method of laying down at least one elastic element in a process for producing tyres for vehicles includes the following steps: determining a first parameter representative of a laying speed at which at least one elastic element is laid down around a tyre forming drum; determining a second parameter representative of a percent elongation to be applied to the elastic element; adjusting, as a function of the first and second parameters, a rotation speed of a control roller positioned upstream of the forming drum and having a radially external surface at least partly in engagement with the elastic element for controlling the laying profile of the at least one elastic element. A process for producing tyres for vehicles and an apparatus for carrying out the laying method are also described. | 07-29-2010 |
Andrea Vergani, Brookline, MA US
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20160067348 | METHOD OF PREVENTING AND TREATING TYPE 1 DIABETES, ALLOGRAFT REJECTION AND LUNG FIBROSIS (BY TARGETING THE ATP/P2X7R AXIS) - The present invention relates to the role of purinergic receptors and ATP in T cell activation and autocrine system signaling. In one embodiment, the present invention provides a method of preventing or treating diabetes by administering a therapeutically effective inhibitor of ATP to a subject. In another embodiment, the present invention provides a method of preventing or treating fibrosis by administering a P2X7R soluble fusion protein. In another embodiment, the present invention provides a method of preventing or treating graft rejection by administering an inhibitor of P2X receptor signaling. | 03-10-2016 |
Domenico Vergani, Rodano IT
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20090239893 | STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN - A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process. | 09-24-2009 |
20100311783 | STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN - A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process. | 12-09-2010 |
20100311784 | STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN - A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process. | 12-09-2010 |
Domenico Vergani, Biassono IT
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20080269494 | Process for the Preparation of Alpha-Aryl-Alpha-Piperid-2-Yl-Acetamides and the Acid Hydrolysis Thereof - A process for the preparation of -aryl-piperid-2-yl-acetamides of formula (I) in which Ar is as defined in the disclosure, by catalytic reduction of α-aryl-α-pyridin-2-yl-acetamides (II) with rhodium catalysts. Acetamides of formula (II) can subsequently by hydrolysed to the corresponding arylacetic acids, e.g. ritalinic acid, a direct precursor of methylphenidate. | 10-30-2008 |
20100016599 | Process for Preparing Fexofenadine - A process for preparing fexofenadine is described that includes the purification of 4-[4-chloro-1-oxobutyl]-2,2-dimethylphenyl acetic acid alkyl ester by means of suspension in a hydrocarbon, preferably n-heptane. The compound thus obtained is dissolved in a suitable solvent and condensed with azacyclanol to give the compound shown below | 01-21-2010 |
20100105942 | Process for the Synthesis of Aryloxypropylamine and Heteroaryloxypropylamine - The present invention relates to a process for the synthesis of aryloxypropylamine and heteroaryloxypropylamine of formula I: | 04-29-2010 |
20110190504 | Process for preparing fexofenadine - A process for preparing fexofenadine is described, which provides for the hydrolysis of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid-alkyl ester, in a mixture of water and optionally an organic solvent, in the presence of a base; the carboxylate salt of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid is thus obtained, which is then directly reduced as carboxylate in a basic environment with hydrogen in the presence of a suitable hydrogenation catalyst to give the carboxylate of fexofenadine, which is precipitated by neutralisation of the solution. | 08-04-2011 |
20120232306 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF - The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below | 09-13-2012 |
20130030216 | PROCESS FOR THE PREPARATION OF LACOSAMIDE - A novel process for the synthesis of Lacosamide using D,L-serine as starting material is described, where the methylation reaction of hydroxyl is carried out using an inexpensive base such as NaOH and an inexpensive alkylating agent, non-toxic and non-carcinogenic, such as methyl p-toluenesulfonate; the R enantiomer is isolated from the racemic mixture of Lacosamide after selective hydrolysis of the acetamide, salification of the racemic mixture with a chiral acid (HX*) in an organic solvent, resolution of the diastereoisomeric mixture, preferably by precipitation of the R enantiomer, and subsequent acetylation of the optically pure intermediate. | 01-31-2013 |
