Van Den Hondel
Cees A.m.j.j. Van Den Hondel, Pz Gouda NL
Patent application number | Description | Published |
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20090239260 | Fungal Transcriptional Activator Useful In Methods for Producing Polypeptides - The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides. | 09-24-2009 |
Cornelis Antonius Maria Jacobus Johannes Van Den Hondel, Leiden NL
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20090117585 | ANTI-FUNGAL SCREENING METHOD - The present invention relates to a method for identification of anti-fungal agents and their mode of actions. In particular, it relates to cell wall disturbing anti-fungal agents and to an assay to identify them. More particularly, it relates to a screening method for the identification of an anti-fungal compound, which method comprises (i) contacting a potential anti-fungal compound with a polypeptide which is involved in cell wall synthesis; and then (ii) identifying the effect which the potential anti-fungal compound has on the activity of the polypeptide, whereby reduced polypeptide activity is indicative for anti-fungal activity of the potential anti-fungal compound. It also relates to an overexpressing host cell and to a kit for performing the assay. | 05-07-2009 |
Cornelis Antonius Maria Jacobus Johannes Van Den Hondel, Gouda NL
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20090047701 | METHOD FOR SCREENING ANTIFUNGAL AGENTS - The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall. It also relates to a kit for screening for antifungal agents which disturb cell wall biogenesis. | 02-19-2009 |
20120295321 | Pentose Transporters and Uses Thereof - The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the | 11-22-2012 |
Cornelius Van Den Hondel, Gouda NL
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20120030839 | Expression and High-Throughput Screening of Complex Expressed DNA Libraries in Filamentous Fungi - The invention provides a method for the expression and subsequent screening of DNA libraries, particularly synthetic, genomic, and cDNA libraries, in filamentous fungal hosts. In particular, the invention provides vectors, host strains, and a method for the expression and screening of complex DNA libraries, including, but not limited to, combinatory (combinatorial) libraries expressing one, two or more variable constituents and/or prepared from two or more sublibraries (e.g., for the expression and screening of immunoglobulin (including fragments and derivatives of whole immunoglobulin proteins) and other receptor or complex DNA libraries or libraries of libraries). The invention is useful for the expression and screening for a large variety of proteins and protein complexes, including human proteins. The present invention also relates to novel fungal protease sequences. | 02-02-2012 |