Patent application number | Description | Published |
20130052623 | SYSTEM FOR ENCOURAGING A USER TO PERFORM SUBSTANTIAL PHYSICAL ACTIVITY - A system for encouraging a user to perform substantial physical activity. The system may include sensors that may be worn by the user while the user is performing a substantial physical activity, such as running or playing basketball. The sensors may detect the magnitude of the physical activity and may transmit data regarding the physical activity to a processing system. The processing system may display a reward to encourage the user for participating in physical activity and the reward provided may be based on the physical activity of the user. | 02-28-2013 |
20130059025 | EXTRUSION OF CEMENTITIOUS MATERIAL WITH DIFFERENT LEVELING CHARACTERISTICS - A cementitious material delivery system may include a flow divider, a first and second chemical agent, a first and second mixer, and a nozzle. The flow divider may be configured to divide a flow of cementitious material into a first stream and a second stream that is separate from the first stream. The first chemical agent may cure the cementitious material at a first rate. A first mixer may be configured to mix the first chemical agent with the first steam of cementitious material. A second chemical agent may be configured to cure the cementitious material at a second rate. A second mixer separately may be configured to mix the second chemical agent with the second steam of cementitious material. A nozzle may be configured to extrude both mixed streams of cementitious material separate from each other. | 03-07-2013 |
20130087020 | CONTINUOUS FLOW SYNTHESIS OF NANOMATERIALS USING IONIC LIQUIDS IN MICROFLUIDIC REACTORS - A method for manufacturing metal nanoparticles includes the use of a microfluidic device. The microfluidic device has a first channel having a first inlet; a second channel having a second inlet; a third channel having a third inlet; and a main channel having a main inlet and an outlet. The first channel, second channel, and third channel all lead into the main channel. The method involves injecting a solution of a metal/ligand into the first inlet, injecting a solution of a reducing agent into the second inlet, injecting a solvent comprised of an ionic liquid into the third inlet, and injecting an inert carrier into the main inlet. The solution of the metal/ligand, the solution of the reducing agent, the solvent and the inert carrier are combined together in the main channel, and the metal/ligand and the reducing agent are reacted for a time sufficient to form a metal nanoparticle. | 04-11-2013 |
20130090633 | OSMOTIC PATCH PUMP - An osmotic patch pump may include a dry agent on a die-cut piece of film that may exert an osmotic pressure when dissolved by a fluid. A chamber may contain the dry agent and have a chamber wall made of a semi-permeable membrane that allows fluid to enter the chamber through the membrane, but does not allow dissolved agent to escape from the chamber through the membrane. A sponge may have a surface in contact with an outer surface of the semi-permeable membrane and may be configured to soak up fluid when placed in contact with the sponge. Flow volume and rate may be controlled by user-operated micro valves. The chamber and fluid communication channels may be embossed on a substrate as part of a simple and low cost manufacturing process. | 04-11-2013 |
20130118906 | METHOD AND SYSTEM FOR ENHANCING CATALYTIC AND PHOTOCATALYTIC PROCESSES - A system for solar energy conversion includes a photoelectric cell. The photoelectric cell includes a cathode and an anode comprising a nanostructure array. The nanostructure array includes a semiconductor photocatalyst; and a plasmon resonant metal nanostructure film arranged on the semiconductor photocatalyst. The system is used in a method to produce methane by placing a photocatalytic cell in an environment containing CO | 05-16-2013 |
20130134394 | Integrated Circuits Based on Aligned Nanotubes - Techniques, apparatus and systems are described for wafer-scale processing of aligned nanotube devices and integrated circuits. In one aspect, a method can include growing aligned nanotubes on at least one of a wafer-scale quartz substrate or a wafer-scale sapphire substrate. The method can include transferring the grown aligned nanotubes onto a target substrate. Also, the method can include fabricating at least one device based on the transferred nanotubes. | 05-30-2013 |
20130137649 | EPIGENETIC MECHANISMS OF ANTI-FIBROTIC ACTION FOR THE LIVER - This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis. | 05-30-2013 |
20130139575 | ACOUSTIC PARTICLE SORTING IN MICROFLUIDIC CHANNELS - A method for sensing and sorting single tiny particles in microfluidic channels may comprise subjecting the particles to ultrasound; detecting scattering of the ultrasound from these particles; and pushing or sorting these particles using ultrasound based on the scattered ultrasound that is detected. | 06-06-2013 |