20130178644 | PROCESS FOR THE SYNTHESIS OF TAPENTADOL AND INTERMEDIATES THEREOF - The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. | 07-11-2013 |
Domenico Vergani, Biassono (mi) IT
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20120322996 | Novel Method for the Preparation of Stavudine Polymorphic Form I and Form II - A novel method for the preparation of stavudine polymorphic form I and form II is described. 5′-acetate-2′,3′-diacetyl-5-methyluridine is reacted with catalytic amounts of sodium methoxide in a C | 12-20-2012 |
Marco Vergani, Seregeno (mb) IT
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20140216444 | METERED DOSE INHALER WITH AN ELECTRONIC DOSE COUNTER - A metered dose inhaler with an electronic dose counter, and method of operating and forming the same. In one embodiment, the metered dose inhaler includes a pressurized canister assembly formed with a memory device affixed thereto. The metered dose inhaler also includes a canister housing into which the pressurized canister assembly is inserted, the canister housing formed with an electronic dose counter including a display configured to display a dose count of a drug in the pressurized canister assembly stored in the memory device. | 08-07-2014 |
Paolo Vergani, Vimercate IT
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20110114226 | METHOD TO PREPARE A STABLE TRANSPARENT ELECTRODE - The present application discloses a method for producing a stable ultra thin metal film that comprises the following steps: a) deposition, on a substrate, of an ultra thin metal film, such as an ultra thin film of nickel, chromium, aluminium, or titanium; b) thermal treatment of the ultra thin metal film, optionally in combination with an O | 05-19-2011 |
20150293426 | Optical Modulator - The invention relates to a folded Mach-Zehnder modulator. The modulator may comprise a beam splitter configured to split an input light beam into a plurality of light beams. The modulator may comprise a plurality of Mach-Zehnder devices configured to receive one or more of the plurality of light beams. The modulator may comprise a U-turn section configured to receive light beams from the Mach-Zehnder devices and to change the direction of the light beams by substantially 180 degrees. The modulator may comprise a polarisation management section configured to combine light beams received from the U-turn section and to output a polarisation multiplexed phase modulated light beam. | 10-15-2015 |
Roberto Vergani, Milan IT
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20140278162 | DETECTING AND LOCATING POWER OUTAGES VIA LOW VOLTAGE GRID MAPPING - In a power grid capable of electrical power delivery and power line communications, a distribution transformer and at least one smart meter is connected to the power grid. In one embodiment, the distribution transformer is configured to map the smart meters on the power grid to a virtual grid based upon measurements of signal metrics received from the various smart meters on the power grid, and the virtual grid is used to determine if a failure has occurred on the physical grid. A communications failure between nodes on the grid suggests a possible power failure, and the failure can be located using mapping information obtained from the virtual grid. A drop in power consumption on the power grid corroborates outages detected via the communications failure. In one embodiment, a cross phase delta value is computed to adjust the signal strength metrics measured between nodes having differing phases of electrical distribution. | 09-18-2014 |
Tarcisio Vergani, Wiltshire GB
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20120006204 | MODULAR VENDING MACHINE AND CARTRIDGE SYSTEM - A refillable vend module includes at least one canister configured to contain an ingredient for a beverage, and a connecting mechanism configured to slidably connect to any one of a plurality of modular vend spaces in a vending machine. In some embodiments, the at least one canister comprises a poka-yoke refill connection configured to couple an ingredient cartridge to the canister, where the poka-yoke refill connection matches a type of the canister to a type of the ingredient cartridge. A vending machine includes a plurality of modular vend spaces and a plurality of refillable vend modules. | 01-12-2012 |
Tarcisio Vergani US
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20110281000 | HIGH PRESSURE COFFEE BREWER - A brewer for brewing different beverages requiring different brewing pressures does not employ an internal valve adjusting an outlet opening to achieve the different pressures. Instead, compression of grinds within the brewer and pressure of water injected to brew the beverage is employed to control the brewing pressure, achieving a greater consistency of brew quality over time. Overheating is implemented for certain beverages based on a time since a last vend, and a back check valve between a flow meter and pump provides greater control over the pump output. | 11-17-2011 |