Unsworth
Edward J. Unsworth, Kensington, MD US
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20100021469 | FUNCTIONAL ROLE OF ADRENOMEDULLIN (AM) AND THE GENE RELATED PRODUCT (PAMP) IN HUMAN PATHOLOGY AND PHYSIOLOGY - The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM. | 01-28-2010 |
Edward J. Unsworth, Westport, MA US
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20090136524 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF TUMORS - Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5 kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD. | 05-28-2009 |
20100322950 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF TUMORS - Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5 kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5 kD and antibodies specific for OPN-5 kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5 kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5 kD. | 12-23-2010 |
20120294870 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF TUMORS - Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD. | 11-22-2012 |
Grant Unsworth, Waterloo CA
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20120014678 | HEATER ASSEMBLY - A heater assembly to be located at a substantially vertical wall for heating air. The heater assembly includes one or more heating elements, and one or more heat transfer elements mounted on the heating element for transferring heat to a column of the air moving substantially upwardly past the heat transfer elements. The column includes an inner portion positioned proximal to the wall and an outer portion positioned distal to the wall. Each heat transfer element is formed to transfer substantially more heat to the outer portion of the column of the air than to the inner portion thereof, to cause the outer portion to rise faster than the inner portion, for at least partially entraining the inner portion with the outer portion, so that at least a part of the inner portion forms a laminar boundary layer flowing along the wall. | 01-19-2012 |
John Unsworth, Dundas CA
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20120253513 | SNAKING ROBOTIC ARM WITH MOVABLE SHAPERS - Presented is a method and apparatus comprising one or more robotic members which are curvaceous or snake-like; having movable shapers through which may pass an articulable column having successive joints formed of alternating ball and socket members. The shapers can be directed up and down the articulable column, to create virtually any radius of curvature, in any direction. The robotic member may also include discrete microelectronic mechanical devices (MEMS) shaper's with embedded addressable controllers. Thus the device, with computerized control is capable of negotiating a tortuous path to access the site of a given operation and to retreat along the same path, without injury to the body in which the arm is directed. Once at the work site, the articulating columns, or parts of them, may be put in compression, causing them to become rigid. | 10-04-2012 |
John Unsworth, Hamilton CA
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20100030377 | Snaking Robotic Arm with Movable Shapers - Presented is a method and apparatus comprising one or more robotic members which are curvaceous or snake-like; having movable shapers through which may pass an articulable column having successive joints formed of alternating ball and socket members. The shapers can be directed up and down the articulable column, to create virtually any radius of curvature, in any direction. The robotic member may also include discrete microelectronic mechanical devices (MEMS) shapers with embedded addressable controllers. Thus the device, with computerized control is capable of negotiating a tortuous path to access the site of a given operation and to retreat along the same path, without injury to the body in which the arm is directed. Once at the work site, the articulating columns, or parts of them, may be put in compression, causing them to become rigid. | 02-04-2010 |
20100036393 | METHODS, SYSTEMS AND DEVICES FOR THREEDIMENSIONAL INPUT, AND CONTROL METHODS AND SYSTEMS BASED THEREON - A Robotic control system has a wand, which emits multiple narrow beams of light, which fall on a light sensor array, or with a camera, a surface, defining the wand's changing position and attitude which a computer uses to direct relative motion of robotic tools or remote processes, such as those that are controlled by a mouse, but in three dimensions and motion compensation means and means for reducing latency. | 02-11-2010 |
20140316435 | METHODS, SYSTEMS AND DEVICES FOR THREE DIMENSIONAL INPUT AND CONTROL METHODS AND SYSTEMS BASED THEREON - A Robotic control system has a wand, which emits multiple narrow beams of light, which fall on a light sensor array, or with a camera, a surface, defining the wand's changing position and attitude which a computer uses to direct relative motion of robotic tools or remote processes, such as those that are controlled by a mouse, but in three dimensions and motion compensation means and means for reducing latency. | 10-23-2014 |
John D. Unsworth, Hamilton CA
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20110257663 | SUTURE SYSTEM FOR MANUAL AND ROBOTIC SURGERY WITH SUTURE THREAD GATHERER AND FUSER AND DOUBLE POINTED SUTURE NEEDLE FOR ONE HAND APPLICATION (3) - The invention is a suture system including a device and a method for manual and robotic surgery with suture thread gatherer and fuser and double pointed suture needle for one hand suture application. | 10-20-2011 |
Marie Josephine Unsworth, Hampshire GB
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20120151884 | Visual Aid - The invention relates to a visual aid ( | 06-21-2012 |
Peter Unsworth, Lewes GB
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20110210615 | MOTOR STARTING AND SWITCHING - A method of starting and apparatus for starting a multiphase electrical machine is disclosed. The aim is to reduce oscillatory pulsation in torque generated by the motor and inrush current that occurs shortly after start-up. The starting method comprises the steps of first connecting at least one, but less than all, of a plurality of windings to a respective phase-shifted supply voltage at a controlled point in the supply phase. Then, after a controlled delay following the first connection, connecting the or each remaining winding of the machine a respective phase-shifted supply voltage. The invention has particular application to multiphase (most usually, 3-phase) motors. However, it can also be applied to other electrical machines, such as generators and transformers. The method can be performed at initial start-up or, in the case of application to a motor, at Y-delta switchover. | 09-01-2011 |
20140265995 | Two-step connection of electric motors by means of electromagnetic switches - A method and apparatus using electromagnetic switching in a two-step connection process is provided to minimize surge currents and torque oscillations in three-phase motors during starts. | 09-18-2014 |
Peter Unsworth, North Yorkshire GB
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20090015798 | Mounting for Interactive Display System - The subject invention concerns a display system comprising an interactive display surface and a projector for projecting images onto the display surface. The display surface and the projector are movable in a vertical direction. Calibration between an image projected from the projector and displayed on the interactive display surface is maintained. Following movement of the display screen and the projector, no re-calibration of the interactive display is required. The movement in a vertical direction is between at least two positions for projecting images onto the display surface. The movement may be continuously between said two positions or in discrete steps. | 01-15-2009 |
Peter Unsworth, Blackburn GB
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20100211902 | INTERACTIVE DISPLAY SYSTEM - There is disclosed an interactive display system comprising an interactive surface for displaying an image and for receiving inputs from remote devices, the system being adapted to detect the presence of at least two remote devices proximate the interactive surface. | 08-19-2010 |