20130144145 | IMPLANTABLE NEURAL TISSUE REPORTING PROBE AND METHODS OF MANUFACTURING AND IMPLANTING SAME - A method of manufacturing an implantable neural tissue reporting probe may include affixing multiple electrodes to polymeric material; heating the polymeric material to a temperature that is above its glass transition temperature, but below its melting temperature; applying force to the polymeric material while heated so as to cause the polymeric material to change into a shape that is suitable for implanting in neural tissue, the shape including a compartment having at least one opening therein sized to permit dendritic growth to occur through the opening from outside of the compartment to within the compartment after the probe is implanted; and allowing the polymeric material to cool down below its glass transition temperature while maintaining the shape of the compartment, including while maintaining the shape of the opening therein. Related probes and methods of implanting them into neural tissue are also disclosed. | 06-06-2013 |
20130144399 | 3-DIMENSIONAL PARYLENE SCAFFOLD CAGE - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane. | 06-06-2013 |
20130149245 | Novel Peptides and Uses Thereof - The invention relates to a peptide of 8-50 amino acids comprising the sequence of KAHKKRAD or KARKKHAD, or a cyclic peptide of 8-50 amino acids comprising the sequence of HKKR or RKKH. Also disclosed are methods of using the peptide for detecting, monitoring, or treating cancer. | 06-13-2013 |
20130149351 | POLYMER SCAFFOLDS AND THEIR USE IN THE TREATMENT OF VISION LOSS - The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss. | 06-13-2013 |
20130150960 | ACCOMMODATING INTRAOCULAR LENS - Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens. | 06-13-2013 |
20130151164 | Systems and Methods for Analyzing Microarrays - The present invention discloses methods and systems for analyzing microarray data. The method includes the general steps of providing microarray data, normalizing the data using a least trimmed squares regression, and then analyzing the normalized microarray data to obtain a desired result such as an expression profile. There is also disclosed a method of subdividing an array into subarrays before normalization. This approach provides a method for improving measurement accuracy and salvaging array data from arrays containing minor defects. Also disclosed is a Probe-Treatment-Reference (PTR) model for streamlining normalization and summarization of microarray data by allowing multiple references. Other aspects of the present invention include computer systems and computer readable media encoding methods of the present invention. | 06-13-2013 |
20130155061 | AUTONOMOUS PAVEMENT CONDITION ASSESSMENT - An autonomous pavement assessment system may receive depth data indicative of the depth of pixels that collectively comprise multiple defective areas of pavement. For each defective area, the system may fit a plane to it; generate a histogram that indicates the frequency of its pixels at different depths; dynamically determine a depth noise threshold for it; generate a binary image of it based on its noise threshold; and generate a depth map of it containing only the pixels that have a depth that meets or exceeds its depth noise threshold. The system may prioritize the multiple defective areas for repair and/or generate optimized rehabilitation routes. Crowd sourcing may be used to gather the depth data, as well as location information for each defective area. | 06-20-2013 |
20130177528 | COMPOSITIONS AND METHODS FOR INHIBITING VIRAL INFECTION - Provided herein are compositions and methods for inhibiting viral infection of a host cell. The methods comprise contacting the the host cell with an effective amount of one or more polypeptides having a disintegrin domain. The polypeptide can be CN, VCN or modified ADAM-derived polypeptide (MAP), or a fusion protein comprising a CN, VCN or MAP. | 07-11-2013 |
20130187919 | 3D Body Modeling, from a Single or Multiple 3D Cameras, in the Presence of Motion - The present disclosure describes systems and techniques relating to generating three dimensional (3D) models from range sensor data. According to an aspect, 3D point clouds are captured using a 3D camera, where each of the 3D point clouds corresponds to a different relative position of the 3D camera with respect to a body. One of the 3D point clouds can be set as a reference point cloud, and transforms can be determined for coordinates of the other captured 3D point clouds to transform these to coordinates of the reference point cloud. The body represented in the reference point cloud can be segmented into body parts corresponding to elements of a 3D part-based volumetric model including cylindrical representations, and a segmented representation of the physical object of interest can be generated in accordance with the 3D part-based volumetric model, while taking localized articulated motion into account. | 07-25-2013 |
