Vanderspek
Adrian Vanderspek, Worcester, MA US
Patent application number | Description | Published |
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20140052700 | Delta Version Clustering and Re-Anchoring - A system, a method, and a computer program product for delta version clustering and re-anchoring are provided. A first anchor having a plurality of delta-compressed versions of data dependent on the first anchor is generated. The first anchor and the plurality of delta-compressed versions form a cluster. A second anchor is generated. The first anchor is replaced with the second anchor. The replacing includes re-computing at least one delta-compressed version in the plurality of delta-compressed versions to be dependent on the second anchor. The second anchor replaces the first anchor as an anchor of the cluster. | 02-20-2014 |
20140143219 | ADAPTIVE SCHEDULED PERIODIC CACHING - A system, a method, and a computer program product for adaptive scheduled periodic caching are disclosed. A data stream is received. The data stream contains a plurality of versions of data arranged in a plurality of data clusters. Each data cluster includes an anchor version having a plurality of versions of data dependent on the anchor version. A size of each anchor version of each data cluster is determined. A number of versions of data dependent on each anchor version is also determined. For each anchor version, a ratio of the determined number of dependent versions of data to the determined size of each anchor is computed. At least one anchor version for storing in a memory location is selected based on the computed ratio. | 05-22-2014 |
Johanna C. Vanderspek, Worcester, MA US
Patent application number | Description | Published |
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20090156502 | DIPHTHERIA TOXIN VARIANT - The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer. | 06-18-2009 |
20120149650 | Diphtheria Toxin Variant - The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer. | 06-14-2012 |
Julius Vanderspek, San Jose, CA US
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20140317385 | TECHNIQUES FOR DETERMINING INSTRUCTION DEPENDENCIES - One embodiment sets forth a method for efficiently determining memory resource dependencies between instructions included in a software application. For each instruction, a dependency analyzer uses overlapping search techniques to identify one or more overlaps between the memory elements included in the current instruction and the memory elements included in previous instructions. The dependency analyzer then maps objects included in the instructions to a set of partition elements wherein each partition element represents a set of memory elements that are functionally equivalent for dependency analysis. Subsequently, the dependency analyzer uses the set of partition elements to determine memory dependencies between the instructions at the memory element level. Advantageously, the disclosed techniques enable the compiler to retain an acceptable compilation speed while tuning the instruction ordering at a fine-grained memory element level, thereby increasing the speed at which the processor may execute the software application. | 10-23-2014 |
20140317386 | TECHNIQUES FOR DETERMINING INSTRUCTION DEPENDENCIES - One embodiment sets forth a method for efficiently determining memory resource dependencies between instructions included in a software application. For each instruction, a dependency analyzer uses overlapping search techniques to identify one or more overlaps between the memory elements included in the current instruction and the memory elements included in previous instructions. The dependency analyzer then maps objects included in the instructions to a set of partition elements wherein each partition element represents a set of memory elements that are functionally equivalent for dependency analysis. Subsequently, the dependency analyzer uses the set of partition elements to determine memory dependencies between the instructions at the memory element level. Advantageously, the disclosed techniques enable the compiler to retain an acceptable compilation speed while tuning the instruction ordering at a fine-grained memory element level, thereby increasing the speed at which the processor may execute the software application. | 10-23-2014 |
Paul J. Vanderspek, Redwood City, CA US
Patent application number | Description | Published |
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20100156907 | DISPLAY SURFACE TRACKING - Display surface tracking techniques are described in which a one or more modules may perform enhanced rendering techniques to output graphics based on tracking of a display device. In an embodiment, one or more tracking sensors may be used to track position of a display relative to a viewer. In at least some embodiments, the tracking sensors include a camera of the device that is used to monitor a position of the viewer relative to the display. Based on tracking performed via the one or more tracking sensors, projection planes used to render graphics on the display may be calculated and a graphics presentation may be output in accordance with the calculated projection planes. | 06-24-2010 |