Vasella
Andrea Vasella, Zürich CH
Patent application number | Description | Published |
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20090170150 | Screening Assay for Ribosomal Antibiotics - The present invention is directed to a method for identifying ribosomal antimicrobial substances being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Specifically, said method is directed to an assay that compares the interaction of a candidate ribosomal antimicrobial substance (i) in a bacterial strain with microbial ribosomes, and (ii) in a bacterial strain with chimeric mitochondrial bacterial ribosomes, and/or (iii) in a bacterial strain with chimeric cytosolic bacterial ribosomes. In a further aspect the present invention also relates to the use of bacterial strains with microbial ribosomes, and bacterial strains with chimeric mitochondrial bacterial ribosomes, and/or bacterial strains with chimeric cytosolic bacterial ribosomes for identifying ribosomal antimicrobial substance being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Furthermore, one or more of the above bacterial strains (i) to (iii) may be substituted by a functionally equivalent cell-free biological system. | 07-02-2009 |
20100144662 | AMINOGLYCOSIDE ANTIBIOTICS TARGETING BACTERIAL 16S RIBOSOMAL RNA - The present invention relates to paromamine-based compounds according to formula I having selective antimicrobial activity directed at ribosomal 16S RNA. Furthermore, the invention is directed to the use of said compounds for preparing a medicament, pharmaceutical preparations and methods for preparing said compounds | 06-10-2010 |
20130165397 | TREATMENT OF BACTERIAL INFECTIOUS DISEASES - The present invention relates to a novel pharmacological treatment of bacterial infectious diseases in humans. Specifically the invention relates to the use of apramycin of formula (I) or apramycin derivatives to treat bacterial infectious diseases in humans. It is demonstrated that apramycin surprisingly does not have the expected high level of toxicity observed with related aminoglycoside antibiotics but actually is even significantly less toxic than compounds already used in human medicine such as gentamicin. | 06-27-2013 |
Andrea Vasella, Zürich CH
Patent application number | Description | Published |
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20090170150 | Screening Assay for Ribosomal Antibiotics - The present invention is directed to a method for identifying ribosomal antimicrobial substances being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Specifically, said method is directed to an assay that compares the interaction of a candidate ribosomal antimicrobial substance (i) in a bacterial strain with microbial ribosomes, and (ii) in a bacterial strain with chimeric mitochondrial bacterial ribosomes, and/or (iii) in a bacterial strain with chimeric cytosolic bacterial ribosomes. In a further aspect the present invention also relates to the use of bacterial strains with microbial ribosomes, and bacterial strains with chimeric mitochondrial bacterial ribosomes, and/or bacterial strains with chimeric cytosolic bacterial ribosomes for identifying ribosomal antimicrobial substance being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Furthermore, one or more of the above bacterial strains (i) to (iii) may be substituted by a functionally equivalent cell-free biological system. | 07-02-2009 |
20100144662 | AMINOGLYCOSIDE ANTIBIOTICS TARGETING BACTERIAL 16S RIBOSOMAL RNA - The present invention relates to paromamine-based compounds according to formula I having selective antimicrobial activity directed at ribosomal 16S RNA. Furthermore, the invention is directed to the use of said compounds for preparing a medicament, pharmaceutical preparations and methods for preparing said compounds | 06-10-2010 |
Daniel Lucius Vasella, Basel CH
Patent application number | Description | Published |
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20090036432 | Combinations of AT1-antagonists, amiloride or triamterine, and a diuretic - The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising | 02-05-2009 |
20120004312 | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases - The invention relates to a combination comprising the renin inhibitor of formula (I) | 01-05-2012 |
20120010295 | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases - The invention relates to a combination comprising the renin inhibitor of formula (I) | 01-12-2012 |
20120016035 | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases - The invention relates to a combination comprising the renin inhibitor of formula (I) | 01-19-2012 |
Mario Vasella, Trubbach CH
Patent application number | Description | Published |
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20140055205 | OSCILLATOR FOR A POWDER SPRAY COATING DEVICE - An oscillator ( | 02-27-2014 |
Marlo Vasella, Trubbach CH
Patent application number | Description | Published |
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20140088769 | CONTROL DEVICE FOR A POWDER SPRAY COATING DEVICE - A control device for a powder spray coating device and a powder spray coating device are specified. With the aim of ensuring operational reliability during the coating operation of the powder spray coating device, while at the same time preserving the required coating efficiency, the solution according to the invention provides for the control device an assessment device, an enabling device and a first communication interface, the assessment device being designed for assessing on the basis of at least one code received from the powder spray coating device by means of the first communication interface whether or not reliable operation of the powder spray coating device is ensured and passing on the assessment result to the enabling device, the enabling device being designed in turn for enabling operation if the assessment result is positive. | 03-27-2014 |
Mauro Alcide Vasella, Zurich CH
Patent application number | Description | Published |
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20080316367 | Selectable Audio Output Configuration - An audio/video apparatus such as a television apparatus includes two or more auxiliary audio inputs (AUX | 12-25-2008 |