20130190008 | PHYSICAL ACTIVITY MONITORING AND INTERVENTION USING SMARTPHONE AND MOBILE APP - A mobile software application may issue an alert when a user is not achieving a heath objective based on track movement of a mobile computer system that is running the application and being carried by the user and physical characteristics of the user. The software application may map information about the physical characteristics of the user to a user model and determine the energy being expended by the user based on the user model and movement information provided by the mobile computer system. The software application may determine the frequency of steps taken by the user by: bandpass filtering a time domain signal that is representative of the movement, transforming the filtered time domain signal into a frequency domain signal, and equating the step frequency with the frequency of the highest peak in the frequency domain signal. | 07-25-2013 |
20130191054 | DIGITAL CIRCUIT POWER MEASUREMENTS USING NUMERICAL ANALYSIS - Power consumed by a digital circuit that contains multiple sub-circuits may be computed. Each sub-circuit may include more than one transistor and have at least one input. A signal transition sensor may be connected to an input to each sub-circuit and configured to count the number of signal transitions at the input or to time the duration of a signal transition at the input. Weight information may be stored that is indicative of an amount of power that is being consumed by each sub-circuit based on a count that is counted by or a time duration that is timed by each signal transition sensor that is connected to an input of that sub-circuit. The amount of power being consumed by the digital circuit may be computed based on a count that is counted by or a time duration that is timed by each signal transition sensor and the weight information. | 07-25-2013 |
20130196369 | Methods of Culturing Retinal Pigmented Epithelium Cells, Including Xeno-Free Production, RPE Enrichment, and Cryopreservation - The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided. | 08-01-2013 |
20130197071 | PRODUCTION OF LIPOXYGENASE INHIBITORS VIA FUNGAL BIOSYNTHETIC PATHWAY - The invention provides methods for producing lipoxygenase inhibitors including the steps set forth in Schemes 2 and 3, and uses of the inhibitors produced by the methods set forth herein in to treat various disease states. | 08-01-2013 |
20130203998 | Synthesis of Drug Conjugates Via Reaction With Epoxide-Containing Linkers - The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases. | 08-08-2013 |
Patent application number | Description | Published |
20130210646 | HEMOMOSAIC: HIGH-THROUGHPUT TECHNIQUE FOR RARE CELL DETECTION IN LIQUID SAMPLES BY MASSIVELY MULTIPLEXED PCR IN A PHOTOLITHOGRAPHIC MATRIX - Described microfluidic technology focused on: 1) direct integration of microfluidic devices with solidified liquid tissue samples, 2) subordination of architectural and operational principles of microfluidic devices specific tissue structure and needs and/or 3) on-chip sample acquisition integrated with the detection measurement within the same device. In contrast to conventional methods of off-chip sample prep and subsequent insertion into a detection device, new applications are possible on solidified liquid or solid tissue samples, such as in situ PCR. | 08-15-2013 |
20130215919 | WIDEBAND TUNABLE LASER LINE-WIDTH REDUCTION - Various examples of feed-forward systems that reduce phase noise in a laser field generated by a laser. These include feed-forward systems that utilize phase and/or frequency discriminators, filters, integrators, voltage controlled oscillators (VCOs), current controlled oscillators (CCOs), phase modulators, and/or amplitude modulators. It also includes systems that use both feed-forward and feedback phase noise reduction systems, tunable semiconductor lasers, and multiple, sequential feed-forward systems. | 08-22-2013 |
20130226348 | SYSTEM AND METHOD FOR CONTROL PERFORMANCE MONITORING - A method for monitoring a control of a parameter of one or more devices or systems in an oil or gas production site includes receiving process data, the process data being a result of the control of the parameter of the one or more devices or systems in the production site; smoothing the process data using a polynomial filter while preserving features of the process data to obtain smoothed data; and applying a pattern recognition algorithm to the smoothed data to determine whether there is a malfunction condition in the one or more devices or systems. | 08-29-2013 |
20130345399 | METHOD OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES - This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity. Various approaches are used including fusion to thioredoxin, cytoplasmic expression of disulfide isomerases, deficiencies in thioredoxin and/or glutathione reductases, deficiencies in proteases, and the like. The method is applicable to express monomeric and dimeric forms of the eukaryotic protein with biological activity such as monomeric and dimeric forms of a disintegrin or a disintegrin domain. Included are the vectors, host cells expressing the proteins, the expressed proteins and methods of using the proteins. | 12-26-2013 |