Uygun
Basak E. Uygun, Cambridge, MA US
Patent application number | Description | Published |
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20150322404 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 11-12-2015 |
Basak E. Uygun, Newton, MA US
Patent application number | Description | Published |
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20130323708 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 12-05-2013 |
Basak Elif Uygun, Cambridge, MA US
Patent application number | Description | Published |
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20140030231 | METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS - The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage. | 01-30-2014 |
Erkut Uygun, Cambridge GB
Patent application number | Description | Published |
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20120023317 | DIGITAL DATA PROCESSING SYSTEMS - A digital data processing system that is designed to facilitate use of UML activity diagrams. | 01-26-2012 |
20130091504 | DATA FLOWS AND THEIR INTERACTION WITH CONTROL FLOWS - A method and apparatus for processing data by a computer and a method of determining data storage requirements of a computer for earning out a data processing task. | 04-11-2013 |
20130262806 | MULTIPROCESSOR SYSTEM, APPARATUS AND METHODS - Embodiments of the present invention provide methods and apparatus in a multiprocessor system, whereby a set of rules relating to memory access are created and implemented in a hardware element. The rules can be updated dynamically, for example by the sequence processor (or sequencer) used to control the multiple processing elements. | 10-03-2013 |
Korkut Uygun, Cambridge, MA US
Patent application number | Description | Published |
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20150322404 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 11-12-2015 |
Mustafa Korkut Uygun, Cambridge, MA US
Patent application number | Description | Published |
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20140030231 | METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS - The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage. | 01-30-2014 |
Mustafa Korkut Uygun, Newton, MA US
Patent application number | Description | Published |
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20130323708 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 12-05-2013 |
Nabi Uygun, Kocaeli TR
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20140170267 | BABY AND INFANT FOOD CONTAINING WHOLE OLIVES - The subject of this invention is the baby and infant food comprising whole olive fruit. Olive oil have an important role in Mediterranean diet. Olive oil helps to protect the cardiovascular system, to regulate immune system and to protect from cancer. Olive oil with all these properties is used in homemade and also industrially manufactured baby foods. However the only constituent that is useful for health is not the oil. Whole olives, other than oil is more rich in respect to vitamin, mineral, fiber and phenolic substances and contains pure oil not submitted to any extraction process. In spite of all these mentioned advantages of olives, olive oil traditionally is used in baby foods, but olives, mainly due to their bitterness. In the world requirements are increasing besides to their health effect, to less refined and minimally processed foods. For this purpose baby/infant foods having bitter/debittered olives are developed by solving the mentioned problem. | 06-19-2014 |
20140178560 | METHOD FOR THE PRODUCTION OF POWDERED OLIVE - The subject of this invention is the production process of whole olive powder with easily pourable properties and natural olive powder that is produced with this processes. Olive and olive oil are used by human beings with different receipts and forms of utilization for more than thousands years. But powdered form of olive production from whole olives was not encountered. When whole olives are ground to obtain a powder, the intracellular oil is released and turn ground olives into a paste. It is impossible to obtain a dry powdered olive product from whole and not deoiled olives that does not release oil during its shelf life, without aggregating and protecting its powdered form just by grinding. The powder obtained from whole olives is more rich from olive oil in vitamins, minerals, fiber, and phenolic substance and it is superior in olive oil than various powders obtained from olive oil wastes as it also contains purest olive oil that has not passed any extraction processes. By the method that has been developed in this invention, an easily pourable, minimally processed natural olive powder has been obtained from dried and whole olives. | 06-26-2014 |