Tyler M.
Tyler M. Dylan, San Diego, CA US
Patent application number | Description | Published |
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20090123367 | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases - The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. | 05-14-2009 |
Tyler M. Johnson, Piedmont, CA US
Patent application number | Description | Published |
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20130019260 | Combining Television Broadcast and Personalized/Interactive Information - The invention provides an improved method and system for interactive broadcast and web information browsing. In embodiments of the invention, web information is presented in conjunction with a broadcast television image, either at an edge of the image screen or overlaid with the image screen in an opaque, transparent or translucent image. The presented web information is fully interactive and can be interacted with by the user using all known features of interactive web presentation. | 01-17-2013 |
Tyler M. Peelen, Kirkland, WA US
Patent application number | Description | Published |
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20110307798 | Merging Modifications to User Interface Components While Preserving User Customizations - An application displays a user interface (UI) component. A client can apply customizations to this UI component. After the client applies customizations to the UI component, the client modifies a solution set containing solutions that modify the UI component. After the client modifies the solution set, the application displays a new version of the UI component. Modifications provided by the solutions in the solution set are applied to the new version of the UI component. In addition, the customizations remain applied to the UI component without the client manually re-applying the customizations to the UI component. | 12-15-2011 |